scholarly journals Examining Bone, Muscle and Fat in Middle-Aged Long-Term Endurance Runners: A Cross-Sectional Study

2020 ◽  
Vol 9 (2) ◽  
pp. 522
Author(s):  
Ulrike H. Mitchell ◽  
Bruce Bailey ◽  
Patrick J. Owen
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Fat Mass ◽  
Lean Mass ◽  
Aerobic Exercise Training ◽  
Middle Aged ◽  
Cross Sectional ◽  
Endurance Runners ◽  
Total Body

Aerobic exercise training has many known cardiovascular benefits that may promote healthy aging. It is not known if long-term aerobic exercise training is also associated with structural benefits (e.g., lower fat mass, higher areal bone mineral density (BMD) and greater muscle mass). We evaluated these parameters in middle-aged long-term endurance runners compared to sex-, age-, height-, and weight-matched non-running controls. Total and regional lean and fat mass and areal BMD were assessed by dual-energy X-ray absorptiometry. Sagittal magnetic resonance images captured the cross-sectional area and thickness of the lumbar multifidus. Runners (n = 10; all male) had a mean (standard deviation; SD) age of 49 (4) years, height of 178.9 (4.9) cm, weight of 67.8 (5.8) kg, body mass index (BMI) of 21.4 (1.4) kg/m2 and had been running 82.6 (27.9) km/week for 23 (13) years. Controls (n = 9) had a mean (SD) age of 51 (5) years, height of 176.0 (5.1) cm, weight of 72.8 (7.1) kg, and BMI of 23.7 (2.1) kg/m2. BMI was greater in controls (p = 0.010). When compared to controls on average, runners had a 10 percentage-point greater total body lean mass than controls (p = 0.001) and 14% greater trunk lean mass (p = 0.010), as well as less total body (8.6 kg; p < 0.001), arm (58%; p = 0.002), leg (52%; p < 0.001), trunk (73%; p < 0.001), android (91%; p < 0.001), and gynoid fat mass (64%; p < 0.001). No differences were observed between groups for BMD outcomes or multifidus size. These results underscore the benefits of endurance running to body composition that carry over to middle-age.

Effects of resistance or aerobic exercise training on total and regional body composition in sedentary overweight middle-aged adults

2012 ◽  
Vol 37 (3) ◽  
pp. 499-509 ◽  
Author(s):  
Cheyne E. Donges ◽  
Rob Duffield
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Body Mass ◽  
Aerobic Fitness ◽  
Fat Free Mass ◽  
Aerobic Exercise Training ◽  
Maximal Heart Rate ◽  
Middle Aged ◽  
Regional Body Composition ◽  
Total Body

The purpose of this study was to examine the effects of 10 weeks of aerobic endurance training (AET), resistance exercise training (RET), or a control (CON) condition on absolute and relative fat mass (FM) or fat-free mass (FFM) in the total body (TB) and regions of interest (ROIs) of sedentary overweight middle-aged males and females. Following prescreening, 102 subjects underwent anthropometric measurements, dual-energy X-ray absorptiometry, and strength and aerobic exercise testing. Randomized subjects (male RET, n = 16; female RET, n = 19; male AET, n = 16; and female AET, n = 25) completed supervised and periodized exercise programs (AET, 30–50 min cycling at 70%–75% maximal heart rate; RET, 2–4 sets × 8–10 repetitions of 5–7 exercises at 70%–75% 1 repetition maximum) or a nonexercising control condition (male CON, n = 13 and female CON, n = 13). Changes in absolute and relative TB-FM and TB-FFM and ROI-FM and ROI-FFM were determined. At baseline, and although matched for age and body mass index, males had greater strength, aerobic fitness, body mass, absolute and relative TB-FFM and ROI-FFM, but reduced absolute and relative TB-FM and ROI-FM, compared with females (p < 0.05). After training, both female exercise groups showed equivalent or greater relative improvements in strength and aerobic fitness than did the male exercise groups (p < 0.05); however, the male exercise groups increased TB-FFM and reduced TB-FM more than did the female exercise groups (p < 0.05). Male AET altered absolute FM more than male RET altered absolute FFM, thus resulting in a greater enhancement of relative FFM. Despite equivalent or greater responses to RET or AET by female subjects, the corresponding respective increases in FFM or reductions in FM were lower than those in males, indicating that a biased dose–response relationship exists between sexes following 10 weeks of exercise training.

Abstract P262: Weight Gain with Aerobic Exercise Training Results from Increased Fat and Lean Mass

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Julie Holden ◽  
Damon Swift ◽  
Neil Johannsen ◽  
Conrad Earnest ◽  
Timothy Church
Keyword(s):  
Weight Loss ◽  
Weight Gain ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Fat Mass ◽  
Lean Mass ◽  
Weight Change ◽  
Linear Models ◽  
Aerobic Exercise Training ◽  
Significant Difference

Hypothesis: Weight gained in response to aerobic exercise represents an increase in lean mass. Methods: Participants from the exercise group (n=68) of the Inflammation and Exercise (INFLAME) study had fat mass, lean mass, and weight measured at baseline and at follow-up. Fat mass and lean mass were measured using DXA. Changes in lean mass and fat mass were quantified across tertiles of weight change in the exercise training group and were analyzed using generalized linear models with adjustment for baseline value. Results: are presented as least squares means with 95% confidence intervals. Results: Overall, participants exhibited a mean (range) weight change of –0.73 kg (–9.00, 7.00; n=68) following exercise training. Tertiles of mean (range) weight change were: tertile 1 (most weight loss) –3.40 kg (–9.00,–1.50; n=23), tertile 2 (some weight loss) –0.70 kg (–1.30, –0.10; n=22), and tertile 3 (weight gain) 1.93 kg (0, 7.00; n=23). For those in tertile 3, we observed a significant increase (p<0.0001) in lean mass of 0.91 kg (95% CI, 0.48, 1.34) compared to those who lost weight −0.85 kg (−1.28,−0.42) in tertile 1 and −0.52 kg (−0.97,−0.08) in tertile 2. However, no significant difference in lean mass change was seen between the two weight loss tertiles. We also observed a significant increase in fat mass in participants who gained weight (tertile 3) 1.07 kg (0.41, 1.73) while those who lost the most weight (tertile 1) −2.55 kg (−3.21,−1.89) had a significant decrease in fat mass. Participants who experienced some weight loss (tertile 2) showed no significant change in fat mass, −0.24 kg (−0.91, 0.44). Conclusion: Weight gained with aerobic exercise training cannot be attributed to increased lean mass only. Our findings suggest that adults who gained weight with exercise showed significant increases in both fat and lean mass.

Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults

2015 ◽  
Vol 309 (10) ◽  
pp. H1642-H1647 ◽  
Author(s):  
Shumpei Fujie ◽  
Natsuki Hasegawa ◽  
Koji Sato ◽  
Satoshi Fujita ◽  
Kiyoshi Sanada ◽  
...  
Keyword(s):  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Cross Sectional Study ◽  
Aerobic Exercise Training ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Older Subjects ◽  
Induced Changes

Aging-induced arterial stiffening is reduced by aerobic exercise training, and elevated production of nitric oxide (NO) participates in this effect. Adropin is a regulator of endothelial NO synthase and NO release, and circulating adropin level decreases with age. However, the effect of habitual aerobic exercise on circulating adropin levels in healthy middle-aged and older adults remains unclear. We sought to determine whether serum adropin level is associated with exercise training-induced changes in arterial stiffness. First, in a cross-sectional study, we investigated the association between serum adropin level and both arterial stiffness and cardiorespiratory fitness in 80 healthy middle-aged and older subjects (65.6 ± 0.9 yr). Second, in an intervention study, we examined the effects of 8-wk aerobic exercise training on serum adropin level and arterial stiffness in 40 healthy middle-aged and older subjects (67.3 ± 1.0 yr) divided into two groups: aerobic exercise training and sedentary controls. In the cross-sectional study, serum adropin level was negatively correlated with carotid β-stiffness ( r = −0.437, P < 0.001) and positively correlated with plasma NOx level ( r = 0.493, P < 0.001) and cardiorespiratory fitness ( r = 0.457, P < 0.001). Serum adropin levels were elevated after the 8-wk aerobic exercise training intervention, and training-induced changes in serum adropin level were correlated with training-induced changes in carotid β-stiffness ( r = −0.399, P < 0.05) and plasma NOx level ( r = 0.623, P < 0.001). Thus the increase in adropin may participate in the exercise-induced reduction of arterial stiffness.

Abstract P137: Aerobic, Resistance or Combination Exercise Training does not Reduce C-Reactive Protein Levels in Individuals with Type 2 Diabetes

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Damon L Swift ◽  
Neil M Johannsen ◽  
Conrad P Earnest ◽  
Steven N Blair ◽  
Timothy S Church
Keyword(s):  
Type 2 Diabetes ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Fat Mass ◽  
Fasting Glucose ◽  
Aerobic Exercise Training ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

Introduction: Type 2 diabetes is associated with elevated C-reactive protein levels (CRP), which is an independent risk factor for cardiovascular disease. Aerobic exercise training especially with weight/adiposity reduction has been shown to improve CRP, however few studies have evaluated the effect of other exercise training modalities (aerobic, resistance or combination training) on CRP in individuals with type 2 diabetes. Hypothesis: We hypothesize that combination training will improve CRP to a greater extent than other modalities of exercise training, and change in CRP levels will be associated with changes in weight and adiposity. Methods: The present study is a secondary analysis of the Health Benefits of Aerobic and Resistance Training in Individuals with Type 2 Diabetes (HART-D) study. Participants (n=204) were randomized to aerobic exercise (aerobic), resistance exercise (resistance) or a combination of both (combination) for nine months. Results: Baseline CRP was correlated with fat mass, waist circumference, BMI, and inversely correlated with VO2 peak (p<0.05). CRP was not reduced in the aerobic (0.16 mg•L-1, 95% CI: -1.0, 1.3), resistance (-0.03 mg•L-1, 95% CI: -1.1, 1.0) or combination (-0.49 mg•L-1, 95% CI: -1.5 to 0.6) groups compared to control (0.35 mg•L-1, 95% CI: -1.0, 1.7). Change in CRP was associated with change in fasting glucose (r=0.20, p= 0.009), glycated hemoglobin (HbA1C) (r=0.21 p=0.005), and fat mass (r=0.19, p=0.016), but not change in fitness or weight (p > 0.05). Conclusions: In conclusion, aerobic, resistance or a combination of both did not reduce CRP levels in individuals with type 2 diabetes. However, exercise related improvements in HbA1C, fasting glucose, and fat mass were associated with reductions in CRP.

Aerobic exercise training reduces plasma endothelin-1 concentration in older women

2003 ◽  
Vol 95 (1) ◽  
pp. 336-341 ◽  
Author(s):  
Seiji Maeda ◽  
Takumi Tanabe ◽  
Takashi Miyauchi ◽  
Takeshi Otsuki ◽  
Jun Sugawara ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Older Women ◽  
Ventilatory Threshold ◽  
Vascular Endothelial Cells ◽  
Aerobic Exercise Training ◽  
Vascular Endothelial ◽  
Middle Aged ◽  
Endothelin 1

Endothelial function deteriorates with aging. On the other hand, exercise training improves the function of vascular endothelial cells. Endothelin-1 (ET-1), which is produced by vascular endothelial cells, has potent constrictor and proliferative activity in vascular smooth muscle cells and, therefore, has been implicated in regulation of vascular tonus and progression of atherosclerosis. We previously reported significantly higher plasma ET-1 concentration in middle-aged than in young humans, and recently we showed that plasma ET-1 concentration was significantly decreased by aerobic exercise training in healthy young humans. We hypothesized that plasma ET-1 concentration increases with age, even in healthy adults, and that lifestyle modification (i.e., exercise) can reduce plasma ET-1 concentration in previously sedentary older adults. We measured plasma ET-1 concentration in healthy young women (21–28 yr old), healthy middle-aged women (31–47 yr old), and healthy older women (61–69 yr old). The plasma level of ET-1 significantly increased with aging (1.02 ± 0.08, 1.33 ± 0.11, and 2.90 ± 0.20 pg/ml in young, middle-aged, and older women, respectively). Thus plasma ET-1 concentration was markedly higher in healthy older women than in healthy young or middle-aged women (by ∼3- and 2-fold, respectively). In healthy older women, we also measured plasma ET-1 concentration after 3 mo of aerobic exercise (cycling on a leg ergometer at 80% of ventilatory threshold for 30 min, 5 days/wk). Regular exercise significantly decreased plasma ET-1 concentration in the healthy older women (2.22 ± 0.16 pg/ml, P < 0.01) and also significantly reduced their blood pressure. The present study suggests that regular aerobic-endurance exercise reduces plasma ET-1 concentration in older humans, and this reduction in plasma ET-1 concentration may have beneficial effects on the cardiovascular system (i.e., prevention of progression of hypertension and/or atherosclerosis by endogenous ET-1).

Aerobic Exercise Training-Induced Reductions in Abdominal Fat and Glucose-Stimulated Insulin Responses in Middle-Aged and Older Men

2000 ◽  
Vol 48 (9) ◽  
pp. 1055-1061 ◽  
Author(s):  
Richard E. Pratley ◽  
James M. Hagberg ◽  
Donald R. Dengel ◽  
Ellen M. Rogus ◽  
Denis C. Muller ◽  
...  
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Older Men ◽  
Abdominal Fat ◽  
Aerobic Exercise Training ◽  
Middle Aged ◽  
Insulin Responses

Aerobic Exercise Training and Cardiorespiratory Fitness in Older Adults: A Randomized Control Trial

1999 ◽  
Vol 7 (4) ◽  
pp. 374-383 ◽  
Author(s):  
Richard A. Boileau ◽  
Edward McAuley ◽  
Demetra Demetriou ◽  
Naveen K. Devabhaktuni ◽  
Gregory L. Dykstra ◽  
...  
Keyword(s):  
Heart Rate ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Exercise Program ◽  
The Elderly ◽  
Aerobic Exercise Training ◽  
Moderate Intensity ◽  
Control Group ◽  
Before And After

A trial was conducted to examine the effect of moderate aerobic exercise training (AET) on cardiorespiratory (CR) fitness. Previously sedentary participants, age 60-75 years, were randomly assigned to either AET treatment or a control group for 6 months. The AET consisted of walking for 40 min three times/week at an intensity that elevated heart rate to 65% of maximum heart rate reserve. The control group performed a supervised stretching program for 40 min three times/week. CR fitness was assessed before and after the treatments during a grade-incremented treadmill walking test. Both absolute and relative peak V̇O2 significantly increased (p < .01) in the AET group, whereas they decreased modestly in the control group. Maximum treadmill time increased significantly (p < .01) in the AET group relative to the control group. These results indicate that CR fitness as measured by peak V̇O2 modestly improves in the elderly with a moderate-intensity, relatively long-term aerobic exercise program.

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