scholarly journals Sustained Release of Lidocaine from Solvent-Free Biodegradable Poly[(d,l)-Lactide-co-Glycolide] (PLGA): In Vitro and In Vivo Study

Materials ◽  
2014 ◽  
Vol 7 (9) ◽  
pp. 6660-6676 ◽  
Author(s):  
Yi-Chuan Kau ◽  
Chia-Chih Liao ◽  
Ying-Chi Chen ◽  
Shih-Jung Liu
Keyword(s):  
Sustained Release ◽  
Solvent Free ◽  
In Vivo Study ◽  
Biodegradable Poly

Formulation and Evaluation of Atorvastatin Calcium-Poly-ε-Caprolactone Nanoparticles Loaded Ocular Inserts for Sustained Release and Antiinflammatory Efficacy

2020 ◽  
Vol 21 (15) ◽  
pp. 1688-1698
Author(s):  
Germeen N.S. Girgis
Keyword(s):  
Sustained Release ◽  
In Vitro Release ◽  
Pluronic F127 ◽  
In Vivo Study ◽  
Average Weight ◽  
Drug Release Profile ◽  
Atorvastatin Calcium ◽  
Anti Inflammatory

Purpose: The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. Methods: First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanoparticles were loaded within inserts formulated with Methylcellulose (MC) and Polyvinyl Alcohol (PVA) by a solvent casting technique and evaluated physically, for in-vitro drug release profile. Finally, an in-vivo study was performed on the selected formulation to prove non-irritability and sustained ocular anti-inflammatory efficacy compared with free drug-loaded ocuserts. Results: The results revealed (ATC-PCL) nanoparticles prepared with 0.5% pluronic F127 were optimized with 181.72±3.6 nm particle size, 0.12±0.02 (PDI) analysis, -27.4± 0.69 mV zeta potential and 62.41%±4.7% entrapment efficiency. Nanoparticles loaded ocuserts manifested compatibility between drug and formulation polymers. Moreover, formulations complied with average weight 0.055±0.002 to 0.143±0.023 mg, and accepted pH. ATC-PCL nanoparticles loaded inserts prepared by 5% MC showed more sustained, prolonged in-vitro release over 24h. In-vivo study emphasized non-irritability, ocular anti-inflammatory effectiveness represented by smaller lid closure scores, and statistically significant lowering in PMN count after 3h. Conclusion: These findings proposed a possibly simple, new and affordable price technique to prepare promising (ATC-PCL) nanoparticles loaded inserts to achieve sustained release with prolonged antiinflammatory efficacy.

Sustained release of antibiotic complexed by multivalent ion: In vitro and in vivo study for the treatment of peritonitis

2014 ◽  
Vol 476 (1-2) ◽  
pp. 213-222 ◽  
Author(s):  
Seung Yeon Na ◽  
Se Heang Oh ◽  
Tae Ho Kim ◽  
Jin A Yoon ◽  
In Soo Lee ◽  
...  
Keyword(s):  
Sustained Release ◽  
In Vivo Study

scholarly journals Sustained release donepezil loaded PLGA microspheres for injection: Preparation, in vitro and in vivo study

2015 ◽  
Vol 10 (5) ◽  
pp. 405-414 ◽  
Author(s):  
Wenjia Guo ◽  
Peng Quan ◽  
Liang Fang ◽  
Dongmei Cun ◽  
Mingshi Yang
Keyword(s):  
Sustained Release ◽  
In Vivo Study ◽  
Plga Microspheres
Sign in / Sign up

Export Citation Format

Share Document