scholarly journals Analysis of plasma myeloperoxidase levels and functional gene –463G>A and –129G>A polymorphisms with early onset of coronary artery disease in South Indian population

2016 ◽  
Vol 11 (4) ◽  
pp. 272-278 ◽  
Author(s):  
Sailaja Maddhuri ◽  
Priyanka Pallapollu ◽  
Srinivas Bandaru ◽  
Gudlla Suresh ◽  
Amaresh Rao Mallempati ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Early Onset ◽  
Indian Population ◽  
Functional Gene ◽  
South Indian Population ◽  
South Indian ◽  
Artery Disease

scholarly journals Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study

2019 ◽  
Vol 9 (2) ◽  
pp. 30 ◽  
Author(s):  
Chandan K Jha ◽  
Rashid Mir ◽  
Imadeldin Elfaki ◽  
Jamsheed Javid ◽  
Abdullatif Taha Babakr ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
South Indian Population ◽  
Genotype Distribution ◽  
South Indian ◽  
Artery Disease

Coronary artery disease (CAD) is a major cause of death all over the world. CAD is caused by atherosclerosis which is induced by the interaction of genetic factors and environmental factors. Traditional environmental risk factors include hyperlipidemia, diabetes mellitus, lack of exercise, obesity, poor diet and others. Genome-wide association studies have revealed the association of certain gene polymorphisms with susceptibility to CAD. Omentin 1 is an adipokine secreted by the visceral adipose tissues and has been reported to have anti-inflammatory, cardioprotective, and enhances insulin sensitivity. In this study, we examined the role of omentin-1 common single nucleotide polymorphisms (SNPs) (rs2274907 A>T and rs2274908 G>A) in CAD. We genotyped 100 CAD patients and 100 matched healthy controls from the south Indian population using an amplification refractory mutation system (ARMS-PCR) and allele-specific PCR (AS-PCR). Our result indicated the rs2274908 G>A is not associated with CAD. Results showed that there was a significant difference in rs2274907 A>T genotype distribution between controls and CAD cases (P-value < 0.05). Results indicated that the AT genotype of the rs2274907 is associated with CAD with OR = 3.0 (95% confidence interval (CI), 1.64 to 5.49), 1.65 (1.27 to 2.163), P = 0.002. The T allele of the rs2274907 was also associated with CAD with OR = 1.82 (95% CI, 1.193 to 2.80), 1.37 (1.08 to 1.74), P = 0.005. Rs2274907 genotype distribution was also correlated with serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), hypertension and diabetes. We conclude that the AT genotype and the T allele of the rs2274907 A>T is associated with Cad in the south Indian population. Further studies on the effect of the rs2274907 A>T on omentin-1 function are recommended, and future well-designed studies with larger sample sizes and in different populations are required to validate our findings.

scholarly journals Significance of the Intima-Media thickness of carotid and thoracic aorta in coronary artery disease in the South Indian population

Heart Views ◽  
2011 ◽  
Vol 12 (4) ◽  
pp. 150 ◽  
Author(s):  
Ramachandran Meenakshisundaram ◽  
AndrewD Michaels ◽  
Chinnasamy Rajendiran ◽  
Soumen Devidutta ◽  
Subramanian Senthilkumaran ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Thoracic Aorta ◽  
Indian Population ◽  
Intima Media Thickness ◽  
South Indian Population ◽  
The South ◽  
Media Thickness ◽  
South Indian ◽  
Artery Disease

scholarly journals Diagnostic role and association of Lp-PLA2 with coronary artery disease in a South Indian population

2017 ◽  
Vol 69 ◽  
pp. S13-S14
Author(s):  
S. Sai Giridhar ◽  
S. Srikanth ◽  
B. Asha ◽  
J. Sai Kiran ◽  
J. Jiten ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian ◽  
Diagnostic Role ◽  
Artery Disease

scholarly journals Comment: “Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study”

2020 ◽  
Vol 10 (4) ◽  
pp. 190
Author(s):  
Karani S. Vimaleswaran
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Indian Population ◽  
Data Interpretation ◽  
Minor Allele ◽  
South Indian Population ◽  
South Indian ◽  
Hardy Weinberg Equilibrium ◽  
Artery Disease ◽  
Dbsnp Database

The study by Jha et al. (2019) demonstrated an association of the single nucleotide polymorphism (SNP) rs2274907 A>T with coronary artery disease (CAD) in 100 CAD patients and 100 matched healthy controls from a South Indian population. There are serious concerns with regard to the interpretations of the study findings. The genotypes of the SNP are not in Hardy–Weinberg equilibrium (HWE) in both cases (p < 0.0001) and controls (p = 0.006), which is indicative of a technical error due to a problematic genotyping method. In addition, the genotype and allele frequencies reported in the study do not match with the frequencies listed in the SNP database for Asian Indians. While the study by Jha et al. reported ”T” allele as the minor allele, the dbSNP database reported ”A” as the minor allele. In summary, it can be concluded that the data presented in the study suffer from genotyping as well as data interpretation error and, hence, the findings should be considered by the reader with caution.

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