scholarly journals Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis

2021 ◽  
Vol 10 (7) ◽  
pp. 1488
Author(s):  
Carlo Cafiero ◽  
Gianrico Spagnuolo ◽  
Gaetano Marenzi ◽  
Ranieri Martuscelli ◽  
Michele Colamaio ◽  
...  
Keyword(s):  
Immune Response ◽  
Early Diagnosis ◽  
Interleukin 1 ◽  
Periodontal Health ◽  
Plaque Score ◽  
Poor Countries ◽  
Whole Saliva ◽  
Bleeding Score ◽  
And Migration ◽  
Meta Analyses

The primary cause of tooth loss in the industrialized world is periodontitis, a bacterial anaerobic infection whose pathogenesis is characterized by composite immune response. At present, the diagnose of periodontitis is made by a complete status check of the patient’s periodontal health; full-mouth plaque score, full-mouth bleeding score, probing depth, clinical attachment level, bleeding on probing, recessions, mobility, and migration are evaluated in order to provides a clear picture of the periodontal conditions of a single patient. Chair-side diagnostic tests based on whole saliva could be routinely used by periodontists for a very early diagnosis of periodontitis, monitoring, prognosis, and management of periodontal patients by biomarker detection, whose diagnostic validity is related to sensitivity and specificity. Recent paper reviews and meta-analyses have focused on five promising host derived biomarkers as candidate for early diagnosis of periodontitis: MMP-8 (Metalloproteinase-8), MIP-1α (Macrophage inflammatory protein-1 alpha), IL-1 β (Interleukin-1 beta), IL-6 (Interleukin-6), and HB (Hemoglobin), and their combinations. Chair-side Lab-on-a-chip (LOC) technology may soon become an important part of efforts to detect such biomarkers in saliva medium to improve worldwide periodontal health in developed nations as well as in underserved communities and poor countries. Their applications in preventive and predictive medicine is now fundamental, and is aimed at the early detection of risk factors or the presence or evolution of the disease, and in personalized medicine, which aims to identify tailor-made treatments for individual patients. The aim of the present paper is to be informative about host derived periodontal biomarkers and, in particular, we intend to report information about the most important immune response derived biomarkers and Hemoglobin as candidates to be routinely utilized in order to obtain a chair-side early diagnosis of periodontal disease.

Relationships between Periodontal Health, Salivary Steroids, and Bacteroides intermedius in Males, Pregnant and Non-pregnant Women

1988 ◽  
Vol 67 (8) ◽  
pp. 1062-1069 ◽  
Author(s):  
R. Jonsson ◽  
B.E. Howland ◽  
G.H.W. Bowden
Keyword(s):  
Pregnant Women ◽  
Subgingival Plaque ◽  
Clinical Parameters ◽  
Periodontal Health ◽  
Gram Negative ◽  
Pregnant Females ◽  
Whole Saliva ◽  
Severe Periodontal Disease ◽  
Gram Negative Organisms ◽  
Bacteriological Parameters

Relationships between four steroids, determined by radio-immunoassay of whole saliva, and clinical and bacteriological parameters were studied in 90 subjects: males, menstruating females, and pregnant females. Pocket depths and both plaque and gingival bleeding scores were recorded. Total counts and percentages of Gram-negative organisms Bacteroides and B. intermedius were determined from anaerobic cultures of subgingival plaque from 9-14 subjects in each group. None of the clinical parameters for the pregnant females differed significantly from those of non-pregnant females, nor did these parameters show any significant correlation with progression of pregnancy. No correlations were detected between bacterial and clinical parameters in the pregnant group. There were no statistically significant differences between the total bacterial counts from the three groups, yet males had significantly higher proportions of Gram-negative bacteria, Bacteroides, and B. intermedius, than did pregnant and non-pregnant females. Proportions of B. intermedius did not differ significantly between the two female groups, nor was there any correlation with progression of pregnancy. While some steroids appeared to affect some clinical or bacteriological parameters in some groups, no obvious patterns consistent with different steroid levels were detected. The results do not indicate that increased hormone levels cause more severe periodontal disease in pregnant women, nor that high salivary steroid levels result in increased recovery of B. intermedius from subgingival plaque.

scholarly journals Interleukins in diagnosis of perinatal asphyxia: A systematic review

2019 ◽  
Author(s):  
Hassan Boskabadi ◽  
Ali Moradi ◽  
Maryam Zakerihamidi
Keyword(s):  
Systematic Review ◽  
Early Diagnosis ◽  
Biochemical Markers ◽  
Web Of Science ◽  
Perinatal Asphyxia ◽  
Interleukin 1 ◽  
Cochrane Library

Background: Biochemical markers including interleukins (ILs) has been proposed for early diagnosis of asphyxia. Objective: This study has aimed to systematically review the significance of IL measurements in the diagnosis of perinatal asphyxia. Materials and Methods: PubMed, Cochrane Library, Web of Science, Embase, and Scopus databases before 2017 were searched for the following keywords: asphyxia, neonatal, interleukin, and diagnosis. A total of 13 out of 300 searched papers were finally selected for evaluation. Interleukins under study were IL6 and interleukin 1

scholarly journals Insulin Signaling in Arthritis

2021 ◽  
Vol 12 ◽  
Author(s):  
Cesare Tripolino ◽  
Jacopo Ciaffi ◽  
Valentina Pucino ◽  
Piero Ruscitti ◽  
Nina van Leeuwen ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Insulin Signaling ◽  
Inflammatory Diseases ◽  
Cellular Membrane ◽  
Effect Relationship ◽  
Increased Risk ◽  
Environmental Agents ◽  
And Migration ◽  
Effect Of Glucose

Inflammatory arthritis is burdened by an increased risk of metabolic disorders. Cytokines and other mediators in inflammatory diseases lead to insulin resistance, diabetes and hyperlipidemia. Accumulating evidence in the field of immunometabolism suggests that the cause-effect relationship between arthritis and metabolic abnormalities might be bidirectional. Indeed, the immune response can be modulated by various factors such as environmental agents, bacterial products and hormones. Insulin is produced by pancreatic cells and regulates glucose, fat metabolism and cell growth. The action of insulin is mediated through the insulin receptor (IR), localized on the cellular membrane of hepatocytes, myocytes and adipocytes but also on the surface of T cells, macrophages, and dendritic cells. In murine models, the absence of IR in T-cells coincided with reduced cytokine production, proliferation, and migration. In macrophages, defective insulin signaling resulted in enhanced glycolysis affecting the responses to pathogens. In this review, we focalize on the bidirectional cause-effect relationship between impaired insulin signaling and arthritis analyzing how insulin signaling may be involved in the aberrant immune response implicated in arthritis and how inflammatory mediators affect insulin signaling. Finally, the effect of glucose-lowering agents on arthritis was summarized.

Analysis of tight junctions during neutrophil transendothelial migration

2000 ◽  
Vol 113 (1) ◽  
pp. 45-57 ◽  
Author(s):  
A.R. Burns ◽  
R.A. Bowden ◽  
S.D. MacDonell ◽  
D.C. Walker ◽  
T.O. Odebunmi ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tight Junctions ◽  
Umbilical Vein ◽  
Interleukin 1 ◽  
Intercellular Junctions ◽  
Barrier Properties ◽  
Transendothelial Migration ◽  
Immunoblot Analysis ◽  
Intimate Contact ◽  
And Migration

Intercellular junctions have long been considered the main sites through which adherent neutrophils (PMNs) penetrate the endothelium. Tight junctions (TJs; zonula occludens) are the most apical component of the intercellular cleft and they form circumferential belt-like regions of intimate contact between adjacent endothelial cells. Whether PMN transmigration involves disruption of the TJ complex is unknown. We report here that endothelial TJs appear to remain intact during PMN adhesion and transmigration. Human umbilical vein endothelial cell (HUVEC) monolayers, a commonly used model for studying leukocyte trafficking, were cultured in astrocyte-conditioned medium to enhance TJ expression. Immunofluorescence microscopy and immunoblot analysis showed that activated PMN adhesion to resting monolayers or PMN migration across interleukin-1-treated monolayers does not result in widespread proteolytic loss of TJ proteins (ZO-1, ZO-2, and occludin) from endothelial borders. Ultrastructurally, TJs appear intact during and immediately following PMN transendothelial migration. Similarly, transendothelial electrical resistance is unaffected by PMN adhesion and migration. Previously, we showed that TJs are inherently discontinuous at tricellular corners where the borders of three endothelial cells meet and PMNs migrate preferentially at tricellular corners. Collectively, these results suggest that PMN migration at tricellular corners preserves the barrier properties of the endothelium and does not involve widespread disruption of endothelial TJs.

Silk Sericin Activates Mild Immune Response and Increases Antibody Production

2021 ◽  
Vol 17 (12) ◽  
pp. 2433-2443
Author(s):  
Yuan Zhang ◽  
Na Shi ◽  
Lun He ◽  
Shanshan Wang ◽  
Xin Li ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
T Cell Activation ◽  
Specific Antibody ◽  
Interleukin 1 ◽  
Mouse Serum ◽  
Enzyme Linked Immunosorbent Assay ◽  
Splenocyte Proliferation ◽  
Mouse Splenocytes ◽  
Silk Sericin

To clarify whether nanoparticles of silk sericin (SS) and silk fibroin (SF) can induce inflammation and immune responses, we analyzed splenocyte proliferation, apoptosis and cytokine release to identify the effects of SS and SF on mouse splenocytes in vitro. We implanted mice with SS and SF through intraperitoneal, intramuscular, and subcutaneous routes to evaluate the innate and adaptive immune response to SS and SF in vivo. Cytokines in the serum and spleen were analyzed by Luminex and antibody array. Antigen-specific antibodies were evaluated by enzyme-linked immunosorbent assay (ELISA) at week 1 and 5 after implantation. Distinct cell populations in the spleen and bone marrow were analyzed by flow cytometry. SS suppressed the proliferation of splenocytes and CD11b+CD27− NK cells, induced splenocyte apoptosis, and increased interleukin-1 β (IL-1 β) and tumor necrosis factor-α (TNF-α) in the culture supernatant. SF suppressed splenocyte proliferation, induced splenocyte apoptosis, and increased the titer of TNF-α in culture supernatants. At both week 1 and 5 after implantation with SS, mouse serum interleukin-1 α (IL-1 α) and keratinocyte chemoattractant (KC) were decreased, SS-specific antibody was increased, the proportion of bone marrow CD4+ T cells was increased, and the proportion of splenic neutrophils was decreased. At week 5 after subcutaneous implantation with SF, mouse serum IL-1α, and splenic IL-6, TIMP-1, IL-4, MCP-1, IFN-γ, TCA-3, TNF-α, and IL-17 were decreased. SS was able to induce a mild immune response, as evidenced by CD4+ T cell activation, splenocyte apoptosis, and antigen-specific antibody secretion. Comparatively, SF had low immunogenicity and anti-inflammatory properties.

Predisposition to Hyperthyroidism May Be Influenced by Functional TNF-α, IL-1, IL-6, and IL-10 Polymorphisms: A Meta-Analysis

2020 ◽  
Vol 181 (12) ◽  
pp. 956-965
Author(s):  
Hong Ma ◽  
Ting Tan ◽  
Jie Wu ◽  
Juan Chen ◽  
Xiaohong Zhang
Keyword(s):  
Meta Analysis ◽  
Interleukin 1 ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Asian Origin ◽  
Tnf Α ◽  
Caucasian Origin ◽  
Meta Analyses ◽  
Factor Α ◽  
Necrosis Factor

<b><i>Background:</i></b> Predisposition to hyperthyroidism may be influenced by functional gene polymorphisms in tumor necrosis factor-α (<i>TNF-α</i>), interleukin-1 (<i>IL-1</i>), interleukin-4 (<i>IL-4</i>), interleukin-6 (<i>IL-6</i>), and interleukin-10 (<i>IL-10</i>). However, the results of the studies published so far remain discrepant, so we conducted a meta-analysis to more robustly investigate relationships between <i>TNF-α</i>/<i>IL-1/IL-4/IL-6/IL-10</i> polymorphisms and predisposition to hyperthyroidism. <b><i>Methods:</i></b> A comprehensive literature retrieval from PubMed, Embase, Web of Science, WanFang, VIP, and CNKI was endorsed by the authors, and 38 studies were found to be eligible for pooled meta-analyses. <b><i>Results:</i></b> We found that genotypic frequencies of <i>TNF-α</i> −308 G/A, <i>IL-1A</i> −889 C/T, <i>IL-6</i> −174 G/C, <i>IL-6</i> −572 G/C, <i>IL-10</i> −819 C/T, and <i>IL-10</i> −1082 A/G polymorphisms among cases were significantly different from those among controls. Moreover, we also found that genotypic frequencies of <i>TNF-α</i> −308 G/A and <i>IL-6</i> −174 G/C polymorphisms among cases of Caucasian origin were significantly different from those among Caucasian controls, and genotypic frequencies of <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −511 C/T, <i>IL-6</i> −174 G/C, <i>IL-6</i> −572 G/C, and <i>IL-10</i> −1,082 A/G polymorphisms among cases of Asian origin were also significantly different from those among Asian controls. <b><i>Conclusions:</i></b> This meta-analysis suggests that <i>TNF-α</i> −308 G/A, <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −511 C/T, <i>IL-6</i> −174 G/C, <i>IL-6</i> −572 G/C, <i>IL-10</i> −819 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms may influence predisposition to hyperthyroidism in certain ethnic groups.

scholarly journals Interleukin 1-induced, T cell-mediated regression of immunogenic murine tumors. Requirement for an adequate level of already acquired host concomitant immunity.

1988 ◽  
Vol 168 (6) ◽  
pp. 2031-2043 ◽  
Author(s):  
R J North ◽  
R H Neubauer ◽  
J J Huang ◽  
R C Newton ◽  
S E Loveless
Keyword(s):  
Immune Response ◽  
T Cells ◽  
T Cell ◽  
Tumor Growth ◽  
Tumor Regression ◽  
Interleukin 1 ◽  
Host Immunity ◽  
Antitumor Action ◽  
Complete Regression ◽  
Subtherapeutic Level

Intraperitoneal injection of human rIL-1 in a dose of 0.5 microgram daily for 5 d, or 1 microgram daily for 3 d, was capable of causing complete regression of immunogenic SA1 sarcoma growing subcutaneously in syngeneic or semisyngeneic mice. Higher doses of IL-1 were not more therapeutic against the SA1 sarcoma, but needed to be given to cause complete regression of the immunogenic L5178Y lymphoma. On the other hand, the P815 mastocytoma was much less responsive to IL-1 therapy, in that it failed to undergo complete regression in response to doses of IL-1 capable of causing regression of the L5178Y lymphoma. IL-1 caused regression of the SA1 sarcoma when given on days 6-8 of tumor growth, but not when given on days 1-3. This refractoriness of a small tumor to IL-1 therapy suggests that the antitumor action of IL-1 is based on an underlying host-immune response that is not generated until after day 3 of tumor growth. Direct evidence for the participation of host immunity in IL-1-induced tumor regression was supplied by results showing that IL-1 was not therapeutic against the SA1 sarcoma growing in T cell-deficient (TXB) mice, unless these mice were first infused with Ly-2+ and L3T4+ T cells from donor mice bearing an established SA1 sarcoma. In contrast, normal T cells, or T cells from donor mice bearing a YAC-1 lymphoma, failed to provide TXB recipients with the ability to cause regression of their SA-1 sarcoma in response to IL-1 treatment. The results are in keeping with the interpretation that exogenous IL-1, by augmenting the production of tumor-sensitized T cells, converts a subtherapeutic level of host immunity to a therapeutic level. The results suggest, in addition, that IL-1 only stimulates the replication of T cells that are already engaged in the antitumor immune response.

scholarly journals Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response

2004 ◽  
Vol 101 (17) ◽  
pp. 6593-6598 ◽  
Author(s):  
N. T. Liberati ◽  
K. A. Fitzgerald ◽  
D. H. Kim ◽  
R. Feinbaum ◽  
D. T. Golenbock ◽  
...  
Keyword(s):  
Immune Response ◽  
Caenorhabditis Elegans ◽  
Interleukin 1 ◽  
Domain Protein

scholarly journals Psychology of Forced Displacement and Migration: A systematic review of the scientific literature

2018 ◽  
Vol 35 (2) ◽  
pp. 127-136
Author(s):  
Jonas CARVALHO e SILVA ◽  
Júlia Sursis Nobre Ferro BUCHER-MALUSCHKE
Keyword(s):  
Systematic Review ◽  
Research Field ◽  
Forced Displacement ◽  
Eligibility Criteria ◽  
Main Research ◽  
Units Of Analysis ◽  
Research Questions ◽  
And Migration ◽  
General Aspects ◽  
Meta Analyses

Abstract Forced displacement is a research field in specific social and cultural contexts. This systematic review aims to identify, describe and analyze the research in Psychology of Forced Displacement and Migration published between 2006 and 2016. The databases selected were PsycINFO, Lilacs and SciELO following the criteria of Preferred Reporting Items for Systematic Reviews and Meta-Analyses, 2009. Content and methodology were assessed by Critical Appraisal Skill Programme. A total of 34 out of 491 articles fulfilled the eligibility criteria and were categorized in a framework that summarizes the main research questions and methodologies, including authors, research questions, units of analysis, dominant theories, and hypotheses. In conclusion, the framework helped to comprehend the general aspects of the existing research and pointed out interdisciplinary tendencies in the studies on this phenomenon.

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