scholarly journals Correction: Haddad, J.G., et al. Doratoxylon apetalum, an Indigenous Medicinal Plant from Mascarene Islands, Is a Potent Inhibitor of Zika and Dengue Virus Infection in Human Cells Int. J. Mol. Sci. 2019, 20, 2382

2020 ◽  
Vol 21 (21) ◽  
pp. 7816
Author(s):  
Juliano G. Haddad ◽  
Andrea Cristine Koishi ◽  
Arnaud Gaudry ◽  
Claudia Nunes Duarte dos Santos ◽  
Wildriss Viranaicken ◽  
...  
Keyword(s):  
Virus Infection ◽  
Medicinal Plant ◽  
Dengue Virus ◽  
Potent Inhibitor ◽  
Human Cells ◽  
Dengue Virus Infection ◽  
Mascarene Islands

The author wishes to make the following correction to this paper [...]

scholarly journals Identification of host cell factors common to both mosquito and human cells in response to Dengue virus infection

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Subrat Narayan Rout ◽  
Kevin Ramkissoon ◽  
David Anderson ◽  
Joseph Perrone ◽  
Rajeev Vaidyanathan ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Host Cell ◽  
Human Cells ◽  
Dengue Virus Infection ◽  
Host Cell Factors

scholarly journals Doratoxylon apetalum, an Indigenous Medicinal Plant from Mascarene Islands, Is a Potent Inhibitor of Zika and Dengue Virus Infection in Human Cells

2019 ◽  
Vol 20 (10) ◽  
pp. 2382 ◽  
Author(s):  
Juliano G. Haddad ◽  
Andrea Cristine Koishi ◽  
Arnaud Gaudry ◽  
Claudia Nunes Duarte dos Santos ◽  
Wildriss Viranaicken ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Medicinal Plant ◽  
Dengue Virus ◽  
Denv Infection ◽  
Antiviral Drugs ◽  
Human Cells ◽  
Host Cells ◽  
Global Public Health ◽  
Denv Serotypes ◽  
Mascarene Islands

Zika virus (ZIKV) and Dengue virus (DENV) are mosquito-borne viruses of the Flavivirus genus that could cause congenital microcephaly and hemorrhage, respectively, in humans, and thus present a risk to global public health. A preventive vaccine against ZIKV remains unavailable, and no specific antiviral drugs against ZIKV and DENV are licensed. Medicinal plants may be a source of natural antiviral drugs which mostly target viral entry. In this study, we evaluate the antiviral activity of Doratoxylum apetalum, an indigenous medicinal plant from the Mascarene Islands, against ZIKV and DENV infection. Our data indicated that D. apetalum exhibited potent antiviral activity against a contemporary epidemic strain of ZIKV and clinical isolates of four DENV serotypes at non-cytotoxic concentrations in human cells. Time-of-drug-addition assays revealed that D. apetalum extract acts on ZIKV entry by preventing the internalisation of virus particles into the host cells. Our data suggest that D. apetalum-mediated ZIKV inhibition relates to virus particle inactivation. We suggest that D. apetalum could be a promising natural source for the development of potential antivirals against medically important flaviviruses.

Modulation of Dengue Virus Infection in Human Cells by Alpha, Beta, and Gamma Interferons

2000 ◽  
Vol 74 (11) ◽  
pp. 4957-4966
Author(s):  
Michael S. Diamond ◽  
T. Guy Roberts ◽  
Dianna Edgil ◽  
Betty Lu ◽  
Joel Ernst ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Human Cells ◽  
Dengue Virus Infection ◽  
Alpha Beta

Mouse Model of Dengue Virus Infection with Serotypes 1 and 2 Clinical Isolates

BIO-PROTOCOL ◽  
2016 ◽  
Vol 6 (23) ◽  
Author(s):  
Satoru Watanabe ◽  
Kitti Wing Chan ◽  
Subhash Vasudevan
Keyword(s):  
Virus Infection ◽  
Mouse Model ◽  
Dengue Virus ◽  
Clinical Isolates ◽  
Dengue Virus Infection
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