scholarly journals Aptamer-Functionalized Hybrid Nanostructures for Sensing, Drug Delivery, Catalysis and Mechanical Applications

2021 ◽  
Vol 22 (4) ◽  
pp. 1803
Author(s):  
Margarita Vázquez-González ◽  
Itamar Willner
Keyword(s):  
Drug Delivery ◽  
Material Science ◽  
Metal Organic Framework ◽  
Sio2 Nanoparticles ◽  
Drug Carriers ◽  
Hybrid Nanostructures ◽  
Stimuli Responsive ◽  
Functionalized Nanomaterials ◽  
Future Challenges ◽  
Metal Organic

Sequence-specific nucleic acids exhibiting selective recognition properties towards low-molecular-weight substrates and macromolecules (aptamers) find growing interest as functional biopolymers for analysis, medical applications such as imaging, drug delivery and even therapeutic agents, nanotechnology, material science and more. The present perspective article introduces a glossary of examples for diverse applications of aptamers mainly originated from our laboratory. These include the introduction of aptamer-functionalized nanomaterials such as graphene oxide, Ag nanoclusters and semiconductor quantum dots as functional hybrid nanomaterials for optical sensing of target analytes. The use of aptamer-functionalized DNA tetrahedra nanostructures for multiplex analysis and aptamer-loaded metal-organic framework nanoparticles acting as sense-and-treat are introduced. Aptamer-functionalized nano and microcarriers are presented as stimuli-responsive hybrid drug carriers for controlled and targeted drug release, including aptamer-functionalized SiO2 nanoparticles, carbon dots, metal-organic frameworks and microcapsules. A further application of aptamers involves the conjugation of aptamers to catalytic units as a means to mimic enzyme functions “nucleoapzymes”. In addition, the formation and dissociation of aptamer-ligand complexes are applied to develop mechanical molecular devices and to switch nanostructures such as origami scaffolds. Finally, the article discusses future challenges in applying aptamers in material science, nanotechnology and catalysis.

Progress of Stimuli-Responsive Nanoscale Metal Organic Frameworks as Controlled Drug Delivery Systems

2020 ◽  
Vol 17 ◽  
Author(s):  
Ailing Feng ◽  
Yanni Wang ◽  
Jinzi Ding ◽  
Rong Xu ◽  
Xiaodong Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Direct Assembly ◽  
Metal Organic ◽  
Organic Framework

Background: Development of controlled drug delivery systems can improve the pharmacokinetic characteristics of drug molecules in the human body, thereby significantly improving the utilization rate of drugs and reducing toxicity and side effects caused by high concentrations of drugs, which can occur when delivery is not controlled. Metal organic frameworks are a new class of very promising crystalline microporous materials, especially when the size is reduced to the nanometer range. Metal organic frameworks exhibit large specific surface areas, tunable compositions, and easy functionalization. In recent years, increasing number of studies have reported the remarkable advances in multifunctional nanoscale metal organic frameworks in drug delivery. Objective: Review the latest research involving advances in stimuli-responsive nanoscale metal organic frameworks as drug delivery systems in controlled-release drugs. Discussion: We first introduce the two main strategies associated with nanoscale metal organic frameworks used in drug loading: direct assembly and post-encapsulation. We next focus on the latest discoveries of nanoscale metal organic framework-based stimulus response systems for drug delivery, including pH, magnetics, light, ion, temperature, and other stimuli, as well as multiple stimulus-responsive drug delivery systems. Finally, we discuss the challenges and future development directions of nanoscale metal organic framework-based controlled drug release.

scholarly journals Metal-Organic Framework-Based Stimuli-Responsive Systems for Drug Delivery

2018 ◽  
Vol 6 (1) ◽  
pp. 1801526 ◽  
Author(s):  
Wen Cai ◽  
Junqing Wang ◽  
Chengchao Chu ◽  
Wei Chen ◽  
Chunsheng Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Stimuli Responsive ◽  
Responsive Systems ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Recent developments on zinc(ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery

MedChemComm ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 2038-2051 ◽  
Author(s):  
Weicong Liu ◽  
Ying Pan ◽  
Weiwei Xiao ◽  
Hongjia Xu ◽  
Dong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Review Article ◽  
The Body ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Stimulus Responsive ◽  
Recent Developments ◽  
Metal Organic ◽  
Organic Framework

In this review article, we discuss the diverse stimuli achieved upon outside activation from single pH-stimulus-responsive or/and multiple pH-stimuli-responsive viewpoints in the body.

Metal–Organic Framework (MOF)-based Nanomaterials for Biomedical Applications

2019 ◽  
Vol 26 (18) ◽  
pp. 3341-3369 ◽  
Author(s):  
Zhidong Luo ◽  
Shuran Fan ◽  
Chuying Gu ◽  
Weicong Liu ◽  
Jinxiang Chen ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
The Body ◽  
Stimuli Responsive ◽  
Future Challenges ◽  
Biomaterial Scaffolds ◽  
Metal Organic

Background: Metal-organic frameworks (MOFs), as a new class of porous organic-inorganic crystalline hybrid materials that governed by the self-assembled of metal atoms and organic struts have attracted tremendous attention because of their special properties. Recently, some more documents have reported different types of nanoscale metal-organic frameworks (NMOFs) as biodegradable and physiological pH-responsive systems for photothermal therapy and radiation therapy in the body. Discussion: n this review paper aims at describing the benefits of using MOF nanoparticles in the field of biomedicine, and putting into perspective their properties in the context of the ones of other NPs. The first section briefly reviews the biomaterial scaffolds of MOFs. The second section presents the main types of stimuli-responsive mechanisms and strategies from two categories: intrinsic (pH, redox state) and extrinsic (temperature, light irradiation and magnetic field) ones. The combinations of photothermal therapy and radiation therapy have been concluded in detail. Finally, clinical applications of MOFs, future challenges and perspectives are also mentioned. Conclusion: This review outlines the most recent advances MOFs design and biomedical applications, from different synthesis to their use as smart drug delivery systems, bioimaging technology or a combination of both.

Stimuli-responsive metal–organic framework nanoparticles for controlled drug delivery and medical applications

2021 ◽  
Vol 50 (7) ◽  
pp. 4541-4563
Author(s):  
Zhixin Zhou ◽  
Margarita Vázquez-González ◽  
Itamar Willner
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Controlled Drug Delivery ◽  
Medical Applications ◽  
Stimuli Responsive ◽  
Metal Organic ◽  
Organic Framework

Different chemical, physical, and biomarker triggers to unlock the metal–organic framework nanoparticles and release the drugs loaded in the particles will be addressed.

Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Medical Science ◽  
Drug Carriers ◽  
Anticancer Drug Delivery ◽  
Ph Values ◽  
Delivery Vector ◽  
Future Challenges ◽  
Smart Drug ◽  
Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

β-Cyclodextrin-based Metal-Organic Framework as a Carrier for Zero-order Drug Delivery

2021 ◽  
pp. 129766
Author(s):  
Yanyi Li ◽  
Haobin Huang ◽  
Chongwei Ding ◽  
Xiaoping Zhou ◽  
Hong Li
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Zero Order ◽  
Metal Organic ◽  
Organic Framework
Sign in / Sign up

Export Citation Format

Share Document