scholarly journals Association of Body Composition and Sarcopenia with NASH in Obese Patients

2021 ◽  
Vol 10 (15) ◽  
pp. 3445
Author(s):  
Sophia Marie-Therese Schmitz ◽  
Lena Schooren ◽  
Andreas Kroh ◽  
Alexander Koch ◽  
Christine Stier ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Fat Mass ◽  
Inflammatory Diseases ◽  
Statistical Significance ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Obese Patients ◽  
Skeletal Muscle Index ◽  
P Values

Obese patients often suffer from sarcopenia or sarcopenic obesity (SO) that can trigger inflammatory diseases including non-alcoholic steatohepatitis (NASH). Sarcopenia and SO can be diagnosed through measuring parameters of body composition such as skeletal muscle mass (SMM), skeletal muscle index (SMI) and fat mass (FM) obtained by bioelectrical impedance analysis (BIA). The aim of this study was to assess the relationship of body composition and NASH in patients with obesity. A total of 138 patients with obesity that underwent bariatric surgery were included in this study. BIA was used to estimate body composition. A liver biopsy was taken intraoperatively and histological assessment of NASH was performed. A total of 23 patients (17%) were classified as NASH and 65 patients (47%) met the criteria for borderline NASH. Body mass index (BMI) was significantly higher in patients with NASH compared to borderline NASH and no NASH (56.3 kg/m2 vs. 51.6 kg/m2 vs. 48.6 kg/m2, p = 0.004). Concerning body composition, FM, but also SMM and SMI were significantly higher in patients with NASH (p-values 0.011, 0.005 and 0.006, resp.). Fat mass index (FMI) and weight-adjusted skeletal muscle index (SMI_weight) failed to reach statistical significance (p-values 0.067 and 0.661). In patients with obesity, higher FM were associated with NASH. Contrary to expectations, SMM and SMI were also higher in patients with NASH. Therefore, higher body fat, rather than sarcopenia and SO, might be decisive for development of NASH in patients with obesity.

scholarly journals Effects on body composition and handgrip strength of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy: a randomised controlled trial

2019 ◽  
Vol 8 ◽  
Author(s):  
George PrayGod ◽  
Andrea M. Rehman ◽  
Jonathan C. K. Wells ◽  
Molly Chisenga ◽  
Joshua Siame ◽  
...  
Keyword(s):  
Body Composition ◽  
Antiretroviral Therapy ◽  
Fat Mass ◽  
Handgrip Strength ◽  
Controlled Trial ◽  
Statistical Significance ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Fat Free Mass ◽  
High Dose

AbstractLipid-based nutrient supplements (LNS) may be beneficial for malnourished HIV-infected patients starting antiretroviral therapy (ART). We assessed the effect of adding vitamins and minerals to LNS on body composition and handgrip strength during ART initiation. ART-eligible HIV-infected patients with BMI <18·5 kg/m2 were randomised to LNS or LNS with added high-dose vitamins and minerals (LNS-VM) from referral for ART to 6 weeks post-ART and followed up until 12 weeks. Body composition by bioelectrical impedance analysis (BIA), deuterium (2H) diluted water (D2O) and air displacement plethysmography (ADP), and handgrip strength were determined at baseline and at 6 and 12 weeks post-ART, and effects of LNS-VM v. LNS at 6 and 12 weeks investigated. BIA data were available for 1461, D2O data for 479, ADP data for 498 and handgrip strength data for 1752 patients. Fat mass tended to be lower, and fat-free mass correspondingly higher, by BIA than by ADP or D2O. At 6 weeks post-ART, LNS-VM led to a higher regain of BIA-assessed fat mass (0·4 (95 % CI 0·05, 0·8) kg), but not fat-free mass, and a borderline significant increase in handgrip strength (0·72 (95 % CI −0·03, 1·5) kg). These effects were not sustained at 12 weeks. Similar effects as for BIA were seen using ADP or D2O but no differences reached statistical significance. In conclusion, LNS-VM led to a higher regain of fat mass at 6 weeks and to a borderline significant beneficial effect on handgrip strength. Further research is needed to determine appropriate timing and supplement composition to optimise nutritional interventions in malnourished HIV patients.

scholarly journals Pandemic effect on body composition. Single center analysis of 2.771 cases.

2021 ◽  
Author(s):  
Fabricio Braga ◽  
Roberto Zagury ◽  
Cristiane Perroni ◽  
Victor Hugo Domecg
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Fat Mass ◽  
Dietary Habits ◽  
Statistical Significance ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
P Value ◽  
Visceral Fat Area ◽  
Significance Level

Background: The COVID-19 pandemic has led to a dramatic increase in the levels of sedentary lifestyle and unhealthy dietary habits. A worsening in populational obesity levels and body composition (BC) is strongly awaited but so far not documented. Objective: To compare BC profile measured by bioelectrical impedance analysis (BIA) between pre-pandemic (P1-03/15th/2017 to 03/16th/2020) and pandemic (P2-3/17th/2020 to 3/10th/2021) period of time. Materials and Methods: BIA were grouped according to the time it was performed. Two comparisons were done: an independent sample comparison (ISC) and a paired sample comparison (PSC) considering patients with at least one BIA in P1 and P2. Age, height, gender, weight, body mass index (BMI), body fat mass (BFM), free fat mass (FFM), skeletal muscle mass (SMM), percentage of body fat (PBF), visceral fat area (VFA) were compared. Statistical significance level was defined for a p value<0.05. Results and Discussion: A total of 3.358 BIA were performed, and 2.771 and 112 were selected for IS and PS, respectively. In ISC, despite an unchanged weight, BFM, FFM, PBF and VFA increased and SSM decreased on P2(p<0.015 for all). A multivariated linear regression model using PBF as dependent variable showed P2 as an independent predictor (β=0.38 95%CI 0.19 to 0.56). In the PSC, PBF also increased from P1 to P2 (p=0.015). To our knowledge this is the first documentation of worsening BC after pandemic. Health authorities should be alert for this phenomenon and their clinical consequences in the days to come.

scholarly journals Pre- and Postoperative Body Composition and Metabolic Characteristics in Patients with Acromegaly: A Prospective Study

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Xiaopeng Guo ◽  
Lu Gao ◽  
Xiaodong Shi ◽  
Hailong Li ◽  
Qiang Wang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Skinfold Thickness ◽  
Metabolic Characteristics ◽  
Postoperative Changes ◽  
Gender And Age ◽  
And Gender ◽  
A Prospective Study

Objective. To investigate the preoperative body composition, metabolic characteristics, and postoperative changes in patients with active acromegaly and analyze the effects of gender and age. Methods. We included 36 patients with untreated acromegaly and 37 patients with nonfunctional pituitary adenomas. Adipose tissue (AT), the visceral fat index (VFI), sclerotin, protein, skeletal muscle, total body water (TBW), intracellular water (ICW), and extracellular water (ECW) were measured using bioelectrical impedance analysis (BIA). Total energy expenditure (TEE) and basal metabolism (BM) were measured with a cardiopulmonary and metabolic analyzer (CMA). Tricep skinfold thickness (TST), bicep circumference, waistline, hipline, and calf circumference were measured with a skinfold caliper and tape. These indices were measured before surgery and 3 months and 1 year after surgery. Results. Overall, AT, VFI, and TST were lower, whereas sclerotin, protein, skeletal muscle, TBW, ICW, ECW, TEE, and BM were higher in acromegaly patients. Postoperatively, TST rose initially and then decreased, the waistline increased, and sclerotin, skeletal muscle, TEE, and BM decreased. Changes in these indices differed with gender and age in unique patterns. Conclusions. Body composition and metabolism in acromegaly patients changed after surgery, and gender and age influenced these changes.

scholarly journals Snoring is associated with body composition in （peri-post）menopausal women

2019 ◽  
Author(s):  
minfang tao ◽  
yang zhou ◽  
fei liu ◽  
changbin li ◽  
yanwei zheng ◽  
...  
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
Chinese Women ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Menopausal Transition ◽  
Cross Sectional ◽  
Obstructive Sleep ◽  
Menopausal Women ◽  
Post Menopausal

Abstract Background: Little attention has been paid to whether snoring frequency is associated with body composition in menopausal women, particularly in China. This study objected to investigate the association between self-reported snoring and body composition in (peri-post) menopausal Chinese women as well as glucose/lipid metabolic indicators. Methods: This cross-sectional study enrolled 715 participants aged 40-67 years from the Menopause Clinic in the Shanghai Sixth People’s Hospital. Participants were categorized into four subgroups stratified by self-reported snoring frequency: never, rarely (<1 night per week), occasionally (1-2 nights per week), regularly (≥3 nights per week), while body composition was measured using bioelectrical impedance analysis(BIA).Besides, blood sample were collected to test the glycolipid indicators. Results: In our sample of investigation, regular snoring (≥3 nights per week) was found to be an independent risk factor for higher fat mass (total, upper limbs, trunk), with the highest risk of 2.4 times for fat mass of trunk after adjusting for glucose/lipid metabolic confounders(p=0.003). Meanwhile, regular snoring was independently associated with higher fat mass (total and each segment) only in the menopausal transition (p=0.023). Conclusion: We suggested that self-reported regular snoring may be taken as a simple alternative to predict higher fat mass (≥17.11kg, upper quartile) in menopausal women. Similarly, body composition should be attached to the great importance to those who in menopausal transition in order to help to prevent obstructive sleep apnea(OSA).

scholarly journals Assessment of adult malnutrition with bioelectrical impedance analysis

2018 ◽  
Author(s):  
Corinna Geisler ◽  
Mark Hübers ◽  
Manfred Müller
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Adipose Tissue ◽  
Muscle Mass ◽  
Bioelectrical Impedance Analysis ◽  
Skeletal Muscle Mass ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Composition Characteristics

The two aims of this study were to evaluate (i) the prevalence of malnutrition based on age, sex and BMI specific PA and (ii) to determinate what specific body composition characteristics (skeletal muscle mass and adipose tissue) are related to a low PA.

scholarly journals Effect of The Body Water and The Body Composition, Calculated by Bioelectrical Impedance Analysis, On Contrast-Enhanced Dynamic Computed Tomography Images of The Liver.

2021 ◽  
Author(s):  
Takanori Masuda ◽  
Takeshi Nakaura ◽  
Yoshinori Funama ◽  
Tomoyasu Sato ◽  
Keiko Arataki ◽  
...  
Keyword(s):  
Body Composition ◽  
Contrast Enhancement ◽  
Abdominal Aorta ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Celiac Artery ◽  
The Body ◽  
Hepatic Parenchyma ◽  
Ct Number ◽  
Skeletal Muscle Index

Abstract To improve its diagnosis on contrast-enhanced dynamic CT (CE-DCT) scans, contrast injection protocol must yield stable arterial contrast enhancement. To investigate how the body-water distribution and the body composition, calculated by bioelectrical impedance analysis (BIA), affect aortic and hepatic enhancement on CE-DCT scans. 236 patients with liver cirrhosis underwent CE-DCT before BIA. The CT number (in Hounsfield units, HU) of the abdominal aorta at the celiac artery level on unenhanced scans and during the hepatic arterial phase (HAP) scans was recorded. And, the mean CT number of the hepatic parenchyma of both hepatic lobes at the celiac artery level on unenhanced and portal venous phase (PVP) scans was recorded. We calculated changes in the iodine dose per contrast enhancement (mgI/HU) (IDCE) to evaluate the effect of the patient age and of various constituents of the body composition by performing BIA. The IDCE of the abdominal aorta during HAP was 121.5 ± 32.1 mgI/HU; it was 698.7 ± 211.1 mgI/HU in the hepatic parenchyma during the PVP. Among the parameters used in our BIA, the total body weight (TBW) was the most important factor affecting the IDCE of the liver abdominal aorta on CE-DCT scans acquired during the HAP (r = 0.83). The TBW and the skeletal muscle index most strongly affected the IDCE of the hepatic parenchyma on CE-DCT scans obtained during the PVP (r = 0.69). The TBW had the strongest effect on contrast enhancement. The skeletal muscle index exhibited the strongest correlation with hepatic parenchymal contrast enhancement during the PVP.

scholarly journals Associations of Growth Impairment and Body Composition among South African School-Aged Children Enrolled in the KaziAfya Project

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2735
Author(s):  
Kurt Z. Long ◽  
Johanna Beckmann ◽  
Christin Lang ◽  
Harald Seelig ◽  
Siphesihle Nqweniso ◽  
...  
Keyword(s):  
Body Composition ◽  
South African ◽  
Fat Mass ◽  
Communicable Disease ◽  
Controlled Trial ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Fat Free Mass ◽  
Linear Regression Models ◽  
School Aged Children

(1) Background: Early childhood malnutrition may result in increased fat mass (FM) among school-aged children in low- and middle-income countries (LMICs). We explored whether South African children with shorter stature have greater overall and abdominal FM compared to normal stature children. (2) Methods: Baseline assessments of body composition and weight were determined among school-aged children enrolled in a randomized controlled trial in Port Elizabeth, South Africa, using bioelectrical impedance analysis. Multiple linear regression models tested associations of children’s height and degree of stunting with FM, fat free mass (FFM), truncal fat mass (TrFM), and truncal fat free mass (TrFFM) overall and by sex. (3) Results: A total of 1287 children (619 girls, 668 boys) were assessed at baseline. Reduced child height was associated with higher FM and lower FFM and TrFFM, but these associations were reversed with increases in height. Girls classified as mildly or moderately/severely stunted had higher FM and TrFM but lower FFM and TrFFM, while no association was found for boys. (4) Conclusions: Our study suggests that efforts to reduce the non-communicable disease burden in LMICs should target growth-impaired children who may have greater overall FM and greater abdominal FM.

scholarly journals Body Composition Changes After Very-Low-Calorie Ketogenic Diet in Obesity Evaluated by 3 Standardized Methods

2016 ◽  
Vol 102 (2) ◽  
pp. 488-498 ◽  
Author(s):  
Diego Gomez-Arbelaez ◽  
Diego Bellido ◽  
Ana I. Castro ◽  
Lucia Ordoñez-Mayan ◽  
Jose Carreira ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Fat Mass ◽  
Bioelectrical Impedance ◽  
Fat Free Mass ◽  
Obese Patients ◽  
Body Composition Assessment ◽  
Visceral Mass ◽  
Low Calorie ◽  
Composition Changes

Abstract Context: Common concerns when using low-calorie diets as a treatment for obesity are the reduction in fat-free mass, mostly muscular mass, that occurs together with the fat mass (FM) loss, and determining the best methodologies to evaluate body composition changes. Objective: This study aimed to evaluate the very-low-calorie ketogenic (VLCK) diet-induced changes in body composition of obese patients and to compare 3 different methodologies used to evaluate those changes. Design: Twenty obese patients followed a VLCK diet for 4 months. Body composition assessment was performed by dual-energy X-ray absorptiometry (DXA), multifrequency bioelectrical impedance (MF-BIA), and air displacement plethysmography (ADP) techniques. Muscular strength was also assessed. Measurements were performed at 4 points matched with the ketotic phases (basal, maximum ketosis, ketosis declining, and out of ketosis). Results: After 4 months the VLCK diet induced a −20.2 ± 4.5 kg weight loss, at expenses of reductions in fat mass (FM) of −16.5 ± 5.1 kg (DXA), −18.2 ± 5.8 kg (MF-BIA), and −17.7 ± 9.9 kg (ADP). A substantial decrease was also observed in the visceral FM. The mild but marked reduction in fat-free mass occurred at maximum ketosis, primarily as a result of changes in total body water, and was recovered thereafter. No changes in muscle strength were observed. A strong correlation was evidenced between the 3 methods of assessing body composition. Conclusion: The VLCK diet-induced weight loss was mainly at the expense of FM and visceral mass; muscle mass and strength were preserved. Of the 3 body composition techniques used, the MF-BIA method seems more convenient in the clinical setting.

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