scholarly journals PMMA-Based Bone Cements and the Problem of Joint Arthroplasty Infections: Status and New Perspectives

Materials ◽  
2019 ◽  
Vol 12 (23) ◽  
pp. 4002 ◽  
Author(s):  
Bistolfi ◽  
Ferracini ◽  
Albanese ◽  
Vernè ◽  
Miola
Keyword(s):  
Bone Cement ◽  
Infection Rate ◽  
Scientific Community ◽  
Antibacterial Properties ◽  
Joint Arthroplasty ◽  
Current Status ◽  
Bone Cements ◽  
Bone Filler ◽  
Pmma Bone Cement ◽  
Bacteria Adhesion

Polymethyl methacrylate (PMMA)-based bone cement is a biomaterial that has been used over the last 50 years to stabilize hip and knee implants or as a bone filler. Although PMMA-based bone cement is widely used and allows a fast-primary fixation to the bone, it does not guarantee a mechanically and biologically stable interface with bone, and most of all it is prone to bacteria adhesion and infection development. In the 1970s, antibiotic-loaded bone cements were introduced to reduce the infection rate in arthroplasty; however, the efficiency of antibiotic-containing bone cement is still a debated issue. For these reasons, in recent years, the scientific community has investigated new approaches to impart antibacterial properties to PMMA bone cement. The aim of this review is to summarize the current status regarding antibiotic-loaded PMMA-based bone cements, fill the gap regarding the lack of data on antibacterial bone cement, and explore the progress of antibacterial bone cement formulations, focusing attention on the new perspectives. In particular, this review highlights the innovative study of composite bone cements containing inorganic antibacterial and bioactive phases, which are a fascinating alternative that can impart both osteointegration and antibacterial properties to PMMA-based bone cement.

The effect on the fatigue strength of bone cement of adding sodium fluoride

2001 ◽  
Vol 215 (2) ◽  
pp. 251-253 ◽  
Author(s):  
C Minari ◽  
M Baleanil ◽  
L Cristofolini ◽  
F Baruffaldi
Keyword(s):  
Fatigue Strength ◽  
Bone Cement ◽  
Sodium Fluoride ◽  
Biomedical Applications ◽  
Cement Mantle ◽  
Fatigue Tests ◽  
Fatigue Performance ◽  
Bone Cements ◽  
The Novel ◽  
Pmma Bone Cement

New bone cements that include several additives are currently being investigated and tested. One such additive is sodium fluoride (NaF), which promotes bone formation, facilitating implant integration and success. The influence of NaF on the fatigue performance of the cement as used in biomedical applications was tested in this paper. In fact fatigue failure of the cement mantle is a major factor limiting the longevity of a cemented implant. An experimental bone cement with added NaF (12wt%) was investigated. The fatigue strength of the novel bone cement was evaluated in comparison with the cement without additives; fatigue tests were conducted according to current standards. The load levels were arranged based on a validated, statistically based optimization algorithm. The curve of stress against number of load cycles and the endurance limit were obtained and compared for both formulations. The results showed that the addition of NaF (12 wt %) to polymethylmethacrylate (PMMA) bone cement does not affect the fatigue resistance of the material. Sodium fluoride can safely be added to the bone cement without altering the fatigue performance of the PMMA bone cement.

scholarly journals Mechanical Failure of Artificial Joint Materials: Wear and Fatigue

2000 ◽  
Author(s):  
L. D. Timmie Topoleski
Keyword(s):  
Cyclic Loading ◽  
Bone Cement ◽  
Fatigue Failure ◽  
Relative Motion ◽  
Wear Mechanisms ◽  
Bone Cements ◽  
Artificial Joint ◽  
Artificial Joints ◽  
Cocrmo Alloy ◽  
Pmma Bone Cement

Abstract Total artificial joint replacements are one of the most effective treatments for arthritis. Artificial joints are used to replace damaged cartilage and act as low-friction articulating materials in joints. During normal human walking, some of the materials used for artificial knee and hip replacements are subjected to both sliding articulation (relative motion) and cyclic loading. A common example is the CoCrMo alloy femoral surface of an artificial knee that articulates against an ultra-high-molecular-weight-polyethylene (UHMWPE) component. Other materials do not experience relative motion (at least not intentionally) and are subjected to only cyclic loading. An example is the poly(methyl methacrylate) or PMMA bone cement used to fix components of artificial joints into bones. In the case of articulating materials, both surfaces are susceptible to wear, from both second-body and third body (in the presence of abrasive particles) mechanisms. Wear of the UHMWPE has received considerable attention recently, since the polymer wear is far more obvious than the metal wear. The Biomaterials field is developing an understanding of the wear mechanisms and how to enhance the wear resistance of UHMWPE. The wear of the metal components has not received as much attention, yet materials wear as a couple; both surfaces play a role in the overall wear. In the UMBC Laboratory for Implantable Materials, we are investigating the mechanisms of CoCrMo alloy wear, and the effect of worn metal components on the wear of UHMWPE. Understanding the wear mechanisms of metal components may help to extend the life of artificial joints by allowing new articulating material combinations and joint designs. For non-articulating materials, fatigue failure is a primary concern. Fatigue of metal components is relatively rare. In the distal portion of an artificial hip, the metal hip stem is fixed into the bone by a layer of PMMA bone cement. The PMMA bone cement is far weaker and less resistant to fracture and fatigue than either the bone or the metal, and thus may be considered the mechanical “weak link” in cemented total joints. We are investigating the fatigue properties of PMMA bone cements, and studying the mechanisms of fatigue crack initiation. If we can determine how fatigue cracks start in bone cement, we may be able to develop, for example, new surgical procedures (e.g., bone preparation) that will reduce the likelihood of fatigue failure. New formulations of bone cement have been developed for both joint fixation, and also for bone repair or replacement. Understanding the failure mechanisms of bone cements may enable safe and effective new uses for new bone cements, and extend the lives of cemented artificial joints.

scholarly journals A promising material for bone repair: PMMA bone cement modified by dopamine-coated strontium-doped calcium polyphosphate particles

2019 ◽  
Vol 6 (10) ◽  
pp. 191028 ◽  
Author(s):  
Xing Liu ◽  
Can Cheng ◽  
Xu Peng ◽  
Hong Xiao ◽  
Chengrui Guo ◽  
...  
Keyword(s):  
Bone Cement ◽  
Bone Repair ◽  
Bone Cements ◽  
The Novel ◽  
Calcium Polyphosphate ◽  
Pmma Bone Cement ◽  
Repair Materials ◽  
Biological Performance ◽  
Bone Repair Materials ◽  
Composite Bone

Polymethyl methacrylate (PMMA) bone cement has been widely used in clinics as bone repair materials for its excellent mechanical properties and good injection properties. However, it also has defects such as poor biological performance, high temperature, and the monomer has certain toxicity. Our study tried to modify the PMMA bone cement by doping with various particle weight fractions (5, 10 and 15%) of SCPP particles and polydopamine-coated SCPP particles (D/SCPP) to overcome its clinical application disadvantages. Our study showed that all results of physical properties of samples are in accordance with ISO 5833. The 15% D/SCPP/PMMA composite bone cement had much better biocompatibility compared with pure PMMA bone cement and SCPP/PMMA composite bone cement due to the best cell growth-promoting mineralization deposition on the surface of 15% D/SCPP/PMMA composite bone cements and Sr 2+ released from SCPP particles. Our research also revealed that the reaction temperature was found to be reduced with an increase in doped particles after incorporating the particles into composite bone cements. The novel PMMA bone cements modified by D/SCPP particles are promising materials for bone repair.

Bioactive bone cements

1998 ◽  
Vol 212 (2) ◽  
pp. 113-120 ◽  
Author(s):  
E J Harper
Keyword(s):  
Bone Cement ◽  
Mechanical Characteristics ◽  
Cement Mantle ◽  
Polymerization Reaction ◽  
Bone Cements ◽  
Surgical Results ◽  
Pmma Bone Cement ◽  
Bioactive Agents ◽  
Pmma Cement ◽  
Surrounding Bone

Poly (methylmethacrylate) (PMMA) bone cement, used to fix implants into the bone, produces good surgical results if used correctly. However, prostheses do eventually become loose and the breakdown of the cement mantle is a factor in this failure. Limitations of PMMA cement, which lead to problems with the fixation of the implant, include its mechanical characteristics and its influence upon surrounding bone, associated with the polymerization reaction. A bioactive bone cement is particularly designed to produce a better interface between the cement and bone. However, an improvement in mechanical properties, especially fatigue, creep and fracture toughness, are an added necessary requirement to increase the lifetime of a cemented implant. The development of a bioactive cement has been conducted mainly in two ways; firstly, to improve existing PMMA cement by the addition of various bioactive agents and secondly, to design an alternative matrix for the bioactive material to be combined with. The most promising investigations which have been conducted, along with their relative benefits and drawbacks, are discussed.

scholarly journals Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and Biocompatibility

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 139
Author(s):  
Eva Paz ◽  
Yolanda Ballesteros ◽  
Juana Abenojar ◽  
Nicholas Dunne ◽  
Juan C. del Real
Keyword(s):  
Thermal Properties ◽  
Bone Cement ◽  
Bending Strength ◽  
Mechanical Performance ◽  
Fatigue Loading ◽  
Negative Influence ◽  
Fatigue Performance ◽  
Bone Cements ◽  
Bending Modulus ◽  
Pmma Bone Cement

The incorporation of well-dispersed graphene (G) powder to polymethyl methacrylate (PMMA) bone cement has been demonstrated as a promising solution to improving its mechanical performance. However, two crucial aspects limit the effectiveness of G as a reinforcing agent: (1) the poor dispersion and (2) the lack of strong interfacial bonds between G and the matrix of the bone cement. This work reports a successful functionalisation route to promote the homogenous dispersion of G via silanisation using 3-methacryloxypropyltrimethoxy silane (MPS). Furthermore, the effects of the silanisation on the mechanical, thermal and biocompatibility properties of bone cements are presented. In comparison with unsilanised G, the incorporation of silanised G (G_MPS1 and G_MPS2) increased the bending strength by 17%, bending modulus by 15% and deflection at failure by 17%. The most impressive results were obtained for the mechanical properties under fatigue loading, where the incorporation of G_MPS doubled the Fatigue Performance Index (I) value of unsilanised G-bone cement—meaning a 900% increase over the I value of the cement without G. Additionally, to ensure that the silanisation did not have a negative influence on other fundamental properties of bone cement, it was demonstrated that the thermal properties and biocompatibility were not negatively impacted—allowing its potential clinical progression.

Thermal Curing and Strength of PMMA Bone Cement

2003 ◽  
Author(s):  
M. A. Sanchez ◽  
W. Sutton ◽  
W. Rizk ◽  
J. Tompkins
Keyword(s):  
Bone Cement ◽  
Room Temperature ◽  
Initial Temperature ◽  
Exothermic Reaction ◽  
Bone Cements ◽  
Thermal Curing ◽  
Heat Transfer Modeling ◽  
Pmma Bone Cement ◽  
Maximum Reaction ◽  
Pmma Cement

Many current bone cements have proprietary minor ingredients that affect the chemical kinetics and heat transfer modeling of the exothermic reaction during bone cement polymerization. In addition, the geometry and the method of cooling/curing the bone cement can vary by application. A method for modeling energy generation, based on temperature measurement of various geometries and conditions, expresses the exothermic reaction and the duration with respect to time. Reaction from the bone cement can yield temperatures above 110°C for the air convective cooling boundary condition. Experiments show that by using cold irrigation cooling (saline) with an initial temperature of 1.5°C, the maximum reaction temperature of the PMMA cement approaches 40°C depending upon the thickness of the cement. For bone cement cooled in air and saline at room temperature, the exothermic reaction begins around 400 seconds (8 min) after the compounds are mixed. When cold saline is applied, the time-delay of the reaction is approximately 300 additional seconds compared to the two room temperature cases. Finally, based on compression testing, the structural behavior of the PMMA cement is improved when the material is cured in a slower and wet environment.

scholarly journals Effect of Calcium Acetate Content on Apatite-Forming Ability and Mechanical Property of PMMA Bone Cement Modified with Quaternary Ammonium

Materials ◽  
2020 ◽  
Vol 13 (21) ◽  
pp. 4998
Author(s):  
Haiyang Wang ◽  
Toshinari Maeda ◽  
Toshiki Miyazaki
Keyword(s):  
Compressive Strength ◽  
Bone Cement ◽  
Setting Time ◽  
Antibacterial Properties ◽  
Calcium Acetate ◽  
The Body ◽  
Apatite Formation ◽  
Pmma Bone Cement ◽  
Pmma Cement

Polymethyl methacrylate (PMMA)-based bone cement is a popular biomaterial used for fixation of artificial joints. A next-generation bone cement having bone-bonding ability, i.e., bioactivity and antibacterial property is desired. We previously revealed that PMMA cement added with 2-(tert-butylamino)ethyl methacrylate, γ-methacryloxypropyltrimethoxysilane and calcium acetate showed in vitro bioactivity and antibacterial activity. This cement contains calcium acetate at 20% of the powder component. Lower content of the calcium acetate is preferable, because the release of a lot of calcium salt may degrade mechanical properties in the body environment. In the present study, we investigate the effects of calcium acetate content on the setting property and mechanical strength of the cement and apatite formation in simulated body fluid (SBF). The setting time increased and the compressive strength decreased with an increase in calcium acetate content. Although the compressive strength decreased after immersion in SBF for 7 d, all the cements still satisfied the requirements of ISO5833. Apatite was formed in SBF within 7 d on the samples where the calcium acetate content was 5% or more. Therefore, it was found that PMMA cement having antibacterial properties and bioactivity can be obtained even if the amount of the calcium acetate is reduced to 5%.

scholarly journals Evidence for Past Life on Early Mars: How the Evidence Stands

2004 ◽  
Vol 213 ◽  
pp. 203-208 ◽  
Author(s):  
Everett K. Gibson ◽  
Kathie L. Thomas-Keprta ◽  
Simon J. Clemett ◽  
David S. Mckay ◽  
Christopher Romanek ◽  
...  
Keyword(s):  
Scientific Community ◽  
Current Status ◽  
Martian Meteorite ◽  
Martian Meteorites ◽  
Past Life ◽  
Early Mars ◽  
World’S Scientific Community

Martian Meteorite ALH84001 contains four unusual features which have been interpreted as possible signatures of relic biogenic activity. After six years of intense study by the world's scientific community, the current status of the biogenic hypothesis is reviewed and shown to still be valid. Furthermore additional features have been observed in two younger Martian meteorites. The strongest argument for possible evidence of biogenic activity within the ALH84001 meteorite is the presence of truncated hexa-octahedral magnetite crystals which are only known on Earth to be the products of biology.

Sign in / Sign up

Export Citation Format

Share Document