scholarly journals An Evaluation of Acylated Ghrelin and Obestatin Levels in Childhood Obesity and Their Association with Insulin Resistance, Metabolic Syndrome, and Oxidative Stress

2016 ◽  
Vol 5 (7) ◽  
pp. 61 ◽  
Author(s):  
Maryam Razzaghy-Azar ◽  
Mitra Nourbakhsh ◽  
Abdolreza Pourmoteabed ◽  
Mona Nourbakhsh ◽  
Davod Ilbeigi ◽  
...  
2014 ◽  
Vol 18 (1 (69)) ◽  
Author(s):  
T. A. Kriachok ◽  
L. L. Vavilova

The results of the investigation show that the primary disturbances of the carbohydrate metabolism, namely – a moderate hyperglycemia as a result of chronic glucose overload led to the complex of proatherogenic disturbances which are typical for an insulin resistance. It was also established the close connection between the syndrome components which is realized through such main mechanisms as hypertriglyceridemia (HTE) systemic inflammation and oxidative stress. These data show the independent significance of hyperglycemia as a factor which initiates the progression of metabolic syndrome.


2021 ◽  
Vol 10 (7) ◽  
pp. 1342
Author(s):  
Oliwia Gawlik-Kotelnicka ◽  
Anna Skowrońska ◽  
Aleksandra Margulska ◽  
Karolina H. Czarnecka-Chrebelska ◽  
Igor Łoniewski ◽  
...  

There is a huge need to search for new treatment options and potential biomarkers of therapeutic response to antidepressant treatment. Depression and metabolic syndrome often coexist, while a pathophysiological overlap, including microbiota changes, may play a role. The paper presents a study protocol that aims to assess the effect of probiotic supplementation on symptoms of depression, anxiety and stress, metabolic parameters, inflammatory and oxidative stress markers, as well as fecal microbiota in adult patients with depressive disorders depending on the co-occurrence of metabolic syndrome. The trial will be a four-arm, parallel-group, prospective, randomized, double-blind, controlled design that will include 200 participants and will last 20 weeks (ClinicalTrials.gov identifier: NCT04756544). The probiotic preparation will contain Lactobacillus helveticus Rosell®-52, Bifidobacterium longum Rosell®-175. We will assess the level of depression, anxiety and stress, quality of life, blood pressure, body mass index and waist circumference, white blood cells count, serum levels of C-reactive protein, high-density lipoprotein (HDL) cholesterol, triglycerides, fasting glucose, fecal microbiota composition and the level of some fecal microbiota metabolites, as well as serum inflammatory markers and oxidative stress parameters. The proposed trial may establish a safe and easy-to-use adjunctive treatment option in a subpopulation of depressive patients only partially responsive to pharmacologic therapy.


Synapse ◽  
2015 ◽  
Vol 69 (9) ◽  
pp. 421-433 ◽  
Author(s):  
Samuel Treviño ◽  
Patrícia Aguilar-Alonso ◽  
Jose Angel Flores Hernandez ◽  
Eduardo Brambila ◽  
Jorge Guevara ◽  
...  

2009 ◽  
Vol 23 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Régine Debin ◽  
Benjamin Lauzier ◽  
Pierre Sicard ◽  
Stéphanie Delemasure ◽  
Sébastien Amoureux ◽  
...  

2015 ◽  
Vol 10 (2) ◽  
pp. e52-e60 ◽  
Author(s):  
Antonio Mancini ◽  
Giuseppe Ettore Martorana ◽  
Marinella Magini ◽  
Roberto Festa ◽  
Sebastiano Raimondo ◽  
...  

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