scholarly journals In Pursuit of Healthy Aging: Effects of Nutrition on Brain Function

2021 ◽  
Vol 22 (9) ◽  
pp. 5026
Author(s):  
Thayza Martins Melzer ◽  
Luana Meller Manosso ◽  
Suk-yu Yau ◽  
Joana Gil-Mohapel ◽  
Patricia S. Brocardo
Keyword(s):  
Cognitive Decline ◽  
Brain Function ◽  
Healthy Aging ◽  
Aging Effects ◽  
Dietary Interventions ◽  
Age Related ◽  
Therapeutic Value ◽  
Current Article ◽  
Age Related Cognitive Decline

Consuming a balanced, nutritious diet is important for maintaining health, especially as individuals age. Several studies suggest that consuming a diet rich in antioxidants and anti-inflammatory components such as those found in fruits, nuts, vegetables, and fish may reduce age-related cognitive decline and the risk of developing various neurodegenerative diseases. Numerous studies have been published over the last decade focusing on nutrition and how this impacts health. The main objective of the current article is to review the data linking the role of diet and nutrition with aging and age-related cognitive decline. Specifically, we discuss the roles of micronutrients and macronutrients and provide an overview of how the gut microbiota-gut-brain axis and nutrition impact brain function in general and cognitive processes in particular during aging. We propose that dietary interventions designed to optimize the levels of macro and micronutrients and maximize the functioning of the microbiota-gut-brain axis can be of therapeutic value for improving cognitive functioning, particularly during aging.

scholarly journals Food for thought: The role of appetitive peptides in age-related cognitive decline

2013 ◽  
Vol 12 (3) ◽  
pp. 764-776 ◽  
Author(s):  
Jim R. Fadel ◽  
Corinne G. Jolivalt ◽  
Lawrence P. Reagan
Keyword(s):  
Cognitive Decline ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals Molecular aspects of age-related cognitive decline: the role of GABA signaling

2015 ◽  
Vol 21 (7) ◽  
pp. 450-460 ◽  
Author(s):  
Joseph A. McQuail ◽  
Charles J. Frazier ◽  
Jennifer L. Bizon
Keyword(s):  
Cognitive Decline ◽  
Age Related ◽  
Gaba Signaling ◽  
Molecular Aspects ◽  
Age Related Cognitive Decline

The Significance of Age-Related Androgen Depletion in Cognitive Impairment: A Review

2004 ◽  
Vol 5 (2) ◽  
pp. 166-176
Author(s):  
Melanie S. Burkhardt ◽  
Jonathan K. Foster ◽  
Ralph N. Martins
Keyword(s):  
Cognitive Decline ◽  
Hormonal Treatment ◽  
Hormone Treatment ◽  
Epidemiological Studies ◽  
Age Related ◽  
Age Related Cognitive Decline ◽  
Androgen Depletion ◽  
Potential Interactions ◽  
Considerable Support

AbstractThe potential role of supplementing sex steroids for the prevention and delay of age-related cognitive decline has received a great deal of recent interest. Although the biological plausibility of hormone treatment has received considerable support, clinical studies of cognitive functioning after hormonal treatment in postmenopausal women with and without dementia have produced mixed results. Much less attention has been given to the corresponding role of androgens in men. In order to establish the relevance of hormonal supplementation for men in delaying or preventing cognitive decline, it is of importance to evaluate both adrenal and gonadal contributions to androgen status. Additionally, consideration must also be given to the potential interactions of androgens with risk and protective factors (e.g., apolipoprotein E genotype and education). Here we review experimental and epidemiological studies of the significance of androgens for cognitive function.

scholarly journals The role of arterial pulsatility and white matter microstructure in age-related cognitive decline.

2015 ◽  
Vol 9 ◽  
Author(s):  
Jolly Todd ◽  
Michie Patricia ◽  
Bateman Grant ◽  
Fulham William ◽  
Cooper Patrick ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
Age Related ◽  
White Matter Microstructure ◽  
Age Related Cognitive Decline

The role of olive oil in Mediterranean diet: Unsaturated fatty acids protect from age-related cognitive decline

1997 ◽  
Vol 135 ◽  
pp. S3
Author(s):  
A. Capurso ◽  
V. Solfrizzi ◽  
F. Panza ◽  
F. Torres ◽  
F. Mastroianni ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cognitive Decline ◽  
Olive Oil ◽  
Mediterranean Diet ◽  
Unsaturated Fatty Acids ◽  
Age Related ◽  
Age Related Cognitive Decline

Role of green tea catechins in prevention of age‐related cognitive decline: Pharmacological targets and clinical perspective

2018 ◽  
Vol 234 (3) ◽  
pp. 2447-2459 ◽  
Author(s):  
Mohammad Hosein Farzaei ◽  
Roodabeh Bahramsoltani ◽  
Zahra Abbasabadi ◽  
Nady Braidy ◽  
Seyed Mohammad Nabavi
Keyword(s):  
Cognitive Decline ◽  
Green Tea ◽  
Clinical Perspective ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Age Related ◽  
Pharmacological Targets ◽  
Age Related Cognitive Decline

scholarly journals Linked Sources of Neural Noise Contribute to Age-related Cognitive Decline

2020 ◽  
Vol 32 (9) ◽  
pp. 1813-1822 ◽  
Author(s):  
Tam T. Tran ◽  
Camarin E. Rolle ◽  
Adam Gazzaley ◽  
Bradley Voytek
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Healthy Aging ◽  
Structural Changes ◽  
Alpha Phase ◽  
Younger Adults ◽  
Neural Noise ◽  
Baseline Noise ◽  
Age Related ◽  
Age Related Cognitive Decline

Healthy aging is associated with a multitude of structural changes in the brain. These physical age-related changes are accompanied by increased variability in neural activity of all kinds, and this increased variability, collectively referred to as “neural noise,” is argued to contribute to age-related cognitive decline. In this study, we examine the relationship between two particular types of neural noise in aging. We recorded scalp EEG from younger (20–30 years old) and older (60–70 years old) adults performing a spatial visual discrimination task. First, we used the 1/ f-like exponent of the EEG power spectrum, a putative marker of neural noise, to assess baseline shifts toward a noisier state in aging. Next, we examined age-related decreases in the trial-by-trial consistency of visual stimulus processing. Finally, we examined to what extent these two age-related noise markers are related, hypothesizing that greater baseline noise would increase the variability of stimulus-evoked responses. We found that visual cortical baseline noise was higher in older adults, and the consistency of older adults' oscillatory alpha (8–12 Hz) phase responses to visual targets was also lower than that of younger adults. Crucially, older adults with the highest levels of baseline noise also had the least consistent alpha phase responses, whereas younger adults with more consistent phase responses achieved better behavioral performance. These results establish a link between tonic neural noise and stimulus-associated neural variability in aging. Moreover, they suggest that tonic age-related increases in baseline noise might diminish sensory processing and, as a result, subsequent cognitive performance.

scholarly journals Enriching hippocampal memory function in older adults through video games

2019 ◽  
Author(s):  
Gregory D. Clemenson ◽  
Shauna M. Stark ◽  
Samantha M. Rutledge ◽  
Craig E.L. Stark
Keyword(s):  
Older Adults ◽  
Video Games ◽  
Cognitive Decline ◽  
Video Game ◽  
Environmental Enrichment ◽  
Healthy Aging ◽  
Memory Function ◽  
Living Environment ◽  
Age Related ◽  
Age Related Cognitive Decline

AbstractHealthy aging is accompanied by a steady cognitive decline with clear losses in memory. Animal studies have consistently demonstrated that simply modifying an animal’s living environment (known as environmental enrichment) can have a positive influence on age-related cognitive decline in the hippocampus. Previously, we showed that playing immersive 3D video games can improve hippocampal-based memory in young healthy adults, suggesting that the exploration of the large open worlds of modern-day video games may act as proxy for environmental enrichment in humans. Here, we replicated our previous video game study in older adults and showing that playing video games for 4 weeks can improve hippocampal-based memory in a population that is already experiencing age-related decline in this memory. Furthermore, we showed that the improvements last for up to 4 weeks past the intervention, highlighting the potential of video games as intervention for age-related cognitive decline.

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