scholarly journals The Association between Adult Weight Gain and Insulin Resistance at Middle Age: Mediation by Visceral Fat and Liver Fat

2019 ◽  
Vol 8 (10) ◽  
pp. 1559 ◽  
Author(s):  
Inge Verkouter ◽  
Raymond Noordam ◽  
Saskia le Cessie ◽  
Rob M. van Dam ◽  
Hildo J. Lamb ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Weight Gain ◽  
Weight Change ◽  
Visceral Fat ◽  
Middle Age ◽  
Liver Fat ◽  
Adult Weight ◽  
Total Body Fat ◽  
Total Body

We aimed to investigate the role of the amount of visceral fat and liver fat in the association between adult weight change and insulin resistance at middle age. In the Netherlands Epidemiology of Obesity study, adult weight change was calculated with recalled body weight at age 20 years and measured body weight at middle age. Measures of insulin resistance were calculated using both fasting and postprandial glucose and insulin concentrations. Visceral fat was assessed by magnetic resonance (MR) imaging and liver fat by proton-MR spectroscopy (N = 1758). We examined the association between adult weight change and insulin resistance with linear regression, adjusted for confounding factors. To investigate mediation, we additionally adjusted for total body fat, visceral fat, and liver fat. In participants who gained ≥50% of body weight during adulthood, homeostatic model assessment for insulin resistance (HOMA-IR) was 3.22 (95% CI 2.76; 3.77) times higher than in weight maintainers. In a joint model, total body fat mediated this association for 8.1% (95% CI −9.2; 25.4), visceral fat for 32.0% (18.6; 45.4%) and liver fat for 22.5% (15.0; 30.1). The association between adult weight gain and insulin resistance at middle age is largely mediated by both visceral fat and liver fat.

scholarly journals The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans

2009 ◽  
Vol 116 (6) ◽  
pp. 531-537 ◽  
Author(s):  
Konstantinos Kantartzis ◽  
Fausto Machicao ◽  
Jürgen Machann ◽  
Fritz Schick ◽  
Andreas Fritsche ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Body Fat ◽  
Visceral Fat ◽  
Magnetic Resonance Tomography ◽  
Liver Fat ◽  
Oral Glucose ◽  
Total Body Fat ◽  
Total Body

The enzyme DGAT (acyl-CoA:diacylglycerol acyltransferase) catalyses the final step of triacylglycerol (triglyceride) synthesis. Mice overexpressing hepatic DGAT2 fed a high-fat diet develop fatty liver, but not insulin resistance, suggesting that DGAT2 induces a dissociation between fatty liver and insulin resistance. In the present study, we investigated whether such a phenotype also exists in humans. For this purpose, we determined the relationships between genetic variability in the DGAT2 gene with changes in liver fat and insulin sensitivity in 187 extensively phenotyped subjects during a lifestyle intervention programme with diet modification and an increase in physical activity. Changes in body fat composition [MR (magnetic resonance) tomography], liver fat and intramyocellular fat (1H-MR spectroscopy) and insulin sensitivity [OGTT (oral glucose tolerance test) and euglycaemic–hyperinsulinaemic clamp] were determined after 9 months of intervention. A change in insulin sensitivity correlated inversely with changes in total body fat, visceral fat, intramyocellular fat and liver fat (OGTT, all P<0.05; clamp, all P≤0.03). Changes in total body fat, visceral fat and intramyocellular fat were not different between the genotypes of the SNPs (single nucleotide polymorphisms) rs10899116 C>T and rs1944438 C>T (all P≥0.39) of the DGAT2 gene. However, individuals carrying two or one copies of the minor T allele of SNP rs1944438 had a smaller decrease in liver fat (−17±10 and −24±5%; values are means±S.E.M.) compared with subjects homozygous for the C allele (−39±7%; P=0.008). In contrast, changes in insulin sensitivity were not different among the genotypes (OGTT, P=0.76; clamp, P=0.53). In conclusion, our findings suggest that DGAT2 mediates the dissociation between fatty liver and insulin resistance in humans. This finding may be important in the prevention and treatment of insulin resistance and Type 2 diabetes in subjects with fatty liver.

Adult weight change in relation to visceral fat and liver fat at middle age: The Netherlands epidemiology of obesity study

2018 ◽  
Vol 43 (4) ◽  
pp. 790-799 ◽  
Author(s):  
Inge Verkouter ◽  
Raymond Noordam ◽  
Albert de Roos ◽  
Hildo J. Lamb ◽  
Frits R. Rosendaal ◽  
...  
Keyword(s):  
The Netherlands ◽  
Weight Change ◽  
Visceral Fat ◽  
Middle Age ◽  
Liver Fat ◽  
Adult Weight

scholarly journals Change in Visceral Fat and Total Body Fat and the Effect on Cardiometabolic Risk Factors During Transgender Hormone Therapy

2021 ◽  
Author(s):  
Maartje Klaver ◽  
Daan van Velzen ◽  
Christel de Blok ◽  
Nienke Nota ◽  
Chantal Wiepjes ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Hormone Therapy ◽  
Body Fat ◽  
Visceral Fat ◽  
Cardiometabolic Risk ◽  
Trans Men ◽  
Total Body Fat ◽  
In Trans ◽  
Trans Women ◽  
Total Body

Abstract Introduction Excess visceral fat increases the risk of type 2 diabetes and cardiovascular disease and is influenced by sex hormones. Our aim was to investigate changes in visceral fat and the ratio of visceral fat to total body fat (VAT/TBF) and their associations with changes in lipids and insulin resistance after 1 year of hormone therapy in trans persons. Methods In 179 trans women and 162 trans men, changes in total body and visceral fat estimated with dual-energy X-ray absorptiometry before and after 1 year of hormone therapy were related to lipids and insulin resistance [homeostatic model assessment of insulin resistance (HOMA-IR)] with linear regression analysis. Results In trans women, total body fat increased by 4.0 kg (95% CI 3.4, 4.7), while the amount of visceral fat did not change (−2 grams; 95% CI −15, 11), albeit with a large range from −318 to 281, resulting in a decrease in the VAT/TBF ratio of 17% (95% CI 15, 19). In trans men, total body fat decreased with 2.8 kg (95% CI 2.2, 3.5), while the amount of visceral fat did not change (3 g; 95% CI −10, 16; range −372, 311), increasing the VAT/TBF ratio by 14% (95% CI 10, 17). In both groups, VAT/TBF was not associated with changes in blood lipids or HOMA-IR. Conclusions Hormone therapy in trans women and trans men resulted in changes in VAT/TBF, mainly due to changes in total body fat and were unrelated to changes in cardiometabolic risk factors, which suggests that any unfavorable cardiometabolic effects of hormone therapy are not mediated by changes in visceral fat or VAT/TBF.

Effect of Insulin and Cortisone on Weight Gain, Protein and Fat Content of Rats

1958 ◽  
Vol 193 (3) ◽  
pp. 455-460 ◽  
Author(s):  
F. X. Hausberger ◽  
B. C. Hausberger
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Fat ◽  
Food Restriction ◽  
Normal Growth ◽  
Fat Content ◽  
The Body ◽  
Body Protein ◽  
Total Body Fat ◽  
Total Body

Male Wister rats weighing 240 ± 2 gm show an average protein and fat content of 41.6 gm, and 13.1 gm. During a period of normal growth, the body weight increases within 14 days to 311 gm, the protein content to 57 gm, and the fat content to 21.7 gm. Several groups of rats were subjected to experimental procedures for 14 days, after having reached a body weight of 240 gm. Administration of protamine zine insulin (12 u/day) greatly enhanced weight gain, and deposition of excess fat, without affecting accumulation of body protein. Cortisone (5 mg/day) produced variable results. Diminished gain of body weight and total body protein occurred in 60% of the animals while accumulation of body fat was normal. Some rats lost weight and body protein but comparatively less fat than animals losing fat due to food restriction. Weight loss was most frequently observed in rats with visible infections. Simultaneous administration of insulin (12 u/day) did not alter the cortisone effect on body protein but markedly increased accumulation of body fat. One hundred twenty units per day accelerated gain of body fat still more. Values were observed comparable to those found in rats receiving insulin only. The amount of total body fat closely paralleled the amount of adipose tissue the composition of which was not significantly altered by any of the hormonal manipulations.

Assessing the utility of cardiorespiratory fitness, visceral fat, and liver fat in predicting changes in insulin sensitivity beyond simple changes in body weight after exercise training in adolescents

2021 ◽  
Vol 46 (1) ◽  
pp. 55-62
Author(s):  
Jennifer L. Kuk ◽  
SoJung Lee
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Glucose Tolerance ◽  
Weight Change ◽  
Visceral Fat ◽  
Liver Fat ◽  
Body Weight Change ◽  
Sensitivity Changes

To examine the utility of changes in cardiorespiratory fitness (CRF) and body composition in response to exercise training in adolescents with obesity beyond simple measures of body weight change. This is a secondary analysis of our previously published randomized trials of aerobic, resistance, and combined training. We included 104 adolescents (body mass index (BMI) ≥85th percentile) who had complete baseline and post-intervention data for CRF, regional body fat, insulin sensitivity, and oral glucose tolerance. Associations between changes in body composition and CRF with cardiometabolic variables were examined adjusted for age, sex, Tanner stage, race, exercise group, and weight loss. At baseline, CRF, visceral fat and liver fat were correlated with insulin sensitivity with and without adjustment for BMI percentile. Training-associated changes in CRF, visceral fat, and liver fat were also correlated with insulin sensitivity changes, but not independent of body weight change. After accounting for body weight change, none of the body composition or CRF were associated with changes in insulin sensitivity, glucose tolerance, systolic blood pressure, or high-density lipoprotein cholesterol. Although CRF and body composition were strong independent correlates of insulin sensitivity at baseline, changes in CRF and visceral fat were not associated with changes in insulin sensitivity after accounting for body weight change. Clinicaltrials.gov registration nos.: NCT00739180, NCT01323088, NCT01938950. Novelty With exercise training, changes in body weight, CRF, visceral fat, and liver fat were correlated with changes in insulin sensitivity. Changes in body composition or CRF generally did not remain significant correlates of changes in insulin sensitivity after adjusting for body weight changes.

scholarly journals Characterization of Body Composition and Fat Mass Distribution 1 Year After Kidney Transplantation

2016 ◽  
Vol 27 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Catherine Pantik ◽  
Young-Eun Cho ◽  
Donna Hathaway ◽  
Elizabeth Tolley ◽  
Ann Cashion
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Kidney Transplantation ◽  
Weight Gain ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Total Body Fat ◽  
Total Body

Purpose: In some recipients, significant weight gain occurs after kidney transplantation. Weight gain is associated with poor outcomes, particularly increased cardiovascular risk. In this study, we characterized changes in body mass index and body fat mass and compared them based on gender and race. Methods: Fifty-two kidney transplant recipients (aged ≥18 years old, 50% men, 58% African American) were enrolled into a prospective study. Body mass index and body fat mass were measured at baseline and 12 months posttransplant. Body fat mass was determined by dual-energy X-ray absorptiometry. Results: The mean increase in body weight was 3.7kg at 12 months; 36.5% (n=19) gained at least 10% of their baseline body weight. Body mass index, percentage of total body fat, and trunk fat were significantly increased. In subgroups, women and African American showed significant increases in body mass index and body fat measures. More participants were classified as obese based on total body fat compared to body mass index. Calories from fat were significantly increased at 12 months and associated with increased body mass index, total body fat, and trunk fat. Days of physical activity were significantly increased. Conclusion: Both body mass index and total body fat mass were significantly increased at 12 months following kidney transplantation, especially for women and African Americans. Importantly, more participants were classified as obese based on total body fat compared to body mass index. Relevant nutrition and physical intervention should be provided, and both body mass index and body fat mass should be evaluated when monitoring weight gain.

Leptin: a significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women

Diabetes ◽  
1996 ◽  
Vol 45 (11) ◽  
pp. 1635-1637 ◽  
Author(s):  
A. Dua ◽  
M. I. Hennes ◽  
R. G. Hoffmann ◽  
D. L. Maas ◽  
G. R. Krakower ◽  
...  
Keyword(s):  
African American ◽  
African American Women ◽  
Body Fat ◽  
Visceral Fat ◽  
American Women ◽  
Total Body Fat ◽  
Total Body ◽  
Insulin Insensitivity

scholarly journals Body mass index and waist circumference are better predictors of insulin resistance than total body fat percentage in middle-aged and elderly Taiwanese

Medicine ◽  
2017 ◽  
Vol 96 (39) ◽  
pp. e8126 ◽  
Author(s):  
Yiu-Hua Cheng ◽  
Yu-Chung Tsao ◽  
I-Shiang Tzeng ◽  
Hai-Hua Chuang ◽  
Wen-Cheng Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Middle Aged ◽  
Fat Percentage ◽  
Total Body Fat ◽  
Total Body

The prophylactic potential of Zingiber officinale flowers and leaves extract to mitigate hyperglycemia in Sprague Dawley rats

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Saira Tanweer ◽  
Tariq Mehmood ◽  
Saadia Zainab ◽  
Zulfiqar Ahmad ◽  
Muhammad Ammar Khan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Zingiber Officinale ◽  
Sprague Dawley ◽  
Content Type ◽  
Sprague Dawley Rats ◽  
Hematological Analysis ◽  
Therapeutic Tools

Purpose Innovative health-promoting approaches of the era have verified phytoceutics as one of the prime therapeutic tools to alleviate numerous health-related ailments. The purpose of this paper is to probe the nutraceutic potential of ginger flowers and leaves against hyperglycemia. Design/methodology/approach The aqueous extracts of ginger flowers and leaves were observed on Sprague Dawley rats for 8 weeks. Two parallel studies were carried out based on dietary regimes: control and hyperglycemic diets. At the end of the experimental modus, the overnight fed rats were killed to determine the concentration of glucose and insulin in serum. The insulin resistance and insulin secretions were also calculated by formulae by considering fasting glucose and fasting insulin concentrations. Furthermore, the feed and drink intakes, body weight gain and hematological analysis were also carried out. Findings In streptozotocin-induced hyperglycemic rats, the ginger flowers extract depicted 5.62% reduction; however, ginger leaves extract reduced the glucose concentration up to 7.11% (p = 0.001). Similarly, ginger flowers extract uplifted the insulin concentration up to 3.07%, while, by ginger leaves extract, the insulin value increased to 4.11% (p = 0.002). For the insulin resistance, the ginger flower showed 5.32% decrease; however, the insulin resistance was reduced to 6.48% by ginger leaves (p = 0.014). Moreover, the insulin secretion increased to 18.9% by flower extract and 21.8% by ginger leave extract (p = 0.001). The feed intake and body weight gain increased momentously by the addition of ginger flowers and leaves; however, the drink intake and hematological analysis remained non-significant by the addition of ginger parts. Originality/value Conclusively, it was revealed that leaves have more hypoglycemic potential as compared to flowers.

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