scholarly journals Diagnosis and Therapeutic Management of Liver Fibrosis by microRNA

2021 ◽  
Vol 22 (15) ◽  
pp. 8139
Author(s):  
Tomoko Tadokoro ◽  
Asahiro Morishita ◽  
Tsutomu Masaki
Keyword(s):  
Liver Fibrosis ◽  
Viral Infections ◽  
Primary Biliary Cholangitis ◽  
Medical Need ◽  
Key Factor ◽  
Complications Of Cirrhosis ◽  
And Control ◽  
Functional Rnas ◽  
Remarkable Progress ◽  
Made In

Remarkable progress has been made in the treatment and control of hepatitis B and C viral infections. However, fundamental treatments for diseases in which liver fibrosis is a key factor, such as cirrhosis, alcoholic/nonalcoholic steatohepatitis, autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis, are still under development and remain an unmet medical need. To solve this problem, it is essential to elucidate the pathogenesis of liver fibrosis in detail from a molecular and cellular perspective and to develop targeted therapeutic agents based on this information. Recently, microRNAs (miRNAs), functional RNAs of 22 nucleotides, have been shown to be involved in the pathogenesis of liver fibrosis. In addition, extracellular vesicles called “exosomes” have been attracting attention, and research is being conducted to establish noninvasive and extremely sensitive biomarkers using miRNAs in exosomes. In this review, we summarize miRNAs directly involved in liver fibrosis, miRNAs associated with diseases leading to liver fibrosis, and miRNAs related to complications of cirrhosis. We will also discuss the efficacy of each miRNA as a biomarker of liver fibrosis and pathology, and its potential application as a therapeutic agent.

ACCESS TO AND CONTROL OVER LAND AS GENDERED: CONTEXTUALIZING WOMEN’S ACCESS AND OWNERSHIP RIGHTS OF LAND IN RURAL GHANA

2016 ◽  
Vol 45 (2) ◽  
pp. 28-48 ◽  
Author(s):  
Isaac Dery
Keyword(s):  
Thematic Analysis ◽  
Rural Women ◽  
Rural Poor ◽  
Rural Ghana ◽  
Secure Access ◽  
Key Factor ◽  
Access Rights ◽  
Ownership Rights ◽  
And Control ◽  
Relationship Of

Women’s access to and control over productive resources, including land, has increasingly been recognized in global discussions as a key factor in reducing poverty, ensuring food security and promoting gender equality. Indeed, this argument has been widely accepted by both feminists and development theorists since the 1980s. Based on qualitative research with 50 purposively selected men and women, this study explored the complexity of women’s access to and control over land within a specific relationship of contestations, negotiations, and manipulations with men. Data were analyzed using thematic analysis. While theoretically, participants showed that women’s [secure] access to and control over land has beneficial consequences to women themselves, households and the community at large, in principle, women's access and control status was premised in the traditional framework which largely deprives women, equal access and/or control over the land. The study indicates that even though land is the most revered resource and indeed, the dominant source of income for the rural poor, especially women, gender-erected discrimination and exclusion lie at the heart of many rural women in gaining access to land. This study argues that women's weak access rights and control over land continue to perpetuate the feminization of gender inequality–while men were reported to possess primary access and control over land as the heads of households, women were argued to have secondary rights due to their ‘stranger statuses’ in their husbands’ families. Overall, the degree of access to land among women was reported to be situated within two broad contexts–marriage and inheritance.

Role of Rasayana in Prevention of COVID-19 - A Review

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 716-722
Author(s):  
Sneha Dhakite ◽  
Sadhana Misar Wajpeyi
Keyword(s):  
Immune System ◽  
Respiratory System ◽  
Viral Infections ◽  
Cost Effective ◽  
The Body ◽  
Healthy Life ◽  
Vital Functions ◽  
Healthy Life Style ◽  
And Control

The “Coronavirus disease 19 (COVID-19)” is caused by “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)”, a newly discovered member of the Coronaviridae family of viruses which is a highly communicable. There is no effective medical treatment till date for Coronavirus disease hence prevention is the best way to keep disease away. Rasayana proved to be highly efficacious and cost effective for the Prevention and Control of viral infections when vaccines and standard therapies are lacking. Rasayana Chikitsa is one of the eight branches of Ashtanga Ayurveda which helps to maintain healthy life style. Rasayana improves immunity and performs many vital functions of human body. Vyadhikshamatva that is immune mechanism of the body is involved in Prevention of the occurrence of a new disease and it also decreases the virulence and progression of an existing disease. In COVID-19 the Respiratory system mainly get affected which is evident from its symptoms like cold, cough and breathlessness. Here the drugs help in enhancing immune system and strengthening functions of Respiratory system can be useful. For this purpose, the Rasayana like Chyavanprasha, Agastya Haritaki, Pippali Rasayana, Guduchi, Yashtimadhu, Haridra, Ashwagandha, Tulsi are used. Rasayana working on Respiratory system are best for Prevention of Coronavirus and boosting immune system. Rasayana Chikitsa can be effective in the Prevention as well as reducing symptoms of COVID-19.

An Efficient Approach for Modeling and Control of a Quadrotor

2016 ◽  
Vol 4 (2) ◽  
pp. 1-16
Author(s):  
Ahmed S. Khusheef
Keyword(s):  
Pid Control ◽  
Control Method ◽  
Mechanical Design ◽  
Loop Control ◽  
Modeling And Control ◽  
Loop Control System ◽  
And Control ◽  
Close Loop Control ◽  
Close Loop Control System ◽  
Made In

 A quadrotor is a four-rotor aircraft capable of vertical take-off and landing, hovering, forward flight, and having great maneuverability. Its platform can be made in a small size make it convenient for indoor applications as well as for outdoor uses. In model there are four input forces that are essentially the thrust provided by each propeller attached to each motor with a fixed angle. The quadrotor is basically considered an unstable system because of the aerodynamic effects; consequently, a close-loop control system is required to achieve stability and autonomy. Such system must enable the quadrotor to reach the desired attitude as fast as possible without any steady state error. In this paper, an optimal controller is designed based on a Proportional Integral Derivative (PID) control method to obtain stability in flying the quadrotor. The dynamic model of this vehicle will be also explained by using Euler-Newton method. The mechanical design was performed along with the design of the controlling algorithm. Matlab Simulink was used to test and analyze the performance of the proposed control strategy. The experimental results on the quadrotor demonstrated the effectiveness of the methodology used.

Targeting unfolded protein response: a new horizon for disease control

2021 ◽  
Vol 23 ◽  
Author(s):  
Madhu Khanna ◽  
Nishtha Agrawal ◽  
Ramesh Chandra ◽  
Gagan Dhawan
Keyword(s):  
Unfolded Protein Response ◽  
Disease Progression ◽  
Viral Infections ◽  
Cancer Type ◽  
Unfolded Protein ◽  
Diseased State ◽  
Protein Response ◽  
And Control ◽  
Er Homeostasis ◽  
Signalling Cascade

Abstract Unfolded protein response (UPR) is an evolutionarily conserved pathway triggered during perturbation of endoplasmic reticulum (ER) homeostasis in response to the accumulation of unfolded/misfolded proteins under various stress conditions like viral infection, diseased states etc. It is an adaptive signalling cascade with the main purpose of relieving the stress from the ER, which may otherwise lead to the initiation of cell death via apoptosis. ER stress if prolonged, contribute to the aetiology of various diseases like cancer, type II diabetes, neurodegenerative diseases, viral infections etc. Understanding the role of UPR in disease progression will help design pharmacological drugs targeting the sensors of signalling cascade acting as potential therapeutic agents against various diseases. The current review aims at highlighting the relevance of different pathways of UPR in disease progression and control, including the available pharmaceutical interventions responsible for ameliorating diseased state via modulating UPR pathways.

scholarly journals Implantable Thin Film Devices as Brain-Computer Interfaces: Recent Advances in Design and Fabrication Approaches

Coatings ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 204
Author(s):  
Yuhao Zhou ◽  
Bowen Ji ◽  
Minghao Wang ◽  
Kai Zhang ◽  
Shuaiqi Huangfu ◽  
...  
Keyword(s):  
Thin Film ◽  
High Resolution ◽  
Future Research ◽  
Nano Fabrication ◽  
Computer Interfaces ◽  
Continuous Progress ◽  
Open Mesh ◽  
Remarkable Progress ◽  
Thin Film Devices ◽  
Made In

Remarkable progress has been made in the high resolution, biocompatibility, durability and stretchability for the implantable brain-computer interface (BCI) in the last decades. Due to the inevitable damage of brain tissue caused by traditional rigid devices, the thin film devices are developing rapidly and attracting considerable attention, with continuous progress in flexible materials and non-silicon micro/nano fabrication methods. Therefore, it is necessary to systematically summarize the recent development of implantable thin film devices for acquiring brain information. This brief review subdivides the flexible thin film devices into the following four categories: planar, open-mesh, probe, and micro-wire layouts. In addition, an overview of the fabrication approaches is also presented. Traditional lithography and state-of-the-art processing methods are discussed for the key issue of high-resolution. Special substrates and interconnects are also highlighted with varied materials and fabrication routines. In conclusion, a discussion of the remaining obstacles and directions for future research is provided.

Decrease in blood borne viral infections, liver fibrosis and drug use in a Danish prison population

2018 ◽  
Vol 68 ◽  
pp. S320-S321
Author(s):  
J. Soeholm ◽  
D. Holm ◽  
B. Mössner ◽  
J. Hansen ◽  
P.B. Christensen
Keyword(s):  
Liver Fibrosis ◽  
Drug Use ◽  
Viral Infections ◽  
Prison Population

557 - Melatonin and Dark Therapy Reduce Biliary Damage, Liver Fibrosis and Angiogenesis in a Murine Model of Early Stage Primary Biliary Cholangitis (PBC)

2018 ◽  
Vol 154 (6) ◽  
pp. S-1096-S-1097
Author(s):  
Lindsey Kennedy ◽  
Nan Wu ◽  
Heather L. Francis ◽  
Julie Venter ◽  
Fanyin Meng ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Murine Model ◽  
Early Stage ◽  
Primary Biliary Cholangitis

scholarly journals The roles and mechanisms of hypoxia in liver fibrosis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jingyao Cai ◽  
Min Hu ◽  
Zhiyang Chen ◽  
Zeng Ling
Keyword(s):  
Quality Of Life ◽  
Liver Fibrosis ◽  
Theoretical Basis ◽  
Liver Diseases ◽  
Molecular Mechanisms ◽  
Clinical Intervention ◽  
Chronic Liver Injury ◽  
Key Factor

AbstractLiver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or hepatocellular carcinoma (HCC), seriously affecting the quality of life of patients, but the current clinical treatments of liver fibrosis have not been developed yet. Recent studies have shown that hypoxia is a key factor promoting the progression of liver fibrosis. Hypoxia can cause liver fibrosis. Liver fibrosis can, in turn, profoundly further deepen the degree of hypoxia. Therefore, exploring the role of hypoxia in liver fibrosis will help to further understand the process of liver fibrosis, and provide the theoretical basis for its diagnosis and treatment, which is of great significance to avoid further deterioration of liver diseases and protect the life and health of patients. This review highlights the recent advances in cellular and molecular mechanisms of hypoxia in developments of liver fibrosis.

scholarly journals Substrate stiffness regulates primary hepatocyte functions

RSC Advances ◽  
2015 ◽  
Vol 5 (99) ◽  
pp. 80956-80966 ◽  
Author(s):  
Vaishaali Natarajan ◽  
Eric J. Berglund ◽  
Dorothy X. Chen ◽  
Srivatsan Kidambi
Keyword(s):  
Liver Fibrosis ◽  
Alcohol Abuse ◽  
Metabolic Disorders ◽  
Viral Infections ◽  
Substrate Stiffness ◽  
Primary Hepatocyte ◽  
Chronic Injuries

Liver fibrosis occurs as a consequence of chronic injuries from viral infections, metabolic disorders, and alcohol abuse.

Sign in / Sign up

Export Citation Format

Share Document