scholarly journals Validation of the SavvyCheckTM Vaginal Yeast Test for Screening Pregnant Women for Vulvovaginal Candidosis: A Prospective, Cross-Sectional Study

2021 ◽  
Vol 7 (3) ◽  
pp. 233
Author(s):  
Philipp Foessleitner ◽  
Herbert Kiss ◽  
Julia Deinsberger ◽  
Julia Ott ◽  
Lorenz Zierhut ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Predictive Value ◽  
Point Of Care ◽  
Cross Sectional Study ◽  
Control Group ◽  
Gram Stain ◽  
Cross Sectional ◽  
Point Of Care Test ◽  
Increased Risk ◽  
Vulvovaginal Candidosis

Pregnant women have an increased risk of vulvovaginal candidosis. Recurrent candidosis is under debate as a contributor to preterm birth, and vertical transmission may cause diaper dermatitis and oral thrush in the newborn. Apart from cultural methods, the gold standard for diagnosing candidosis is Gram staining, which is time-consuming and requires laboratory facilities. The objective of this prospective study was to validate a point-of-care vaginal yeast detection assay (SavvyCheckÔ Vaginal Yeast Test) and to evaluate it in asymptomatic pregnant women. We enrolled 200 participants, 100 of whom had vulvovaginal candidosis according to Gram stain (study group) and 100 were healthy pregnant controls (control group). Of these, 22 participants (11%) had invalid test results. The point-of-care test of the remaining 85 and 93 study participants in the study and control groups, respectively, showed a sensitivity of 94.1%, specificity of 98.9%, positive predictive value of 90.3%, and negative predictive value of 99.4% when compared with Gram stain. In conclusion, we found a high correlation between the SavvyCheckÔ Vaginal Yeast Test and Gram-stained smears during pregnancy. This suggests a potential role of this point-of-care test as a screening tool for asymptomatic pregnant women in early gestation.

scholarly journals Screening Pregnant Women for Bacterial Vaginosis Using a Point-of-Care Test: A Prospective Validation Study

2021 ◽  
Vol 10 (11) ◽  
pp. 2275
Author(s):  
Philipp Foessleitner ◽  
Herbert Kiss ◽  
Julia Deinsberger ◽  
Julia Ott ◽  
Lorenz Zierhut ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Bacterial Vaginosis ◽  
Pregnant Women ◽  
Predictive Value ◽  
Screening Tool ◽  
Point Of Care ◽  
Sialidase Activity ◽  
Point Of Care Test ◽  
Gram Staining ◽  
Increased Risk

Bacterial vaginosis in early pregnancy is associated with an increased risk of preterm birth. The introduction of a simple screen-and-treat program into antenatal care was shown to significantly reduce the rate of preterm birth. The gold standard for diagnosing bacterial vaginosis is Gram staining, which is, however, time-consuming and requires laboratory facilities. The objective of this prospective study was to validate a point-of-care sialidase activity detection test (OSOM® BVBLUE® Test) for asymptomatic pregnant women and evaluate its accuracy as a screening tool. We enrolled 200 pregnant participants, 100 with Gram staining-confirmed bacterial vaginosis and 100 healthy controls. Compared to Gram staining, the point-of-care test showed a sensitivity of 81%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 98.1%. In conclusion, we found that the OSOM® BVBLUE® Test was an accurate method for diagnosing bacterial vaginosis in asymptomatic pregnant women. This point-of-care test can therefore be considered a reliable and easy-to-use screening tool for bacterial vaginosis during pregnancy.

scholarly journals SARS-CoV-2 antibody prevalence among homeless people, sex workers and shelter workers in Denmark: a nationwide cross-sectional study

2021 ◽  
Author(s):  
Alexandra R. Roethlin Eriksen ◽  
Kamille Fogh ◽  
Rasmus Bo Hasselbalch ◽  
Henning Bundgaard ◽  
Susanne Dam Nielsen ◽  
...  
Keyword(s):  
Sex Work ◽  
Sex Workers ◽  
Point Of Care ◽  
Homeless People ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Point Of Care Test ◽  
Background Population ◽  
Increased Risk ◽  
Shelter Workers

Background People experiencing homelessness (PEH) and associated shelter workers may be at higher risk of infection with 'Severe acute respiratory syndrome coronavirus 2' (SARS-CoV-2). The aim of this study was to determine the prevalence of SARS-CoV-2 among PEH and shelter workers in Denmark. Design and methods In November 2020, we conducted a nationwide cross-sectional seroprevalence study among PEH and shelter workers at 21 recruitment sites in Denmark. The assessment included a point-of-care test for antibodies against SARS-CoV-2, followed by a questionnaire. The seroprevalence was compared to that of geographically matched blood donors considered as a proxy for the background population, tested using a total Ig ELISA assay. Results We included 827 participants in the study, of whom 819 provided their SARS-CoV-2 antibody results. Of those, 628 were PEH (median age 50.8 (IQR 40.9-59.1) years, 35.5% female) and 191 were shelter workers (median age 46.6 (IQR 36.1-55.0) years and 74.5% female). The overall seroprevalence was 6.7% and was similar among PEH and shelter workers (6.8% vs 6.3%, p=0.87); and 12% among all participants who engaged in sex work. The overall participant seroprevalence was significantly higher than that of the background population (2,9%, p <0.001). Participants engaging in sex work had a significantly increased risk of seropositivity compared to other participants (95% CI: 0.86-2.36, p=0.02). Seropositive and seronegative participants reported a similar presence of at least one SARS-CoV-2 associated symptom (49% and 54%, respectively). Interpretations The prevalence of SARS-CoV-2 antibodies was more than twice as high among PEH and associated shelter workers, compared to the background population. The subset of the study participants who were also sex workers were at particularly high risk of COVID-19 infection. Funding Tryg and HelseFonden.

scholarly journals Association between Pre-pregnant Overweight and Obesity and Periodontal Disease during Pregnancy: A Cross Sectional Study

2017 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Eman Ali Abd El Moaty Sheha ◽  
Hanan Elzeblawy Hassan ◽  
Wafaa Mostafa Ahmed Gamel
Keyword(s):  
Periodontal Disease ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
University Hospital ◽  
Public Health Issue ◽  
Obese Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk

Background: Obesity is considered а noteworthy public health issue in both developed & developing countries. Among the 1.5 billion overweight individuals worldwide, 300 million of them were obese women. In the general, the prevalence of maternal obesity has increased 60% in the previous two decades with nearly 1 in 3 women now entering pregnancy obese. Also, the periodontаl disease has been observed to be prevalent in pregnant women with the prevalence ranging from 20% to more than 50%, especially economically disadvantaged women.Aim: explore the relation between pre-pregnant overweight and obesity with periodontal disease during pregnancy.Subjects & Methods: cross-sectional study among 400 pregnant women were booked in the high-risk obstetric departments and the antenatal outpatient clinics at governmental general hospitals in El-Fayoum City and governmental university hospital in El-Mansoura city.Results: The mean age of pregnant women was 29.9 ± 6.2 with increase the prevalence of periodontal disease in pregnant women (83.5%). Statistically significant correlation was found between prenatal weight and periodontаl disease during pregnancy (p ≤ 0.0001) with increasing the prevalence of periodontal disease in prenatal obese women (53.2%) and over weight (39.7%) were observed in women who were in their 3rd trimester (р = 0.011). Increase prevalence of periodontal with poor oral hygiene and sedentary activity.Conclusion: increased pre-pregnancy obesity & overweight are positively correlated with periodontal disease prevalence among pregnant women, and Pregnancy itself may also be associated with аn increased risk of periodontal disease.Recommendations: Activating the role of the maternity and community health nurse in branches of Obstetrics and antenatal clinics to enhance pregnant women's knowledge regarding oral health risks of obesity & overweight.

scholarly journals Profile of D-dimer in Uncomplicated Pregnancy

2019 ◽  
pp. 283-287
Author(s):  
Rahajuningsih Dharma ◽  
Mercy T. Panjaitan ◽  
Kanadi Sumapradja ◽  
Rianto Setiabudy
Keyword(s):  
Pregnant Women ◽  
Clinical Pathology ◽  
Cross Sectional Study ◽  
Control Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Uncomplicated Pregnancy ◽  
D Dimer

Abstract Objective: To obtain the profile of D-dimer in uncomplicated pregnancy. Methods: A cross sectional study was done on 90 uncomplicated pregnant women consisted of 30 women in each trimester and 30 healthy, nonpregnant women as control group from July to August 2012. D-dimer level was measured by particle enhanced immunoturbidimetry method using Innovance D-dimer and Sysmex CA 1500 in the Department of Clinical Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta. Results: All women in the control group showed normal D-dimer level (<0.,5 mg/L FEU). The median and range of D-dimer level in the 1st trimester, 2nd trimester, and 3rd trimester were 0.42 mg/L FEU and 0.1-1.07 mg/L FEU, 0.97 mg/L FEU and  0.6-3.34 mg/L FEU, and 1.56 mg/L FEU and  0.69-3.75 mg/L FEU, respectively.  Increased D-dimer level was found in 27% of pregnant women in 1st trimester, 87% in 2nd trimester, and 100% in 3rd trimester. Conclusion: Increased D-dimer level was found in  27% of pregnant women in 1st trimester, 87% in 2nd trimester, and  100% in 3rd trimester. The range of D-dimer level in the 1st trimester was 0.1-1.07 mg/L FEU, in the 2nd trimester was 0.6-3.34 mg/L FEU, and in the 3rd trimester was 0.69-3.75 mg/L FEU. Keywords: D-dimer, trimester, uncomplicated pregnancy   Abstrak Tujuan : Untuk mendapatkan profil  D-dimer pada kehamilan tanpa komplikasi. Metode : Penelitian potong lintang dilakukan pada 90 perempuan hamil tanpa komplikasi yang terdiri atas 30 perempuan pada tiap trimester dan 30 perempuan sehat yang tidak hamil, sebagai kelompok kontrol dari bulan Juli sampai Agustus 2012. Kadar D-dimer diukur dengan cara particle enhanced immunoturbidimetry  menggunakan reagen InnovanceÒ D-dimer dan koagulometer SysmexÒ CA 1500 di  Deparemen Patologi Klinik, Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Jakarta. Hasil: Seluruh perempuan dalam kelompok kontrol mempunyai kadar D-dimer dalam batas normal (<0.,5 mg/L FEU). Median (rentang) kadar D-dimer  pada trimester pertama, kedua, dan ketiga berturut-turut  0.42 mg/L FEU  (0.1-1.07 mg/L FEU), 0.97 mg/L FEU (0.6-3.34 mg/L FEU), dan 1.56 mg/L FEU   (0.69-3.75 mg/L FEU).  Peningkatan kadar D-dimer ditemukan pada 27% perempuan hamil trimester pertama, 87%  trimester kedua, dan pada 100%  trimester ketiga.   Kesimpulan: Peningkatan kadar  D-dimer ditemukan pada  27% perempuan hamil trimester pertama,  87% trimester kedua dan   100% pada trimester ketiga.  Rentang kadar D-dimer level pada trimester pertama adalah 0.1-1.07 mg/L FEU, pada trimester kedua  0.6-3.34 mg/L FEU, dan pada trimester ketiga  0.69-3.75 mg/L FEU. Kata kunci: D-dimer, kehamilan tanpa komplikasi, trimester

scholarly journals A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)

Pathogens ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 348
Author(s):  
Sonia Ortiz-Martínez ◽  
José-Manuel Ramos-Rincón ◽  
María-Esteyner Vásquez-Chasnamote ◽  
Jhonatan Alarcón-Baldeón ◽  
Jorge Parraguez-de-la-Cruz ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Amazon Basin ◽  
Cross Sectional Study ◽  
Index Test ◽  
Peruvian Amazon ◽  
Sectional Study ◽  
Cross Sectional ◽  
Baermann Technique

Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. Objectives: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. Material and Methods: We performed a cross-sectional study of strongyloidiasis in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using serology (Strongyloides IgG IVD-ELISA kit) as an index test and the modified Baermann technique and/or charcoal fecal culture as the parasitological reference standard. Results: The reference tests showed S. stercoralis in the stool of 30 women (prevalence: 10%; 95% confidence interval [CI] 7.1% to 13.9%), while 101 women tested positive on the blood test (prevalence: 33.7%; 95% CI 28.6% to 39.4%). Fourteen of the 15 women (93.3%) with positive results according to the modified Baermann technique, and 14 of the 23 women (56.5%) with positive charcoal cultures also had positive serological results. Serology showed a sensitivity of 63.3% and a negative predictive value of 94.4%. Conclusion: In Iquitos, pregnant women have a high prevalence of S stercoralis. S. stercoralis ELISA could be an excellent tool for population-based screening, as it has a high negative predictive value that can help to rule out the presence of active infection.

Cortisol secretion pattern in overweight/obese and normal-weight infants: a cross-sectional study

2020 ◽  
Vol 33 (2) ◽  
pp. 241-246
Author(s):  
Ana Cristina Resende Camargos ◽  
Pedro Henrique Scheidt Figueiredo ◽  
Sueli Ferreira da Fonseca ◽  
Mariana Aguiar de Matos ◽  
Katherine Simone Caires Oliveira ◽  
...  
Keyword(s):  
Salivary Cortisol ◽  
Area Under The Curve ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Control Group ◽  
Cortisol Secretion ◽  
Cross Sectional ◽  
Increased Risk ◽  
Highly Sensitive ◽  
Cortisol Levels

AbstractBackgroundThe salivary circadian diurnal cortisol plays an important role in growth and development. Inappropriate levels may induce changes associated with an increased risk of obesity later in life. It is unknown if there are differences in cortisol secretion pattern between overweight/obese infants when compared with theirs peers in infancy. Thus, this study aimed to compare the salivary cortisol secretion pattern in overweight/obese and normal-weight infants.MethodsThirty-three (overweight/obese = 17 and normal weight = 16) infants between 6 and 24 months of age had saliva samples collected upon awakening (T1), 30 min after waking (T2), at 12:00 am or before the baby’s meal (T3), and prior to bedtime (T4). Highly sensitive enzyme immunoassays were used for cortisol analyses.ResultsSalivary cortisol levels were similar between the groups: T1 (p = 0.22; 95% confidence interval [CI]: −5.65, 1.37), T2 (p = 0.24; 95% CI: −8.23, 2.17), T3 (p = 0.95; 95% CI: −3.16, 2.96), and T4 (p = 0.81; 95% CI: −1.39, 1.08); and no differences were observed between area under the curve (AUC) (p = 0.80; 95% CI: −4.58–13.66). The cortisol level reduced in T4 (95% CI: 1.35–2.96) compared to T1 (95% CI: 5.15–8.49) and T2 in the overweight/obese group (p < 0.001; 95% CI: 6.02–11.04). In the normal-weight group, the cortisol reduced in T3 (95% CI: 2.86–8.18) compared to T1 (95% CI: 5.64–12.28) and decreased until T4 (p = 0.001; 95% CI: 1.25–3.37).ConclusionsThe overweight/obese infant group presented a different pattern of cortisol secretion, although cortisol levels did not differ between the control group.

scholarly journals Point-of-Care Troponin T Testing in the Management of Patients with Chest Pain in the Swedish Primary Care

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Staffan Nilsson ◽  
Per O. Andersson ◽  
Lars Borgquist ◽  
Ewa Grodzinsky ◽  
Magnus Janzon ◽  
...  
Keyword(s):  
Health Care ◽  
Primary Health Care ◽  
Chest Pain ◽  
Troponin T ◽  
Point Of Care ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Primary Health ◽  
Increased Risk ◽  
The Cost

Objective. To investigate the diagnostic accuracy and clinical benefit of point-of-care Troponin T testing (POCT-TnT) in the management of patients with chest pain. Design. Observational, prospective, cross-sectional study with followup. Setting. Three primary health care (PHC) centres using POCT-TnT and four PHC centres not using POCT-TnT in the southeast of Sweden. Patients. All patients ≥35 years old, contacting one of the primary health care centres for chest pain, dyspnoea on exertion, unexplained weakness, and/or fatigue with no other probable cause than cardiac, were included. Symptoms should have commenced or worsened during the last seven days. Main Outcome Measures. Emergency referrals, patients with acute myocardial infarctions (AMI), or unstable angina (UA) within 30 days of study enrolment. Results. 25% of the patients from PHC centres with POCT-TnT and 43% from PHC centres without POCT-TnT were emergently referred by the GP (P=0.011 ). Seven patients (5.5%) from PHC centres with POCT-TnT and six (8.8%) from PHC centres without POCT-TnT were diagnosed as AMI or UA (P=0.369). Two patients with AMI or UA from PHC centres with POCT-TnT were judged as missed cases in primary health care. Conclusion. The use of POCT-TnT may reduce emergency referrals but probably at the cost of an increased risk to miss patients with AMI or UA.

scholarly journals Evaluation of Cortez Onestep Chlamydia RapicardTM Insta Test for the Detection of Chlamydia Trachomatis in Pregnant Women at Mbare Polyclinic in Harare, Zimbabwe

2016 ◽  
Vol 6 (1) ◽  
pp. 19 ◽  
Author(s):  
Stephen Stephen, MSc ◽  
Chiwoneso Gwyneth Elizabeth Muchaneta-Kubara, PhD ◽  
Marshall Wesley Munjoma, PhD ◽  
Gibson Mandozana, PhD
Keyword(s):  
Chlamydia Trachomatis ◽  
Pregnant Women ◽  
Point Of Care ◽  
Rapid Test ◽  
Neonatal Infection ◽  
Antenatal Clinic ◽  
Cross Sectional Study ◽  
Chlamydia Infection ◽  
Cross Sectional ◽  
Predictive Values

Background: Cervical chlamydia infection poses high risk of pregnancy complications and neonatal infection. Reference methods for the detection of chlamydia infection are not available for routine use in developing countries. Point-of-care (POC) tests can bridge this gap. This study evaluated Cortez Onestep Chlamydia RapicardTM insta test for the detection of Chlamydia trachomatis in pregnant women at Mbare Polyclinic and determined the prevalence of C. trachomatis.Methods: This was a cross sectional study in 242 pregnant women aged ≥18 years attending their first ANC visit at Mbare polyclinic in Harare, Zimbabwe. Data collection form was used to obtain demographic and predisposing factors to Chlamydia infection and two endocervical swabs were collected from each patient. One specimen was examined by the POC test at the clinic and the other by SDA method in the laboratory.Results: The sensitivity, specificity, positive and negative predictive values of the rapid kit were 71.4%, 99.6%, 90.9% and 98.3% respectively. Prevalence of C. trachomitis was 5.8% by SDA method.Conclusion and Global Health Implications: The kit’s sensitivity (71.4%) and specificity (99.6%) implies that the rapid test is an important test which needs further evaluations. The prevalence of C. trichomitis of 5.8% is comparable to studies done elsewhere in Africa.Key words: Chlamydia trachomatis • Antenatal Clinic • Point of Care Tests • Rapid Test • Cortez One Step Chlamydia TestCopyright © 2017 Stephen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Effect of maternal BMI on labor outcomes in primigravida pregnant women

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eissa Khalifa ◽  
Alaa El-Sateh ◽  
Mohamed Zeeneldin ◽  
Ahmed M. Abdelghany ◽  
Mahmoud Hosni ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Active Phase ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Group Iii ◽  
Second Stage Of Labor ◽  
Group I ◽  
Increased Risk ◽  
Group Ii ◽  
Labor Outcomes

Abstract Background This study aims to detect the effects of increased BMI on labor outcomes in primigravida pregnant women. Methods A cross-sectional study involved 600 full-term singleton primigravida pregnant women who presented in the active phase of labor to the labor ward. They were divided according to BMI into three equals groups; women with normal BMI (group I), overweight women (group II), and women with class I obesity (group III). Results We found that high BMI was associated with a significantly increased risk of Caesarean section (C.S.) (13% in group I, 18% in group II and 40% in group III). Women with higher BMI and delivered vaginally had a significantly prolonged first and second stage of labor, consequently increased the need for oxytocin augmentation as well as the oxytocin dose. Regarding the maternal and fetal outcomes, there are significantly increased risks of postpartum sepsis, perineal tears, wound infection, as well as significantly increased birth weight and longer neonatal stay in the neonatal unit (NNU). Conclusion Obese primigravida pregnant women were at higher risk of suboptimal outcomes. Besides, prolonged first and second stages of labor and the incidence of C.S. have also been increased.

scholarly journals Increased Risk for Maternal Anxiety during the COVID-19 Outbreak in Brazil among Pregnant Women without Comorbidities

2021 ◽  
Vol 43 (12) ◽  
pp. 932-939
Author(s):  
Roseli Mieko Yamamoto Nomura ◽  
Ana Carla Franco Ubinha ◽  
Isabela de Paula Tavares ◽  
Maria Laura Costa ◽  
Maria Lucia da Rocha Opperman ◽  
...  
Keyword(s):  
High School ◽  
Pregnant Women ◽  
Protective Factor ◽  
Secondary Analysis ◽  
Cross Sectional Study ◽  
Maternal Anxiety ◽  
Maternal Knowledge ◽  
Cross Sectional ◽  
Self Confidence ◽  
Increased Risk

Abstract Objective To study maternal anxiety in pregnant women without comorbidities in the context of the COVID-19 outbreak in Brazil and to study maternal knowledge and concerns about the pandemic. Methods This is a secondary analysis from a national multicenter cross-sectional study performed in 10 cities, from June to August, 2020, in Brazil. Interviewed postpartum women, without medical or obstetrical comorbidities, were included in the present subanalysis. A structured questionnaire and the Beck Anxiety Inventory (BAI) were applied. Results Out of the 1,662 women, 763 (45.9%) met the criteria for the current analysis and 16.1% presented with moderate and 11.5% with severe maternal anxiety. Moderate or severe maternal anxiety was associated with high school education (odds ratio [OR]:1.58; 95% confidence interval [CI]:1.04–2.40). The protective factor was cohabiting with a partner (OR: 0.46; 95%CI: 0.29–0.73). There was a positive correlation between the total BAI score and receiving information about care in the pandemic (rpartial 0.15; p < 0.001); concern about vertical transmission of COVID-19 (rpartial 0.10; p = 0.01); receiving information about breastfeeding (rpartial 0.08; p = 0.03); concerns about prenatal care (rpartial 0.10; p = 0.01), and concerns about the baby contracting COVID-19 (rpartial 0.11; p = 0.004). The correlation was negative in the following aspects: self-confidence in protecting from COVID-19 (rpartial 0.08; p = 0.04), having learned (rpartial 0.09; p = 0.01) and self-confidence in breastfeeding (rpartial 0.22; p < 0.001) in the context of the pandemic. Conclusion The anxiety of pregnant women without medical or obstetrical comorbidities was associated to high school educational level and not living with a partner during the COVID-19 pandemic. Self-confidence in protecting against COVID-19 and knowledge about breastfeeding care during the pandemic reduced maternal anxiety.

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