scholarly journals One Step Forward towards the Development of Eco-Friendly Antifouling Coatings: Immobilization of a Sulfated Marine-Inspired Compound

Marine Drugs ◽  
2020 ◽  
Vol 18 (10) ◽  
pp. 489
Author(s):  
Cátia Vilas-Boas ◽  
Francisca Carvalhal ◽  
Beatriz Pereira ◽  
Sílvia Carvalho ◽  
Emília Sousa ◽  
...  
Keyword(s):  
Water Solubility ◽  
Exposure Period ◽  
Natural Seawater ◽  
Chemical Immobilization ◽  
Antifouling Activity ◽  
Marine Biofouling ◽  
Marine Coatings ◽  
Antifouling Coatings ◽  
Environmental Properties ◽  
One Step

Marine biofouling represents a global economic and ecological challenge and few eco-friendly antifouling agents are available. The aim of this work was to establish the proof of concept that a recently synthesized nature-inspired compound (gallic acid persulfate, GAP) can act as an eco-friendly and effective antifoulant when immobilized in coatings through a non-release strategy, promoting a long-lasting antifouling effect. The synthesis of GAP was optimized to provide quantitative yields. GAP water solubility was assessed, showing values higher than 1000 mg/mL. GAP was found to be stable in sterilized natural seawater with a half-life (DT50) of 7 months. GAP was immobilized into several commercial coatings, exhibiting high compatibility with different polymeric matrices. Leaching assays of polydimethylsiloxane and polyurethane-based marine coatings containing GAP confirmed that the chemical immobilization of GAP was successful, since releases up to fivefold lower than the conventional releasing systems of polyurethane-based marine coatings were observed. Furthermore, coatings containing immobilized GAP exhibited the most auspicious anti-settlement effect against Mytilus galloprovincialis larvae for the maximum exposure period (40 h) in laboratory trials. Overall, GAP promises to be an agent capable of improving the antifouling activity of several commercial marine coatings with desirable environmental properties.

scholarly journals Experimental Assessment of the Performance of Two Marine Coatings to Curb Biofilm Formation of Microfoulers

Coatings ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 893 ◽  
Author(s):  
Sara I. Faria ◽  
Rita Teixeira-Santos ◽  
Luciana C. Gomes ◽  
Elisabete R. Silva ◽  
João Morais ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Laser Scanning ◽  
Critical Role ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Marine Biofouling ◽  
Marine Coatings ◽  
Antifouling Coatings ◽  
Wet Weight ◽  
Biofilm Structure

Biofilms formed on submerged marine surfaces play a critical role in the fouling process, causing increased fuel consumption, corrosion, and high maintenance costs. Thus, marine biofouling is a major issue and motivates the development of antifouling coatings. In this study, the performance of two commercial marine coatings, a foul-release silicone-based paint (SilRef) and an epoxy resin (EpoRef), was evaluated regarding their abilities to prevent biofilm formation by Cyanobium sp. and Pseudoalteromonas tunicata (common microfoulers). Biofilms were developed under defined hydrodynamic conditions to simulate marine settings, and the number of biofilm cells, wet weight, and thickness were monitored for 7 weeks. The biofilm structure was analyzed by confocal laser scanning microscopy (CLSM) at the end-point. Results demonstrated that EpoRef surfaces were effective in inhibiting biofilm formation at initial stages (until day 28), while SilRef surfaces showed high efficacy in decreasing biofilm formation during maturation (from day 35 onwards). Wet weight and thickness analysis, as well as CLSM data, indicate that SilRef surfaces were less prone to biofilm formation than EpoRef surfaces. Furthermore, the efficacy of SilRef surfaces may be dependent on the fouling microorganism, while the performance of EpoRef was strongly influenced by a combined effect of surface and microorganism.

scholarly journals Flavonoid Glycosides with a Triazole Moiety for Marine Antifouling Applications: Synthesis and Biological Activity Evaluation

Marine Drugs ◽  
2020 ◽  
Vol 19 (1) ◽  
pp. 5
Author(s):  
Daniela Pereira ◽  
Catarina Gonçalves ◽  
Beatriz T. Martins ◽  
Andreia Palmeira ◽  
Vitor Vasconcelos ◽  
...  
Keyword(s):  
Qsar Model ◽  
Quantitative Structure Activity Relationship ◽  
Artemia Salina ◽  
Flavonoid Glycosides ◽  
Antifouling Activity ◽  
Antifouling Coatings ◽  
Marine Industry ◽  
Low Toxicity ◽  
Polymethoxylated Flavones ◽  
First Time

Over the last decades, antifouling coatings containing biocidal compounds as active ingredients were used to prevent biofouling, and eco-friendly alternatives are needed. Previous research from our group showed that polymethoxylated chalcones and glycosylated flavones obtained by synthesis displayed antifouling activity with low toxicity. In this work, ten new polymethoxylated flavones and chalcones were synthesized for the first time, including eight with a triazole moiety. Eight known flavones and chalcones were also synthesized and tested in order to construct a quantitative structure-activity relationship (QSAR) model for these compounds. Three different antifouling profiles were found: three compounds (1b, 11a and 11b) exhibited anti-settlement activity against a macrofouling species (Mytilus galloprovincialis), two compounds (6a and 6b) exhibited inhibitory activity against the biofilm-forming marine bacteria Roseobacter litoralis and one compound (7b) exhibited activity against both mussel larvae and microalgae Navicula sp. Hydrogen bonding acceptor ability of the molecule was the most significant descriptor contributing positively to the mussel larvae anti-settlement activity and, in fact, the triazolyl glycosylated chalcone 7b was the most potent compound against this species. The most promising compounds were not toxic to Artemia salina, highlighting the importance of pursuing the development of new synthetic antifouling agents as an ecofriendly and sustainable alternative for the marine industry.

scholarly journals Semisynthetic Analogs of the Antibiotic Fidaxomicin – Design, Synthesis, and Biological Evaluation

2020 ◽  
Author(s):  
Andrea Dorst ◽  
Regina Berg ◽  
Christoph Gertzen ◽  
Daniel Schäfle ◽  
katja zerbe ◽  
...  
Keyword(s):  
Structural Design ◽  
Water Solubility ◽  
Biological Evaluation ◽  
Protecting Group ◽  
Design Synthesis ◽  
Gram Positive Bacteria ◽  
Excellent Activity ◽  
One Step ◽  
Hybrid Antibiotics ◽  
Synthesis And Biological Evaluation

<p>The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good to excellent activity against Gram-positive bacteria and was approved for the treatment of Clostridium difficile infections (CDI). Main limitations of the compound include low water solubility, which impacts further clinical use. We report on the synthesis of new fidaxomicin derivatives based on structural design and utilizing an operationally simple one-step protecting group-free preparative approach from the natural product. An increase in solubility of up to 25-fold with largely retained activity was observed. Furthermore, hybrid antibiotics were prepared that show improved antibiotic activities</p>

scholarly journals Recent Advances in Mussel-Inspired Synthetic Polymers as Marine Antifouling Coatings

Coatings ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 653 ◽  
Author(s):  
Ioannis Manolakis ◽  
Usaid Azhar
Keyword(s):  
Amino Acid Derivative ◽  
Self Healing ◽  
Underwater Adhesion ◽  
Marine Biofouling ◽  
Recent Advances ◽  
Antifouling Coatings ◽  
The Common ◽  
Active Research ◽  
Research Domain ◽  
Marine Antifouling

Synthetic oligomers and polymers inspired by the multifunctional tethering system (byssus) of the common mussel (genus Mytilus) have emerged since the 1980s as a very active research domain within the wider bioinspired and biomimetic materials arena. The unique combination of strong underwater adhesion, robust mechanical properties and self-healing capacity has been linked to a large extent to the presence of the unusual α-amino acid derivative l-DOPA (l-3,4-dihydroxyphenylalanine) as a building block of the mussel byssus proteins. This paper provides a short overview of marine biofouling, discussing the different marine biofouling species and natural defenses against these, as well as biomimicry as a concept investigated in the marine antifouling context. A detailed discussion of the literature on the Mytilus mussel family follows, covering elements of their biology, biochemistry and the specific measures adopted by these mussels to utilise their l-DOPA-rich protein sequences (and specifically the ortho-bisphenol (catechol) moiety) in their benefit. A comprehensive account is then given of the key catechol chemistries (covalent and non-covalent/intermolecular) relevant to adhesion, cohesion and self-healing, as well as of some of the most characteristic mussel protein synthetic mimics reported over the past 30 years and the related polymer functionalisation strategies with l-DOPA/catechol. Lastly, we review some of the most recent advances in such mussel-inspired synthetic oligomers and polymers, claimed as specifically aimed or intended for use in marine antifouling coatings and/or tested against marine biofouling species.

scholarly journals Antifouling Napyradiomycins from Marine-Derived Actinomycetes Streptomyces aculeolatus

Marine Drugs ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 63 ◽  
Author(s):  
Florbela Pereira ◽  
Joana R. Almeida ◽  
Marisa Paulino ◽  
Inês R. Grilo ◽  
Helena Macedo ◽  
...  
Keyword(s):  
Mytilus Galloprovincialis ◽  
Cost Effective ◽  
In Silico Prediction ◽  
Antifouling Activity ◽  
Marine Biofouling ◽  
Immersed Surfaces ◽  
Madeira Archipelago ◽  
Order Of Magnitude ◽  
Environmentally Safe ◽  
Approved Drugs

The undesired attachment of micro and macroorganisms on water-immersed surfaces, known as marine biofouling, results in severe prevention and maintenance costs (billions €/year) for aquaculture, shipping and other industries that rely on coastal and off-shore infrastructures. To date, there are no sustainable, cost-effective and environmentally safe solutions to address this challenging phenomenon. Therefore, we investigated the antifouling activity of napyradiomycin derivatives that were isolated from actinomycetes from ocean sediments collected off the Madeira Archipelago. Our results revealed that napyradiomycins inhibited ≥80% of the marine biofilm-forming bacteria assayed, as well as the settlement of Mytilus galloprovincialis larvae (EC50 < 5 µg/ml and LC50/EC50 >15), without viability impairment. In silico prediction of toxicity end points are of the same order of magnitude of standard approved drugs and biocides. Altogether, napyradiomycins disclosed bioactivity against marine micro and macrofouling organisms, and non-toxic effects towards the studied species, displaying potential to be used in the development of antifouling products.

scholarly journals Polymeric Coatings Based on Water-Soluble Trimethylammonium Copolymers for Antifouling Applications

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1678
Author(s):  
Artemis Tsagdi ◽  
Denisa Druvari ◽  
Dionisios Panagiotaras ◽  
Pavlos Avramidis ◽  
Vlasoula Bekiari ◽  
...  
Keyword(s):  
Polymeric Materials ◽  
Water Soluble ◽  
Random Copolymers ◽  
Polymeric Coatings ◽  
Short Time Period ◽  
Antifouling Activity ◽  
Antifouling Coatings ◽  
Time Period ◽  
Contact Killing ◽  
Short Time

Crosslinked polymeric materials based on a quaternary trimethylammonium compound were developed and evaluated as potential antifouling coatings. For this purpose, two water-soluble random copolymers, poly(4-vinylbenzyltrimethylammonium chloride-co-acrylic acid) P(VBCTMAM-co-AAx) and poly(N,N-dimethylacrylamide-co-glycidylmethacrylate) P(DMAm-co-GMAx), were synthesized via free radical polymerization. A water based approach for the synthesis of P(VBCTMAM-co-AAx) copolymer was used. Coatings of the complementary reactive copolymers in different compositions were obtained by curing at 120 °C for one day and were used to coat aquaculture nets. These nets were evaluated in respect to their release rate using Total Organic Carbon (TOC) and Total Nitrogen (TN) measurements. Finally, the antifouling efficacy of these newly-composed durable coatings was investigated for 14 days in accelerated conditions. The results showed that this novel polymeric material provides contact-killing antifouling activity for a short time period, whereas it functions efficiently in biofouling removal after high-pressure cleaning.

Simultaneous bio-reduction of trichloroethene, trichloroethane, and chloroform using a hydrogen-based membrane biofilm reactor

2008 ◽  
Vol 58 (3) ◽  
pp. 495-501 ◽  
Author(s):  
Jinwook Chung ◽  
Bruce E. Rittmann
Keyword(s):  
Electron Donor ◽  
Water Solubility ◽  
Chlorinated Solvents ◽  
Technological Advance ◽  
Biofilm Reactor ◽  
Treatment Technology ◽  
Chlorinated Compounds ◽  
Membrane Biofilm Reactor ◽  
One Step ◽  
Inhibitory Interactions

The contamination of water by chlorinated solvents is recognized as a serious and widespread problem throughout the industrialized world. Here, we focus on three chlorinated solvents that are among those most commonly detected and that have distinct chemical features: trichloroethene (TCE), trichloroethane (TCA), and chloroform (CF). Because many contaminated waters contain mixtures of the chlorinated solvents, a treatment technology that detoxifies all of them simultaneously is highly desirable. The membrane biofilm reactor (MBfR) is a recent technological advance that makes it possible to deliver H2 gas to bacteria efficiently and safely, despite hydrogen's low water solubility and risk of forming a combustible atmosphere when mixed with air. The objectives of this work are to document whether or not the three chlorinated compounds can be dechlorinated simultaneously in a H2-based MBfR and to determine if competitive or inhibitory interactions affect bio-reduction of any of the solvents. The main finding is a demonstration that directly using H2 as the electron donor makes it possible to bio-reduce combinations of different chlorinated solvents. This finding supports that the H2-based MBfR can treat multiple chlorinated solvents in one step, addressing a common groundwater situation. We saw possible evidence of inhibition by CF at a concentration greater than about 1 μM, competition for H2 from sulfate and nitrate reductions, and possible inhibition of TCE reduction from the accumulation of chloroethane (CA) or chloromethane (CM).

Green Synthetic Fluorescent Carbon Quantum Dot as pH Sensor Applied to Real Water Samples Determination

NANO ◽  
2021 ◽  
pp. 2150093
Author(s):  
Yong Zhang ◽  
Sijie Cheng ◽  
Yanteng Xiao ◽  
Yingte Wang
Keyword(s):  
Water Samples ◽  
Water Solubility ◽  
Ph Sensor ◽  
Blue Emission ◽  
Carbon Quantum Dots ◽  
Raw Material ◽  
Narrow Particle Size Distribution ◽  
Ph Response ◽  
Real Water Samples ◽  
One Step

Willow, a common tree species, is mainly distributed in temperate regions of the Northern Hemisphere. Catkins are the seeds of willow. In addition to propagating new willows, it is of great significance to study its application in other areas. Carbon quantum dots (CQDs) have attracted extensive attention owing to their excellent luminescence properties, low toxicity and water solubility. The use of CQDs for accurate measurement of pH is of great significance in environmental, medical and other fields. Based on this, blue-emission fluorescent CQDs with 4.93% quantum yield (Q.Y.) are prepared via natural product catkins as the only raw material by one-step hydrothermal method. The prepared CQDs exhibit excellent water solubility, narrow particle size distribution, excitation-dependent photoluminescence properties and sensitive pH response behavior. The fluorescence intensity of CQDs has a good linear relationship with pH in the range of 6–12, and the correlation coefficient is 0.994. In addition, the CQDs have good stability, and the response to pH displays excellent reversibility, which can be developed as a pH sensor to quantitatively monitor the pH values in real water samples. Thereby, the potential practical application is promising.

Research Progress of Environmentally Friendly Marine Antifouling Coatings

2021 ◽  
Author(s):  
Mengyue Liu ◽  
Shaonan Li ◽  
Hao Wang ◽  
Rijia Jiang ◽  
Xing Zhou
Keyword(s):  
Environmentally Friendly ◽  
Research Progress ◽  
Marine Biofouling ◽  
Antifouling Coatings ◽  
Marine Antifouling

Marine biofouling has brought a serious impact on human marine production and transportation activities. Applying antifouling coatings is an effective method to prevent marine biofouling. Here, we have conducted a...

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