Role of green tea catechins in prevention of age‐related cognitive decline: Pharmacological targets and clinical perspective

2018 ◽  
Vol 234 (3) ◽  
pp. 2447-2459 ◽  
Author(s):  
Mohammad Hosein Farzaei ◽  
Roodabeh Bahramsoltani ◽  
Zahra Abbasabadi ◽  
Nady Braidy ◽  
Seyed Mohammad Nabavi
Keyword(s):  
Cognitive Decline ◽  
Green Tea ◽  
Clinical Perspective ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Age Related ◽  
Pharmacological Targets ◽  
Age Related Cognitive Decline

scholarly journals Green Tea Catechins Trigger Immediate-Early Genes in the Hippocampus and Prevent Cognitive Decline and Lifespan Shortening

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1484 ◽  
Author(s):  
Keiko Unno ◽  
Monira Pervin ◽  
Kyoko Taguchi ◽  
Tomokazu Konishi ◽  
Yoriyuki Nakamura
Keyword(s):  
Cognitive Decline ◽  
Green Tea ◽  
Brain Function ◽  
Immediate Early Genes ◽  
Immediate Early ◽  
Memory Retention ◽  
Tea Catechins ◽  
Early Genes ◽  
Green Tea Catechins ◽  
Age Related

Senescence-accelerated mouse prone 10 (SAMP10) mice, after ingesting green tea catechins (GT-catechin, 60 mg/kg), were found to have suppressed aging-related decline in brain function. The dose dependence of brain function on GT-catechin indicated that intake of 1 mg/kg or more suppressed cognitive decline and a shortened lifespan. Mice that ingested 1 mg/kg GT-catechin had the longest median survival, but the dose was less effective at suppressing cognitive decline. The optimal dose for improving memory acquisition was 60 mg/kg, and memory retention was higher in mice that ingested 30 mg/kg or more. To elucidate the mechanism by which cognitive decline is suppressed by GT-catechin, changes in gene expression in the hippocampus of SAMP10 mice one month after ingesting GT-catechin were analyzed. The results show that the expression of immediate-early genes such as nuclear receptor subfamily 4 (Nr4a), FBJ osteosarcoma oncogene (Fos), early growth response 1 (Egr1), neuronal PAS domain protein 4 (Npas4), and cysteine-rich protein 61 (Cyr61) was significantly increased. These results suggest that GT-catechin suppresses age-related cognitive decline via increased expression of immediate-early genes that are involved in long-term changes in plasticity of synapses and neuronal circuits.

scholarly journals Active Component in Green Tea Catechins and Effective Intake Period for Prevention of Age-related Brain Dysfunction

2011 ◽  
Vol 8 (6) ◽  
pp. 75-81 ◽  
Author(s):  
Keiko Unno ◽  
Hiroyuki Yamamoto ◽  
Toshiya Ohtaki ◽  
Yuichi Ishikawa ◽  
Shigenori Noda ◽  
...  
Keyword(s):  
Green Tea ◽  
Active Component ◽  
Brain Dysfunction ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Age Related

scholarly journals Food for thought: The role of appetitive peptides in age-related cognitive decline

2013 ◽  
Vol 12 (3) ◽  
pp. 764-776 ◽  
Author(s):  
Jim R. Fadel ◽  
Corinne G. Jolivalt ◽  
Lawrence P. Reagan
Keyword(s):  
Cognitive Decline ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals Molecular aspects of age-related cognitive decline: the role of GABA signaling

2015 ◽  
Vol 21 (7) ◽  
pp. 450-460 ◽  
Author(s):  
Joseph A. McQuail ◽  
Charles J. Frazier ◽  
Jennifer L. Bizon
Keyword(s):  
Cognitive Decline ◽  
Age Related ◽  
Gaba Signaling ◽  
Molecular Aspects ◽  
Age Related Cognitive Decline

The Significance of Age-Related Androgen Depletion in Cognitive Impairment: A Review

2004 ◽  
Vol 5 (2) ◽  
pp. 166-176
Author(s):  
Melanie S. Burkhardt ◽  
Jonathan K. Foster ◽  
Ralph N. Martins
Keyword(s):  
Cognitive Decline ◽  
Hormonal Treatment ◽  
Hormone Treatment ◽  
Epidemiological Studies ◽  
Age Related ◽  
Age Related Cognitive Decline ◽  
Androgen Depletion ◽  
Potential Interactions ◽  
Considerable Support

AbstractThe potential role of supplementing sex steroids for the prevention and delay of age-related cognitive decline has received a great deal of recent interest. Although the biological plausibility of hormone treatment has received considerable support, clinical studies of cognitive functioning after hormonal treatment in postmenopausal women with and without dementia have produced mixed results. Much less attention has been given to the corresponding role of androgens in men. In order to establish the relevance of hormonal supplementation for men in delaying or preventing cognitive decline, it is of importance to evaluate both adrenal and gonadal contributions to androgen status. Additionally, consideration must also be given to the potential interactions of androgens with risk and protective factors (e.g., apolipoprotein E genotype and education). Here we review experimental and epidemiological studies of the significance of androgens for cognitive function.

scholarly journals The role of arterial pulsatility and white matter microstructure in age-related cognitive decline.

2015 ◽  
Vol 9 ◽  
Author(s):  
Jolly Todd ◽  
Michie Patricia ◽  
Bateman Grant ◽  
Fulham William ◽  
Cooper Patrick ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
Age Related ◽  
White Matter Microstructure ◽  
Age Related Cognitive Decline

Potential role of green tea catechins in the management of oxidative stress-associated infertility

2017 ◽  
Vol 34 (5) ◽  
pp. 487-498 ◽  
Author(s):  
Shubhadeep Roychoudhury ◽  
Ashok Agarwal ◽  
Gurpriya Virk ◽  
Chak-Lam Cho
Keyword(s):  
Oxidative Stress ◽  
Green Tea ◽  
Potential Role ◽  
Tea Catechins ◽  
Green Tea Catechins

scholarly journals In Pursuit of Healthy Aging: Effects of Nutrition on Brain Function

2021 ◽  
Vol 22 (9) ◽  
pp. 5026
Author(s):  
Thayza Martins Melzer ◽  
Luana Meller Manosso ◽  
Suk-yu Yau ◽  
Joana Gil-Mohapel ◽  
Patricia S. Brocardo
Keyword(s):  
Cognitive Decline ◽  
Brain Function ◽  
Healthy Aging ◽  
Aging Effects ◽  
Dietary Interventions ◽  
Age Related ◽  
Therapeutic Value ◽  
Current Article ◽  
Age Related Cognitive Decline

Consuming a balanced, nutritious diet is important for maintaining health, especially as individuals age. Several studies suggest that consuming a diet rich in antioxidants and anti-inflammatory components such as those found in fruits, nuts, vegetables, and fish may reduce age-related cognitive decline and the risk of developing various neurodegenerative diseases. Numerous studies have been published over the last decade focusing on nutrition and how this impacts health. The main objective of the current article is to review the data linking the role of diet and nutrition with aging and age-related cognitive decline. Specifically, we discuss the roles of micronutrients and macronutrients and provide an overview of how the gut microbiota-gut-brain axis and nutrition impact brain function in general and cognitive processes in particular during aging. We propose that dietary interventions designed to optimize the levels of macro and micronutrients and maximize the functioning of the microbiota-gut-brain axis can be of therapeutic value for improving cognitive functioning, particularly during aging.

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