scholarly journals Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3167
Author(s):  
Poornima Ramburrun ◽  
Nadine A. Pringle ◽  
Admire Dube ◽  
Razia Z. Adam ◽  
Sarah D’Souza ◽  
...  
Keyword(s):  
Metallic Nanoparticles ◽  
Bacterial Infections ◽  
Dental Materials ◽  
Titanium Implants ◽  
Continuous Exposure ◽  
Dental Resins ◽  
Dental Procedures ◽  
Tooth Surfaces ◽  
Contact Killing ◽  
Dental Applications

The risk of secondary bacterial infections resulting from dental procedures has driven the design of antimicrobial and antifouling dental materials to curb pathogenic microbial growth, biofilm formation and subsequent oral and dental diseases. Studies have investigated approaches based primarily on contact-killing or release-killing materials. These materials are designed for addition into dental resins, adhesives and fillings or as immobilized coatings on tooth surfaces, titanium implants and dental prosthetics. This review discusses the recent developments in the different classes of biomaterials for antimicrobial and antifouling dental applications: polymeric drug-releasing materials, polymeric and metallic nanoparticles, polymeric biocides and antimicrobial peptides. With modifications to improve cytotoxicity and mechanical properties, contact-killing and anti-adhesion materials show potential for incorporation into dental materials for long-term clinical use as opposed to short-lived antimicrobial release-based coatings. However, extended durations of biocompatibility testing, and adjustment of essential biomaterial features to enhance material longevity in the oral cavity require further investigations to confirm suitability and safety of these materials in the clinical setting. The continuous exposure of dental restorative and regenerative materials to pathogenic microbes necessitates the implementation of antimicrobial and antifouling materials to either replace antibiotics or improve its rational use, especially in the day and age of the ever-increasing problem of antimicrobial resistance.

scholarly journals The Benefits of Smart Nanoparticles in Dental Applications

2021 ◽  
Vol 22 (5) ◽  
pp. 2585
Author(s):  
Silvia Vasiliu ◽  
Stefania Racovita ◽  
Ionela Aurica Gugoasa ◽  
Maria-Andreea Lungan ◽  
Marcel Popa ◽  
...  
Keyword(s):  
Metallic Nanoparticles ◽  
Periodontal Diseases ◽  
Dental Materials ◽  
Moisture Stress ◽  
New Methods ◽  
Strong Trend ◽  
Scientific World ◽  
Oral Environment ◽  
Recent Developments ◽  
Dental Applications

Dentistry, as a branch of medicine, has undergone continuous evolution over time. The scientific world has focused its attention on the development of new methods and materials with improved properties that meet the needs of patients. For this purpose, the replacement of so-called “passive” dental materials that do not interact with the oral environment with “smart/intelligent” materials that have the capability to change their shape, color, or size in response to an externally stimulus, such as the temperature, pH, light, moisture, stress, electric or magnetic fields, and chemical compounds, has received much attention in recent years. A strong trend in dental applications is to apply nanotechnology and smart nanomaterials such as nanoclays, nanofibers, nanocomposites, nanobubbles, nanocapsules, solid-lipid nanoparticles, nanospheres, metallic nanoparticles, nanotubes, and nanocrystals. Among the nanomaterials, the smart nanoparticles present several advantages compared to other materials, creating the possibility to use them in various dental applications, including preventive dentistry, endodontics, restoration, and periodontal diseases. This review is focused on the recent developments and dental applications (drug delivery systems and restoration materials) of smart nanoparticles.

scholarly journals Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review

2020 ◽  
Vol 25 ◽  
pp. e00427 ◽  
Author(s):  
Anirudh Singh ◽  
Pavan Kumar Gautam ◽  
Arushi Verma ◽  
Vishal Singh ◽  
Pingali M. Shivapriya ◽  
...  
Keyword(s):  
Green Synthesis ◽  
Metallic Nanoparticles ◽  
Bacterial Infections

scholarly journals Adhesion of Hydroxyapatite Nanoparticles to Dental Materials under Oral Conditions

Scanning ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Cíntia Mirela Guimarães Nobre ◽  
Norbert Pütz ◽  
Matthias Hannig
Keyword(s):  
Electron Microscopy ◽  
Dental Materials ◽  
Hydroxyapatite Nanoparticles ◽  
Pellicle Formation ◽  
Transmission Electron ◽  
Different Shapes ◽  
Oral Conditions ◽  
Dental Applications

Hydroxyapatite nanoparticles (nano-HAP) are receiving considerable attention for dental applications, and their adhesion to enamel is well established. However, there are no reports concerning the effects of HAP on other dental materials, and most of the studies in this field are based on in vitro designs, neglecting the salivary pellicle-apatite interactions. Thus, this in situ pilot study aims to evaluate the effects of three hydroxyapatite-based solutions and their interactions with different dental material surfaces under oral conditions. Hence, two volunteers carried intraoral splints with mounted samples from enamel and from three dental materials: titanium, ceramics, and polymethyl-methacrylate (PMMA). Three HAP watery solutions (5%) were prepared with different shapes and sizes of nano-HAP (HAP I, HAP II, HAP III). After 3 min of pellicle formation, 10 ml rinse was performed during 30 sec. Rinsing with water served as control. Samples were accessed immediately after rinsing, 30 min and 2 h after rinsing. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to characterize the particles, and SEM evaluated the pellicle-HAP interactions. SEM and TEM results showed a high variation in the size range of the particles applied. A heterogeneous HAP layer was present after 2 h on enamel, titanium, ceramics, and PMMA surfaces under oral conditions. Bridge-like structures were visible between the nano-HAP and the pellicle formed on enamel, titanium, and PMMA surfaces. In conclusion, nano-HAP can adhere not only to enamel but also to artificial dental surfaces under oral conditions. The experiment showed that the acquired pellicle act as a bridge between the nano-HAP and the materials’ surface.

scholarly journals Polyphenols in Dental Applications

2020 ◽  
Vol 7 (3) ◽  
pp. 72 ◽  
Author(s):  
Naji Kharouf ◽  
Youssef Haikel ◽  
Vincent Ball
Keyword(s):  
Surface Chemistry ◽  
Biological Activities ◽  
Broad Class ◽  
Dental Materials ◽  
Biological Properties ◽  
Dental Tissues ◽  
Metallic Cations ◽  
Almost All ◽  
Dental Applications ◽  
Large Repertoire

(1) Background: polyphenols are a broad class of molecules extracted from plants and have a large repertoire of biological activities. Biomimetic inspiration from the effects of tea or red wine on the surface of cups or glass lead to the emergence of versatile surface chemistry with polyphenols. Owing to their hydrogen bonding abilities, coordination chemistry with metallic cations and redox properties, polyphenols are able to interact, covalently or not, with a large repertoire of chemical moieties, and can hence be used to modify the surface chemistry of almost all classes of materials. (2) Methods: the use of polyphenols to modify the surface properties of dental materials, mostly enamel and dentin, to afford them with better adhesion to resins and improved biological properties, such as antimicrobial activity, started more than 20 years ago, but no general overview has been written to our knowledge. (3) Results: the present review is aimed to show that molecules from all the major classes of polyphenolics allow for low coast improvements of dental materials and engineering of dental tissues.

scholarly journals Niobium-Treated Titanium Implants with Improved Cellular and Molecular Activities at the Tissue–Implant Interface

Materials ◽  
2019 ◽  
Vol 12 (23) ◽  
pp. 3861 ◽  
Author(s):  
Aude Falanga ◽  
Pascal Laheurte ◽  
Henri Vahabi ◽  
Nguyen Tran ◽  
Sara Khamseh ◽  
...  
Keyword(s):  
Growth Rate ◽  
Control Sample ◽  
Niobium Alloy ◽  
Titanium Implants ◽  
Cell Counting ◽  
Tissue Culture Polystyrene ◽  
Collagen Iii ◽  
Coarse Surface ◽  
Dental Applications ◽  
Endothelial Growth Factor

There have been several attempts to improve the cellular and molecular interactions at the tissue–implant interface. Here, the biocompatibility of titanium-based implants (e.g., Grade 2 Titanium alloy (Ti-40) and titanium–niobium alloy (Ti-Nb)) has been assessed using different cellular and molecular examinations. Cell culture experiments were performed on three substrates: Ti-40, Ti-Nb, and tissue culture polystyrene as control. Cells number and growth rate were assessed by cell counting in various days and cell morphology was monitored using microscopic observations. The evaluation of cells’ behavior on the surface of the implants paves the way for designing appropriate biomaterials for orthopedic and dental applications. It was observed that the cell growth rate on the control sample was relatively higher than that of the Ti-40 and Ti-Nb samples because of the coarse surface of the titanium-based materials. On the other hand, the final cell population was higher for titanium-based implants; this difference was attributed to the growth pattern, in which cells were not monolayered on the surface. Collagen I was not observed, while collagen III was secreted. Furthermore, interleukin (IL)-6 and vascular endothelial growth factor (VEGF) secretion were enhanced, and IL-8 secretion decreased. Moreover, various types of cells can be utilized with a series of substrates to unfold the cell behavior mechanism and cell–substrate interaction.

scholarly journals Limitations of Recent Studies Dealing with the Antibacterial Properties of Silver Nanoparticles: Fact and Opinion

Nanomaterials ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1775 ◽  
Author(s):  
Raphaël E. Duval ◽  
Jimmy Gouyau ◽  
Emmanuel Lamouroux
Keyword(s):  
Silver Nanoparticles ◽  
Infectious Diseases ◽  
Metallic Nanoparticles ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Therapeutic Option ◽  
Antibacterial Properties ◽  
Antimicrobial Activities ◽  
Synthetic Process ◽  
Great Heterogeneity

Due to the constant increase in the number of infectious diseases and the concomitant lack of treatment available, metallic nanoparticles (e.g., silver nanoparticles) have been of particular interest in the last decades. Indeed, several studies suggest that silver nanoparticles have valuable antimicrobial activities, especially against bacteria, which may lead us to think that these nanoparticles may one day be an attractive therapeutic option for the treatment of bacterial infections. Unfortunately, when we look a little closer to these studies, we can see a very great heterogeneity (e.g., in the study design, in the synthetic process of nanoparticles, in the methods that explore the antibacterial properties of nanoparticles and in the bacteria chosen) making cross-interpretation between these studies impossible, and significantly limiting the interest of silver nanoparticles as promising antibacterial agents. We have selected forty-nine international publications published since 2015, and propose to discuss, not the results obtained, but precisely the different methodologies developed in these publications. Through this discussion, we highlighted the aspects to improve, or at least to homogenize, in order to definitively establish the interest of silver nanoparticles as valuable antibacterial agents.

scholarly journals Recent Advances in Material and Geometrical Modelling in Dental Applications

2018 ◽  
Vol 6 (6) ◽  
pp. 1138-1144
Author(s):  
Waleed M. S. Al Qahtani ◽  
Salah A Yousief ◽  
Mohamed I. El-Anwar
Keyword(s):  
Computer Aided Design ◽  
New Technology ◽  
Dental Materials ◽  
Geometric Modelling ◽  
Cad System ◽  
Geometrical Modelling ◽  
Recent Advances ◽  
Wide Range ◽  
Computer Aided ◽  
Dental Applications

This article touched, in brief, the recent advances in dental materials and geometric modelling in dental applications. Most common categories of dental materials as metallic alloys, composites, ceramics and nanomaterials were briefly demonstrated. Nanotechnology improved the quality of dental biomaterials. This new technology improves many existing materials properties, also, to introduce new materials with superior properties that covered a wide range of applications in dentistry. Geometric modelling was discussed as a concept and examples within this article. The geometric modelling with engineering Computer-Aided-Design (CAD) system(s) is highly satisfactory for further analysis or Computer-Aided-Manufacturing (CAM) processes. The geometric modelling extracted from Computed-Tomography (CT) images (or its similar techniques) for the sake of CAM also reached a sufficient level of accuracy, while, obtaining efficient solid modelling without huge efforts on body surfaces, faces, and gaps healing is still doubtable. This article is merely a compilation of knowledge learned from lectures, workshops, books, and journal articles, articles from the internet, dental forum, and scientific groups' discussions.

scholarly journals Awareness on Nanoparticles Incorporation in Dental Materials among Undergraduate Students - A Cross Sectional Survey

2020 ◽  
pp. 63-74
Author(s):  
Aarthi Muthukumar ◽  
Revathi Duraisamy ◽  
Dhanraj Ganapathy
Keyword(s):  
Undergraduate Students ◽  
Dental Materials ◽  
Simple Random Sampling ◽  
Dental Students ◽  
Titanium Implants ◽  
P Value ◽  
Oral Diseases ◽  
Cross Sectional Survey ◽  
Chi Square ◽  
Cross Sectional

Nanotechnology is widely used in day to day life including its use in medicine. Using nanotechnology it is easy to analyse the atoms , chemical bonds and molecules present between various compounds. Use of nanoparticles in the field of dentistry is called nano dentistry. Chemical, physical and biological aspects of nanoparticles should be taken into account while choosing nanoparticles for the use in the field of nano dentistry. Nanoparticles are used in innovations of dentistry. Nano materials can be used for preventing and curing oral diseases such as oral cancer and to maintain oral health care. This study aims at evaluating knowledge and awareness of nanoparticles incorporated in dental materials among undergraduate dental students. A questionnaire with a set of 9 questions to assess the students knowledge and awareness about nanoparticles incorporation in dental materials. The sample size of 99 participants of dental students of Saveetha Dental College were selected by a simple random sampling method. The participants were asked to fill the questionnaire in an online site called survey planet. The results were collected and statistically analysed. Chi square test was done and it was found that 71% of the participants were aware about the use of nanoparticles in dental materials, even though it is statistically not significant (p value- 0.436), 73% of respondents were aware about nanoparticle incorporation in impression materials with p value 0.449 (not significant) and 72% were aware about use of nanomaterials in titanium implants(p value-0.340). Within the limitations of the study, it can be observed that the undergraduate students at the Faculty of Dentistry of Saveetha were well aware about the use of nanoparticles in dental materials.

Preparation of Leucite Powder with Controlled c-Phase Fraction for a Variety of Dental Applications

2007 ◽  
Vol 361-363 ◽  
pp. 897-900
Author(s):  
Alexandra Kloužková ◽  
M. Mrázová ◽  
M. Kohoutková
Keyword(s):  
Particle Size ◽  
Low Temperature ◽  
Dental Materials ◽  
Hydrothermal Conditions ◽  
Preparation Technology ◽  
Low Temperature Preparation ◽  
Main Crystalline Phase ◽  
Materials Used ◽  
Dental Applications ◽  
Temperature Preparation

Leucite (KAlSi2O6) is the main crystalline phase in feldspathic dental materials used for ceramic-fused-to-metal restorations. It occurs in two modifications, low temperature – tetragonal and at temperatures above 600 °C high temperature – cubic modification. The aim of this work was to develop a low-temperature preparation technology of submicron leucite powders with varying ratio of tetragonal and cubic modification. The results show that analcime synthesized in hydrothermal conditions is the suitable precursor for the preparation of leucite with controlled fraction of the c-modification. Homogenous t-leucite having particle size from 2 - 4 μm was prepared by 4h ion-exchange in 4M KCl. Partially stabilized c-leucite was obtained by dual ionexchange; 4h in 4M CsCl led to 48 % of c-modification in the final product.

Preparation of a novel anti shrinking agent (SOC DA) and its evaluation in dental resins

2013 ◽  
Vol 1609 ◽  
Author(s):  
Ricardo Acosta Ortiz ◽  
Luis Alberto Reyna Medina ◽  
María Lydia Berlanga Duarte ◽  
Aida Esmeralda Garcia Valdez
Keyword(s):  
Dental Materials ◽  
Acrylic Resin ◽  
Dental Composite ◽  
Molar Ratio ◽  
Dental Resin ◽  
Dental Resins ◽  
Acrylic Monomers ◽  
Urethane Dimethacrylate ◽  
Acrylate Monomers ◽  
Triethyleneglycol Dimethacrylate

AbstractIn this work is discussed the synthesis of a novel antishrinking agent (SOC DA) and the evaluation of its performance in an acrylic dental resin. SOC DA was photopolymerized in conjunction with the components of a conventional acrylic resin, which includes a mixture of diacrylate monomers [glycerolate bisphenol A dimethacrylate (BIS-GMA) / Urethane dimethacrylate (UDMA) / triethyleneglycol dimethacrylate (TEGDMA)] in 50/30/20 molar ratio). SOC DA was added in a range between 5.0-20.0 mol % with respect to the total amount of moles of the acrylic monomers. It was found that increasing concentrations of SOC DA, promoted higher conversions of the dimethacrylate monomers without decreasing the photopolymerization rate of the acrylate monomers. The study of the effect of SOC DA on the mechanical properties of the dental composite filled with 70 % of silicon dioxide, revealed that the presence of the antishrinking agent improved both the compressive and the flexural strength of the dental materials. Besides, it was found that by using the SOC DA at 20%, the shrinkage was reduced 52%, compared with the same formulation without SOC DA.

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