scholarly journals FAK is Required for Tumor Metastasis-Related Fluid Microenvironment in Triple-Negative Breast Cancer

2019 ◽  
Vol 8 (1) ◽  
pp. 38 ◽  
Author(s):  
Mei-Ren Pan ◽  
Ming-Feng Hou ◽  
Fu Ou-Yang ◽  
Chun-Chieh Wu ◽  
Shu-Jyuan Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Fluid Shear Stress ◽  
Physical Factors ◽  
Interstitial Fluid Flow ◽  
Cancer Treatments ◽  
Significant Independent Predictor ◽  
Patients With Cancer ◽  
Cell Metastasis

Cancer cell metastasis is the main cause of death in patients with cancer. Many studies have investigated the biochemical factors that affect metastasis; however, the role of physical factors such as fluid shear stress (FSS) in tumorigenesis and metastasis have been less investigated. Triple-negative breast cancer (TNBC) has a higher incidence of lymph node invasion and distant metastasis than other subtypes of breast cancer. In this study, we investigated the influence of FSS in regulating the malignant behavior of TNBC cells. Our data demonstrate that low FSS promotes cell migration, invasion, and drug resistance, while high FSS has the opposite results; additionally, we found that these phenomena were regulated through focal adhesion kinase (FAK). Using immunohistochemistry staining, we show that FAK levels correlate with the nodal stage and that FAK is a significant independent predictor of overall survival in patients. Altogether, these data implicate FAK as a fluid mechano-sensor that regulates the cell motility induced by FSS and provide a strong rationale for cancer treatments that combine the use of anti-cancer drugs and strategies to modulate tumor interstitial fluid flow.

Endothelial cells promote triple‐negative breast cancer cell metastasis via PAI‐1 and CCL5 signaling

2017 ◽  
Vol 32 (1) ◽  
pp. 276-288 ◽  
Author(s):  
Wenwen Zhang ◽  
Jing Xu ◽  
Hehui Fang ◽  
Lin Tang ◽  
Weiwei Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cell Metastasis ◽  
Pai 1

scholarly journals Drug Repositioning and Subgroup Discovery for Precision Medicine Implementation in Triple Negative Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6278
Author(s):  
Zainab Al-Taie ◽  
Mark Hannink ◽  
Jonathan Mitchem ◽  
Christos Papageorgiou ◽  
Chi-Ren Shyu
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Drug Repositioning ◽  
Subgroup Discovery ◽  
Patients With Cancer ◽  
Wet Lab ◽  
The Common ◽  
Genetic Profiles ◽  
Substantial Heterogeneity

Breast cancer (BC) is the leading cause of death among female patients with cancer. Patients with triple-negative breast cancer (TNBC) have the lowest survival rate. TNBC has substantial heterogeneity within the BC population. This study utilized our novel patient stratification and drug repositioning method to find subgroups of BC patients that share common genetic profiles and that may respond similarly to the recommended drugs. After further examination of the discovered patient subgroups, we identified five homogeneous druggable TNBC subgroups. A drug repositioning algorithm was then applied to find the drugs with a high potential for each subgroup. Most of the top drugs for these subgroups were chemotherapy used for various types of cancer, including BC. After analyzing the biological mechanisms targeted by these drugs, ferroptosis was the common cell death mechanism induced by the top drugs in the subgroups with neoplasm subdivision and race as clinical variables. In contrast, the antioxidative effect on cancer cells was the common targeted mechanism in the subgroup of patients with an age less than 50. Literature reviews were used to validate our findings, which could provide invaluable insights to streamline the drug repositioning process and could be further studied in a wet lab setting and in clinical trials.

scholarly journals Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1

Oncogenesis ◽  
2015 ◽  
Vol 4 (10) ◽  
pp. e168-e168 ◽  
Author(s):  
L V Rhodes ◽  
C R Tate ◽  
V T Hoang ◽  
H E Burks ◽  
D Gilliam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cell Metastasis ◽  
Liver Kinase B1

Identification of new therapeutic leads for triple negative breast cancer subtypes

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
AJ Robles ◽  
L Du ◽  
S Cai ◽  
RH Cichewicz ◽  
SL Mooberry
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Breast Cancer Subtypes ◽  
Cancer Subtypes ◽  
Therapeutic Leads
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