scholarly journals Marine Natural Products from Microalgae: An -Omics Overview

Marine Drugs ◽  
2019 ◽  
Vol 17 (5) ◽  
pp. 269 ◽  
Author(s):  
Chiara Lauritano ◽  
Maria Immacolata Ferrante ◽  
Alessandra Rogato
Keyword(s):  
Natural Products ◽  
Metabolic Pathways ◽  
Marine Natural Products ◽  
Biomedical Applications ◽  
Bioactive Metabolites ◽  
Future Perspectives ◽  
Genome Sequences ◽  
Comprehensive Overview ◽  
Wide Range ◽  
Broad Variety

Over the last decade, genome sequences and other -omics datasets have been produced for a wide range of microalgae, and several others are on the way. Marine microalgae possess distinct and unique metabolic pathways, and can potentially produce specific secondary metabolites with biological activity (e.g., antipredator, allelopathic, antiproliferative, cytotoxic, anticancer, photoprotective, as well as anti-infective and antifouling activities). Because microalgae are very diverse, and adapted to a broad variety of environmental conditions, the chances to find novel and unexplored bioactive metabolites with properties of interest for biotechnological and biomedical applications are high. This review presents a comprehensive overview of the current efforts and of the available solutions to produce, explore and exploit -omics datasets, with the aim of identifying species and strains with the highest potential for the identification of novel marine natural products. In addition, funding efforts for the implementation of marine microalgal -omics resources and future perspectives are presented as well.

scholarly journals 2nd GCC Marine Biotechnology conference: emerging opportunities and future perspectives

2019 ◽  
Vol 23 ◽  
pp. 48
Author(s):  
Sergey Dobretsov
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Plenary Lecture ◽  
Future Perspectives ◽  
Marine Biotechnology ◽  
Sultan Qaboos University ◽  
Final Session ◽  
Marine Biofouling ◽  
Center Of Excellence ◽  
Poster Presentations

2nd GCC Marine biotechnology conference was held at Sultan Qaboos University, 31 October – 1 November 2017. The conference was organized by the Center of Excellence in Marine Biotechnology, SQU. The conference focused on four major themes, including Genetics and biodiversity, Marine biofouling and its prevention, Marine natural products, and Aquaculture and fisheries. In total, 160 delegates from 23 different countries were registered for this conference and 106 delegates attended the conference. One plenary lecture and three keynote addresses were given, 39 oral and 30 poster presentations were made. The final session reviewed national and regional issues and identified some of the main challenges in marine biotechnology in the region.

scholarly journals Marine Natural Products: A Source of Novel Anticancer Drugs

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 491 ◽  
Author(s):  
Shaden A. M. Khalifa ◽  
Nizar Elias ◽  
Mohamed A. Farag ◽  
Lei Chen ◽  
Aamer Saeed ◽  
...  
Keyword(s):  
Natural Products ◽  
Anticancer Drugs ◽  
Marine Natural Products ◽  
Molecular Mechanisms ◽  
Biological Effects ◽  
Marine Organisms ◽  
New Drugs ◽  
Bioactive Metabolites ◽  
Chemical Structures ◽  
The Impact

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

Total synthesis of bryostatin 3

Science ◽  
2020 ◽  
Vol 368 (6494) ◽  
pp. 1007-1011 ◽  
Author(s):  
Barry M. Trost ◽  
Youliang Wang ◽  
Andreas K. Buckl ◽  
Zhongxing Huang ◽  
Minh H. Nguyen ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Step Count ◽  
Total Syntheses ◽  
Linear Sequence ◽  
Wide Range

Bryostatins are a family of 21 complex marine natural products with a wide range of potent biological activities. Among all the 21 bryostatins, bryostatin 3 is structurally the most complex. Whereas nine total syntheses of bryostatins have been achieved to date, bryostatin 3 has only been targeted once and required the highest number of steps to synthesize (43 steps in the longest linear sequence and 88 total steps). Here, we report a concise total synthesis of bryostatin 3 using 22 steps in the longest linear sequence and 31 total steps through a highly convergent synthetic plan by the use of highly atom-economical and chemoselective transformations in which alkynes played a major role in reducing step count.

Conopeptides, Marine Natural Products from Venoms: Biomedical Applications and Future Research Applications

2015 ◽  
pp. 463-496 ◽  
Author(s):  
Baldomero Olivera ◽  
Helena Safavi-­Hemami ◽  
Martin Horvath ◽  
Russell Teichert
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biomedical Applications ◽  
Future Research

scholarly journals Marine Natural Products from Tunicates and Their Associated Microbes

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 308
Author(s):  
Chatragadda Ramesh ◽  
Bhushan Rao Tulasi ◽  
Mohanraju Raju ◽  
Narsinh Thakur ◽  
Laurent Dufossé
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Biological Properties ◽  
Anticancer Activities ◽  
Microbial Association ◽  
Wide Range ◽  
Microbial Groups ◽  
Global Oceans

Marine tunicates are identified as a potential source of marine natural products (MNPs), demonstrating a wide range of biological properties, like antimicrobial and anticancer activities. The symbiotic relationship between tunicates and specific microbial groups has revealed the acquisition of microbial compounds by tunicates for defensive purpose. For instance, yellow pigmented compounds, “tambjamines”, produced by the tunicate, Sigillina signifera (Sluiter, 1909), primarily originated from their bacterial symbionts, which are involved in their chemical defense function, indicating the ecological role of symbiotic microbial association with tunicates. This review has garnered comprehensive literature on MNPs produced by tunicates and their symbiotic microbionts. Various sections covered in this review include tunicates’ ecological functions, biological activities, such as antimicrobial, antitumor, and anticancer activities, metabolic origins, utilization of invasive tunicates, and research gaps. Apart from the literature content, 20 different chemical databases were explored to identify tunicates-derived MNPs. In addition, the management and exploitation of tunicate resources in the global oceans are detailed for their ecological and biotechnological implications.

Chemical and Bioactive Marine Natural Products of Coral-Derived Microorganisms (2015-2017)

2019 ◽  
Vol 26 (38) ◽  
pp. 6930-6941 ◽  
Author(s):  
Xue-Mei Hou ◽  
Yang Hai ◽  
Yu-Cheng Gu ◽  
Chang-Yun Wang ◽  
Chang-Lun Shao
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Pathogenic Bacteria ◽  
Tumor Cell Lines ◽  
Biological Targets ◽  
Wide Range ◽  
New Compounds ◽  
Novel Products

: Coral-derived microorganisms are known for their inherent ability to produce novel products of pharmaceutical importance. Nearly 260 marine natural products (MNPs) have been isolated from coral-derived microorganisms till 2014. In the last three years, 118 MNPs have been isolated from coral-associated microorganisms including 46 new compounds, two with a novel skeleton, and four new natural products. Most of them exhibited in vitro or in vivo activities against tumor cell lines, parasites, pathogenic bacteria, fungi and virus. We reviewed the natural products reported from 2015 to 2017 that have a wide range of bioactivities against different biological targets.

scholarly journals Promising Activities of Marine Natural Products against Hematopoietic Malignancies

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 645
Author(s):  
Assunta Saide ◽  
Sara Damiano ◽  
Roberto Ciarcia ◽  
Chiara Lauritano
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Who Classification ◽  
Mechanisms Of Action ◽  
Bioactive Metabolites ◽  
Hematopoietic Malignancies ◽  
Bioactive Secondary Metabolites ◽  
Classification Of Tumors ◽  
Hematological Tumors

According to the WHO classification of tumors, more than 150 typologies of hematopoietic and lymphoid tumors exist, and most of them remain incurable diseases that require innovative approaches to improve therapeutic outcome and avoid side effects. Marine organisms represent a reservoir of novel bioactive metabolites, but they are still less studied compared to their terrestrial counterparts. This review is focused on marine natural products with anticancer activity against hematological tumors, highlighting recent advances and possible perspectives. Until now, there are five commercially available marine-derived compounds for the treatment of various hematopoietic cancers (e.g., leukemia and lymphoma), two molecules in clinical trials, and series of compounds and/or extracts from marine micro- and macroorganisms which have shown promising properties. In addition, the mechanisms of action of several active compounds and extracts are still unknown and require further study. The continuous upgrading of omics technologies has also allowed identifying enzymes with possible bioactivity (e.g., l-asparaginase is currently used for the treatment of leukemia) or the enzymes involved in the synthesis of bioactive secondary metabolites which can be the target of heterologous expression and genetic engineering.

scholarly journals 2nd GCC Marine Biotechnology conference: emerging opportunities and future perspectives

2019 ◽  
Vol 23 (1) ◽  
pp. 48
Author(s):  
Sergey Dobretsov
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Plenary Lecture ◽  
Future Perspectives ◽  
Marine Biotechnology ◽  
Sultan Qaboos University ◽  
Final Session ◽  
Marine Biofouling ◽  
Center Of Excellence ◽  
Poster Presentations

2nd GCC Marine biotechnology conference was held at Sultan Qaboos University, 31 October – 1 November 2017. The conference was organized by the Center of Excellence in Marine Biotechnology, SQU. The conference focused on four major themes, including Genetics and biodiversity, Marine biofouling and its prevention, Marine natural products, and Aquaculture and fisheries. In total, 160 delegates from 23 different countries were registered for this conference and 106 delegates attended the conference. One plenary lecture and three keynote addresses were given, 39 oral and 30 poster presentations were made. The final session reviewed national and regional issues and identified some of the main challenges in marine biotechnology in the region.

scholarly journals Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5769
Author(s):  
Florence Nwakaego Mbaoji ◽  
Justus Amuche Nweze ◽  
Liyan Yang ◽  
Yangbin Huang ◽  
Shushi Huang ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Marine Natural Products ◽  
Cancer Cell Line ◽  
Cancer Cell Lines ◽  
Wide Range

Secondary metabolites from marine sources have a wide range of biological activity. Marine natural products are promising candidates for lead pharmacological compounds to treat diseases that plague humans, including cancer. Cancer is a life-threatening disorder that has been difficult to overcome. It is a long-term illness that affects both young and old people. In recent years, significant attempts have been made to identify new anticancer drugs, as the existing drugs have been useless due to resistance of the malignant cells. Natural products derived from marine sources have been tested for their anticancer activity using a variety of cancer cell lines derived from humans and other sources, some of which have already been approved for clinical use, while some others are still being tested. These compounds can assault cancer cells via a variety of mechanisms, but certain cancer cells are resistant to them. As a result, the goal of this review was to look into the anticancer potential of marine natural products or their derivatives that were isolated from January 2019 to March 2020, in cancer cell lines, with a focus on the class and type of isolated compounds, source and location of isolation, cancer cell line type, and potency (IC50 values) of the isolated compounds that could be a guide for drug development.

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