scholarly journals Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration

2021 ◽  
Vol 22 (12) ◽  
pp. 6203
Author(s):  
Elham Pishavar ◽  
Hongrong Luo ◽  
Mahshid Naserifar ◽  
Maryam Hashemi ◽  
Shirin Toosi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Repair ◽  
Recent Progress ◽  
Human Mesenchymal Stem Cells ◽  
Synthetic Polymers ◽  
Hydrogel Scaffolds ◽  
Concise Review ◽  
Free Treatment

Hydrogels are known as water-swollen networks formed from naturally derived or synthetic polymers. They have a high potential for medical applications and play a crucial role in tissue repair and remodeling. MSC-derived exosomes are considered to be new entities for cell-free treatment in different human diseases. Recent progress in cell-free bone tissue engineering via combining exosomes obtained from human mesenchymal stem cells (MSCs) with hydrogel scaffolds has resulted in improvement of the methodologies in bone tissue engineering. Our research has been actively focused on application of biotechnological methods for improving osteogenesis and bone healing. The following text presents a concise review of the methodologies of fabrication and preparation of hydrogels that includes the exosome loading properties of hydrogels for bone regenerative applications.

scholarly journals Stimuli-responsive supramolecules for bone tissue engineering

2020 ◽  
Vol 10 (2) ◽  
pp. 5122-5127
Keyword(s):  
Tissue Engineering ◽  
Ionic Strength ◽  
Regenerative Medicine ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Repair ◽  
3D Bioprinting ◽  
Stimuli Responsive ◽  
Hydrogel Scaffolds ◽  
Physical Stimuli

In the recent scenario Stimuli responsive supramolecules are used for bone tissue engineering. Stimuli responsive Supramolecules are responding towards the desired stimuli. This has a property to change their dynamics and undergo impulsive and continual assembly or disassembly processes under specific conditions. These supramolecules respond towards chemical and physical stimuli which include: pH, temperature, light, ionic strength, magnetic and electric field sensitive. Stimuli responsive supramolecules are used to various preparations such as hydrogels, scaffolds, hydrogel scaffolds, 3D bioprinting, 4D bioprinting, nanogels and microgels used for the bone tissue repair and regenerative medicine. Manuscript deals with various approaches used to prepare stimuli responsive supramolecules for bone engineering applications.

Recent progress in 3D-printed polymeric scaffolds for bone tissue engineering

2020 ◽  
pp. 59-81 ◽  
Author(s):  
Pierre P.D. Kondiah ◽  
Yahya E. Choonara ◽  
Pariksha J. Kondiah ◽  
Thashree Marimuthu ◽  
Lisa C. du Toit ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Recent Progress ◽  
Polymeric Scaffolds ◽  
3D Printed

scholarly journals Concise Review: Cell-Based Strategies in Bone Tissue Engineering and Regenerative Medicine

2013 ◽  
Vol 3 (1) ◽  
pp. 98-107 ◽  
Author(s):  
Jinling Ma ◽  
Sanne K. Both ◽  
Fang Yang ◽  
Fu-Zhai Cui ◽  
Juli Pan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Concise Review

Nanosheets-incorporated bio-composites containing natural and synthetic polymers/ceramics for bone tissue engineering

2020 ◽  
Vol 164 ◽  
pp. 1960-1972
Author(s):  
S. Pranav Adithya ◽  
D. Saleth Sidharthan ◽  
R. Abhinandan ◽  
K. Balagangadharan ◽  
N. Selvamurugan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Synthetic Polymers ◽  
Natural And Synthetic

scholarly journals Biocompatibility and Biological Efficiency of Inorganic Calcium Filled Bacterial Cellulose Based Hydrogel Scaffolds for Bone Bioengineering

2018 ◽  
Vol 19 (12) ◽  
pp. 3980 ◽  
Author(s):  
Probal Basu ◽  
Nabanita Saha ◽  
Radostina Alexandrova ◽  
Boyka Andonova-Lilova ◽  
Milena Georgieva ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bacterial Cellulose ◽  
Bone Tissue ◽  
Human Fibroblasts ◽  
Biological Efficiency ◽  
Hydrogel Scaffold ◽  
Hydrogel Scaffolds ◽  
Depth Analysis

The principal focus of this work is the in-depth analysis of the biological efficiency of inorganic calcium-filled bacterial cellulose (BC) based hydrogel scaffolds for their future use in bone tissue engineering/bioengineering. Inorganic calcium was filled in the form of calcium phosphate (β-tri calcium phosphate (β-TCP) and hydroxyapatite (HA)) and calcium carbonate (CaCO3). The additional calcium, CaCO3 was incorporated following in vitro bio-mineralization. Cell viability study was performed with the extracts of BC based hydrogel scaffolds: BC-PVP, BC-CMC; BC-PVP-β-TCP/HA, BC-CMC-β-TCP/HA and BC-PVP-β-TCP/HA-CaCO3, BC-CMC-β-TCP/HA-CaCO3; respectively. The biocompatibility study was performed with two different cell lines, i.e., human fibroblasts, Lep-3 and mouse bone explant cells. Each hydrogel scaffold has facilitated notable growth and proliferation in presence of these two cell types. Nevertheless, the percentage of DNA strand breaks was higher when cells were treated with BC-CMC based scaffolds i.e., BC-CMC-β-TCP/HA and BC-CMC-β-TCP/HA-CaCO3. On the other hand, the apoptosis of human fibroblasts, Lep-3 was insignificant in BC-PVP-β-TCP/HA. The scanning electron microscopy confirmed the efficient adhesion and growth of Lep-3 cells throughout the surface of BC-PVP and BC-PVP-β-TCP/HA. Hence, among all inorganic calcium filled hydrogel scaffolds, ‘BC-PVP-β-TCP/HA’ was recommended as an efficient tissue engineering scaffold which could facilitate the musculoskeletal (i.e., bone tissue) engineering/bioengineering.

scholarly journals Calciumphosphate scaffolds for bone tissue repair and applications – in vitro characterisation

2012 ◽  
Vol 31 (1) ◽  
Author(s):  
Ilse Wepener ◽  
W. Richter ◽  
Annie Joubert
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Repair

The purpose of this study was to generate electrospun biphasic nanobioceramic scaffolds forin vitro testing, ultimately contributing to bone tissue engineering.

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