Sustained Release of 5-Fluorouracil from Chitosan Nanoparticles Surface Modified Intra Ocular Lens to Prevent Posterior Capsule Opacification: An In Vitro and In Vivo Study

2013 ◽  
Vol 29 (2) ◽  
pp. 208-215 ◽  
Author(s):  
Xiao Huang ◽  
Yue Wang ◽  
Ji-Ping Cai ◽  
Xiao-Ye Ma ◽  
You Li ◽  
...  
Keyword(s):  
Sustained Release ◽  
Chitosan Nanoparticles ◽  
Posterior Capsule Opacification ◽  
In Vivo Study ◽  
Posterior Capsule ◽  
Ocular Lens ◽  
Surface Modified

scholarly journals CTGF Contributes to the Development of Posterior Capsule Opacification: an in vitro and in vivo study

2018 ◽  
Vol 14 (4) ◽  
pp. 437-448 ◽  
Author(s):  
Bo Ma ◽  
Ruihua Jing ◽  
Jie Liu ◽  
Lan Yang ◽  
Jingming Li ◽  
...  
Keyword(s):  
Posterior Capsule Opacification ◽  
In Vivo Study ◽  
Posterior Capsule

Formulation and Evaluation of Atorvastatin Calcium-Poly-ε-Caprolactone Nanoparticles Loaded Ocular Inserts for Sustained Release and Antiinflammatory Efficacy

2020 ◽  
Vol 21 (15) ◽  
pp. 1688-1698
Author(s):  
Germeen N.S. Girgis
Keyword(s):  
Sustained Release ◽  
In Vitro Release ◽  
Pluronic F127 ◽  
In Vivo Study ◽  
Average Weight ◽  
Drug Release Profile ◽  
Atorvastatin Calcium ◽  
Anti Inflammatory

Purpose: The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. Methods: First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanoparticles were loaded within inserts formulated with Methylcellulose (MC) and Polyvinyl Alcohol (PVA) by a solvent casting technique and evaluated physically, for in-vitro drug release profile. Finally, an in-vivo study was performed on the selected formulation to prove non-irritability and sustained ocular anti-inflammatory efficacy compared with free drug-loaded ocuserts. Results: The results revealed (ATC-PCL) nanoparticles prepared with 0.5% pluronic F127 were optimized with 181.72±3.6 nm particle size, 0.12±0.02 (PDI) analysis, -27.4± 0.69 mV zeta potential and 62.41%±4.7% entrapment efficiency. Nanoparticles loaded ocuserts manifested compatibility between drug and formulation polymers. Moreover, formulations complied with average weight 0.055±0.002 to 0.143±0.023 mg, and accepted pH. ATC-PCL nanoparticles loaded inserts prepared by 5% MC showed more sustained, prolonged in-vitro release over 24h. In-vivo study emphasized non-irritability, ocular anti-inflammatory effectiveness represented by smaller lid closure scores, and statistically significant lowering in PMN count after 3h. Conclusion: These findings proposed a possibly simple, new and affordable price technique to prepare promising (ATC-PCL) nanoparticles loaded inserts to achieve sustained release with prolonged antiinflammatory efficacy.

scholarly journals Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo

2017 ◽  
Vol 12 (5) ◽  
pp. 418-423 ◽  
Author(s):  
Li Sun ◽  
Yunna Chen ◽  
Yali Zhou ◽  
Dongdong Guo ◽  
Yufan Fan ◽  
...  
Keyword(s):  
Sustained Release ◽  
Chitosan Nanoparticles ◽  
Release In Vitro

scholarly journals Chitosan Nanoparticles of 5-Fluorouracil for Ophthalmic Delivery: Characterization, in-Vitro and in-Vivo Study

2011 ◽  
Vol 59 (2) ◽  
pp. 272-278 ◽  
Author(s):  
Ramesh Chand Nagarwal ◽  
Paras Nath Singh ◽  
Shri Kant ◽  
Pralay Maiti ◽  
Jayanta Kumar Pandit
Keyword(s):  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Ophthalmic Delivery

Sustained release of antibiotic complexed by multivalent ion: In vitro and in vivo study for the treatment of peritonitis

2014 ◽  
Vol 476 (1-2) ◽  
pp. 213-222 ◽  
Author(s):  
Seung Yeon Na ◽  
Se Heang Oh ◽  
Tae Ho Kim ◽  
Jin A Yoon ◽  
In Soo Lee ◽  
...  
Keyword(s):  
Sustained Release ◽  
In Vivo Study
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