scholarly journals Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin

2021 ◽  
Vol 22 (14) ◽  
pp. 7342
Author(s):  
Lucio Díaz-Flores ◽  
Ricardo Gutiérrez ◽  
Maria Pino García ◽  
Miriam González-Gómez ◽  
Rosa Rodríguez-Rodriguez ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Close Association ◽  
Dermatofibrosarcoma Protuberans ◽  
Granular Cell ◽  
Skin Tumor ◽  
Seborrheic Keratosis ◽  
Reactive Component ◽  
Bulge Region ◽  
Fibrous Tumor ◽  
Nevus Sebaceous

We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other authors in the normal dermis regarding CD34+SC/TC characteristics and distribution around vessels, nerves and cutaneous annexes, highlighting their practical absence in the papillary dermis and presence in the bulge region of perifollicular groups of very small CD34+ stromal cells. In non-tumoral skin pathology, we studied examples of the principal histologic patterns in which CD34+SCs/TCs have (1) a fundamental pathophysiological role, including (a) fibrosing/sclerosing diseases, such as systemic sclerosis, with loss of CD34+SCs/TCs and presence of stromal cells co-expressing CD34 and αSMA, and (b) metabolic degenerative processes, including basophilic degeneration of collagen, with stromal cells/telocytes in close association with degenerative fibrils, and cutaneous myxoid cysts with spindle-shaped, stellate and bulky vacuolated CD34+ stromal cells, and (2) a secondary reactive role, encompassing dermatitis—e.g., interface (erythema multiforme), acantholytic (pemphigus, Hailey–Hailey disease), lichenoid (lichen planus), subepidermal vesicular (bullous pemphigoid), psoriasiform (psoriasis), granulomatous (granuloma annulare)—vasculitis (leukocytoclastic and lymphocytic vasculitis), folliculitis, perifolliculitis and inflammation of the sweat and sebaceous glands (perifolliculitis and rosacea) and infectious dermatitis (verruca vulgaris). In skin tumor and tumor-like conditions, we studied examples of those in which CD34+ stromal cells are (1) the neoplastic component (dermatofibrosarcoma protuberans, sclerotic fibroma and solitary fibrous tumor), (2) a neoplastic component with varying presentation (fibroepithelial polyp and superficial myxofibrosarcoma) and (3) a reactive component in other tumor/tumor-like cell lines, such as those deriving from vessel periendothelial cells (myopericytoma), epithelial cells (trichoepithelioma, nevus sebaceous of Jadassohn and seborrheic keratosis), Merkel cells (Merkel cell carcinoma), melanocytes (dermal melanocytic nevi) and Schwann cells (neurofibroma and granular cell tumor).

scholarly journals Telocytes in the Normal and Pathological Peripheral Nervous System

2020 ◽  
Vol 21 (12) ◽  
pp. 4320 ◽  
Author(s):  
Lucio Díaz-Flores ◽  
Ricardo Gutiérrez ◽  
Mª Pino García ◽  
Sara Gayoso ◽  
Emma Gutiérrez ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Stromal Cells ◽  
Klinefelter Syndrome ◽  
Light And Electron Microscopy ◽  
Sensory Nerve ◽  
Gastrointestinal Stromal Tumour ◽  
Granular Cell ◽  
Granular Cell Tumour ◽  
Charcot Marie Tooth Disease

We studied telocytes/CD34+ stromal cells in the normal and pathological peripheral nervous system (PNS), for which we reviewed the literature and contributed our observations under light and electron microscopy in this field. We consider the following aspects: (A) general characteristics of telocytes and the terminology used for these cells (e.g., endoneurial stromal cells) in PNS; (B) the presence, characteristics and arrangement of telocytes in the normal PNS, including (i) nerve epi-perineurium and endoneurium (e.g., telopodes extending into the endoneurial space); (ii) sensory nerve endings (e.g., Meissner and Pacinian corpuscles, and neuromuscular spindles); (iii) ganglia; and (iv) the intestinal autonomic nervous system; (C) the telocytes in the pathologic PNS, encompassing (i) hyperplastic neurogenic processes (neurogenic hyperplasia of the appendix and gallbladder), highly demonstrative of telocyte characteristics and relations, (ii) PNS tumours, such as neurofibroma, schwannoma, granular cell tumour and nerve sheath myxoma, and interstitial cell of Cajal-related gastrointestinal stromal tumour (GIST), (iii) tumour-invaded nerves and (iv) traumatic, metabolic, degenerative or genetic neuropathies, in which there are fewer studies on telocytes, e.g., neuroinflammation and nerves in undescended testicles (cryptorchidism), Klinefelter syndrome, crush injury, mucopolysaccharidosis II (Hunter’s syndrome) and Charcot–Marie–Tooth disease.

scholarly journals Giant acquired acral fibrokeratoma: A case report

2019 ◽  
Vol 11 (2) ◽  
Author(s):  
Hend M. Al-Atif
Keyword(s):  
Dorsal Surface ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Skin Tumor ◽  
Central Hospital ◽  
First Line ◽  
Fibrous Tumor ◽  
The Right ◽  
Histopathology Examination ◽  
Saudi Male

Acquired acral fibrokeratoma (AAF) is a rare benign fibrous tumor. Its size is usually small (i.e., <0.5 cm). However, few cases with giant lesions (i.e., >1 cm) have been reported. A 17-year-old Saudi male presented to the Dermatology Outpatient Clinic of Aseer Central Hospital, Aseer Region, Saudi Arabia, with a painless rounded skin-colored exophytic nodule arising from the dorsal surface of the right middle toe, 1.7 cm in diameter. The tumor was surgically excised. Histopathology examination revealed a giant polyploid lesion, composed of massive hyperkeratosis, acanthosis, a core of thick collagen bundles and vertically oriented small dermal blood vessels. The diagnosis was giant AAF. There was no evidence of recurrence after surgical excision. AAF is a rare benign skin tumor which should be differentiated from other similar skin lesions. Surgical excision is the first line for treatment.

PLEXIFORM PATTERN IN DERMATOFIBROSARCOMA PROTUBERANS AND GRANULAR CELL DERMATOFIBROMA.

1998 ◽  
Vol 20 (6) ◽  
pp. 605
Author(s):  
Campos A. Pérez ◽  
Lois C. González ◽  
Pinilla S.M. Rodríguez ◽  
G. Alvarez ◽  
Peralto J. L. Rodriguez
Keyword(s):  
Dermatofibrosarcoma Protuberans ◽  
Granular Cell

scholarly journals Highly restricted expression of a stromal cell determinant in mouse bone marrow in vivo.

1992 ◽  
Vol 176 (4) ◽  
pp. 927-935 ◽  
Author(s):  
K Jacobsen ◽  
K Miyake ◽  
P W Kincade ◽  
D G Osmond
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Stromal Cell ◽  
Plasma Membranes ◽  
Cell Clone ◽  
Close Association ◽  
Lymphoid Cells ◽  
Mouse Bone Marrow ◽  
Hemopoietic Cells

B lymphocyte precursor cells in mouse bone marrow develop in close association with stromal cells which provide essential growth signals. To identify molecules that may normally play a role in this interaction we have examined the in vivo binding of a new monoclonal antibody (mAb) (KMI6) that recognizes a determinant on a bone marrow stromal cell line (BMS2) in vitro. Flow cytometric and radioautographic evaluations revealed that the antigen recognized by KMI6 is represented on the surface of an extremely small number of cells in bone marrow cell suspensions from adult mice. An apparent molecular mass of 110 kD was obtained by surface labeling of a stromal cell clone and immunoprecipitation. Purified mAb KMI6 labeled with 125I was then given intravenously to young C3H/HeJ mice. Unbound mAb was washed out by cardiac perfusion and femoral bone marrow was examined by light and electron microscope radioautography. KMI6 labeling was heavy on the plasma membrane of many stromal cells, especially those located towards the outer subosteal region. The KMI6-labeled stromal cells were usually associated with cells of lymphoid morphology which they often completely surrounded. The labeling was restricted to areas of stromal cell plasma membranes in contact with lymphoid cells. The lymphoid cells themselves, as well as macrophages and other hemopoietic cells, failed to bind mAb KMI6 significantly. Stromal cells in bone marrow depleted of hemopoietic cells by gamma-irradiation (9,5 Gy) bound mAb KMI6 at reduced intensity. The results demonstrate that the KMI6 determinant, a 110-kD protein, is expressed on bone marrow stromal cells in vivo. Its restriction to areas of interaction with lymphoid cells suggests a role in forming microenvironmental niches of B lymphopoiesis. The surface membrane of individual stromal cells may thus be functionally polarized towards interacting B cell precursors and other hemopoietic cells.

scholarly journals Clonal seborrheic keratosis: a rare skin tumor

2019 ◽  
Vol 34 ◽  
Author(s):  
Marwa Bouhamed ◽  
Dhouha Bacha ◽  
Fadoua Abdelmoula ◽  
Sana Ben Slama ◽  
Ahlem Lahmar ◽  
...  
Keyword(s):  
Skin Tumor ◽  
Seborrheic Keratosis

scholarly journals Topical Treatments for Seborrheic Keratosis: A Systematic Review

2020 ◽  
Vol 54 (3) ◽  
Author(s):  
Ma. Celina Cephyr C. Gonzalez ◽  
Veronica Marie E. Ramos ◽  
Cynthia P. Ciriaco-Tan
Keyword(s):  
Hydrogen Peroxide ◽  
Randomized Controlled Trials ◽  
Case Reports ◽  
Skin Tumor ◽  
Controlled Trials ◽  
Seborrheic Keratosis ◽  
Level Of Evidence ◽  
Invasive Approach ◽  
Randomized Controlled ◽  
Ammonium Lactate

Background. Seborrheic keratosis is a benign skin tumor removed through electrodessication, cryotherapy, or surgery. Alternative options may be beneficial to patients with contraindications to standard treatment, or those who prefer a non-invasive approach. Objectives. To determine the effectiveness and safety of topical medications on seborrheic keratosis in the clearance of lesions, compared to placebo or standard therapy. Methods. Studies involving seborrheic keratosis treated with any topical medication, compared to cryotherapy, electrodessication or placebo were obtained from MEDLINE, HERDIN, and Cochrane electronic databases from 1990 to June 2018. Results. The search strategy yielded sixty articles. Nine publications (two randomized controlled trials, two non randomized controlled trials, three cohort studies, two case reports) covering twelve medications (hydrogen peroxide, tacalcitol, calcipotriol, maxacalcitol, ammonium lactate, tazarotene, imiquimod, trichloroacetic acid, urea, nitric-zinc oxide, potassium dobesilate, 5-fluorouracil) were identified. The analysis showed that hydrogen peroxide 40% presented the highest level of evidence and was significantly more effective in the clearance of lesions compared to placebo. Conclusion. Most of the treatments reviewed resulted in good to excellent lesion clearance, with a few well tolerated minor adverse events. Topical therapy is a viable option; however, the level of evidence is low. Standard invasive therapy remains to be the more acceptable modality.

scholarly journals Rare giant dermatofibrosarcoma protuberans with uncommon fibrosarcomatous transformation - case report and review of literature

2021 ◽  
Vol 8 (10) ◽  
pp. 3171
Author(s):  
Manisha Aggarwal ◽  
Dinesh Manchikanti ◽  
Sunayana Misra ◽  
Shaji Thomas ◽  
Ashish Arsia ◽  
...  
Keyword(s):  
Clinical Course ◽  
Dermatofibrosarcoma Protuberans ◽  
Distant Metastases ◽  
Metastatic Potential ◽  
Recurrence Risk ◽  
Skin Tumor ◽  
Rapid Progression ◽  
Split Skin Grafting ◽  
Aggressive Clinical Course ◽  
Slow Growing

Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma with aggressive local behavior but with a low metastatic potential. Although slow growing and indolent, they rarely reach huge sizes. Very uncommonly, these locally invasive tumors undergo fibrosarcomatous transformation with a more aggressive clinical course, with higher rate of recurrence risk and distant metastases. A 32-years-old lady, presented with a gradually progressive lump in the upper central back for the past 6 years, with rapid progression in size during the last 6 months. On examination, she had a single lump of size 18×18 cm in the midline of the upper back, with prominent veins over its surface. Magnetic resonance imaging (MRI) showed no connection with the spinal canal and appeared flush with the paraspinal muscles. Core needle biopsy showed DFSP. The patient underwent a wide local excision with split skin grafting. The histopathology now showed a fibrosarcomatous transformation of DFSP. The patient again underwent a wide re-excision with a 3 cm margin. Histology reported no evidence of tumor cells in the specimen. The patient’s postoperative period was uneventful and she was referred for adjuvant radiotherapy. DFSP is a rare, slow-growing malignant fibroblastic mesenchymal skin tumor with low metastatic potential. However, in any patient with long standing DFSP with a recent increase in size, this fibrosarcomatous transformation must be kept in mind as it represents an uncommon form of DFSP that tends to follow a more aggressive clinical course, with higher rate of recurrence risk and distant metastases.

scholarly journals PROFIL TUMOR JINAK KULIT DI POLIKLINIK KULIT DAN KELAMIN RSUP PROF. DR. R. D KANDOU MANADO PERIODE 2009-2011

e-CliniC ◽  
2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Grace Agustin Gefilem
Keyword(s):  
Medical Records ◽  
Malignant Tumors ◽  
Skin Tumor ◽  
Benign Tumors ◽  
Tumor Type ◽  
Age Group ◽  
Seborrheic Keratosis ◽  
Men And Women ◽  
Verruca Vulgaris ◽  
Dermatology Clinic

Abstract: Introduction: Benign skin tumor manifestation of chaos skin growths that are congenital or akuisita, without the invasive and metastatic tendency, can be derived from vascular and non-vascular. Benign tumors was often said to be dangerouly because it is not develop into malignant tumors, howver skin tumor needs to be understood because causing disability (ruin the appearance) and also at an advanced stage can be fatal in body health.Objective: To know the profile of patients benign skin tumor, age, gender and employment in the Dermatology Clinic Dr Prof Dr. R. D. Kandou Manado for 3 years (January 2009 - December 2011). Subjects and Methods: A retrospective study of benign skin tumor of the medical records of new patients based on tumor type, age, sex, and occupation.Results: There were 478 (15.65%) patients of benign skin tumor among 3055 new patients. Verruca vulgaris (28.03%) and seborrheic keratosis (24.69%) most frequently encountered. Highest age group is 15-44 years is 49.16%. The ratio of men and women for benign skin tumor is 1:1,12. Most jobs are housewives (26.36%). Conclusion: verruca vulgaris is the most benign skin tumor. Benign skin tumor was more common in women. Highest age group is 15-44 years. Most jobs are housewives.Keywords: skin tumors, benignAbstrakPendahuluan: Tumor jinak kulit merupakan manifestasi dari kekacauan pertumbuhan kulit yang bersifat kongenital atau akuisita, tanpa tendensi invasif dan metastasis, dapat berasal dari vaskuler dan non vaskuler. Tumor jinak sering dikatakan tidak berbahaya karena tidak sampai berkembang menjadi keganasan namun demikian, tumor kulit perlu dipahami karena selain menyebabkan kecacatan (merusak penampilan) juga pada stadium lanjut dapat berakibat fatal kesehatan tubuh.Tujuan: Mengetahui profil pasien tumor jinak kulit berdasarkan jenis tumor, umur, jenis kelamin dan pekerjaan di Poliklinik Kulit dan Kelamin RSUP Prof Dr. R. D. Kandou Manado selama 3 tahun (Januari 2009- Desember 2011).Subyek dan Metode: Penelitian retrospektif tumor jinak kulit terhadap catatan medis kasus baru berdasarkan jenis tumor, usia, jenis kelamin, dan pekerjaan.Hasil: Terdapat 478 (15,65 %) pasien tumor jinak kulit di antara 3055 pasien baru. Veruka vulgaris (28,03%) dan keratosis seboroik (24,69%) paling sering dijumpai. Kelompok usia terbanyak adalah 15–44 tahun sejumlah 49,16%. Rasio laki-laki dan perempuan untuk tumor jinak kulit ialah 1:1,12. Pekerjaan terbanyak ialah ibu rumah tangga (26,36%).Kesimpulan: Veruka vulgaris merupakan tumor kulit jinak terbanyak. Tumor kulit jinak lebih sering terjadi pada perempuan. Kelompok usia tertinggi adalah 15–44 tahun. Pekerjaan terbanyak adalah ibu rumah tangga.Kata kunci: tumor kulit, jinak

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