scholarly journals Biological Effects of Bioresorbable Materials in Alveolar Ridge Augmentation: Comparison of Early and Slow Resorbing Osteosynthesis Materials

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3286
Author(s):  
Hotaka Kawai ◽  
Shintaro Sukegawa ◽  
Keisuke Nakano ◽  
Kiyofumi Takabatake ◽  
Sawako Ono ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Alveolar Bone ◽  
Biological Effects ◽  
Polyglycolic Acid ◽  
Bone Alkaline Phosphatase ◽  
Histological Evaluation ◽  
Alveolar Ridge ◽  
Bone Augmentation ◽  
Alveolar Ridge Augmentation ◽  
Ridge Augmentation

The purpose of this study was to investigate the bone healing properties and histological environment of a u-HA/PLLA/PGA (u-HA—uncalcined and unsintered hydroxyapatite, PLLA—Poly L-lactic acid, PGA—polyglycolic acid) composite device in humans, and to understand the histological dynamics of using this device for maxillofacial treatments. Twenty-one subjects underwent pre-implant maxillary alveolar ridge augmentation with mandibular cortical bone blocks using u-HA/PLLA or u-HA/PLLA/PGA screws for fixation. Six months later, specimens of these screws and their adjacent tissue were retrieved. A histological and immunohistochemical evaluation of these samples was performed using collagen 1a, ALP (alkaline phosphatase), and osteocalcin. We observed that alveolar bone augmentation was successful for all of the subjects. Upon histological evaluation, the u-HA/PLLA screws had merged with the bone components, and the bone was directly connected to the biomaterial. In contrast, direct bone connection was not observed for the u-HA/PLLA/PGA screw. Immunohistological findings showed that in the u-HA/PLLA group, collagen 1a was positive for fibers that penetrated vertically into the bone. Alkaline phosphatase was positive only in the u-HA/PLLA stroma, and the stroma was negative for osteocalcin. In this study, u-HA/PLLA showed a greater bioactive bone conductivity than u-HA/PLLA/PGA and a higher biocompatibility for direct bone attachment. Furthermore, u-HA/PLLA was shown to have the potential for bone formation in the stroma.

scholarly journals Comparison of Calcium Sulfate and Bovine Collagen Barriers for Alveolar Ridge Augmentation

2014 ◽  
Vol 4 (3) ◽  
pp. 129-138
Author(s):  
Robert Spears ◽  
Ibtisam Al-Hashimi ◽  
Eric S Solomon ◽  
David G Kerns ◽  
William W Hallmon ◽  
...  
Keyword(s):  
Bone Graft ◽  
Calcium Sulfate ◽  
Autogenous Bone ◽  
Collagen Membrane ◽  
Alveolar Ridge ◽  
Bone Augmentation ◽  
Alveolar Ridge Augmentation ◽  
Ridge Augmentation ◽  
Bovine Collagen ◽  
Bone Gain

ABSTRACT Calcium sulfate is a biologically compatible osteoconductive graft material that binds underlying bone graft and provide space maintenance. The purpose of this study was to evaluate calcium sulfate as a barrier compared to a collagen membrane for augmentation of a standardized surgically created ridge defect. For this purpose, bilateral extraction of mandibular premolars was performed on six foxhounds (Canis familiaris). Eight weeks later, a standardized osseous ridge defects (24 total) were created using a 6 mm trephine. The study was approved by the Institutional Animal Care and Use Committee (IACUC) at Baylor College of Dentistry. The osseous defects were allocated into three groups (8 defects each): group 1 received autogenous bone graft covered with collagen membrane (CM); group 2 received autogenous bone graft covered with calcium sulfate barrier (CS), and group 3 was used as control and did not receive bone augmentation and was used as control. The animals were sacrificed after 12 weeks following bone augmentation and sites were evaluated histologically for total ridge width, percentage of bone gain and cortical bone thickness. Results All sites exhibited bony fill within the defect. Analysis of variance did not reveal statistically significant difference in the mean total bone gain among CM, CS, and control groups (12.2,11.6, and 11.9) mm2, respectively, p = 0.875. Conclusion Calcium sulfate does not appear to improve bone regeneration in an osseous defect. How to cite this article Heaton ML, Kerns DG, Hallmon WW, Kessler HP, Spears R, Solomon ES, Al-Hashimi I. Comparison of Calcium Sulfate and Bovine Collagen Barriers for Alveolar Ridge Augmentation. J Contemp Dent 2014;4(3):129-138.

scholarly journals Surgical Approaches Based on Biological Objectives: GTR versus GBR Techniques

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Gaia Pellegrini ◽  
Giorgio Pagni ◽  
Giulio Rasperini
Keyword(s):  
Periodontal Disease ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Surgical Techniques ◽  
Surgical Approaches ◽  
Alveolar Ridge ◽  
Therapeutic Approaches ◽  
Alveolar Ridge Augmentation ◽  
Biological Basis ◽  
Ridge Augmentation

Guided tissue regenerative (GTR) therapies are performed to regenerate the previously lost tooth supporting structure, thus maintaining the aesthetics and masticatory function of the available dentition. Alveolar ridge augmentation procedures (GBR) intend to regain the alveolar bone lost following tooth extraction and/or periodontal disease. Several biomaterials and surgical approaches have been proposed. In this paper we report biomaterials and surgical techniques used for periodontal and bone regenerative procedures. Particular attention will be adopted to highlight the biological basis for the different therapeutic approaches.

scholarly journals Alveolar Bone Augmentation

2014 ◽  
Vol 614 ◽  
pp. 89-94 ◽  
Author(s):  
Cena Dimova ◽  
Kiro Papakoca ◽  
Velko Papakoca
Keyword(s):  
Dental Implant ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Bone Volume ◽  
The Body ◽  
Surgical Reconstruction ◽  
Bone Augmentation ◽  
Alveolar Ridge Augmentation ◽  
Ridge Augmentation ◽  
Implant Placement

Bones and teeth are the only structureswithin the body where calciumandphosphate participate asfunctional pillars. Despite their mineralnature, both organs are vital and dynamic. The aim was to remark the indications for alveolar augmentation after tooth extraction and prior the placement of endoosseous dental implants. The autograft, allograft, alloplast, and xenograftmaterials all have reported success, alone or in combination,for particulate bone augmentation. Theparticulate autograft is the gold standard for mostcraniofacial bone grafting, including the treatmentof dental implant–related defects. Advantages of alveolar ridge augmentation with sufficient bone volume to adjust for uncompromised and esthetic implant placement, renders these procedures more than effective for majority of patients. Surgical reconstruction of the tissues and the procedure of ridge augmentation and subsequent placement of dental implant are necessary.

Horizontal Augmentation Through the Ridge-Split Procedure: A Predictable Surgical Modality in Implant Reconstruction

2013 ◽  
Vol 39 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Len Tolstunov ◽  
Bruce Hicke
Keyword(s):  
Alveolar Bone ◽  
Inferior Alveolar Nerve ◽  
Bony Defect ◽  
Alveolar Ridge ◽  
Bone Augmentation ◽  
Ridge Augmentation ◽  
Augmentation Techniques ◽  
Ridge Split ◽  
Maxilla And Mandible ◽  
Careful Manipulation

Among alveolar ridge augmentation techniques, the ridge-split procedure demonstrates many benefits, including no need for a second (donor) surgical site, rare risk of inferior alveolar nerve injury, and less pain and swelling, and others. Lateral bone augmentation through the ridge-split works best in a localized lateral bony defect intended for 1 or 2 implants and where the ridge is vertically intact. In this article, the authors present a detailed description of the implant-driven technique of alveolar ridge-split procedure in small and large bone deficiencies, in maxilla and mandible, supplemented by multiple photographs. The authors emphasize the need for careful manipulation of the thin ridge based on knowledge of precise surgical principles and stress that a practitioner needs specialized training and experience to perform this type of alveolar bone augmentation.

scholarly journals Candidates Cell Sources to Regenerate Alveolar Bone from Oral Tissue

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Masahiro Nishimura ◽  
Kazuma Takase ◽  
Fumio Suehiro ◽  
Hiroshi Murata
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Mesenchymal Cells ◽  
Gingival Tissue ◽  
Rational Approach ◽  
Alveolar Ridge ◽  
Alveolar Ridge Augmentation ◽  
Differentiation Potential ◽  
Ridge Augmentation ◽  
Oral Site

Most of the cases of dental implant surgery, especially the bone defect extensively, are essential for alveolar ridge augmentation. As known as cell therapy exerts valuable effects on bone regeneration, numerous reports using various cells from body to regenerate bone have been published, including clinical reports. Mesenchymal cells that have osteogenic activity and have potential to be harvested from intra oral site might be a candidate cells to regenerate alveolar bone, even dentists have not been harvested the cells outside of mouth. This paper presents a summary of somatic cells in edentulous tissues which could subserve alveolar bone regeneration. The candidate tissues that might have differentiation potential as mesenchymal cells for bone regeneration are alveolar bone chip, bone marrow from alveolar bone, periosteal tissue, and gingival tissue. Understanding their phenotype consecutively will provide a rational approach for alveolar ridge augmentation.

scholarly journals Human Studies of Vertical and Horizontal Alveolar Ridge Augmentation Comparing Different Types of Bone Graft Materials: A Systematic Review

2018 ◽  
Vol 44 (1) ◽  
pp. 74-84 ◽  
Author(s):  
Suraj Chavda ◽  
Liran Levin
Keyword(s):  
Systematic Review ◽  
Bone Graft ◽  
Case Series ◽  
Human Studies ◽  
Autogenous Bone ◽  
Alveolar Ridge ◽  
Bone Augmentation ◽  
Alveolar Ridge Augmentation ◽  
Ridge Augmentation ◽  
Different Types

Alveolar ridge augmentation can be completed with various types of bone augmentation materials (autogenous, allograft, xenograft, and alloplast). Currently, autogenous bone is labeled as the “gold standard” because of faster healing times and integration between native and foreign bone. No systematic review has currently determined whether there is a difference in implant success between various bone augmentation materials. The purpose of this article was to systematically review comparative human studies of vertical and horizontal alveolar ridge augmentation comparing different types of bone graft materials (autogenous, allograft, xenograft, and alloplast). A MEDLINE search was conducted under the 3 search concepts of bone augmentation, dental implants, and alveolar ridge augmentation. Studies pertaining to socket grafts or sinus lifts were excluded. Case reports, small case series, and review papers were excluded. A bias assessment tool was applied to the final articles. Overall, 219 articles resulted from the initial search, and 9 articles were included for final analysis. There were no discernible differences in implant success between bone augmentation materials. Generally, patients preferred nonautogenous bone sources as there were fewer hospital days, less pain, and better recovery time. Two articles had industrial support; however, conclusions of whether that support influenced the outcomes could not be determined. Future comparative studies should compare nonautogenous bone sources and have longer follow-up times.

scholarly journals Advantage of Alveolar Ridge Augmentation with Bioactive/Bioresorbable Screws Made of Composites of Unsintered Hydroxyapatite and Poly-L-lactide

Materials ◽  
2019 ◽  
Vol 12 (22) ◽  
pp. 3681 ◽  
Author(s):  
Shintaro Sukegawa ◽  
Hotaka Kawai ◽  
Keisuke Nakano ◽  
Kiyofumi Takabatake ◽  
Takahiro Kanno ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Transcription Factor ◽  
Leptin Receptor ◽  
Histological Evaluation ◽  
Bone Block ◽  
Alveolar Ridge ◽  
Alveolar Ridge Augmentation ◽  
Ridge Augmentation

We studied human bone healing characteristics and the histological osteogenic environment by using devices made of a composite of uncalcined and unsintered hydroxyapatite (u-HA) and poly-L-lactide (PLLA). In eight cases of fixation, we used u-HA/PLLA screws for maxillary alveolar ridge augmentation, for which mandibular cortical bone block was used in preimplantation surgery. Five appropriate samples with screws were evaluated histologically and immunohistochemically for runt-related transcription factor 2 (RUNX2), transcription factor Sp7 (Osterix), and leptin receptor (LepR). In all cases, histological evaluation revealed that bone components had completely surrounded the u-HA/PLLA screws, and the bone was connected directly to the biomaterial. Inflammatory cells did not invade the space between the bone and the u-HA/PLLA screw. Immunohistochemical evaluation revealed that many cells were positive for RUNX2 or Osterix, which are markers for osteoblast and osteoprogenitor cells, in the tissues surrounding u-HA/PLLA. In addition, many bone marrow–derived mesenchymal stem cells were notably positive for both LepR and RUNX2. The u-HA/PLLA material showed excellent bioactive osteoconductivity and a highly biocompatibility with bone directly attached. In addition, our findings suggest that many bone marrow–derived mesenchymal stem cells and mature osteoblast are present in the osteogenic environment created with u-HA/PLLA screws and that this environment is suitable for osteogenesis.

scholarly journals Alveolar Ridge Augmentation using the Allograft Bone Shell Technique

2015 ◽  
Vol 16 (9) ◽  
pp. 768-773 ◽  
Author(s):  
Mogammad Thabit Peck
Keyword(s):  
Alveolar Bone ◽  
Bone Plates ◽  
Bony Defect ◽  
Allograft Bone ◽  
Alveolar Ridge ◽  
Alveolar Ridge Augmentation ◽  
Suitable Alternative ◽  
Ridge Augmentation ◽  
Anterior Teeth ◽  
Increased Risk

ABSTRACT Background The loss of teeth, whether it is from trauma or pathology, is accompanied by a concomitant loss of the surrounding alveolar bone. Khoury introduced a new method for grafting ridge defects in 2007. This technique involved using thin cortical plates harvested from the ramus, and in a ‘sandwich’ type manner, interposed these bone plates with cancellous bone harvested from the same site. Although this has shown success, the technique suffers from similar disadvantages of most harvesting techniques, i.e. a need for a second surgical site, and donor site morbidity. In this case presentation, we report the use of an allograft bone plate in a similar manner as was previously described by Khoury, to reconstruction lost alveolar bone in order to facilitate the correct three dimensional (3D) placement of dental implants. Case description A 53-year-old female presented for the restoration of her missing dentition in her upper jaw. The cone bean computed tomography (CBCT) revealed a large horizontal bony defect in the region of the upper anterior teeth, with minimal remaining bone. Using bone fixation screws, the bone plates were fixed to the buccal defect and the space between the plate and the existing palatal bone wall was then filled using a combination of autograft bone scrapings and xenograft bone particles. Six months after the initial surgery, the grafted sites were surgically re-entered and showed a marked increase in ridge width. Conclusion Evidence exists for the use of bone allografts for a variety of alveolar bone augmentation procedures. The case presented outlines another use for this versatile biomaterial. Clinical significance Bone harvesting for large alveolar defects is invariably associated with increased morbidity and an increased risk of postoperative complications. The above technique described by the author, may be used as a suitable alternative to reconstruct these defects, without harvesting bone from a second surgical site. How to cite this article Peck MT. Alveolar Ridge Augmentation using the Allograft Bone Shell Technique. J Contemp Dent Pract 2015;16(9):768-773.

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