scholarly journals A Feasibility Study of an Extrusion-Based Fabrication Process for Personalized Drugs

2020 ◽  
Vol 10 (1) ◽  
pp. 16 ◽  
Author(s):  
Ilhan Yu ◽  
Roland K. Chen
Keyword(s):  
Manufacturing System ◽  
High Efficiency ◽  
Hydroxypropyl Methylcellulose ◽  
Active Pharmaceutical Ingredient ◽  
Immediate Release ◽  
Release Profile ◽  
Fabrication Process ◽  
Dissolution Test ◽  
Fabrication Method ◽  
Fabrication Time

Developing a high-efficiency manufacturing system for personalized medicine plays an important role in increasing the feasibility of personalized medication. The purpose of this study is to investigate the feasibility of a new extrusion-based fabrication process for personalized drugs with a faster production rate. This process uses two syringe pumps with a coaxial needle as an extruder, which extrudes two materials with varying ratios into a capsule. The mixture of hydrogel, polyethylene glycol (PEG), hydroxypropyl methylcellulose, poly acrylic acid and the simulated active pharmaceutical ingredient, Aspirin, was used. To validate the method, samples with different ratios of immediate release (IR) and sustained release (SR) mixtures were fabricated. The results of a dissolution test show that it is feasible to control the release profile by changing the IR and SR ratio using this fabrication setup. The fabrication time for each capsule is about 20 seconds, which is significantly faster than the current 3D printing methods. In conclusion, the proposed fabrication method shows a clear potential to step toward the feasibility of personalized medication.

Development, Evaluation and Optimization of Osmotic Controlled Tablets of Aceclofenac for Rheumatoid Arthritis Management

2019 ◽  
Vol 9 (1) ◽  
pp. 29-36
Author(s):  
Bijaya Ghosh ◽  
Niraj Mishra ◽  
Preeta Bose ◽  
Moumita D. Kirtania
Keyword(s):  
Rheumatoid Arthritis ◽  
Polyethylene Glycol ◽  
Sodium Chloride ◽  
Cellulose Acetate ◽  
Hydroxypropyl Methylcellulose ◽  
Release Profile ◽  
Polyethylene Glycol 400 ◽  
Permeable Membrane ◽  
Cumulative Release ◽  
The Core

Objective: Rheumatoid arthritis is a dreaded disease, characterized by pain, inflammation and stiffness of joints, leading to severe immobility problems. The disease shows circadian variation and usually gets aggravated in early morning hours. Aceclofenac, a BCS Class II compound is routinely used in the treatment of pain and inflammation associated with rheumatoid arthritis. The objective of this study was to develop an osmotic delivery system of Aceclofenac that after administration at bedtime would deliver the drug in the morning hours. </P><P> Methods: A series of osmotically controlled systems of aceclofenac was developed by using lactose, sodium chloride and hydroxypropyl methylcellulose K100M as osmogens. Cellulose acetate (2% w/v in acetone) with varying concentrations of polyethylene glycol-400 was used as the coating polymer to create semi permeable membrane and dissolution was carried out in 290 mOsm phosphate buffer. Formulation optimization was done from four considerations: cumulative release at the end of 6 hours (lag time), cumulative release at the end of 7 hours (burst time), steady state release rate and completeness of drug release. </P><P> Results: A formulation having swelling polymer hydroxypropyl methylcellulose in the core and lactose and sodium chloride as osmogens, polyethylene glycol-400 (16.39 %) as pore former, with a coating weight of 5% was a close fit to the target release profile and was chosen as the optimum formulation. Conclusion: Aceclofenac tablets containing lactose, HPMC and sodium chloride in the core, given a coating of cellulose acetate and PEG-400 (5% wt gain), generated a release profile for optimum management of rheumatoid arthritic pain.

scholarly journals Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 619
Author(s):  
Krisztián Pamlényi ◽  
Katalin Kristó ◽  
Orsolya Jójárt-Laczkovich ◽  
Géza Regdon
Keyword(s):  
Drug Delivery ◽  
Tensile Strength ◽  
Sodium Alginate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymer Films ◽  
Hydroxypropyl Methylcellulose ◽  
Chemical Properties ◽  
Active Pharmaceutical Ingredient ◽  
Swallowing Problems

Currently, pharmaceutical companies are working on innovative methods, processes and products. Oral mucoadhesive systems, such as tablets, gels, and polymer films, are among these possible products. Oral mucoadhesive systems possess many advantages, including the possibility to be applied in swallowing problems. The present study focused on formulating buccal mucoadhesive polymer films and investigating the physical and physical–chemical properties of films. Sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) were used as film-forming agents, glycerol (GLY) was added as a plasticizer, and cetirizine dihydrochloride (CTZ) was used as an active pharmaceutical ingredient (API). The polymer films were prepared at room temperature with the solvent casting method by mixed two-level and three-level factorial designs. The thickness, tensile strength (hardness), mucoadhesivity, surface free energy (SFE), FTIR, and Raman spectra, as well as the dissolution of the prepared films, were investigated. The investigations showed that GLY can reduce the mucoadhesivity of films, and CTZ can increase the tensile strength of films. The distribution of CTZ proved to be homogeneous in the films. The API could dissolve completely from all the films. We can conclude that polymer films with 1% and 3% GLY concentrations are appropriate to be formulated for application on the buccal mucosa as a drug delivery system.

scholarly journals Benznidazole Extended-Release Tablets for Improved Treatment of Chagas Disease: Preclinical Pharmacokinetic Study

2016 ◽  
Vol 60 (4) ◽  
pp. 2492-2498 ◽  
Author(s):  
Marcelo Gomes Davanço ◽  
Michel Leandro Campos ◽  
Talita Atanazio Rosa ◽  
Elias Carvalho Padilha ◽  
Alejandro Henao Alzate ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Extended Release ◽  
Hydroxypropyl Methylcellulose ◽  
Immediate Release ◽  
Relative Bioavailability ◽  
Pharmacokinetic Parameters ◽  
Therapeutic Success ◽  
Preclinical Pharmacokinetics ◽  
Bioavailability Study

ABSTRACTBenznidazole (BNZ) is the first-line drug for the treatment of Chagas disease. The drug is available in the form of immediate-release tablets for 100-mg (adult) and 12.5-mg (pediatric) doses. The drug is administered two or three times daily for 60 days. The high frequency of daily administrations and the long period of treatment are factors that significantly contribute to the abandonment of therapy, affecting therapeutic success. Accordingly, this study aimed to evaluate the preclinical pharmacokinetics of BNZ administered as extended-release tablets (200-mg dose) formulated with different types of polymers (hydroxypropyl methylcellulose K4M and K100M), compared to the tablets currently available. The studies were conducted with rabbits, and BNZ quantification was performed in plasma and urine by ultraperformance liquid chromatography methods previously validated. The bioavailability of BNZ was adequate in the administration of extended-release tablets; however, with the administration of the pediatric tablet, the bioavailability was lower than with other tablets, which showed that the clinical use of this formulation should be monitored. The pharmacokinetic parameters demonstrated that the extended-release tablets prolonged drug release from the pharmaceutical matrix and provided an increase in the maintenance of the drug concentrationin vivo, which would allow the frequency of administration to be reduced. Thus, a relative bioavailability study in humans will be planned for implementation of a new product for the treatment of Chagas disease.

scholarly journals Formulation, Development and Evaluation of Bilayer Floating Tablet of Gemfibrozil

2019 ◽  
Vol 9 (4) ◽  
pp. 574-578
Author(s):  
Mohammad Faizan Mohammad Gufran ◽  
Sailesh Kumar Ghatuary ◽  
Reena Shende ◽  
Prabhat Kumar Jain ◽  
Geeta Parkhe
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Hydroxypropyl Methylcellulose ◽  
Immediate Release ◽  
In Vitro Dissolution ◽  
Log P ◽  
Physical Parameters ◽  
Direct Compression ◽  
Formulation Development ◽  
Compression Technique

Formulation development is an important part of drug design and development. Bioavailability and bioequivalence are totally dependent on formulation development. Now-a-days formulation development is done by following QbD (Quality by Design).The aim of present study is to formulate Gemfibrozil (Gem) sustained release (SR) and immediate release (IR) bilayer tablet by different concentration of Hydroxypropyl methylcellulose (HPMC) and HPMC K 100 M to control the release pattern. The sustained release layer of Gem was prepared by using different grades of HPMC like, HPMC K-15, HPMC K-4 along with other excipients by direct compression technique. The immediate release layer of Gem was prepared by Cross carmellose sodium, Crospovidone and Sodium starch glycolate by direct compression technique. The powders were evaluated for their flow properties and the finished tablets were evaluated for their physical parameters. The both immediate release and sustained release layers of Gem were characterized by FT-IR and in vitro dissolution studies. The drug release study of Gem was evaluated using USP-II paddle type dissolution apparatus. The release rate of Gem in immediate release layer was studied for 15 min in 0.1 N HCL media and that of Gem in sustained release layer was studied for 12 h in 0.1 N HCL. From the nine batches F6 batch showed good release behaviour 99.85% of drug is released over 12 hours. Gem belongs to BCS Class II (log P 3.6) with poor solubility and high permeability resulting in limited and variable bioavailability. Total four trial batches of each drug have been manufactured to optimize and develop a robust and stable formulation, the stability studies of the products also comply with ICH guideline. Keywords: Bilayer floating tablets, Gemfibrozil, Biphasic drug release, HPMC K 15.

Influence of Liquid Phase Migration on Intermittent Extrusion of Aqueous Al2O3 Paste

2011 ◽  
Vol 189-193 ◽  
pp. 177-180
Author(s):  
Hong Jun Liu
Keyword(s):  
Liquid Phase ◽  
Solid Freeform Fabrication ◽  
Extrusion Process ◽  
Fabrication Process ◽  
Extrusion Pressure ◽  
Strong Impact ◽  
Fabrication Method ◽  
Liquid Content ◽  
Freeform Fabrication ◽  
Paste Extrusion

Extrusion Freeform Fabrication Process (EFF) is an environmentally friendly solid freeform fabrication method that uses aqueous pastes to fabricate ceramic-based components. The Liquid Phase Migration (LPM) causes variation in liquid content and consequently problems in the paste extrusion. To get uniform ceramics parts with desired composition, the LPM should be avoided in extrusion process. This paper investigated the influence of LPM on extrusion process for aqueous alumina paste in EFF process. It shows that the liquid phase migration occurs in Freeform Extrusion Fabrication process and has a strong impact on extrusion pressure. The LPM can be characterized by the extrusion pressure-ram displacement profiles. The liquid phase migration becomes more serious in intermittent extrusion at low ram velocity.

PEDOT:PSS monolayers to enhance the hole extraction and stability of perovskite solar cells

2018 ◽  
Vol 6 (34) ◽  
pp. 16583-16589 ◽  
Author(s):  
Lijun Hu ◽  
Meng Li ◽  
Ke Yang ◽  
Zhuang Xiong ◽  
Bo Yang ◽  
...  
Keyword(s):  
Solar Cells ◽  
High Efficiency ◽  
Perovskite Solar Cells ◽  
Fabrication Process ◽  
Working Model

A possible high efficiency working model of a monolayer PEDOT:PSS film and a brief fabrication process.

New Fabrication Process and New Materials for High Efficiency A-Si Solar Cells

1987 ◽  
pp. 425-429
Author(s):  
S. Nakano ◽  
H. Tarui ◽  
T. Takahama ◽  
M. Isomura ◽  
T. Matsuyama ◽  
...  
Keyword(s):  
Solar Cells ◽  
High Efficiency ◽  
Fabrication Process ◽  
New Materials ◽  
Si Solar Cells

scholarly journals Controlled Release of 5-FU from Chi–DHA Nanoparticles Synthetized with Ionic Gelation Technique: Evaluation of Release Profile Kinetics and Cytotoxicity Effect

2020 ◽  
Vol 11 (3) ◽  
pp. 48
Author(s):  
Mariarosa Ruffo ◽  
Ortensia Ilaria Parisi ◽  
Francesco Patitucci ◽  
Marco Dattilo ◽  
Rocco Malivindi ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
High Efficiency ◽  
Drug Loading ◽  
In Vitro Release ◽  
Release Profile ◽  
Order Kinetic ◽  
Ionic Gelation ◽  
Cytotoxicity Studies ◽  
Order Kinetic Model

The ionic gelation technique allows us to obtain nanoparticles able to function as carriers for hydrophobic anticancer drugs, such as 5-fluoruracil (5-FU). In this study, reticulated chitosan– docosahexaenoic acid (Chi–DHAr) nanoparticles were synthesized by using a chemical reaction between amine groups of chitosan (Chi) and carboxylic acids of docosahexaenoic acid (DHA) and the presence of a link between Chi and DHA was confirmed by FT-IR, while the size and morphology of the obtained Chi-DHAr nanoparticles was evaluated with dynamic light scattering (DLS) and scanning electron microscopy (SEM), respectively. Drug-loading content (DLC) and drug-loading efficiency (DLE) of 5-FU in Chi-DHAr nanoparticles were 33.74 ± 0.19% and 7.9 ± 0.26%, respectively, while in the non-functionalized nanoparticles (Chir + 5FU), DLC, and DLE were in the ranges of 23.73 ± 0.14%, 5.62%, and 0.23%, respectively. The in vitro release profile, performed in phosphate buffer saline (PBS, pH 7.4) at 37 °C, indicated that the synthetized Chi–DHAr nanoparticles provided a sustained release of 5-FU. Based on the obtained regression coefficient value (R2), the first order kinetic model provided the best fit for both Chir and Chi-DHAr nanoparticles. Finally, cytotoxicity studies of chitosan, 5-FU, Chir, Chir + 5-FU, Chi-DHAr, and Chi-DHAr + 5-FU nanoparticles were conducted. Overall, Chi-DHAr nanoparticles proved to be much more biocompatible than Chir nanoparticles while retaining the ability to release the drug with high efficiency, especially towards specific types of cancerous cells.

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