scholarly journals Reply to Comment: Evaluation of the Association of Omentin 1 rs2274907 A > T and rs2274908 G > A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case–Control Study

2020 ◽  
Vol 10 (4) ◽  
pp. 194
Author(s):  
Chandan K. Jha ◽  
Rashid Mir ◽  
Imadeldin Elfaki ◽  
Jamsheed Javid ◽  
Abdullatif Taha Babakr ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Association Studies ◽  
Large Sample Size ◽  
South Indian Population ◽  
Genome Wide Association Studies ◽  
South Indian ◽  
Artery Disease

Coronary artery disease (CAD) is a major cause of death all over the world. CAD is caused by atherosclerosis which is induced by the interaction of genetic factors and environmental factors. Genome-wide association studies have revealed the association of certain gene polymorphisms with susceptibility to CAD. Omentin 1 is an adipokine secreted by the visceral adipose tissues and has been reported to have anti-inflammatory, cardioprotective, and enhances insulin sensitivity. In this study, we examined the role of omentin-1 common single nucleotide polymorphisms (SNPs) (rs2274907 A > T and rs2274908 G > A) in CAD. We conclude that the AT genotype and the T allele of the rs2274907 A > T is associated with Cad in the south Indian population. Our results indicated that the rs2274907 SNP may be associated with CAD in this population. This finding needs further validation in well-designed and large-sample size studies before being introduced in clinical settings.

scholarly journals Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study

2019 ◽  
Vol 9 (2) ◽  
pp. 30 ◽  
Author(s):  
Chandan K Jha ◽  
Rashid Mir ◽  
Imadeldin Elfaki ◽  
Jamsheed Javid ◽  
Abdullatif Taha Babakr ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
South Indian Population ◽  
Genotype Distribution ◽  
South Indian ◽  
Artery Disease

Coronary artery disease (CAD) is a major cause of death all over the world. CAD is caused by atherosclerosis which is induced by the interaction of genetic factors and environmental factors. Traditional environmental risk factors include hyperlipidemia, diabetes mellitus, lack of exercise, obesity, poor diet and others. Genome-wide association studies have revealed the association of certain gene polymorphisms with susceptibility to CAD. Omentin 1 is an adipokine secreted by the visceral adipose tissues and has been reported to have anti-inflammatory, cardioprotective, and enhances insulin sensitivity. In this study, we examined the role of omentin-1 common single nucleotide polymorphisms (SNPs) (rs2274907 A>T and rs2274908 G>A) in CAD. We genotyped 100 CAD patients and 100 matched healthy controls from the south Indian population using an amplification refractory mutation system (ARMS-PCR) and allele-specific PCR (AS-PCR). Our result indicated the rs2274908 G>A is not associated with CAD. Results showed that there was a significant difference in rs2274907 A>T genotype distribution between controls and CAD cases (P-value < 0.05). Results indicated that the AT genotype of the rs2274907 is associated with CAD with OR = 3.0 (95% confidence interval (CI), 1.64 to 5.49), 1.65 (1.27 to 2.163), P = 0.002. The T allele of the rs2274907 was also associated with CAD with OR = 1.82 (95% CI, 1.193 to 2.80), 1.37 (1.08 to 1.74), P = 0.005. Rs2274907 genotype distribution was also correlated with serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), hypertension and diabetes. We conclude that the AT genotype and the T allele of the rs2274907 A>T is associated with Cad in the south Indian population. Further studies on the effect of the rs2274907 A>T on omentin-1 function are recommended, and future well-designed studies with larger sample sizes and in different populations are required to validate our findings.

scholarly journals Analysis of plasma myeloperoxidase levels and functional gene –463G>A and –129G>A polymorphisms with early onset of coronary artery disease in South Indian population

2016 ◽  
Vol 11 (4) ◽  
pp. 272-278 ◽  
Author(s):  
Sailaja Maddhuri ◽  
Priyanka Pallapollu ◽  
Srinivas Bandaru ◽  
Gudlla Suresh ◽  
Amaresh Rao Mallempati ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Early Onset ◽  
Indian Population ◽  
Functional Gene ◽  
South Indian Population ◽  
South Indian ◽  
Artery Disease

scholarly journals The SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Gorre Manjula ◽  
Rayabarapu Pranavchand ◽  
Irgam Kumuda ◽  
B. Sriteja Reddy ◽  
Battini Mohan Reddy
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Indian Population ◽  
Interaction Analysis ◽  
Association Studies ◽  
Specific Marker ◽  
Genome Wide Association Studies ◽  
Coronary Syndrome ◽  
Increased Risk ◽  
Artery Disease

AbstractDevelopment of coronary artery disease (CAD) is primarily due to the process of atherosclerosis, however the prognosis of CAD depends on pleiotropic effects of the genes located at 9p21.3 region. Genome wide association studies revealed association of variants in this region with CAD pathology. However, specific marker in predicting CAD development or progression is not yet identified. In the present study, 35 SNPs at 9p21.3 region, located in the cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) genes, were genotyped among 350 CAD cases and 480 controls from the southern Indian population of Hyderabad using fluidigm nanofluidic SNP genotyping system and the data were analyzed using PLINK and R softwares. Of the 35 SNPs analysed, only one SNP, rs7865618, was found to be highly significantly associated with CAD, even after correction for multiple testing (p = 0.008). The AG and GG genotypes of this SNP conferred 3.08 and 1.93 folds increased risk for CAD respectively. In particular, this SNP was significantly associated with severe anatomic (triple vessel disease p = 0.023) and phenotypic (acute coronary syndrome p = 0.007) categories of CAD. Pair wise SNP interaction analysis between the SNPs of 9p21.3 and 11q23.3 regions revealed significantly increased risk of three SNPs of 11q23.3 region that were not associated individually, in conjunction with rs7865618 of 9p21.3.

scholarly journals Significance of the Intima-Media thickness of carotid and thoracic aorta in coronary artery disease in the South Indian population

Heart Views ◽  
2011 ◽  
Vol 12 (4) ◽  
pp. 150 ◽  
Author(s):  
Ramachandran Meenakshisundaram ◽  
AndrewD Michaels ◽  
Chinnasamy Rajendiran ◽  
Soumen Devidutta ◽  
Subramanian Senthilkumaran ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Thoracic Aorta ◽  
Indian Population ◽  
Intima Media Thickness ◽  
South Indian Population ◽  
The South ◽  
Media Thickness ◽  
South Indian ◽  
Artery Disease

scholarly journals Diagnostic role and association of Lp-PLA2 with coronary artery disease in a South Indian population

2017 ◽  
Vol 69 ◽  
pp. S13-S14
Author(s):  
S. Sai Giridhar ◽  
S. Srikanth ◽  
B. Asha ◽  
J. Sai Kiran ◽  
J. Jiten ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian ◽  
Diagnostic Role ◽  
Artery Disease
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