scholarly journals Pre- and Postoperative Body Composition and Metabolic Characteristics in Patients with Acromegaly: A Prospective Study

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Xiaopeng Guo ◽  
Lu Gao ◽  
Xiaodong Shi ◽  
Hailong Li ◽  
Qiang Wang ◽  
...  

Objective. To investigate the preoperative body composition, metabolic characteristics, and postoperative changes in patients with active acromegaly and analyze the effects of gender and age. Methods. We included 36 patients with untreated acromegaly and 37 patients with nonfunctional pituitary adenomas. Adipose tissue (AT), the visceral fat index (VFI), sclerotin, protein, skeletal muscle, total body water (TBW), intracellular water (ICW), and extracellular water (ECW) were measured using bioelectrical impedance analysis (BIA). Total energy expenditure (TEE) and basal metabolism (BM) were measured with a cardiopulmonary and metabolic analyzer (CMA). Tricep skinfold thickness (TST), bicep circumference, waistline, hipline, and calf circumference were measured with a skinfold caliper and tape. These indices were measured before surgery and 3 months and 1 year after surgery. Results. Overall, AT, VFI, and TST were lower, whereas sclerotin, protein, skeletal muscle, TBW, ICW, ECW, TEE, and BM were higher in acromegaly patients. Postoperatively, TST rose initially and then decreased, the waistline increased, and sclerotin, skeletal muscle, TEE, and BM decreased. Changes in these indices differed with gender and age in unique patterns. Conclusions. Body composition and metabolism in acromegaly patients changed after surgery, and gender and age influenced these changes.

2021 ◽  
Vol 10 (15) ◽  
pp. 3445
Author(s):  
Sophia Marie-Therese Schmitz ◽  
Lena Schooren ◽  
Andreas Kroh ◽  
Alexander Koch ◽  
Christine Stier ◽  
...  

Obese patients often suffer from sarcopenia or sarcopenic obesity (SO) that can trigger inflammatory diseases including non-alcoholic steatohepatitis (NASH). Sarcopenia and SO can be diagnosed through measuring parameters of body composition such as skeletal muscle mass (SMM), skeletal muscle index (SMI) and fat mass (FM) obtained by bioelectrical impedance analysis (BIA). The aim of this study was to assess the relationship of body composition and NASH in patients with obesity. A total of 138 patients with obesity that underwent bariatric surgery were included in this study. BIA was used to estimate body composition. A liver biopsy was taken intraoperatively and histological assessment of NASH was performed. A total of 23 patients (17%) were classified as NASH and 65 patients (47%) met the criteria for borderline NASH. Body mass index (BMI) was significantly higher in patients with NASH compared to borderline NASH and no NASH (56.3 kg/m2 vs. 51.6 kg/m2 vs. 48.6 kg/m2, p = 0.004). Concerning body composition, FM, but also SMM and SMI were significantly higher in patients with NASH (p-values 0.011, 0.005 and 0.006, resp.). Fat mass index (FMI) and weight-adjusted skeletal muscle index (SMI_weight) failed to reach statistical significance (p-values 0.067 and 0.661). In patients with obesity, higher FM were associated with NASH. Contrary to expectations, SMM and SMI were also higher in patients with NASH. Therefore, higher body fat, rather than sarcopenia and SO, might be decisive for development of NASH in patients with obesity.


2018 ◽  
Author(s):  
Corinna Geisler ◽  
Mark Hübers ◽  
Manfred Müller

The two aims of this study were to evaluate (i) the prevalence of malnutrition based on age, sex and BMI specific PA and (ii) to determinate what specific body composition characteristics (skeletal muscle mass and adipose tissue) are related to a low PA.


2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Amanda Faith Casey

Background. Research shows obesity to be more prevalent amongst individuals with intellectual disability (ID) making correct measurement of body composition crucial. This study reviewed the validity and reliability of methods used for assessing body composition in individuals with ID.Methods. Authors conducted electronic searches through PubMed (1990 to present) and PsycINFO (1990 to present) and assessed relevant articles independently based on scoping review guidelines. Reviewers included primary research related to the validity and reliability of body composition measures on individuals with ID.Results. Searches identified six articles assessing body composition methods used on individuals with ID including body mass index (BMI), skinfold thickness, bioelectrical impedance analysis (BIA), waist circumference, tibia length, and anthropometric girth measurements. BMI and waist circumference appear suitable measures but skinfold thickness measurements may not be advisable due to participants' noncompliance resulting in a lack of precision and inaccurate results.Conclusions. The current literature contains too few well-conducted studies to determine the precision and validity of body composition measures on individuals with ID. There may be a need to devise further regression equations that apply to individuals with specific types of ID in order to increase the reliability and validity of body composition measurements.


Author(s):  
Adam W. Powell ◽  
Samuel G. Wittekind ◽  
Tarek Alsaied ◽  
Adam M. Lubert ◽  
Clifford Chin ◽  
...  

Background Adults with a Fontan circulation tend to have myopenia and elevated adiposity when measured by dual energy x‐ray absorptiometry. Bioelectrical impedance analysis is an alternative validated approach to assess body composition. We used bioelectrical impedance analysis to compare body composition between pediatric patients with a Fontan circulation and control individuals without heart disease. Methods and Results A retrospective chart review identified all patients aged <22 years with a Fontan circulation who presented for cardiopulmonary exercise testing and bioelectrical impedance analysis from April 2019 to January 2020. Data were compared with control subjects tested during the same period. We studied 47 patients with a Fontan circulation (53% boys; 15±3.1 years) and 165 controls (48% boys; 14.4±2.5 years). Fontan status was associated with shorter height, but similar age, sex, and overall body mass. Patients with Fontan had lower lean body mass (−12.0±22%, Z‐score −0.5±1, P =0.005), skeletal muscle mass (−13.6±1.4%; Z‐score, −0.5±1; P =0.004), skeletal muscle indexed to height (−10.3±13.3%; Z‐score, −0.5±1; P =0.005), and higher percent body fat (+13.8±18.6%; Z‐score, 0.4±1.2; P =0.03). Greater skeletal muscle mass was associated with higher peak oxygen consumption ( r 2 =0.52, P <0.0001) and oxygen pulse ( r 2 =0.68, P <0.0001). Patients who had suffered a late complication (ie, heart transplant referral or evidence of extracardiac organ dysfunction) of the Fontan operation (13 of 47, 27.7%) had lower skeletal muscle mass ( P =0.048) and higher body fat percentage ( P =0.003). Conclusions The Fontan circulation is associated with marked myopenia and increased adiposity. Higher muscle mass was associated with better exercise capacity. Fontan complications are associated with lower muscle mass and increased adiposity.


Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1075
Author(s):  
Andreas M. Kasper ◽  
Carl Langan-Evans ◽  
James F. Hudson ◽  
Thomas E. Brownlee ◽  
Liam D. Harper ◽  
...  

Whilst the assessment of body composition is routine practice in sport, there remains considerable debate on the best tools available, with the chosen technique often based upon convenience rather than understanding the method and its limitations. The aim of this manuscript was threefold: (1) provide an overview of the common methodologies used within sport to measure body composition, specifically hydro-densitometry, air displacement plethysmography, bioelectrical impedance analysis and spectroscopy, ultra-sound, three-dimensional scanning, dual-energy x-ray absorptiometry (DXA) and skinfold thickness; (2) compare the efficacy of what are widely believed to be the most accurate (DXA) and practical (skinfold thickness) assessment tools and (3) provide a framework to help select the most appropriate assessment in applied sports practice including insights from the authors’ experiences working in elite sport. Traditionally, skinfold thickness has been the most popular method of body composition but the use of DXA has increased in recent years, with a wide held belief that it is the criterion standard. When bone mineral content needs to be assessed, and/or when it is necessary to take limb-specific estimations of fat and fat-free mass, then DXA appears to be the preferred method, although it is crucial to be aware of the logistical constraints required to produce reliable data, including controlling food intake, prior exercise and hydration status. However, given the need for simplicity and after considering the evidence across all assessment methods, skinfolds appear to be the least affected by day-to-day variability, leading to the conclusion ‘come back skinfolds, all is forgiven’.


2010 ◽  
Vol 54 (4) ◽  
pp. 398-405 ◽  
Author(s):  
Valeria Bender Braulio ◽  
Valéria Cristina Soares Furtado ◽  
Maria das Graças Silveira ◽  
Maria Helena Fonseca ◽  
José Egídio Oliveira

OBJECTIVE: The purpose of this study was to compare skinfold thickness (SKF) and bioelectrical impedance analysis (BIA) of body composition using three different equations against dual-energy X-ray absorptiometry (DXA) in overweight and obese Brazilian women. SUBJECTS AND METHOD: Thirty-four women (age 43.8 ± 10.9 years; body mass index [BMI] 32.1 ± 4.3 kg/m²) had percentage body fat (BF%), fat mass (FM) and fat-free mass (FFM) estimated by DXA, SKF and BIA (BIA-man: manufacturer's equation; and predictive obesity-specific equations of Segal and of Gray). Regression analysis, Bland-Altman plot analysis and intra-class correlation coefficient (ICC) were used to compare methods. RESULTS: Absolute agreement between DXA and BIA-man was poor for all measures of body composition (BF% -6.8% ± 3.7%, FM -3.1 ± 3.6 kg, FFM 5.7 ± 2.8 kg). BIA-Segal equation showed good absolute agreement with DXA for BF% (1.5% ± 1.5%), FM (1.0 ± 3.2 kg) and FFM (1.5 ± 2.6 kg), albeit the limits of agreement were wide. BIA-Gray equation showed good absolute agreement with DXA for FM (2.3 ± 4.1 kg), and smaller biases for BF% (0.05% ± 4.4%) and FFM (0.2 ± 2.9 kg), although wide limits of agreement. BIA-Gray and DXA showed the highest ICC among the pairs of methods. A good absolute agreement was observed between DXA and SKF for BF% (-2.3% ± 5.8%), FM (0.09 ± 4.7 kg), and FFM (2.4 ± 4.4 kg), although limits of agreement were wider and ICC between DXA and SKF for BF% indicated poor degree of reproducibility. CONCLUSION: These findings show that both BIA-Segal and BIA-Gray equations are suitable for BF%, FM and FFM estimations in overweight and obese women.


2020 ◽  
Vol 124 (3) ◽  
pp. 349-360
Author(s):  
Sharin Asadi ◽  
Frank H. Bloomfield ◽  
Tanith Alexander ◽  
Chris J. D. McKinlay ◽  
Elaine C. Rush ◽  
...  

AbstractMeasurement of body composition is increasingly important in research and clinical settings but is difficult in very young children. Bioelectrical impedance analysis (BIA) and air displacement plethysmography (ADP) are well-established but require specialist equipment so are not always feasible. Our aim was to determine if anthropometry and skinfold thickness measurements can be used as a substitute for BIA or ADP for assessing body composition in very young New Zealand children. We used three multi-ethnic cohorts: 217 children at a mean age of 24·2 months with skinfold and BIA measurements; seventy-nine infants at a mean age of 20·9 weeks and seventy-three infants at a mean age of 16·2 weeks, both with skinfold and ADP measurements. We used Bland–Altman plots to compare fat and fat-free mass calculated using all potentially relevant equations with measurements using BIA or ADP. We also calculated the proportion of children in the same tertile for measured fat or fat-free mass and tertiles (i) calculated using each equation, (ii) each absolute skinfold, and (iii) sum of skinfold thicknesses. We found that even for the best equation for each cohort, the 95 % limits of agreement with standard measures were wide (25–200 % of the mean) and the proportion of children whose standard measures fell in the same tertile as the skinfold estimates was ≤69 %. We conclude that none of the available published skinfold thickness equations provides good prediction of body composition in multi-ethnic cohorts of very young New Zealand children with different birth history and growth patterns.


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