scholarly journals Systemic Antibiotics and Obesity: Analyses from a Population-Based Cohort

2021 ◽  
Vol 10 (12) ◽  
pp. 2601
Author(s):  
So Young Park ◽  
Morena Ustulin ◽  
SangHyun Park ◽  
Kyung-Do Han ◽  
Joo Young Kim ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adult Population ◽  
Antibiotic Use ◽  
Population Based ◽  
Obesity Risk ◽  
Gram Negative ◽  
Korean Adult ◽  
Korean National Health Insurance ◽  
Gram Negative Organisms ◽  
Systemic Antibiotics

Background: In this study, we analyzed the association between antibiotic use and obesity and metabolic syndrome (MS) in a Korean adult population. Methods: Subjects using the Korean National Health Insurance Service sample cohort were retrospectively analyzed in 2015. The differences in obesity and metabolic syndrome (MS) status were compared and analyzed according to duration of systemic antibiotic treatment in the previous 10 years (non-users, 1st, 2nd, and 3rd tertile). Results: Subjects who used systemic antibiotics for longer periods were older, satisfied more criteria for MS, and had more comorbidities than non-users (non-users vs. 3rd tertile, p < 0.0001 for all). After adjusting for confounding factors, the risk of obesity was higher in subjects who used systemic antibiotics for longer periods than in non-users (non-users vs. 3rd tertile, OR (odds ratio) (95% CI (confidence interval)); 1.20 (1.12–1.38)). The criteria for MS were more satisfied in the 3rd tertile than in non-users. A higher obesity risk was also found in subjects treated with antibiotics targeting Gram-negative organisms than in those targeting Gram-positive organisms. Conclusion: The risk of obesity was higher in subjects who took systemic antibiotics more frequently. The risk was more prominent when they took antibiotics targeting Gram-negative bacteria.

scholarly journals Association of Dietary and Lifestyle Inflammation Score With Metabolic Syndrome in a Sample of Iranian Adults

2021 ◽  
Vol 8 ◽  
Author(s):  
Fatemeh Dehghani Firouzabadi ◽  
Ahmad Jayedi ◽  
Elaheh Asgari ◽  
Zahra Akbarzadeh ◽  
Nasim Janbozorgi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adult Population ◽  
Positive Association ◽  
Population Based ◽  
Cross Sectional Study ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
General Adult Population ◽  
Education Status ◽  
Inflammation Score

Objective: We aimed to evaluate the association between the dietary and lifestyle inflammation score (DLIS) and metabolic syndrome (MetS) and its components in a sample of Iranian adults.Design: Population-based cross-sectional study.Setting: General adult population living in Tehran, Iran.Subjects: We included 827 adult men and women with an age range of 18–59 years who were referred to health centers in different districts of Tehran, Iran. Dietary intake was assessed by a semiquantitative food frequency questionnaire with 168 items. The DLIS was calculated based on four components, including dietary inflammation score, physical activity, cigarette smoking, and general obesity. Higher DLIS represents a more proinflammatory diet and lifestyle. The odds ratio (OR) and 95% confidence interval (CI) of the MetS across quartiles of the DLIS was calculated by using logistic regression analysis, controlling for age, sex, energy intake, marital status, education status, and occupation.Results: A total of 827 participants (31% men) were included, with a mean age of 44.7 ± 10.7 years. The prevalence of the MetS was 30.5%. The DLIS ranged between −2.35 and +3.19 (mean ± SD: 0.54 ± 1.09). There was a significant positive association between the DLIS and odds of MetS (OR fourthvs.thefirstquartile: 1.57, 95% CI: 1.01–2.45) in the fully adjusted model.Conclusion: Our results showed a significant positive association between the DLIS and odds of MetS. The results of the present crosssectional study suggested that having a more proinflammatory lifestyle can be associated with MetS. More prospective studies are needed to confirm the findings.

scholarly journals The Importance of Screening for Thyroid Cancer in Patients with Metabolic Syndrome or its Components: A Nationwide Population-Based Cohort Study.

2021 ◽  
Author(s):  
Jae Hyun Park ◽  
Hyun Seok Cho ◽  
Gilseong Moon ◽  
Jong Ho Yoon
Keyword(s):  
Metabolic Syndrome ◽  
Thyroid Cancer ◽  
Large Scale ◽  
Proportional Hazards ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Relative Risks ◽  
Increased Risk ◽  
Korean National Health Insurance

Abstract Background The rapidly increasing coincidence of thyroid cancer and metabolic syndrome (MS) in recent decades suggests an association between the two disorders. To investigate this association, we conducted a nationwide study of a large-scale patient cohort. Methods Between 2009 and 2011, data were collected by the Korean National Health Insurance Service for 4,658,473 persons aged 40–70 years without thyroid cancer. During the 6-year follow-up period, participants were monitored for the development of thyroid cancer. The relative risks and incidences of thyroid cancer were calculated using multivariate Cox proportional hazards regression analyses after adjusting for age and body mass index. Results At the end of the study, 47,325 subjects (1.0%) were newly diagnosed with thyroid cancer. The risk of thyroid cancer was significantly elevated in men and women with MS or MS components, except for hyperglycaemia (p = 0.723) or hypertriglyceridemia (p = 0.211) in men. The incidence of thyroid cancer per 10,000 person-years in individuals with MS was significantly higher in men (6.2, p < 0.001) and women (21.3, p < 0.001) compared to those without MS. Additionally, the risk of thyroid cancer increased significantly with an increasing number of MS components even in individuals with only one or two MS components. Conclusions MS and its components were significantly associated with increased risk of developing thyroid cancer. Patients with MS or MS components should be regularly screened for thyroid cancer to enable swift therapeutic response in this at-risk population.

scholarly journals Dietary Habits and its Association with Metabolic Syndrome in a large sample of Iranian adults: a population-based study

2020 ◽  
Author(s):  
Elnaz Lorzadeh ◽  
Zohreh Sadat Sangsefidi ◽  
Masoud Mirzaei ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Dietary Habits ◽  
Adult Population ◽  
Middle Eastern ◽  
Population Based ◽  
Cross Sectional Study ◽  
Health Study ◽  
Cross Sectional ◽  
Logistic Regression Method

Abstract Background Central obesity, insulin resistance, dyslipidemia and hypertension are the core components of metabolic syndrome (MetS) which is coincident with unhealthy dietary habits in the Middle-Eastern countries. The aim of this study was to explore the association between dietary habits and MetS of adult population living in Yazd Greater Area, Iran. Methods This is a cross-sectional study which uses the data of a population-based cohort study on Iranian adults, known as Yazd Health Study (YaHS). The relationship between dietary habits and metabolic syndrome among adults (n = 2896) were analyzed using multiple logistic regression method. Results The prevalence of the MetS among the participants was 32.2%. Outcomes from logistic regression examining show that breakfast consumption has a significant inverse effect on the occurrence of MetS after adjustment for age, education level, physical activity statue, history of chronic diseases and smoking (odds ratio (OR) = 0.38, 95% confidence interval (CI) = 0.14, 0.97). This effect remains significant even after adjustment for body mass index (BMI) and reveals that odds of having MetS is 69% lower in breakfast consumers in contrast to non-consumers (OR = 0.31, 95% CI = 0.11, 0.87). However, no significant relationship was observed between other dietary habits including consumption of sweetened drinks, sugar cubes, and fast foods and MetS after adjustment for all potential confounders Conclusions This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. Finding out stronger evidence in relation between dietary habits and MetS, more researches especially population-based cohort studies are needed to be conducted.

Breakfast consumption is inversely associated with metabolic syndrome in a sample of Iranian adults

2020 ◽  
Author(s):  
Elnaz Lorzadeh ◽  
Zohreh Sadat Sangsefidi ◽  
Masoud Mirzaei ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Dietary Habits ◽  
Adult Population ◽  
Middle Eastern ◽  
Population Based ◽  
Cross Sectional Study ◽  
Health Study ◽  
Cross Sectional ◽  
Breakfast Consumption

Abstract Background: Central obesity, insulin resistance, dyslipidemia and hypertension are the core components of metabolic syndrome (MetS) which is coincident with unhealthy dietary habits in the Middle-Eastern countries. The aim of this study was to explore the association between dietary habits and metabolic syndrome of adult population living in Yazd Greater Area, Iran. Methods: This is a cross-sectional study which uses the data of a population-based cohort study on Iranian adults, known as Yazd Health Study (YaHS). The relationship between dietary habits and metabolic syndrome among adults (n= 2896) were analyzed using multiple logistic regression method. Results: Outcomes from logistic regression examining show that breakfast consumption has a significant inverse effect on the occurrence of metabolic syndrome after adjustment for age, education level, physical activity statue, history of chronic diseases and smoking (odds ratio (OR)= 0.38, 95% confidence interval (CI)= 0.14, 0.97). This effect remains significant even after adjustment for body mass index (BMI) and reveals that odds of having MetS is 69 % lower in breakfast consumers in contrast to non-consumers (OR=0.31, 95% CI= 0.11, 0.87). However, no significant relationship was observed between other dietary habits and MetS after adjustment for all potential confounders Conclusions: This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. Finding out stronger evidence in relation between dietary habits and metabolic syndrome, more researches especially population-based cohort studies are needed to be conducted.

scholarly journals Extended-spectrum β-lactamase-producing Gram-negative bacteria causing neonatal sepsis in India in rural and urban settings

2011 ◽  
Vol 60 (4) ◽  
pp. 500-507 ◽  
Author(s):  
Dinesh S. Chandel ◽  
Judith A. Johnson ◽  
Rama Chaudhry ◽  
Nidhi Sharma ◽  
Nandita Shinkre ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Bacterial Species ◽  
Age Groups ◽  
Antibiotic Use ◽  
Drug Susceptibility ◽  
Population Based ◽  
Drug Susceptibility Testing ◽  
Prior History ◽  
Gram Negative ◽  
Extended Spectrum

Extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacilli (GNB) are of increasing clinical concern in all age groups worldwide. Whilst sepsis continues to be the leading cause of morbidity and mortality in Indian neonates in the community, identification of microbiological attributes in this population is lacking. This population-based study enrolled 1738 infants with a diagnosis of clinical sepsis at four participating centres in India. Each study site conducted Bactec blood culture, identified bacterial species by API test and stored isolates at −70 °C. From 252 GNB isolates, 155 (113 Klebsiella species, 21 Escherichia coli and 21 other) were subjected to drug susceptibility testing, ESBL phenotyping and testing for clonal relatedness of ESBL strains by PFGE. The results demonstrated that Klebsiella species and E. coli are the most common GNB causes of neonatal sepsis in India, and over one-third are ESBL producers in both community and hospital settings. ESBL-producing strains exhibited frequent co-resistance to aminoglycosides and ciprofloxacin, but remained susceptible to imipenem. PFGE analysis revealed extensive genetic diversity within the ESBL-producing isolates, showing multiple profiles (total of 23). Over 40 % of all ESBL-producing isolates formed three pulsed-field profiles (PFP I–III), with PFP-II being the largest cluster (>20 % of all ESBL-producing isolates), sharing strains from two distant locations. Identification of a common clone at two geographically distant centres indicated that predominant clones with increased virulence may exist, even in the absence of any clear outbreak. The presence of ESBL-producing strains in community infants with no prior history of hospitalization or antibiotic use dictates heightened vigilance and further studies on the ecology of these organisms.

scholarly journals Dietary Habits and its Association with Metabolic Syndrome in a large sample of Iranian adults: a population-based study

2020 ◽  
Author(s):  
Elnaz Lorzadeh ◽  
Zohreh Sadat Sangsefidi ◽  
Masoud Mirzaei ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Dietary Habits ◽  
Adult Population ◽  
Middle Eastern ◽  
Population Based ◽  
Cross Sectional Study ◽  
Health Study ◽  
Cross Sectional ◽  
Inverse Effect

Abstract Background Central obesity, insulin resistance, dyslipidemia and hypertension are the core components of metabolic syndrome (MetS) which is coincident with unhealthy dietary habits in the Middle-Eastern countries. The aim of this study was to explore the association between dietary habits and MetS of adult population living in Yazd Greater Area, Iran.Methods This is a cross-sectional study which uses the data of a population-based cohort study on Iranian adults, known as Yazd Health Study (YaHS). The relationship between dietary habits and metabolic syndrome among adults (n = 2896) were analyzed using multiple logistic regression method.Results The prevalence of the MetS among the participants was 32.2%. Outcomes from logistic regression examining show that breakfast consumption has a significant inverse effect on the occurrence of MetS after adjustment for age, education level, physical activity statue, history of chronic diseases and smoking (odds ratio (OR) = 0.38, 95% confidence interval (CI) = 0.14, 0.97). This effect remains significant even after adjustment for body mass index (BMI) and reveals that odds of having MetS is 69% lower in breakfast consumers in contrast to non-consumers (OR = 0.31, 95% CI = 0.11, 0.87). However, no significant relationship was observed between other dietary habits including consumption of sweetened drinks, sugar cubes, and fast foods and MetS after adjustment for all potential confoundersConclusions This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. Finding out stronger evidence in relation between dietary habits and MetS, more researches especially population-based cohort studies are needed to be conducted.

scholarly journals The Importance of Metabolic Syndrome Status for the Risk of Non-Viral Hepatocellular Carcinoma: A Nationwide Population-Based Study

2021 ◽  
Author(s):  
Yuri Cho ◽  
Eun Ju Cho ◽  
Jeong-Ju Yoo ◽  
Young Chang ◽  
Goh Eun Chung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Metabolic Syndrome ◽  
Cox Regression ◽  
Positive Association ◽  
Population Based ◽  
Cox Regression Analysis ◽  
Hazard Ratios ◽  
Development Data ◽  
Baseline Status ◽  
Korean National Health Insurance

Abstract The positive association between metabolic syndrome (MetS) and hepatocellular carcinoma (HCC) has been suggested. However, no studies have yet looked at how the risk of developing HCC varies with changes in MetS status. Therefore, we aimed to investigate the association between changes in MetS and subsequent HCC development. Data were obtained from the Korean National Health Insurance Service. 5,975,308 individuals who participated in health screenings both in 2009–2010 and 2011–2012 were included. Subjects were divided into four groups according to change in MetS status during the two-year interval screening (from 2009 to 2011): sustained non-MetS, transition to MetS, transition to non-MetS, and sustained MetS. Cox regression analysis was used to examine the hazard ratios of HCC. During a median of 7.3 years follow-up, 25,880 incident HCCs were identified. Compared to the sustained non-MetS group, age, sex, smoking, alcohol, regular exercise, and body mass index-adjusted hazard ratios (95% confidence interval) for HCC development were 1.01 (0.97–1.05) for the transition to MetS group; 1.05 (1.003–1.09) for the transition to non-Met group; and 1.07 (1.03–1.10) for the sustained MetS group. Stratified analyses according to age, sex, smoking, alcohol intake, exercise, diabetes mellitus, hypertension, dyslipidemia, and chronic kidney disease showed similar results. A significantly increased HCC risk was observed in the sustained MetS and transition to non-MetS groups. The baseline status of MetS was associated with the risk of HCC development. Strategies to improve MetS, especially targeting insulin resistance might prevent HCC development.

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