MiR‐6838‐5p suppresses cell metastasis and the EMT process in triple‐negative breast cancer by targeting WNT3A to inhibit the Wnt pathway

2019 ◽  
Vol 21 (12) ◽  
Author(s):  
Guozhu Liu ◽  
Ping Wang ◽  
Hao Zhang
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Wnt Pathway ◽  
Triple Negative ◽  
Cell Metastasis

Endothelial cells promote triple‐negative breast cancer cell metastasis via PAI‐1 and CCL5 signaling

2017 ◽  
Vol 32 (1) ◽  
pp. 276-288 ◽  
Author(s):  
Wenwen Zhang ◽  
Jing Xu ◽  
Hehui Fang ◽  
Lin Tang ◽  
Weiwei Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cell Metastasis ◽  
Pai 1

scholarly journals FAK is Required for Tumor Metastasis-Related Fluid Microenvironment in Triple-Negative Breast Cancer

2019 ◽  
Vol 8 (1) ◽  
pp. 38 ◽  
Author(s):  
Mei-Ren Pan ◽  
Ming-Feng Hou ◽  
Fu Ou-Yang ◽  
Chun-Chieh Wu ◽  
Shu-Jyuan Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Fluid Shear Stress ◽  
Physical Factors ◽  
Interstitial Fluid Flow ◽  
Cancer Treatments ◽  
Significant Independent Predictor ◽  
Patients With Cancer ◽  
Cell Metastasis

Cancer cell metastasis is the main cause of death in patients with cancer. Many studies have investigated the biochemical factors that affect metastasis; however, the role of physical factors such as fluid shear stress (FSS) in tumorigenesis and metastasis have been less investigated. Triple-negative breast cancer (TNBC) has a higher incidence of lymph node invasion and distant metastasis than other subtypes of breast cancer. In this study, we investigated the influence of FSS in regulating the malignant behavior of TNBC cells. Our data demonstrate that low FSS promotes cell migration, invasion, and drug resistance, while high FSS has the opposite results; additionally, we found that these phenomena were regulated through focal adhesion kinase (FAK). Using immunohistochemistry staining, we show that FAK levels correlate with the nodal stage and that FAK is a significant independent predictor of overall survival in patients. Altogether, these data implicate FAK as a fluid mechano-sensor that regulates the cell motility induced by FSS and provide a strong rationale for cancer treatments that combine the use of anti-cancer drugs and strategies to modulate tumor interstitial fluid flow.

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