scholarly journals Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank

Marine Drugs ◽  
2017 ◽  
Vol 15 (9) ◽  
pp. 280 ◽  
Author(s):  
Chiung-Yao Huang ◽  
Jui-Hsin Su ◽  
Chih-Chuang Liaw ◽  
Ping-Jyun Sung ◽  
Pei-Lun Chiang ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Soft Coral ◽  
Ester Group ◽  
Side Chain

Synthesis of oxytocin analogues modified in the tripeptide side-chain by condensation of aminoterminal linear hexapeptide with the carboxyterminal tripeptide

1979 ◽  
Vol 44 (1) ◽  
pp. 275-287 ◽  
Author(s):  
Jan Hlaváček ◽  
Tomislav Barth ◽  
Karel Bláha ◽  
Karel Jošt
Keyword(s):  
Methyl Ester ◽  
Side Chain ◽  
Glycine Methyl Ester

For the synthesis of oxytocin (Ia) analogues modified in the carboxyterminal part of the molecule, a method based on the condensation of protected aminoterminal hexapeptide with tripeptides by the action of dicyclohexylcarbodiimide and pentafluorophenol in the presence of 1-hydroxybenzotriazole was devised. Using this method [7-[U-13C]proline]oxytocin (Ib), des-9-glycine-oxytocin (Ic) and methyl ester of oxytocinoic acid ([9-glycine methyl ester]oxytocin) (Id) were prepared.

Cocaine: Pharmacokinetics and biotransformation in man

1989 ◽  
Vol 67 (9) ◽  
pp. 1154-1157 ◽  
Author(s):  
T. Inaba
Keyword(s):  
Methyl Ester ◽  
Ester Group ◽  
Oral Route ◽  
Plasma Cholinesterase ◽  
Pharmacokinetic Studies ◽  
Hydrolytic Cleavage ◽  
Bicyclic Structure ◽  
Anesthetic Action ◽  
Pharmacologically Active ◽  
Cytochrome P 450

Pharmacokinetic studies of cocaine have been carried out only in the last decade, although its local anesthetic action and addictive properties have been known for almost 100 years. Elimination half-lives of cocaine in man estimated from serial plasma concentration are relatively short and range from 0.5 to 1.1 h after i.v. and 0.9–1.5 h after administration by the nasal or oral route. The bioavailability after nasal inhalation is about 60%. The bicyclic structure of cocaine is characterized by functional groups including N-methyl, carboxyl methyl ester, and benzoyl ester, which are susceptible to biotransformation. Hydrolysis of the benzoyl group to ecgonine methyl ester is catalyzed by plasma cholinesterase and is thus under monogenic control. The hydrolytic cleavage of the other ester group, methyl ester, to benzoyl ecgonine occurs spontaneously at body temperature. In contrast, N-demethylation of cocaine mediated by microsomal cytochrome P-450 produces norcocaine and this metabolite was shown to be pharmacologically active, the action being similar to cocaine.Key words: cocaine, hydrolysis, plasma cholinesterase, cytochrome P-450.

Synthetic Approaches to the Bifunctional Chelators for Radio­nuclides Based On Pyridine-Containing Azacrown Compounds

Synthesis ◽  
2019 ◽  
Vol 52 (07) ◽  
pp. 1087-1095
Author(s):  
Anastasia D. Zubenko ◽  
Anna A. Shchukina ◽  
Olga A. Fedorova
Keyword(s):  
Drug Delivery ◽  
Methyl Ester ◽  
Targeted Drug Delivery ◽  
Pyridine Ring ◽  
Ester Group ◽  
Metal Chelation ◽  
Carboxylate Groups ◽  
Pyridine Fragment ◽  
Targeted Drug ◽  
Synthetic Approaches

Synthetic ways to introduce functional groups (CO2Me, CO2H, OCH2CO2H, OCH2C≡CH, CH2OH, CH2Cl, CH2N3) into the pyridine ring of pyridine-containing azacrown compounds are described. These groups were introduced at position-4 of the pyridine ring, while keeping the macrocyclic carboxylate groups available for metal chelation. The derivatives were obtained by macrocyclization reaction of 4-substituted, trimethyl pyridine-2,4,6-tricarboxylate or by modification of methyl ester group in pyridine fragment of macrocycles. Obtained derivatives can be applied for preparing radiotherapeutic agents by conjugation to different vector biomolecules for targeted drug delivery to cancer cells without damaging healthy tissue.

New sesquiterpenoids bearing 11-methyl ester group of agarwood

Fitoterapia ◽  
2020 ◽  
Vol 143 ◽  
pp. 104557
Author(s):  
Wei Li ◽  
Yi-Ling Yang ◽  
Li Yang ◽  
Hao Wang ◽  
Wen-Hua Dong ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Ester Group

scholarly journals Methyl 3,5-bis(cyclohexylmethoxy)benzoate

2014 ◽  
Vol 70 (4) ◽  
pp. o400-o401 ◽  
Author(s):  
Peter W. R. Corfield ◽  
Michele L. Paccagnini ◽  
Amy M. Balija
Keyword(s):  
Methyl Ester ◽  
Hydrogen Bonds ◽  
Aromatic Ring ◽  
Title Compound ◽  
Ester Group ◽  
Interplanar Distance ◽  
Compound C ◽  
The Mean

In the title compound, C22H32O4, the atoms of the methyl ester group and the alkoxy O atoms are all coplanar with the central aromatic ring, with an r.m.s. deviation of 0.008 Å. Bonds to the methylene and cyclohexyl groups are also very close to this plane, so that the molecule is essentially flat, apart from the cyclohexyl groups. The mean planes through the cyclohexyl groups are tilted by 30.08 (9) and 36.14 (7)° with respect to the central aromatic ring. In the crystal, pairs of molecules linked by C—H...O hydrogen bonds form planar units which are stacked along theaaxis, with an average interplanar distance of 3.549 (2) Å. Stacking appears to be stabilized by further weak C—H...O hydrogen bonds.

Amidation of methyl ester side chain bearing poly(2-oxazoline)s with tyramine: a quest for a selective and quantitative approach

2019 ◽  
Vol 10 (8) ◽  
pp. 954-962 ◽  
Author(s):  
Joachim F. R. Van Guyse ◽  
Maarten A. Mees ◽  
Maarten Vergaelen ◽  
Mathijs Baert ◽  
Bart Verbraeken ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Quantitative Approach ◽  
Side Chain

Three new amidation approaches are evaluated to incorporate tyramine on methyl ester functional poly(2-oxazolines).

Determination of Aspartame in Beverages Using an Alcohol Oxidase Enzyme Electrode

1989 ◽  
Vol 72 (1) ◽  
pp. 30-33
Author(s):  
Vicki J Smith ◽  
Richard A Green ◽  
Thomas R Hopkins
Keyword(s):  
Liquid Chromatography ◽  
Standard Deviation ◽  
Methyl Ester ◽  
Alcohol Oxidase ◽  
Ester Group ◽  
Oxygen Electrode ◽  
Artificial Sweetener ◽  
Relative Standard ◽  
Oxidase Enzyme

Abstract A new method for the determination of the artificial sweetener aspartame is described. α-Chymotrypsin is used to cleave the methyl ester group of aspartame, producing methanol hydrolytically. The methanol is detected using an electrode which is constructed by physically trapping yeast alcohol oxidase enzyme at the tip of a dissolved oxygen electrode. The decrease in oxygen concentration, which occurs as methanol is enzymatically oxidized to formaldehyde, is measured amperometrically. Aspartame levels in diet soft drinks as determined by the proposed method and by liquid chromatography are in excellent agreement. The relative standard deviation of the measurements is 0.83%. The methanol present in diet cola as a result of aspartame degradation can also be measured by using the electrode without α-chymotrypsin.

Volume phase transition induced by temperature sensitive DL-amino acid methyl ester side chain based copolymer gels

2000 ◽  
Vol 3 (3) ◽  
pp. 381-387 ◽  
Author(s):  
Akihiro Hiroki ◽  
Hideaki Iwakami ◽  
Masaru Yoshida ◽  
Takeshi Suwa ◽  
Masaharu Asano ◽  
...  
Keyword(s):  
Phase Transition ◽  
Amino Acid ◽  
Methyl Ester ◽  
Acid Methyl Ester ◽  
Side Chain ◽  
Temperature Sensitive ◽  
Volume Phase Transition ◽  
Volume Phase ◽  
Acid Methyl ◽  
Amino Acid Methyl Ester

A 2-methylene-β-alanine methyl ester derivative from the soft coral Sinularia dissecta

1999 ◽  
Vol 27 (6) ◽  
pp. 661-662 ◽  
Author(s):  
P. Ramesh ◽  
N. Srinivasa Reddy ◽  
T. Prabakar Rao ◽  
J. Venkateswara Rao ◽  
Y. Venkateswarlu
Keyword(s):  
Methyl Ester ◽  
Soft Coral ◽  
Methyl Ester Derivative ◽  
Ester Derivative
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