scholarly journals Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential

Marine Drugs ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 197
Author(s):  
Imen Saadaoui ◽  
Rihab Rasheed ◽  
Nabeel Abdulrahman ◽  
Touria Bounnit ◽  
Maroua Cherif ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chemical Structure ◽  
Large Scale ◽  
Causes Of Death ◽  
Value Added ◽  
Economic Feasibility ◽  
Bioactive Molecules ◽  
Promising Alternative ◽  
Promising Source ◽  
Derivatives Of

Lung cancer is one of the major causes of death worldwide. Natural molecules with anti-lung cancer potential are of a great interest and considered as very promising alternative to substitute or enhance the efficiency of the conventional drugs. Recently, algae as source of high value-added compounds are considered as very promising source of these bioactive molecules. These are secondary metabolites that consist mainly of derivatives of peptides, carbohydrates, and lipids with various structures. Accordingly, various mechanisms by which different algae molecules demonstrate attenuation of tumor angiogenesis were stated and discussed. The mode of action of the algae bioactives is closely related to their nature and chemical structure. Furthermore, this literature review considers the synergistic effect between microalgae bioactives and conventional drugs and discuss the economic feasibility of producing microalgae bioactives at large scale to conclude with some future perspectives related to algae-based drug discovery.

scholarly journals Towards the Large-Scale Electrochemical Reduction of Carbon Dioxide

Catalysts ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 253
Author(s):  
Subin Park ◽  
Devina Thasia Wijaya ◽  
Jonggeol Na ◽  
Chan Woo Lee
Keyword(s):  
Electrochemical Reduction ◽  
Large Scale ◽  
Value Added ◽  
Co2 Concentration ◽  
Causative Factor ◽  
Economic Feasibility ◽  
Practical Implementation ◽  
Scale Production ◽  
Chemical Production ◽  
Faradaic Efficiency

The severe increase in the CO2 concentration is a causative factor of global warming, which accelerates the destruction of ecosystems. The massive utilization of CO2 for value-added chemical production is a key to commercialization to guarantee both economic feasibility and negative carbon emission. Although the electrochemical reduction of CO2 is one of the most promising technologies, there are remaining challenges for large-scale production. Herein, an overview of these limitations is provided in terms of devices, processes, and catalysts. Further, the economic feasibility of the technology is described in terms of individual processes such as reactions and separation. Additionally, for the practical implementation of the electrochemical CO2 conversion technology, stable electrocatalytic performances need to be addressed in terms of current density, Faradaic efficiency, and overpotential. Hence, the present review also covers the known degradation behaviors and mechanisms of electrocatalysts and electrodes during electrolysis. Furthermore, strategic approaches for overcoming the stability issues are introduced based on recent reports from various research areas involved in the electrocatalytic conversion.

Role of Exosomes in Photodynamic Anticancer Therapy

2020 ◽  
Vol 27 (40) ◽  
pp. 6815-6824 ◽  
Author(s):  
Yuan Jiang ◽  
Chuanshan Xu ◽  
Wingnang Leung ◽  
Mei Lin ◽  
Xiaowen Cai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Basic Principle ◽  
Photochemical Reaction ◽  
Cell Communication ◽  
Anticancer Therapy ◽  
Bioactive Molecules ◽  
Promising Alternative ◽  
Tumor Tissues ◽  
Significant Attention

Photodynamic Therapy (PDT) is a promising alternative treatment for malignancies based on photochemical reaction induced by Photosensitizers (PS) under light irradiation. Recent studies show that PDT caused the abundant release of exosomes from tumor tissues. It is well-known that exosomes as carriers play an important role in cell-cell communication through transporting many kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore the role of exosomes in photodynamic anticancer therapy has been attracting significant attention. In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and boost the development of PDT.

Efficient Schedule of Energy-Constrained UAV Using Crowdsourced Buses in Last-Mile Parcel Delivery

2021 ◽  
Vol 5 (1) ◽  
pp. 1-23
Author(s):  
Yan Pan ◽  
Shining Li ◽  
Qianwu Chen ◽  
Nan Zhang ◽  
Tao Cheng ◽  
...  
Keyword(s):  
Traffic Congestion ◽  
Large Scale ◽  
Load Capacity ◽  
Scheduling Algorithm ◽  
Cost Effective ◽  
Promising Alternative ◽  
Logistics Industry ◽  
Last Mile ◽  
Delivery Scheduling ◽  
Schedule Approach

Stimulated by the dramatical service demand in the logistics industry, logistics trucks employed in last-mile parcel delivery bring critical public concerns, such as heavy cost burden, traffic congestion and air pollution. Unmanned Aerial Vehicles (UAVs) are a promising alternative tool in last-mile delivery, which is however limited by insufficient flight range and load capacity. This paper presents an innovative energy-limited logistics UAV schedule approach using crowdsourced buses. Specifically, when one UAV delivers a parcel, it first lands on a crowdsourced social bus to parcel destination, gets recharged by the wireless recharger deployed on the bus, and then flies from the bus to the parcel destination. This novel approach not only increases the delivery range and load capacity of battery-limited UAVs, but is also much more cost-effective and environment-friendly than traditional methods. New challenges therefore emerge as the buses with spatiotemporal mobility become the bottleneck during delivery. By landing on buses, an Energy-Neutral Flight Principle and a delivery scheduling algorithm are proposed for the UAVs. Using the Energy-Neutral Flight Principle, each UAV can plan a flying path without depleting energy given buses with uncertain velocities. Besides, the delivery scheduling algorithm optimizes the delivery time and number of delivered parcels given warehouse location, logistics UAVs, parcel locations and buses. Comprehensive evaluations using a large-scale bus dataset demonstrate the superiority of the innovative logistics UAV schedule approach.

scholarly journals Multi-Country Scale Assessment of Available Energy Recovery Potential Using Micro-Hydropower in Drinking, Pressurised Irrigation and Wastewater Networks, Covering Part of the EU

Water ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 899
Author(s):  
Djordje Mitrovic ◽  
Miguel Crespo Chacón ◽  
Aida Mérida García ◽  
Jorge García Morillo ◽  
Juan Antonio Rodríguez Diaz ◽  
...  
Keyword(s):  
Drinking Water ◽  
Northern Ireland ◽  
Energy Recovery ◽  
Large Scale ◽  
Significant Proportion ◽  
Value Added ◽  
Cost Effective ◽  
Net Energy ◽  
Water Networks ◽  
Scale Assessment

Studies have shown micro-hydropower (MHP) opportunities for energy recovery and CO2 reductions in the water sector. This paper conducts a large-scale assessment of this potential using a dataset amassed across six EU countries (Ireland, Northern Ireland, Scotland, Wales, Spain, and Portugal) for the drinking water, irrigation, and wastewater sectors. Extrapolating the collected data, the total annual MHP potential was estimated between 482.3 and 821.6 GWh, depending on the assumptions, divided among Ireland (15.5–32.2 GWh), Scotland (17.8–139.7 GWh), Northern Ireland (5.9–8.2 GWh), Wales (10.2–8.1 GWh), Spain (375.3–539.9 GWh), and Portugal (57.6–93.5 GWh) and distributed across the drinking water (43–67%), irrigation (51–30%), and wastewater (6–3%) sectors. The findings demonstrated reductions in energy consumption in water networks between 1.7 and 13.0%. Forty-five percent of the energy estimated from the analysed sites was associated with just 3% of their number, having a power output capacity >15 kW. This demonstrated that a significant proportion of energy could be exploited at a small number of sites, with a valuable contribution to net energy efficiency gains and CO2 emission reductions. This also demonstrates cost-effective, value-added, multi-country benefits to policy makers, establishing the case to incentivise MHP in water networks to help achieve the desired CO2 emissions reductions targets.

scholarly journals Multigram synthesis of an orthogonally protected pentasaccharide for use as glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide

2021 ◽  
Author(s):  
Johan Cornil ◽  
Zhaoyu Hu ◽  
Marion Bouchet ◽  
Laurence A. MULARD
Keyword(s):  
Conjugate Vaccine ◽  
Large Scale ◽  
Shigella Flexneri ◽  
Bioactive Molecules

The rapidly growing interest for carbohydrate-based bioactive molecules calls for strategies enabling appropriate design and large scale delivery of the glycan moiety. Here, we described a robust and high-yielding chemical...

scholarly journals Prenatal Nutritional Strategies to Reduce the Risk of Preterm Birth

2021 ◽  
pp. 1-9
Author(s):  
Karen Patricia Best ◽  
Judith Gomersall ◽  
Maria Makrides
Keyword(s):  
Preterm Birth ◽  
Large Scale ◽  
Cochrane Review ◽  
Cost Effective ◽  
Omega 3 ◽  
Promising Alternative ◽  
Nutritional Interventions ◽  
Dietary Nutrients ◽  
Preterm Babies ◽  
Nutritional Strategies

Worldwide, around 15 million preterm babies are born annually, and despite intensive research, the specific mechanisms triggering preterm birth (PTB) remain unclear. Cost-effective primary prevention strategies to reduce PTB are required, and nutritional interventions offer a promising alternative. Nutrients contribute to a variety of mechanisms that are potentially important to preterm delivery, such as infection, inflammation, oxidative stress, and muscle contractility. Several observational studies have explored the association between dietary nutrients and/or dietary patterns and PTB, often with contrasting results. Randomized trial evidence on the effects of supplementation with zinc, multiple micronutrients (iron and folic acid), and vitamin D is promising; however, results are inconsistent, and many studies are not adequately powered for outcomes of PTB. Large-scale clinical trials with PTB as the primary outcome are needed before any firm conclusions can be drawn for these nutrients. The strongest evidence to date for a nutritional solution exists for omega-3 long-chain polyunsaturated fatty acids (LCPUFAs), key nutrients in fish. In 2018, a Cochrane Review (including 70 studies) showed that prenatal supplementation with omega-3 LCPUFAs reduced the risk of PTB and early PTB (EPTB) compared with no omega-3 supplementation. However, the largest trial of omega-3 supplementation in pregnancy, the Omega-3 to Reduce the Incidence of Prematurity (ORIP) trial (<i>n</i> = 5,544), showed no reduction in EPTB and a reduction in PTB only in a prespecified analysis of singleton pregnancies. Exploratory analyses from the ORIP trial found that women with low baseline total omega-3 status were at higher risk of EPTB, and that this risk was substantially reduced with omega-3 supplementation. In contrast, women with replete or high baseline total omega-3 status were already at low risk of EPTB and additional omega-3 supplementation increased the risk of EPTB compared to control. These findings suggest that determining an individual woman’s PUFA status may be the most precise way to inform recommendations to reduce her risk of PTB.

scholarly journals Stand-Alone Direct Current Power Network Based on Photovoltaics and Lithium-Ion Batteries for Reverse Osmosis Desalination Plant

Energies ◽  
2021 ◽  
Vol 14 (10) ◽  
pp. 2772
Author(s):  
Vishwas Powar ◽  
Rajendra Singh
Keyword(s):  
Reverse Osmosis ◽  
Direct Current ◽  
Cyber Security ◽  
Large Scale ◽  
Lithium Ion ◽  
Economic Feasibility ◽  
Power Network ◽  
Variable Effect ◽  
Desalination Plant ◽  
Reverse Osmosis Desalination

Plummeting reserves and increasing demand of freshwater resources have culminated into a global water crisis. Desalination is a potential solution to mitigate the freshwater shortage. However, the process of desalination is expensive and energy-intensive. Due to the water-energy-climate nexus, there is an urgent need to provide sustainable low-cost electrical power for desalination that has the lowest impact on climate and related ecosystem challenges. For a large-scale reverse osmosis desalination plant, we have proposed the design and analysis of a photovoltaics and battery-based stand-alone direct current power network. The design methodology focusses on appropriate sizing, optimum tilt and temperature compensation techniques based on 10 years of irradiation data for the Carlsbad Desalination Plant in California, USA. A decision-tree approach is employed for ensuring hourly load-generation balance. The power flow analysis evaluates self-sufficient generation even during cloud cover contingencies. The primary goal of the proposed system is to maximize the utilization of generated photovoltaic power and battery energy storage with minimal conversions and transmission losses. The direct current based topology includes high-voltage transmission, on-the-spot local inversion, situational awareness and cyber security features. Lastly, economic feasibility of the proposed system is carried out for a plant lifetime of 30 years. The variable effect of utility-scale battery storage costs for 16–18 h of operation is studied. Our results show that the proposed design will provide low electricity costs ranging from 3.79 to 6.43 ¢/kWh depending on the debt rate. Without employing the concept of baseload electric power, photovoltaics and battery-based direct current power networks for large-scale desalination plants can achieve tremendous energy savings and cost reduction with negligible carbon footprint, thereby providing affordable water for all.

scholarly journals Optimizing the catalytic activities of methanol and thermotolerant Kocuria flava lipases for biodiesel production from cooking oil wastes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Azhar Najjar ◽  
Elhagag Ahmed Hassan ◽  
Nidal Zabermawi ◽  
Saber H. Saber ◽  
Leena H. Bajrai ◽  
...  
Keyword(s):  
Ph Value ◽  
Energy Content ◽  
Value Added ◽  
Relative Activity ◽  
Economic Feasibility ◽  
Biodiesel Production ◽  
Molar Ratios ◽  
Cooking Oil ◽  
Enzyme Biocatalysis ◽  
Methanol Tolerant

AbstractIn this study, two highly thermotolerant and methanol-tolerant lipase-producing bacteria were isolated from cooking oil and they exhibited a high number of catalytic lipase activities recording 18.65 ± 0.68 U/mL and 13.14 ± 0.03 U/mL, respectively. Bacterial isolates were identified according to phenotypic and genotypic 16S rRNA characterization as Kocuria flava ASU5 (MT919305) and Bacillus circulans ASU11 (MT919306). Lipases produced from Kocuria flava ASU5 showed the highest methanol tolerance, recording 98.4% relative activity as well as exhibited high thermostability and alkaline stability. Under the optimum conditions obtained from 3D plots of response surface methodology design, the Kocuria flava ASU5 biocatalyst exhibited an 83.08% yield of biodiesel at optimized reaction variables of, 60 ○C, pH value 8 and 1:2 oil/alcohol molar ratios in the reaction mixture. As well as, the obtained results showed the interactions of temperature/methanol were significant effects, whereas this was not noted in the case of temperature/pH and pH/methanol interactions. The obtained amount of biodiesel from cooking oil was 83.08%, which was analyzed by a GC/Ms profile. The produced biodiesel was confirmed by Fourier-transform infrared spectroscopy (FTIR) approaches showing an absorption band at 1743 cm−1, which is recognized for its absorption in the carbonyl group (C=O) which is characteristic of ester absorption. The energy content generated from biodiesel synthesized was estimated as 12,628.5 kJ/mol. Consequently, Kocuria flava MT919305 may provide promising thermostable, methanol-tolerant lipases, which may improve the economic feasibility and biotechnology of enzyme biocatalysis in the synthesis of value-added green chemicals.

Value-added derivatives of soda lignin from alfa grass (Stipa tenacissima). I. Modification and characterization

2010 ◽  
Vol 115 (3) ◽  
pp. 1546-1554 ◽  
Author(s):  
H. Nadji ◽  
Y. Bedard ◽  
A. Benaboura ◽  
D. Rodrigue ◽  
T. Stevanovic ◽  
...  
Keyword(s):  
Value Added ◽  
Stipa Tenacissima ◽  
Soda Lignin ◽  
Derivatives Of
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