scholarly journals Multifocal Orthokeratology versus Conventional Orthokeratology for Myopia Control: A Paired-Eye Study

2021 ◽  
Vol 10 (3) ◽  
pp. 447
Author(s):  
Martin Loertscher ◽  
Simon Backhouse ◽  
John R. Phillips
Keyword(s):  
Visual Acuity ◽  
Axial Length ◽  
Length Change ◽  
Fellow Eye ◽  
Eye Growth ◽  
Treatment Zone ◽  
Ocular Biometry ◽  
Center Distance ◽  
Myopia Control ◽  
Posterior Cornea

We conducted a prospective, paired-eye, investigator masked study in 30 children with myopia (−1.25 D to −4.00 D; age 10 to 14 years) to test the efficacy of a novel multifocal orthokeratology (MOK) lens compared to conventional orthokeratology (OK) in slowing axial eye growth. The MOK lens molded a center-distance, multifocal surface onto the anterior cornea, with a concentric treatment zone power of +2.50 D. Children wore an MOK lens in one eye and a conventional OK lens in the fellow eye nightly for 18 months. Eye growth was monitored with non-contact ocular biometry. Over 18 months, MOK-treated eyes showed significantly less axial expansion than OK-treated eyes (axial length change: MOK 0.173 mm less than OK; p < 0.01), and inner axial length (posterior cornea to anterior sclera change: MOK 0.156 mm less than OK, p < 0.01). The reduced elongation was constant across different baseline progression rates (range −0.50 D/year to −2.00 D/year). Visual acuity was less in MOK vs. OK-treated eyes (e.g., at six months, MOK: 0.09 ± 0.01 vs. OK: 0.02 ± 0.01 logMAR; p = 0.01). We conclude that MOK lenses significantly reduce eye growth compared to conventional OK lenses over 18 months.

scholarly journals Orthokeratology lenses and myopia control

The Eye ◽  
2019 ◽  
Vol 126 (2019-2) ◽  
pp. 13-20
Author(s):  
Pyotr Nagorsky ◽  
Nikolai Kikhtenko ◽  
Vera Milyukhina
Keyword(s):  
Axial Length ◽  
Growth Dynamics ◽  
Control Group ◽  
Myopia Progression ◽  
Eye Growth ◽  
Vision Correction ◽  
Uncorrected Visual Acuity ◽  
Progressive Myopia ◽  
Observation Period ◽  
Myopia Control

Purpose: To estimate the stabilizing effect of orthokeratology lenses (ortho-K, OK-lenses) on myopia progression by evaluating axial eye growth dynamics and clinical refraction. Material and methods. Ortho-K group consisted of 68 children (135 eyes) aged 7–17 years (mean age 12.2) with progressive myopia (initially -0.75–6.75 D). Observation period varied from 7 to 30 months (mean period 11.68±4.39). All patients used OK-lenses for overnight wear. The control group consisted of 90 patients (180 eyes) with myopia who were prescribed single vision spectacles for vision correction. Comparative analysis was performed for clinical refraction parameters as well as for axial length (AL). The data was obtained with the use of IOL-Master optical biometer (“Carl Zeiss”). Results. The parameters were stable in patients of ortho-K group: axial length, subjective and objective clinical refraction, the required power of corrective lenses. However, the parameters changed significantly in the control group during the observation period: uncorrected visual acuity (UCVA) decreased, the required power of corrective lenses increased, the indices of objective clinical refraction strengthened, annual gradient of progression (AGP) amounted to 0.26±0.19 and 0.16±0,39 mm in patients with low and moderate myopia, respectively. Conclusion. The use of OK-lenses ensures a significant deceleration of myopia progression in children. The results obtained suggest a wider use of ortho-K among pediatric ophthalmologists in their clinical practice as it is an effective preventive and therapeutic method for patients with progressive myopia.

scholarly journals Spectacle Lenses With Slightly Aspherical Lenslets for Myopia Control: Clinical Trial Design and Baseline Data

2021 ◽  
Author(s):  
Junhong Chen ◽  
Ran Zhuo ◽  
Jiayan Chen ◽  
Adeline Yang ◽  
Ee Woon Lim ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Visual Acuity ◽  
Refractive Error ◽  
Axial Length ◽  
Baseline Data ◽  
Major Public Health Problem ◽  
Spherical Equivalent ◽  
Single Vision ◽  
Significant Difference ◽  
Myopia Control

Abstract Objectives: Myopia is a major public health problem and it is essential to find safe and effective means to control its progression. The study design and baseline data are presented for a one-year prospective, double-masked, cross-over, randomized clinical trial evaluating the efficacy of single vision spectacle lenses with concentric rings of slightly aspherical contiguous lenslets technology (SAL) on myopia control. Methods: One hundred 8- to 13-year old Chinese children with a refractive error of -0.75 D to -4.75 D were assigned into two groups. In Group 1, SAL then single vision lenses were each worn for 6 months, and Group 2 wore the lenses in the reversed order. Primary outcomes are axial length and spherical equivalent of cycloplegic refractive error. Secondary outcomes include corneal thickness, anterior chamber depth, lens thickness, visual acuity, and lens adaptation.Results: No significant differences in baseline parameters (cycloplegic spherical equivalent, axial length, age) were found between groups (0.49 < p < 0.94). All children adapted well to the test lenses and there was no significant difference in visual acuity between the SAL and single vision lenses (p = 0.27).Conclusions: The children in the two well balanced groups had comparable visual acuity and adapted well to the test lenses. These results imply the visual acuity can be well improved by SAL lens. Clear visual acuity provide the assurance for good compliance in this longitudinal study.

scholarly journals MYOPIA INDIAN EYES: COMPARING CALCULATED AND MEASURED AXIAL LENGTH IN YOUNG PATIENTS

2020 ◽  
pp. 80-82
Author(s):  
Nirav Mehta ◽  
Shivani Kansara ◽  
Rupam Desai
Keyword(s):  
Axial Length ◽  
Young Patients ◽  
Coefficient Of Determination ◽  
Ocular Biometry ◽  
Corneal Radius ◽  
Eye Examination ◽  
Children And Young Adults ◽  
Schematic Eye ◽  
Preventable Blindness ◽  
Myopia Control

Myopia is the leading cause of preventable blindness in children and young adults in the world. As age increases axial length increasing risks of myopia for causing ocular morbidity including retinal detachment, glaucoma, myopic macular degeneration, and cataracts. In India, much patient eye examination done at primary eye clinic, where to estimate axial length is difficult. Our aim of the study was to assess the reliability of formula by comparing Predicted Axial Length (AL) uses corneal radius and Spherical equivalent (SE) to the measured AL using Ocular Biometry. Method: 96 myopic eyes were included, Comprehensive eye examination with Auto-refractokeratometer using TOPCON-800 and Axial length with Ocular Biometry (IOL Master-500) Calculated Axial length with formula by using AVE-K and SE which is obtained from original Gullstrand simplified Schematic eye: AL= (24.00×AVE-K/7.80–SE×0.40) for both K-reading. Result: Mean Calculated AL(mm) was 24.67 ± .90 and Measured AL (mm) which was 24.28 ± .96mm in 9-25yr age (P<0.001) with Mean difference 0.3±0.4. All groups show statistically significant correlation between Calculate AL and Mean AL (p<0.01, r>0.9). The coefficient of determination (R2) was 82% in 9-25yr age group. Conclusion: Study provides strong agreement between Measured AL and Calculated AL. Alternate method of AL measurement with a calculated formula can be implemented in all primary eye care for predicting Axial length and managing myopic patients for monitoring myopia control.

scholarly journals The Influence of Genetics in Myopia Control: A Pilot Study

2021 ◽  
Vol 10 (4) ◽  
pp. 808
Author(s):  
Cristina Alvarez-Peregrina ◽  
Miguel Ángel Sánchez-Tena ◽  
Clara Martinez-Perez ◽  
Catalina Santiago-Dorrego ◽  
Thomas Yvert ◽  
...  
Keyword(s):  
Pilot Study ◽  
Treatment Response ◽  
Axial Length ◽  
Contact Lenses ◽  
Control Method ◽  
Saliva Sample ◽  
Experimental Studies ◽  
Strong Linkage Disequilibrium ◽  
Student’S T ◽  
Myopia Control

Background: Many epidemiological and experimental studies have established that myopia is caused by a complex interaction between common genetic and environmental factors. The objective of this study was to describe and compare the allelic and genotypic frequencies of the rs524952 (GJD2), rs8000973 (ZIC2), rs1881492 (CHRNG), rs1656404 (PRSS56), rs235770 (BMP2), and rs7744813 (KCNQ5) SNPs (single-nucleotide polymorphism) between responder and nonresponder patients who had undergone a two-year treatment with lenses for myopia control. Method: Twenty-eight participants from the MiSight Assessment Study Spain (MASS), who had received treatment for myopia control for two years with MiSight contact lenses, were examined. The criteria for better/worse treatment response was the change in the axial length (< / ≥ 0.22 mm two years after the treatment). The clinical procedure consisted of the extraction of a saliva sample, and the participants also underwent an optometric examination. Genetic data were analyzed using SNPStats software (Catalan Institute of Oncology, Barcelona, Spain), and statistical analysis was performed using SPSS v.25 (SPSS Inc., Chicago, IL, USA). Demographic variables were analyzed using the Student’s t-test. Results: The T allele, the one with the lowest frequency, of the “rs235770” SNP was associated with a better treatment response [AL/CR (axial length/corneal radius): OR = 3.37; CI = 1.079–10.886; SE (spherical equivalent): OR = 1.26; CI: = 0.519–57.169; p = 0.019). By performing haplotype analysis, significant differences were found between the rs235770…rs1881492 and rs235770–rs1656404 polymorphisms. The latter presented a strong linkage disequilibrium with each other (r2 ≥ 0.54). Conclusion: The result of lens therapies for myopia control could vary depending on genetic variants. Studies with a larger sample are needed to confirm the results presented in this pilot study.

scholarly journals Myopia Control with Combination Low-Dose Atropine and Peripheral Defocus Soft Contact Lenses: A Case Series

2021 ◽  
pp. 548-554
Author(s):  
Nir Erdinest ◽  
Naomi London ◽  
Nadav Levinger ◽  
Yair Morad
Keyword(s):  
Low Dose ◽  
Contact Lenses ◽  
Case Series ◽  
Concentric Circle ◽  
Retrospective Case ◽  
Soft Contact ◽  
Myopia Progression ◽  
Soft Contact Lenses ◽  
Center Distance ◽  
Myopia Control

The goal of this retrospective case series is to demonstrate the effectivity of combination low-dose atropine therapy with peripheral defocus, double concentric circle design with a center distance soft contact lenses at controlling myopia progression over 1 year of treatment. Included in this series are 3 female children aged 8–10 years with progressing myopia averaging −4.37 ± 0.88 D at the beginning of treatment. Their average annual myopic progression during the 3 years prior to therapy was 1.12 ± 0.75 D. They had not attempted any myopia control treatments prior to this therapy. The children were treated with a combination of 0.01% atropine therapy with spherical peripheral defocus daily replacement soft lenses MiSight<sup>®</sup> 1 day (Cooper Vision, Phoenix, AZ, USA). They underwent cycloplegic refraction, and a slit-lamp evaluation every 6 months which confirmed no adverse reactions or staining was present. Each of the 3 children exhibited an average of 0.25 ± 0.25 D of myopia progression at the end of 1 year of treatment. To the best of the authors’ knowledge, this is the first published study exhibiting that combining low-dose atropine and peripheral defocus soft contact lenses is effective at controlling children’s moderate to severe myopia progression during 1 year of therapy.

scholarly journals Neovascular age-related macular degeneration: is it worthwhile treating an eye with poor visual acuity, if the visual acuity of the fellow eye is good?

Eye ◽  
2017 ◽  
Vol 31 (6) ◽  
pp. 978-980 ◽  
Author(s):  
A Rasmussen ◽  
J Fuchs ◽  
L H Hansen ◽  
M Larsen ◽  
B Sander ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Fellow Eye ◽  
Age Related

scholarly journals Refractive errors, ocular biometry and diabetic retinopathy: a systematic review

2020 ◽  
Author(s):  
Miao He ◽  
Haiying Chen ◽  
Wei Wang
Keyword(s):  
Systematic Review ◽  
Diabetic Retinopathy ◽  
Axial Length ◽  
Protective Factor ◽  
Posterior Vitreous Detachment ◽  
Anterior Chamber Depth ◽  
Protective Role ◽  
Protective Mechanism ◽  
Ocular Biometry ◽  
Systemic Factors

ABSTRACTDiabetic retinopathy (DR) is one of the major causes of visual impairment and blindness worldwide. The onset and progression of DR are influenced by systemic factors such as hyperglycemia and hypertension as well as ocular parameters. A better knowledge of the risk factors for DR is vital to improving the outcome of patients with DR and risk stratification. More recently, there has been increasing focus on the influence of myopia on DR development. Some observational studies have reported myopia being a protective factor for the development of DR, however the findings were inconsistent. In addition, it remains unclear whether it was myopia, axial length (AL), or other refractive factors that play the protective role. The protective mechanism against DR may be related to ocular elongation, posterior vitreous detachment, low perfusion in the retina and the abnormal cytokine profile. This systematic review will summarize the association of DR with refractory status as well as different refractive components including anterior chamber depth, refractory power of the lens, AL, and axial length-to-corneal radius ratio.

scholarly journals Fast Recovery of the Amblyopic Eye Acuity of Kittens following Brief Exposure to Total Darkness Depends on the Fellow Eye

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Donald E. Mitchell ◽  
Elise Aronitz ◽  
Philip Bobbie-Ansah ◽  
Nathan Crowder ◽  
Kevin R. Duffy
Keyword(s):  
Visual Acuity ◽  
Neural Activity ◽  
Early Life ◽  
Monocular Deprivation ◽  
Total Darkness ◽  
Visual Recovery ◽  
Fast Recovery ◽  
Fellow Eye ◽  
Neural Connections ◽  
Short Period

Recent studies conducted on kittens have revealed that the reduced visual acuity of the deprived eye following a short period of monocular deprivation imposed in early life is reversed quickly following a 10-day period spent in total darkness. This study explored the contribution of the fellow eye to the darkness-induced recovery of the acuity of the deprived eye. Upon emergence of kittens from darkness, the fellow eye was occluded for different lengths of time in order to investigate its effects on either the speed or the extent of the recovery of acuity of the deprived eye. Occlusion of the fellow eye for even a day immediately following the period spent in darkness blocked any recovery of the acuity of the deprived eye. Moreover, occlusion of the fellow eye two days after the period of darkness blocked any further visual recovery beyond that achieved in the short period when both eyes were open. The results imply that the darkness-induced recovery of the acuity of the deprived eye depends upon, and is guided by, neural activity in the mature neural connections previously established by the fellow eye.

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