scholarly journals ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A

Marine Drugs ◽  
2018 ◽  
Vol 16 (3) ◽  
pp. 77 ◽  
Author(s):  
Xuemei Wan ◽  
Jeffrey Serrill ◽  
Ian Humphreys ◽  
Michelle Tan ◽  
Kerry McPhail ◽  
...  
Keyword(s):  
Coibamide A

Efficient Synthesis and Stereochemical Revision of Coibamide A

2015 ◽  
Vol 137 (42) ◽  
pp. 13488-13491 ◽  
Author(s):  
Guiyang Yao ◽  
Zhengyin Pan ◽  
Chunlei Wu ◽  
Wei Wang ◽  
Lijing Fang ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Coibamide A

scholarly journals Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65250 ◽  
Author(s):  
Andrew M. Hau ◽  
Jeffrey A. Greenwood ◽  
Christiane V. Löhr ◽  
Jeffrey D. Serrill ◽  
Philip J. Proteau ◽  
...  
Keyword(s):  
Cell Death ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Coibamide A ◽  
Human Glioblastoma Cells

Solid-phase Total Synthesis of Amide Analogues of Coibamide A: Azacoibamide A andO-Desmethyl Azacoibamide A

2016 ◽  
Vol 37 (3) ◽  
pp. 330-334 ◽  
Author(s):  
Ganesh A. Sable ◽  
Jaekwan Park ◽  
Soo-Jeong Lim ◽  
Dongyeol Lim
Keyword(s):  
Total Synthesis ◽  
Solid Phase ◽  
Coibamide A

Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts

2015 ◽  
Vol 34 (1) ◽  
pp. 24-40 ◽  
Author(s):  
Jeffrey D. Serrill ◽  
Xuemei Wan ◽  
Andrew M. Hau ◽  
Hyo Sang Jang ◽  
Daniel J. Coleman ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Coibamide A

scholarly journals Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

2019 ◽  
Author(s):  
Dale Tranter ◽  
Anja Paatero ◽  
Shinsaku Kawaguchi ◽  
Soheila Kazemi ◽  
Jeffrey D. Serrill ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Protein Import ◽  
Human Cancer ◽  
Binding Mode ◽  
Marine Natural Product ◽  
Resistance Mutations ◽  
Human Cancer Cells ◽  
Channel Inhibition ◽  
Coibamide A ◽  
Nci60 Panel

Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. Despite promising antitumor activity, the mechanism of cytotoxicity and specific cellular target remain unknown. Here, we develop an optimized synthetic CbA photoaffinity probe (photo-CbA) and use it to demonstrate that CbA directly targets the Sec61α subunit of the trimeric Sec61 translocon. CbA binding to Sec61 results in broad substrate-nonselective inhibition of ER protein import and potent cytotoxicity against specific cancer cell lines. CbA targets a lumenal cavity of Sec61α that is partially shared with known Sec61 inhibitors, yet profiling against resistance conferring Sec61α mutations identified from human HCT116 cells suggests a distinct binding mode for CbA. Specifically, despite conferring strong resistance to all previously known Sec61 inhibitors, the Sec61α mutant R66I remains sensitive to CbA. A further unbiased screen for Sec61α resistance mutations identified the CbA-resistant mutation S71P, which confirms non-identical binding sites for CbA and apratoxin A and supports the susceptibility of the Sec61 plug region for channel inhibition. Remarkably, CbA, apratoxin A andipomoeassin F do not display comparable patterns of potency and selectivity in the NCI60 panel of human cancer cell lines.Our work connecting CbA activity with selective prevention of secretory and membrane protein biogenesis by inhibition of Sec61 opens up possibilities for developing new Sec61 inhibitors with improved drug-like properties that are based on the coibamide pharmacophore.

scholarly journals Coibamide A, a Potent Antiproliferative Cyclic Depsipeptide from the Panamanian Marine CyanobacteriumLeptolyngbyasp.

2008 ◽  
Vol 130 (20) ◽  
pp. 6324-6325 ◽  
Author(s):  
Rebecca A. Medina ◽  
Douglas E. Goeger ◽  
Patrice Hills ◽  
Susan L. Mooberry ◽  
Nelson Huang ◽  
...  
Keyword(s):  
Cyclic Depsipeptide ◽  
Coibamide A

Coibamide A kills cancer cells through inhibiting autophagy

2021 ◽  
Vol 547 ◽  
pp. 52-58
Author(s):  
Wenli Shi ◽  
Danyi Lu ◽  
Chunlei Wu ◽  
Meiqing Li ◽  
Zhihao Ding ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Coibamide A

Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide

2014 ◽  
Vol 55 (44) ◽  
pp. 6109-6112 ◽  
Author(s):  
Wei He ◽  
Hai-Bo Qiu ◽  
Yi-Jie Chen ◽  
Jie Xi ◽  
Zhu-Jun Yao
Keyword(s):  
Total Synthesis ◽  
Coibamide A

scholarly journals Design of Coibamide A Mimetics with Improved Cellular Bioactivity

2021 ◽  
Author(s):  
Takashi Kitamura ◽  
Rikito Suzuki ◽  
Shinsuke Inuki ◽  
Hiroaki Ohno ◽  
Kerry L. McPhail ◽  
...  
Keyword(s):  
Coibamide A

scholarly journals Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A

2021 ◽  
Vol 183 ◽  
pp. 114317
Author(s):  
Soheila Kazemi ◽  
Shinsaku Kawaguchi ◽  
Christian E. Badr ◽  
Daphne R. Mattos ◽  
Ana Ruiz-Saenz ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Erbb Family ◽  
Coibamide A
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