scholarly journals The Incidence and Outcomes of Recurrence of Infection after Therapeutic Penetrating Keratoplasty for Medically-Uncontrolled Infectious Keratitis

2020 ◽  
Vol 9 (11) ◽  
pp. 3696
Author(s):  
Jayoon Moon ◽  
Chang Ho Yoon ◽  
Mee Kum Kim ◽  
Joo Youn Oh
Keyword(s):  
Penetrating Keratoplasty ◽  
Positive Culture ◽  
Primary Outcome Measure ◽  
Close Monitoring ◽  
Infectious Keratitis ◽  
Tertiary Referral Center ◽  
Included Patient ◽  
Operative Findings ◽  
Therapeutic Penetrating Keratoplasty ◽  
Infection Recurrence

Background: This study aimed to investigate the outcome of therapeutic penetrating keratoplasty (TPK) for medically-uncontrolled infectious keratitis, and to determine the factors associated with the recurrence of infection after TPK. Methods: A 10-year retrospective study of medically-uncontrolled infectious keratitis with positive culture results, who received TPK at a tertiary referral center in Korea was performed. Data collection included patient demographics, medical history, pre- and post-operative findings, surgical procedures, causative microorganisms, and visual acuities (VA). The primary outcome measure was the recurrence of infection after TPK, and the factors were compared between patients with and without recurrence. Results: A total of 19 patients (19 eyes) were analyzed, of which 6 eyes (31.6%) had infection recurrence at 21.6 ± 22.84 months after TPK. Recurrence occurred more frequently in the female sex (vs. male, p = 0.013) and in longer duration (>30 days) from infection onset to TPK (vs. ≤30 days, p = 0.025). Final best-corrected-VA was poorer in patients with recurrence than those without (LogMAR 1.60 ± 0.97 vs. 2.40 ± 0.46, p = 0.026). Evisceration was performed in 2 out of 6 patients with recurrence (33.3%), while none was performed in those without recurrence (p = 0.028). Conclusion: Infection recurrence after TPK was 31.6%. Given the poor outcome of TPK in eyes with recurrence, close monitoring and intensive treatment are required post-TPK.

Outcome of Therapeutic Penetrating Keratoplasty Using Glycerol-Preserved Donor Corneas in Infectious Keratitis

Cornea ◽  
2016 ◽  
Vol 35 (9) ◽  
pp. 1175-1178 ◽  
Author(s):  
Onsiri Thanathanee ◽  
Wathanee Sripawadkul ◽  
Orapin Anutarapongpan ◽  
Patanaree Luanratanakorn ◽  
Olan Suwan-Apichon
Keyword(s):  
Penetrating Keratoplasty ◽  
Infectious Keratitis ◽  
Therapeutic Penetrating Keratoplasty ◽  
Donor Corneas

scholarly journals FUNGAL PROFILE OF INFECTIOUS KERATITIS IN A TERTIARY CARE HOSPITAL - OUR EXPERIENCE

2012 ◽  
Vol 02 (02) ◽  
pp. 10-14
Author(s):  
Sanjeev H. ◽  
Karnaker Vimal K. ◽  
Pai Vijay ◽  
Pai Asha K. B. ◽  
Rai Rekha ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Positive Culture ◽  
Clinical Findings ◽  
Care Hospital ◽  
Infectious Keratitis ◽  
Mycotic Keratitis ◽  
Direct Microscopy ◽  
Ocular Morbidity ◽  
Positive Direct ◽  
High Degree

AbstractInfectious keratitis world wide are a leading cause of ocular morbidity and blindness. A large number of filamentous fungi, Yeasts and Zygomycetes have been incriminated as the causative agent of mycotic keratitis. Early diagnosis and treatment is important in preventing complications like corneal perforation, scleral spread and endopthalmitis. The present study was conducted to elucidate the epidemiological features of mycotic keratitis and study the fungal profile of mycotic keratitis of patients attending our hospital, which is situated on the coastal area of Karnataka.A total of 127 patients with infectious keratitis were investigated between January 2009 to June 2010. Corneal scraping was obtained from 127 patients under aseptic precaution. The scraping was subjected to 10% KOH wet mount, Gram's staining and culture. Of the total 127 patients suspected of having infectious keratitis, 44 (34.65%) were found to be positive for fungal aetiology. Of these, 40(90.90%) cases were positive on direct microscopy for fungal elements and 26(59.09%) cases showed growth on culture after incubation for 2-8 days. In 14 (31.81%) cases, the culture was found to be sterile despite positive direct microscopic findings, but the results were consistent with clinical findings. Positive culture was obtained in 4(09.09%) cases where direct microscopy was found to be negative. The commonest fungi isolated were Aspergillus species (61.5%)Mycotic keratitis continues to be an important cause of ocular morbidity, predominantly among rural population. Prompt diagnosis and early institution of antifungal therapy may limit the ocular morbidity and the sequelae of infectious keratitis. As the manifestation of mycotic keratitis is often confusing, a high degree of suspicion with sound knowledge of predisposing factors and microbiological confirmation is very essential to initiate appropriate therapy.

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