scholarly journals A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure

Materials ◽  
2020 ◽  
Vol 13 (22) ◽  
pp. 5277
Author(s):  
Kai Li ◽  
Yuting Zhu ◽  
Qiang Zhang ◽  
Xiaoli Shi ◽  
Feng Liang ◽  
...  
Keyword(s):  
Wound Repair ◽  
Structural Similarity ◽  
Skin Wound ◽  
Good Effect ◽  
Self Healing ◽  
Rat Skin ◽  
Simple Strategy ◽  
High Structural Similarity ◽  
Good Biocompatibility ◽  
Skin Healing

Although there have been many studies on using hydrogels as substitutes for natural extracellular matrices (ECMs), hydrogels that mimic the structure and properties of ECM remain a contentious topic in current research. Herein, a hierarchical biomimetic fiber hydrogel was prepared using a simple strategy, with a structure highly similar to that of the ECM. Cell viability experiments showed that the hydrogel not only has good biocompatibility but also promotes cell proliferation and growth. It was also observed that cells adhere to the fibers in the hydrogel, mimicking the state of cells in the ECM. Lastly, through a rat skin wound repair experiment, we demonstrated that this hydrogel has a good effect on promoting rat skin healing. Its high structural similarity to the ECM and good biocompatibility make this hydrogel a good candidate for prospective applications in the field of tissue engineering.

scholarly journals Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing

2020 ◽  
Vol 6 (12) ◽  
pp. eaay3704 ◽  
Author(s):  
Denise Gay ◽  
Giulia Ghinatti ◽  
Christian F. Guerrero-Juarez ◽  
Rubén A. Ferrer ◽  
Federica Ferri ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Wound Repair ◽  
Skin Condition ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Single Cell Rna Sequencing ◽  
Wnt Inhibitor ◽  
Skin Healing ◽  
Skin Wounding ◽  
Regenerative Repair

Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN wounds, increased expression of phagocytic/lysosomal genes in macrophages associated with predominance of fibrotic myofibroblasts in fibrotic wounds. Investigation revealed that macrophages in the late wound drive fibrosis by phagocytizing dermal Wnt inhibitor SFRP4 to establish persistent Wnt activity. In accordance, phagocytosis abrogation resulted in transient Wnt activity and a more regenerative healing. Phagocytosis of SFRP4 was integrin-mediated and dependent on the interaction of SFRP4 with the EDA splice variant of fibronectin. In the human skin condition hidradenitis suppurativa, phagocytosis of SFRP4 by macrophages correlated with fibrotic wound repair. These results reveal that macrophages can modulate a key signaling pathway via phagocytosis to alter the skin wound healing fate.

scholarly journals Promotion of Wound Healing and Prevention of Frostbite Injury in Rat Skin by Exopolysaccharide from the Arctic Marine Bacterium Polaribacter sp. SM1127

Marine Drugs ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 48 ◽  
Author(s):  
Mei-Ling Sun ◽  
Fang Zhao ◽  
Xiu-Lan Chen ◽  
Xi-Ying Zhang ◽  
Yu-Zhong Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Injury Prevention ◽  
Marine Bacterium ◽  
Skin Wound ◽  
Dermal Fibroblasts ◽  
The Arctic ◽  
Good Effect ◽  
Rat Skin ◽  
Skin Wound Healing ◽  
Sd Rats

Many marine microorganisms synthesize exopolysaccharides (EPSs), and some of these EPSs have been reported to have potential in different fields. However, the pharmaceutical potentials of marine EPSs are rarely reported. The EPS secreted by the Artic marine bacterium Polaribacter sp. SM1127 has good antioxidant activity, outstanding moisture-retention ability, and considerable protective property on human dermal fibroblasts (HDFs) at low temperature. Here, the effects of SM1127 EPS on skin wound healing and frostbite injury prevention were studied. Scratch wound assay showed that SM1127 EPS could stimulate the migration of HDFs. In the full-thickness cutaneous wound experiment of Sprague–Dawley (SD) rats, SM1127 EPS increased the wound healing rate and stimulated tissue repair detected by macroscopic observation and histologic examination, showing the ability of SM1127 EPS to promote skin wound healing. In the skin frostbite experiment of SD rats, pretreatment of rat skin with SM1127 EPS increased the rate of frostbite wound healing and promoted the repair of the injured skin significantly, indicating the good effect of SM1127 EPS on frostbite injury prevention. These results suggest the promising potential of SM1127 EPS in the pharmaceutical area to promote skin wound healing and prevent frostbite injury.

scholarly journals Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3264
Author(s):  
Wan-Hua Tsai ◽  
Chia-Hsuan Chou ◽  
Tsuei-Yin Huang ◽  
Hui-Ling Wang ◽  
Peng-Ju Chien ◽  
...  
Keyword(s):  
Wound Repair ◽  
Therapeutic Potential ◽  
Cell Model ◽  
Fibroblast Cell ◽  
Lipoteichoic Acid ◽  
Skin Wound ◽  
Cutaneous Wounds ◽  
Alternative Approach ◽  
Skin Healing ◽  
Systemic Infections

Probiotics are defined as microorganisms with beneficial health effects when consumed by humans, being applied mainly to improve allergic or intestinal diseases. Due to the increasing resistance of pathogens to antibiotics, the abuse of antibiotics becomes inefficient in the skin and in systemic infections, and probiotics may also provide the protective effect for repairing the healing of infected cutaneous wounds. Here we selected two Lactobacillus strains, L. plantarum GMNL-6 and L. paracasei GMNL-653, in heat-killed format to examine the beneficial effect in skin wound repair through the selection by promoting collagen synthesis in Hs68 fibroblast cells. The coverage of gels containing heat-killed GMNL-6 or GMNL-653 on the mouse tail with experimental wounds displayed healing promoting effects with promoting of metalloproteinase-1 expression at the early phase and reduced excessive fibrosis accumulation and deposition in the later tail-skin recovery stage. More importantly, lipoteichoic acid, the major component of Lactobacillus cell wall, from GMNL-6/GMNL-653 could achieve the anti-fibrogenic benefit similar to the heat-killed bacteria cells in the TGF-β stimulated Hs68 fibroblast cell model. Our study offers a new therapeutic potential of the heat-killed format of Lactobacillus as an alternative approach to treating skin healing disorders.

scholarly journals An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Hao Chen ◽  
Ruoyu Cheng ◽  
Xin Zhao ◽  
Yuhui Zhang ◽  
Allison Tam ◽  
...  
Keyword(s):  
Wound Repair ◽  
Skin Wound ◽  
Self Healing

scholarly journals Injectable Self-Healing Ceria-based Nanocomposite Hydrogel with ROS-scavenging Activity for Skin Wound Repair

2021 ◽  
Author(s):  
Xueyun Gong ◽  
Meng Luo ◽  
Min Wang ◽  
Wen Niu ◽  
Yidan Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Skin Wound ◽  
Scavenging Activity ◽  
Self Healing ◽  
Nanocomposite Hydrogel ◽  
Full Thickness ◽  
Ros Scavenging ◽  
Full Thickness Skin ◽  
Thickness Skin

Abstract Excessive reactive oxygen species (ROS) in the injured skin may impede the wound repair and skin regeneration. Herein, we develop an injectable self-healing ceria-based nanocomposite hydrogel with ROS-scavenging activity to accelerate wound healing. The nanocomposite hydrogels were successfully prepared by coating cerium oxide nanorods with polyethylenimine (PEI) and crosslinked with benzaldehyde-terminated F127 (F127-CHO) through the dynamic Schiff-base reaction (FVEC hydrogel). The results showed that the FVEC hydrogel possessed the good thermosensitivity, injectability, self-healing ability and ROS scavenging activity. The subcutaneous implantation experiments in mice confirmed that FVEC hydrogels are biocompatible and biodegradable in vivo. The full-thickness skin wound studies showed that FVEC hydrogel could significantly enhance the wound healing and epithelium regeneration with the formation of hair follicle and adipocyte tissue. This work provides a new strategy for the development of multifunctional Ce-based nanocomposite hydrogel for full-thickness skin wound healing and regeneration.

scholarly journals A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jian Zhang ◽  
Yongjun Zheng ◽  
Jimmy Lee ◽  
Jieyu Hua ◽  
Shilong Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Skin Wound ◽  
Large Animal ◽  
Skin Wounds ◽  
Tgfβ Signaling ◽  
Pulsatile Release ◽  
Ecm Extracellular Matrix

AbstractEffective healing of skin wounds is essential for our survival. Although skin has strong regenerative potential, dysfunctional and disfiguring scars can result from aberrant wound repair. Skin scarring involves excessive deposition and misalignment of ECM (extracellular matrix), increased cellularity, and chronic inflammation. Transforming growth factor-β (TGFβ) signaling exerts pleiotropic effects on wound healing by regulating cell proliferation, migration, ECM production, and the immune response. Although blocking TGFβ signaling can reduce tissue fibrosis and scarring, systemic inhibition of TGFβ can lead to significant side effects and inhibit wound re-epithelization. In this study, we develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for skin wounds. The material enhances skin wound closure while effectively suppressing scar formation in murine skin wounds and large animal preclinical models. Our study presents a strategy for scarless wound repair.

Current knowledge of immunomodulation strategies for chronic skin wound repair

2021 ◽  
Author(s):  
Parisa Heydari ◽  
Mahshid Kharaziha ◽  
Jaleh Varshosaz ◽  
Shaghayegh Haghjooy Javanmard
Keyword(s):  
Wound Repair ◽  
Current Knowledge ◽  
Skin Wound ◽  
Chronic Skin

Poly(aspartic acid) based self-healing hydrogels with antibacterial and light-emitting properties for wound repair

2021 ◽  
Vol 200 ◽  
pp. 111568
Author(s):  
Jiafu Shen ◽  
Ziwei Zhou ◽  
Danyang Chen ◽  
Yong Wang ◽  
Yingna He ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Wound Repair ◽  
Self Healing ◽  
Light Emitting

scholarly journals Microwave Imaging of Breast Skin Utilizing Elliptical UWB Antenna and Reverse Problems Algorithm

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 647
Author(s):  
Sameer Alani ◽  
Zahriladha Zakaria ◽  
Tale Saeidi ◽  
Asmala Ahmad ◽  
Muhammad Ali Imran ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Imaging System ◽  
Signal Transmission ◽  
Similarity Index ◽  
Structural Similarity ◽  
Microwave Imaging ◽  
Ultra Wideband ◽  
Uwb Antenna ◽  
System A ◽  
High Structural Similarity

Skin cancer is one of the most widespread and fast growing of all kinds of cancer since it affects the human body easily due to exposure to the Sun’s rays. Microwave imaging has shown better outcomes with higher resolution, faster processing time, mobility, and less cutter and artifact effects. A miniaturized elliptical ultra-wideband (UWB) antenna and its semi-spherical array arrangement were used for signal transmission and reception from the defected locations in the breast skin. Several conditions such as various arrays of three, six, and nine antenna elements, smaller tumor, multi-tumors, and skin on a larger breast sample of 30 cm were considered. To assess the ability of the system, a breast shape container with a diameter of 130 mm and height of 60 mm was 3D printed and then filled with fabricated skin and breast fat to perform the experimental investigation. An improved modified time-reversal algorithm (IMTR) was used to recreate 2D images of tumors with the smallest radius of 1.75 mm in any location within the breast skin. The reconstructed images using both simulated and experimental data verified that the system can be a reliable imaging system for skin cancer diagnosis having a high structural similarity index and resolution.

Super-ductile, injectable, fast self-healing collagen-based hydrogels with multi-responsive and accelerated wound-repair properties

2021 ◽  
Vol 405 ◽  
pp. 126756
Author(s):  
Min Zhang ◽  
Feng Deng ◽  
Lele Tang ◽  
Hui Wu ◽  
Yonghao Ni ◽  
...  
Keyword(s):  
Wound Repair ◽  
Self Healing
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