scholarly journals A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector

2008 ◽  
Vol 9 (11) ◽  
pp. 2278-2289 ◽  
Author(s):  
Hongliang Huang ◽  
Hai Yu ◽  
Da Li ◽  
Yang Liu ◽  
Fenping Shen ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Low Molecular Weight ◽  
Gene Delivery Vector ◽  
Delivery Vector

A novel nonviral gene delivery vector: Low-molecular-weight polyethylenimine-graft-ovalbumin

2009 ◽  
Vol 114 (6) ◽  
pp. 3744-3750 ◽  
Author(s):  
Dan Chen ◽  
Yang Liu ◽  
Anna Lehtinen ◽  
Qiying Jiang ◽  
Jun Liu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Nonviral Gene Delivery ◽  
Low Molecular Weight ◽  
Gene Delivery Vector ◽  
Delivery Vector

Exosome as a Natural Gene Delivery Vector for Cancer Treatment

2020 ◽  
Vol 20 (11) ◽  
pp. 821-830
Author(s):  
Prasad Pofali ◽  
Adrita Mondal ◽  
Vaishali Londhe
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Cancer Treatment ◽  
Intestinal Barrier ◽  
Gene Carrier ◽  
Gene Delivery Vector ◽  
Delivery Vector

Background: Current gene therapy vectors such as viral, non-viral, and bacterial vectors, which are used for cancer treatment, but there are certain safety concerns and stability issues of these conventional vectors. Exosomes are the vesicles of size 40-100 nm secreted from multivesicular bodies into the extracellular environment by most of the cell types in-vivo and in-vitro. As a natural nanocarrier, exosomes are immunologically inert, biocompatible, and can cross biological barriers like the blood-brain barrier, intestinal barrier, and placental barrier. Objective: This review focusses on the role of exosome as a carrier to efficiently deliver a gene for cancer treatment and diagnosis. The methods for loading of nucleic acids onto the exosomes, advantages of exosomes as a smart intercellular shuttle for gene delivery and therapeutic applications as a gene delivery vector for siRNA, miRNA and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and also the limitations of exosomes as a gene carrier are all reviewed in this article. Methods: Mostly, electroporation and chemical transfection are used to prepare gene loaded exosomes. Results: Exosome-mediated delivery is highly promising and advantageous in comparison to the current delivery methods for systemic gene therapy. Targeted exosomes, loaded with therapeutic nucleic acids, can efficiently promote the reduction of tumor proliferation without any adverse effects. Conclusion: In the near future, exosomes can become an efficient gene carrier for delivery and a biomarker for the diagnosis and treatment of cancer.

Polyelectrolyte Complexes of Low Molecular Weight PEI and Citric Acid as Efficient and Nontoxic Vectors for in Vitro and in Vivo Gene Delivery

2016 ◽  
Vol 27 (3) ◽  
pp. 549-561 ◽  
Author(s):  
M. Dolores Giron-Gonzalez ◽  
Rafael Salto-Gonzalez ◽  
F. Javier Lopez-Jaramillo ◽  
Alfonso Salinas-Castillo ◽  
Ana Belen Jodar-Reyes ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Citric Acid ◽  
Gene Delivery ◽  
Low Molecular Weight ◽  
Polyelectrolyte Complexes ◽  
In Vivo Gene Delivery

Low Molecular Weight Polyethylenimine-graft-Tween 85 for Effective Gene Delivery: Synthesis and in Vitro Characteristics

2012 ◽  
Vol 23 (2) ◽  
pp. 222-231 ◽  
Author(s):  
Jisheng Xiao ◽  
Xiaopin Duan ◽  
Qi Yin ◽  
Lingli Chen ◽  
Zhiwen Zhang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Low Molecular Weight

In Vitro Design and Characterization of the Nonviral Gene Delivery Vector Iopamidol, Protamine, Ethiodized Oil Reagent

2011 ◽  
Vol 22 (10) ◽  
pp. 1457-1463.e2 ◽  
Author(s):  
Luke J. Higgins ◽  
Gloria L. Hwang ◽  
Jarrett Rosenberg ◽  
Regina H. Katzenberg ◽  
Nishita Kothary ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Nonviral Gene Delivery ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Ethiodized Oil

Low Molecular Weight Polyethylenimine GraftedN-Maleated Chitosan for Gene Delivery: Properties and In Vitro Transfection Studies

2008 ◽  
Vol 9 (10) ◽  
pp. 2594-2600 ◽  
Author(s):  
Bo Lu ◽  
Xiao-Ding Xu ◽  
Xian-Zheng Zhang ◽  
Si-Xue Cheng ◽  
Ren-Xi Zhuo
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Low Molecular Weight ◽  
In Vitro Transfection

Molecular weight and architectural dependence of well-defined star-shaped poly(lysine) as a gene delivery vector

2013 ◽  
Vol 1 (12) ◽  
pp. 1223 ◽  
Author(s):  
Mark Byrne ◽  
Danielle Victory ◽  
Alan Hibbitts ◽  
Martin Lanigan ◽  
Andreas Heise ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Gene Delivery Vector ◽  
Delivery Vector
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