Predisposition to Hyperthyroidism May Be Influenced by Functional TNF-α, IL-1, IL-6, and IL-10 Polymorphisms: A Meta-Analysis

2020 ◽  
Vol 181 (12) ◽  
pp. 956-965
Author(s):  
Hong Ma ◽  
Ting Tan ◽  
Jie Wu ◽  
Juan Chen ◽  
Xiaohong Zhang
Keyword(s):  
Meta Analysis ◽  
Interleukin 1 ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Asian Origin ◽  
Tnf Α ◽  
Caucasian Origin ◽  
Meta Analyses ◽  
Factor Α ◽  
Necrosis Factor

<b><i>Background:</i></b> Predisposition to hyperthyroidism may be influenced by functional gene polymorphisms in tumor necrosis factor-α (<i>TNF-α</i>), interleukin-1 (<i>IL-1</i>), interleukin-4 (<i>IL-4</i>), interleukin-6 (<i>IL-6</i>), and interleukin-10 (<i>IL-10</i>). However, the results of the studies published so far remain discrepant, so we conducted a meta-analysis to more robustly investigate relationships between <i>TNF-α</i>/<i>IL-1/IL-4/IL-6/IL-10</i> polymorphisms and predisposition to hyperthyroidism. <b><i>Methods:</i></b> A comprehensive literature retrieval from PubMed, Embase, Web of Science, WanFang, VIP, and CNKI was endorsed by the authors, and 38 studies were found to be eligible for pooled meta-analyses. <b><i>Results:</i></b> We found that genotypic frequencies of <i>TNF-α</i> −308 G/A, <i>IL-1A</i> −889 C/T, <i>IL-6</i> −174 G/C, <i>IL-6</i> −572 G/C, <i>IL-10</i> −819 C/T, and <i>IL-10</i> −1082 A/G polymorphisms among cases were significantly different from those among controls. Moreover, we also found that genotypic frequencies of <i>TNF-α</i> −308 G/A and <i>IL-6</i> −174 G/C polymorphisms among cases of Caucasian origin were significantly different from those among Caucasian controls, and genotypic frequencies of <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −511 C/T, <i>IL-6</i> −174 G/C, <i>IL-6</i> −572 G/C, and <i>IL-10</i> −1,082 A/G polymorphisms among cases of Asian origin were also significantly different from those among Asian controls. <b><i>Conclusions:</i></b> This meta-analysis suggests that <i>TNF-α</i> −308 G/A, <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −511 C/T, <i>IL-6</i> −174 G/C, <i>IL-6</i> −572 G/C, <i>IL-10</i> −819 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms may influence predisposition to hyperthyroidism in certain ethnic groups.

scholarly journals Whether the risk of gestational diabetes mellitus is affected by TNF-α, IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Qiqi Huang ◽  
Yi Wang ◽  
Binbin Gu ◽  
Yanwen Xu
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Tnf Α ◽  
Quantitative Analyses ◽  
Factor Α ◽  
Positive Results ◽  
Necrosis Factor

Abstract Background Whether polymorphisms in tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10) or adiponectin (ADIPOQ) influence the risk of gestational diabetes mellitus (GDM) or not remain inconclusive. Therefore, the authors conducted a meta-analysis to robustly assess relationships between polymorphisms in TNF-α, IL-6, IL-10 or ADIPOQ and the risk of GDM by merging the results of eligible publications. Methods A through literature searching in Medline, Embase, Wanfang, VIP and CNKI was conducted by the authors to identify eligible publications, and twenty-two publications were finally found to be eligible for merged quantitative analyses. Results The merged quantitative analyses revealed that ADIPOQ + 45T/G (rs2241766) polymorphism was significantly associated with the risk of GDM in overall population (dominant comparison: OR = 0.70, p < 0.001; recessive comparison: OR = 1.95, p < 0.001; over-dominant comparison: OR = 1.18, p = 0.03; allele comparison: OR = 0.71, p < 0.001) and Asians (dominant comparison: OR = 0.70, p < 0.001; recessive comparison: OR = 1.94, p < 0.001; allele comparison: OR = 0.72, p < 0.001). Nevertheless, we did not observe any positive results for TNF-α − 238G/A (rs361525), TNF-α − 308G/A (rs1800629), IL6 − 174G/C (rs1800795), IL-10 − 819C/T (rs1800871), IL-10 − 592C/A (rs1800872), IL-10 − 1082A/G (rs1800896) and ADIPOQ + 276G/T (rs1501299) polymorphisms. Conclusions The present meta-analysis shows that among investigated TNF-α, IL-6, IL-10 or ADIPOQ polymorphisms, only ADIPOQ + 45T/G (rs2241766) polymorphism may affect the risk of GDM.

scholarly journals The effects of chrysin on cypermethrin-induced acute intoxication in rainbow trout (Oncorhynchus mykiss)

2019 ◽  
Vol 27 (2) ◽  
pp. 102-111
Author(s):  
Ozge Cerit ◽  
Feride Koc
Keyword(s):  
Interleukin 1 ◽  
Interleukin 10 ◽  
Control Group ◽  
Interleukin 1 Beta ◽  
Tissue Samples ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Tnf Α ◽  
Factor Α ◽  
Oxidative Effects ◽  
Necrosis Factor

Abstract Cypermethrin (CP) is a toxic insecticide to fishes. Chrysin (CR) is a flavonoid, which can be obtained from plants. The aim of this study was to determine the effects of CR in fishes that had acute CP toxicity. In the study, a total of 60 fishes were used and added to feed and water with CR and CP for 10 days. Blood and tissue samples were collected. The serum enzymes aspartate transaminase (AST) and alanine aminotransferase (ALT), interleukin-1 beta (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) levels/activities were determined for liver and kidneys. In this study, when the CP group was compared to the control group, an increase was observed in the levels/activities of AST, ALT, IL-1ß, TNF-α, and IL-6, otherwise, there was a decrease in the IL-10 level in the CP group. Additionally, an increase of MDA levels and a decrease of SOD, GSH-Px, and CAT levels/activities were observed in the CP group. When the CP group was compared to the CR groups, there was a decrease in IL-1β, IL-6, TNF-α, ALT, AST, and MDA levels/activities and there was an increase, depending on the dosage in GSH-Px, SOD, and CAT levels/activities of the CR groups. In conclusion, CR can prevent tissue damage, affecting oxidation via anti-inflammatory and anti-oxidative effects of acute toxicity of fishes exposed to CP.

Interleukin Polymorphisms and Predisposition of Systemic Lupus Erythematosus: A Meta-Analysis

2021 ◽  
pp. 1-9
Author(s):  
Zongqing Liu ◽  
Tong Sun ◽  
Linjian Song ◽  
Xiaoxing Xue ◽  
Shuang Liu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Web Of Science ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Systemic Lupus ◽  
Comprehensive Search ◽  
Meta Analyses

<b><i>Background:</i></b> It is plausible that interleukin polymorphisms may affect predisposition of autoimmune disorders such as systemic lupus erythematosus (SLE), but the results of so far published studies remain controversial. <b><i>Objectives:</i></b> The authors conducted this meta-analysis to clarify relationships between interleukin-1 (<i>IL-1</i>)<i>/</i>interleukin-4 (<i>IL-4</i>)<i>/</i>interleukin-6 (<i>IL-6</i>)<i>/</i>interleukin-10 (<i>IL-10</i>) polymorphisms and SLE by pooling the findings of eligible studies. <b><i>Methods:</i></b> A comprehensive search of PubMed, EMBASE, Web of Science, and CNKI was endorsed by the authors to identify already published studies. Fifty-seven studies were found to be eligible for meta-analyses. <b><i>Results:</i></b> The overall pooled meta-analyses yielded positive findings for <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −31 T/C, <i>IL-6</i> −174 G/C, <i>IL-4</i> −590 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms. In addition, we also detected similar positive findings for <i>IL-1B</i> −511 C/T, <i>IL-4</i> −590 C/T, <i>IL-10</i> −592 A/C, <i>IL-10</i> −819 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms in Asians, and such positive findings were also observed for <i>IL-1A</i> −889 C/T, <i>IL-6</i> −174 G/C, and <i>IL-10</i> −1,082 A/G polymorphisms in Caucasians. <b><i>Conclusions:</i></b> The meta-analyses’ results suggest that <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −31 T/C, <i>IL-6</i> −174 G/C, <i>IL-4</i> −590 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms might affect predisposition of SLE.

scholarly journals Tear Levels of Inflammatory Cytokines in Keratoconus: A Meta-Analysis of Case-Control and Cross-Sectional Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Huan Zhang ◽  
Xiupeng Cao ◽  
Ying Liu ◽  
Peihong Wang ◽  
Xuan Li
Keyword(s):  
Inflammatory Cytokines ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Systemic Review ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Tnf Α ◽  
Significant Difference

Purpose. To assess the tear levels of inflammatory cytokines in patients with keratoconus (KC). Design. Systemic review and meta-analysis. Methods. The following electronic databases and search engine were searched: PubMed, EMBASE, Web of Science, and Google Scholar. A systematic search of all relevant studies published through January 2021 was conducted, and the standardized mean difference (SMD) and 95% confidence interval (CI) of cytokine levels were calculated to estimate the pooled effects. Sensitivity analysis, subgroup analysis, and metaregression were applied to explore the sources of heterogeneity. Results. A total of 7 studies with 374 participants (374 eyes) from clinical studies were included. The tear levels of interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α) were significantly increased in KC compared with normal controls. The SMD of IL-1β was 1.93 (95% CI 0.22 to 3.65, P = 0.03 ). The SMD of IL-6 was 1.22 (95% CI 0.59 to 1.84, P < 0.001 ). The SMD of TNF-α was 1.75 (95% CI 0.66 to 2.83, P = 0.002 ). There was no significant difference between the two groups on interleukin-4 (IL-4) and interleukin-10 (IL-10). The SMD for IL-4 was 2.36 (95% CI -0.28 to 5.00, P = 0.08 ) and for IL-10 was 0.30 (95% CI -1.29 to 1.89, P = 0.71 ). Meta-regression analysis indicated that the heterogeneity maybe significantly correlated with the method of detection, the different ages, and the source of population. Conclusions. Our meta-analysis demonstrated that proinflammatory cytokines IL-1β, IL-6, and TNF-α were increased, indicating that cytokine profile changed in KC tears and inflammation may play an important role in the pathogenesis and development of KC.

The Effects of Cytokine Polymorphisms on Predisposition to Microvascular Complications of Diabetes Mellitus: A Meta-Analysis

2021 ◽  
pp. 1-10
Author(s):  
Feng Shen ◽  
Dan Liu
Keyword(s):  
Diabetes Mellitus ◽  
Web Of Science ◽  
Meta Analysis ◽  
Microvascular Complications ◽  
Complications Of Diabetes ◽  
Tnf Α ◽  
Comprehensive Search ◽  
Meta Analyses ◽  
Factor Α ◽  
Necrosis Factor

<b><i>Background:</i></b> It is plausible that gene polymorphisms in tumor necrosis factor-α (<i>TNF-α</i>), interleukin (<i>IL</i>)-<i>1</i>, <i>IL-6</i>, <i>IL-8</i>, and <i>IL-18</i> may affect predisposition to microvascular complications of diabetes mellitus (DM), but the results of the so far published studies remain controversial. <b><i>Objectives:</i></b> We conducted this meta-analysis to clarify relationships between <i>TNF-α/IL-1/IL-4/IL-8/IL-18</i> polymorphisms and predisposition to microvascular complications of DM by pooling the findings of eligible studies. <b><i>Methods:</i></b> A comprehensive search of PubMed, Embase, Web of Science, and CNKI was endorsed by us to identify already published studies. Forty-nine studies were found to be eligible for the meta-analyses. <b><i>Results:</i></b> The pooled meta-analyses results showed that genotypic frequencies of <i>TNF-α</i> −238 G/A, <i>TNF-α</i> −308 G/A, <i>TNF-α</i> −1,031 T/C, <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −511 C/T, <i>IL-6</i> −572 G/C, and <i>IL-18</i> −137 G/C polymorphisms among patients with diabetic nephropathy (DN) and controls differed significantly. Moreover, genotypic frequencies of <i>TNF-α</i> −238 G/A and <i>IL-8</i> −251 A/T polymorphisms among patients with diabetic retinopathy (DR) and controls also differed significantly. <b><i>Conclusions:</i></b> This meta-analysis suggested that <i>TNF-α</i> −238 G/A, <i>TNF-α</i> −308 G/A, <i>TNF-α</i> −1,031 T/C, <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −511 C/T, <i>IL-6</i> −572 G/C, and <i>IL-18</i> −137 G/C polymorphisms may affect predisposition of DN. Moreover, <i>TNF-α</i> −238 G/A and <i>IL-8</i> −251 A/T polymorphisms may affect predisposition of DR.

The Role of Tumor Necrosis Factor-α (TNF-α) Polymorphisms in Gastric Cancer: a Meta-Analysis

2021 ◽  
Author(s):  
Maryam Gholamalizadeh ◽  
Samaneh Mirzaei Dahka ◽  
Hadi Sedigh Ebrahim-Saraie ◽  
Mohammad Esmail Akbari ◽  
Azam Pourtaheri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Meta Analysis ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Tumor necrosis factor-α and interleukin-1 β levels in recurrent and persistent otitis media with effusion

2002 ◽  
Vol 126 (4) ◽  
pp. 417-422 ◽  
Author(s):  
Sertac Yetiser ◽  
Bulent Satar ◽  
Atilla Gumusgun ◽  
Faruk Unal ◽  
Yalcin Ozkaptan
Keyword(s):  
Tumor Necrosis Factor ◽  
Otitis Media ◽  
Tumor Necrosis ◽  
Otitis Media With Effusion ◽  
Interleukin 1 ◽  
Tertiary Referral Center ◽  
Adenoid Tissue ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

OBJECTIVE: Based on interleukin (IL)-1β and tumor necrosis factor (TNF)-α levels in effusions, our goals were to specify either recurrent or persistent otitis media with effusion (OME) is a mid stage in the development of chronic disease and to identify the factors that have an influence on cytokine levels. STUDY DESIGN: Samples from groups with recurrent (n = 15) and persistent (n = 39) OME were essayed for IL-1 β and TNF-α. Children were also grouped with respect to age, sex, quality of effusion, and the presence of pharyngeal adenoid tissue. SETTING: Tertiary referral center. RESULTS: In recurrent and persistent OME groups, IL-1β was higher than TNF-α ( P < 0.01). IL-β was higher in recurrent OME than in persistent OME ( P < 0.05). CONCLUSION: Recurrent OME seems to be closer to the chronic stage of the disease relative to persistent OME in terms of higher IL-1 β levels. Each exacerbation of acute disease in recurrent otitis media is likely to be mediated by IL-1 β. SIGNIFICANCE: We were able to clarify that recurrent OME is a stage that occurs before chronic OME. Therefore, the prevention of acute attacks in recurrent disease would also impede long-term damage to the middle ear.

The Augmented Productions of Neopterin and Cytokines from Macrophages/monocytes in vitro

Pteridines ◽  
1996 ◽  
Vol 7 (3) ◽  
pp. 72-76
Author(s):  
Tadashi Lizuka ◽  
Mitsuyo Sasaki ◽  
Hitomi Kamisako ◽  
Ko Oishi ◽  
Shigeru Uemura ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Interleukin 1 ◽  
Poly I:C ◽  
Recombinant Interferon ◽  
Preliminary Examination ◽  
Tnf Α ◽  
Ifn Γ ◽  
Factor Α ◽  
Necrosis Factor

Summary In Kawasaki disease patients, increases in excretion of urinary neopterin coincided with fever and monocytosis in peripheral blood. We examined the products of neopterin, tumor necrosis factor-α (TNFα) and Interleukin-1 β (1L-1β) from healthy adult macrophages/monocytes (Mφ>/M), after stimulation with several activators to obtain some understanding of Kawasaki disease. Upon stimulation with either lipopolysaccharide (LPS) or polyinosinate-polycytidylate (Poly I:C), the Mφ/M released neopterin and pyogenic products (TNF-α or 1L-1β). The release of neopterin was eliminated by the addition of the anti-interferon-y antibody. The production of both TNF-α, 1L-1β and neopterin from Mφ/M upon stimulation of LPS was augmented in a co-culture with low dose recombinant interferon-y (rIFN-γ). Upon stimulation with rIFN-γ alone, however, the Mφ/M released neopterin but not the pyogenic products. A preliminary examination failed to detect. any difference in the response of the Mφ/M in adults annd children after stimulation with LPS. We concluded that some endotoxins could trigger the onset of Kawasaki disease and that endogenous IFN-γ can play an important role in the abnormality of Kawasaki disease patients

scholarly journals Maternal Expressions (Serum Levels) of Alpha Tumour Necrosis Factor, Interleukin 10, Interleukin 6 and Interleukin 4 in Malaria Infected Pregnant Women Based on Parity in a Tertiary Hospital in Southeast, Nigeria

2020 ◽  
pp. 35-41
Author(s):  
Obeagu, Emmanuel Ifeanyi ◽  
Obeagu, Getrude Uzoma ◽  
Amaeze, Augustine Amaeze ◽  
Asogwa, Eucharia Ijego ◽  
Chukwurah, Ejike Felix ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Tumour Necrosis Factor ◽  
Interleukin 6 ◽  
Tumour Necrosis ◽  
Public Health Problem ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Tnf Α ◽  
Necrosis Factor

Malaria has been reported as a condition caused by infestation with Plasmodium parasite specie, which is a great public health problem globally, particularly in developing countries like Nigeria. This study was carried out in Federal Medical Centre Umuahia in Abia State, Nigeria. The study was done to determine the maternal serum levels of alpha tumour necrosis factor, interleukin 10, interleukin 6, and interleukin 4 in malaria-infected pregnant women based on parities in Southeast, Nigeria.  A total of 150 subjects between the ages of 18-45 years were recruited for the study comprising 50 subjects each of 3 parities (groups A-C). A commercial ELISA Kit was used to measure all the cytokines. Neither statistically significant differences were found for TNF-α (p=0.636), IL-10 (p=0.892), IL-6 (p=0.306) and IL-4 (p=0.222) between prime parity and second parity nor for TNF-α (p=0.356), IL-10 (p=0.896), IL-6 (p=0.304) and IL-4 (p=0.298) between prime parity and multi-parity of malaria-infected pregnant women. TNF-α (p=0.255), IL-10 (p=0.524), IL-6 (p=0.616), and IL-4 (p=0.672) between second parity and on multi-parity respectively. The study showed no changes in the cytokines studied among the malaria-infected pregnant women based on parities. It shows that the number of pregnancies in women infected with malaria has no changes in the levels of the cytokines studied.

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