Conopeptides, Marine Natural Products from Venoms: Biomedical Applications and Future Research Applications

2015 ◽  
pp. 463-496 ◽  
Author(s):  
Baldomero Olivera ◽  
Helena Safavi-­Hemami ◽  
Martin Horvath ◽  
Russell Teichert
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biomedical Applications ◽  
Future Research

scholarly journals Marine Natural Products from Microalgae: An -Omics Overview

Marine Drugs ◽  
2019 ◽  
Vol 17 (5) ◽  
pp. 269 ◽  
Author(s):  
Chiara Lauritano ◽  
Maria Immacolata Ferrante ◽  
Alessandra Rogato
Keyword(s):  
Natural Products ◽  
Metabolic Pathways ◽  
Marine Natural Products ◽  
Biomedical Applications ◽  
Bioactive Metabolites ◽  
Future Perspectives ◽  
Genome Sequences ◽  
Comprehensive Overview ◽  
Wide Range ◽  
Broad Variety

Over the last decade, genome sequences and other -omics datasets have been produced for a wide range of microalgae, and several others are on the way. Marine microalgae possess distinct and unique metabolic pathways, and can potentially produce specific secondary metabolites with biological activity (e.g., antipredator, allelopathic, antiproliferative, cytotoxic, anticancer, photoprotective, as well as anti-infective and antifouling activities). Because microalgae are very diverse, and adapted to a broad variety of environmental conditions, the chances to find novel and unexplored bioactive metabolites with properties of interest for biotechnological and biomedical applications are high. This review presents a comprehensive overview of the current efforts and of the available solutions to produce, explore and exploit -omics datasets, with the aim of identifying species and strains with the highest potential for the identification of novel marine natural products. In addition, funding efforts for the implementation of marine microalgal -omics resources and future perspectives are presented as well.

scholarly journals Overview of bioactivity studies on marine natural products

2021 ◽  
Vol 944 (1) ◽  
pp. 012029
Author(s):  
N P Zamani ◽  
L Rahman ◽  
R L Rosada ◽  
W Tirtama
Keyword(s):  
Natural Products ◽  
Product Development ◽  
Mass Production ◽  
Marine Natural Products ◽  
Research Collaboration ◽  
Gap Analysis ◽  
Raw Materials ◽  
Marine Organisms ◽  
Future Research ◽  
Marine Biodiversity

Abstract Marine natural products are sourced from marine biodiversity as natural raw materials for various commercial products. This study aims to review natural products of marine organisms and gap analysis for future research or challenges. A total of 109 references from 24 countries were collected. The analysis was carried out quantitatively and qualitatively. The bioactive compounds produced wereantioxidants, antibacterial, anticancer, antimicrobial, anti-fouling, antifungal, and anti-tumoral substances. Some marine organisms that can store chemical compounds through secondary metabolite processes are mangroves, seagrasses, macroalgae, microalgae, soft corals, molluscs, echinoderms, gastropods, cnidarians, sponges, fungi, and bacteria. Most of the papers only discuss the identification stage of the active compound, and some focus on product development. There are very few studies on prospects of commercialization and mass production. The problem to achieve mass production is due to the lack of interdisciplinary research collaboration. Future research challenges need to develop a transdisciplinary approach to study bioprospection research from upstream to downstream, starting from the potential identification of bioactive ingredients, product development, the availability of raw materials for mass production as well as commercialization and marketing.

The discoipyrroles: A multifaceted approach to understand a novel family of marine natural products

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DA Colosimo ◽  
F Cai ◽  
Y Hu ◽  
MB Potts ◽  
MA White ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Multifaceted Approach

Synthesis of Marine Natural Products 1

1992 ◽  
Author(s):  
K. F. Albizati ◽  
V. A. Martin ◽  
M. R. Agharahimi ◽  
D. A. Stolze
Keyword(s):  
Natural Products ◽  
Marine Natural Products

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

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