scholarly journals Epigenetic Regulation of Breast Cancer Stem Cells Contributing to Carcinogenesis and Therapeutic Implications

2021 ◽  
Vol 22 (15) ◽  
pp. 8113
Author(s):  
Hsing-Ju Wu ◽  
Pei-Yi Chu
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Progression ◽  
Epigenetic Regulation ◽  
Therapeutic Resistance ◽  
Small Subset ◽  
Breast Cancer Stem Cells ◽  
Therapeutic Implications ◽  
Selection Of

Globally, breast cancer has remained the most commonly diagnosed cancer and the leading cause of cancer death among women. Breast cancer is a highly heterogeneous and phenotypically diverse group of diseases, which require different selection of treatments. Breast cancer stem cells (BCSCs), a small subset of cancer cells with stem cell-like properties, play essential roles in breast cancer progression, recurrence, metastasis, chemoresistance and treatments. Epigenetics is defined as inheritable changes in gene expression without alteration in DNA sequence. Epigenetic regulation includes DNA methylation and demethylation, as well as histone modifications. Aberrant epigenetic regulation results in carcinogenesis. In this review, the mechanism of epigenetic regulation involved in carcinogenesis, therapeutic resistance and metastasis of BCSCs will be discussed, and finally, the therapies targeting these biomarkers will be presented.

scholarly journals Dual or multiple drug loaded nanoparticles to target breast cancer stem cells

RSC Advances ◽  
2020 ◽  
Vol 10 (32) ◽  
pp. 19089-19105 ◽  
Author(s):  
Yu Gao ◽  
Mingtan Tang ◽  
Euphemia Leung ◽  
Darren Svirskis ◽  
Andrew Shelling ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Resistance ◽  
Multiple Drug ◽  
Breast Cancer Stem Cells ◽  
Disease Relapse

Breast cancer stem(-like) cells (BCSCs) have been found to be responsible for therapeutic resistance and disease relapse.

scholarly journals The Role of Breast Cancer Stem Cells in Metastasis and Therapeutic Implications

2011 ◽  
Vol 179 (1) ◽  
pp. 2-11 ◽  
Author(s):  
Marco A. Velasco-Velázquez ◽  
Vladimir M. Popov ◽  
Michael P. Lisanti ◽  
Richard G. Pestell
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells ◽  
Therapeutic Implications

scholarly journals Epigenetic Regulation of miRNAs and Breast Cancer Stem Cells

2015 ◽  
Vol 1 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Nadire Duru ◽  
Ramkishore Gernapudi ◽  
Gabriel Eades ◽  
Richard Eckert ◽  
Qun Zhou
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Epigenetic Regulation ◽  
Breast Cancer Stem Cells

scholarly journals LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 380
Author(s):  
Nadia Flores-Huerta ◽  
Macrina B. Silva-Cázares ◽  
Lourdes A. Arriaga-Pizano ◽  
Jessica L. Prieto-Chávez ◽  
César López-Camarillo
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Molecular Mechanisms ◽  
Small Subset ◽  
Breast Cancer Stem Cells ◽  
Tumor Initiating Cells ◽  
Aberrant Expression ◽  
Self Renewal ◽  
Non Coding Rnas

Breast cancer is an aggressive disease with a high incidence in women worldwide. Two decades ago, a controversial hypothesis was proposed that cancer arises from a subpopulation of “tumor initiating cells” or “cancer stem cells-like” (CSC). Today, CSC are defined as small subset of somatic cancer cells within a tumor with self-renewal properties driven by the aberrant expression of genes involved in the maintenance of a stemness-like phenotype. The understanding of the underlying cellular and molecular mechanisms involved in the maintenance of CSC subpopulation are fundamental in the development and persistence of breast cancer. Nowadays, the hypothesis suggests that genetic and epigenetic alterations give rise to breast cancer stem cells (bCSC), which are responsible for self-renewal, tumor growth, chemoresistance, poor prognosis and low survival in patients. However, the prominence of bCSC, as well as the molecular mechanisms that regulates and promotes the malignant phenotypes, are still poorly understood. The role of non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) acting as oncogenes or tumor suppressor genes has been recently highlighted by a plethora of studies in breast cancer. These ncRNAs positively or negatively impact on different signaling pathways that govern the cancer hallmarks associated with bCSC, making them attractive targets for therapy. In this review, we present a current summary of the studies on the pivotal roles of lncRNAs and microRNAs in the regulation of genes associated to stemness of bCSC.

Breast cancer stem cells: Biology and therapeutic implications

2019 ◽  
Vol 107 ◽  
pp. 38-52 ◽  
Author(s):  
Ramesh Butti ◽  
Vinoth Prasanna Gunasekaran ◽  
Totakura V.S. Kumar ◽  
Pinaki Banerjee ◽  
Gopal C. Kundu
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells ◽  
Therapeutic Implications

Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications

2021 ◽  
Vol 163 ◽  
pp. 105320
Author(s):  
Xiaobin Zeng ◽  
Chengxiao Liu ◽  
Jie Yao ◽  
Haoqiang Wan ◽  
Guoqing Wan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells ◽  
Therapeutic Implications
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