Immune Cell Phenotypes that Determine Disease Severity and Long-Term Neutralizing Antibody Titers after Natural Dengue Virus Infection

2020 ◽  
Author(s):  
Angeline Rouers ◽  
Melissa Chng ◽  
Bernett Lee ◽  
Menaka P. Rajapakse ◽  
Kaval Kaur ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Immune Cell ◽  
Neutralizing Antibody ◽  
Dengue Virus Infection ◽  
Antibody Titers ◽  
Cell Phenotypes

scholarly journals Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection

2021 ◽  
Vol 2 (5) ◽  
pp. 100278
Author(s):  
Angeline Rouers ◽  
Melissa Hui Yen Chng ◽  
Bernett Lee ◽  
Menaka P. Rajapakse ◽  
Kaval Kaur ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Immune Cell ◽  
Neutralizing Antibody ◽  
Dengue Virus Infection ◽  
Antibody Titers ◽  
Cell Phenotypes

scholarly journals Human Serum With High Neutralizing Antibody Titers Against Both Zika and Dengue Virus Shows Delayed In Vitro Antibody-Dependent Enhancement of Dengue Virus Infection

2018 ◽  
Vol 5 (7) ◽  
Author(s):  
William G Valiant ◽  
Tahaniyat Lalani ◽  
Heather C Yun ◽  
Anjali Kunz ◽  
Timothy H Burgess ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Zika Virus ◽  
Neutralizing Antibodies ◽  
Dengue Infection ◽  
Neutralizing Antibody ◽  
Naive Subject ◽  
Dengue Virus Infection ◽  
Antibody Titers

Abstract Zika virus infection in a dengue virus–naïve subject was associated with the induction of high levels of cross-reactive binding antibodies. These responses were, however, largely non-neutralizing and displayed a capacity to enhance dengue infection in vitro at significantly low dilution (1:10). In contrast, a subject who had high levels of neutralizing antibodies against both dengue and Zika viruses enhanced infection at a dilution of 1:10 000. These results suggest that high levels of dengue cross-neutralizing antibodies could potentially prevent the enhancement of dengue infection in Zika virus–convalescent individuals.

scholarly journals Detection of Proteinuria by Colorimetric Method and Correlation with Disease Severity in Patients Dengue

2021 ◽  
Vol 27 (3) ◽  
pp. 244
Author(s):  
Acivrida Mega Charisma ◽  
Elis Anita Farida ◽  
Farida Anwari
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Dengue Infection ◽  
Urine Samples ◽  
P Value ◽  
Urine Protein ◽  
Dengue Virus Infection ◽  
Chi Square ◽  
Chi Square Test

Severe dengue virus infection often causes proteinuria through several mechanisms, such as leakage of plasma proteins caused by higher protein filtering in the kidneys. The condition of proteinuria in patients with dengue shock syndrome will affect the management, prognosis, and mortality of patients with dengue virus infection. The objectives of this study were to determine the presence of protein in urine samples in patients in which IgG/IgM dengue was detected, to determine the presence of protein in urine samples in patients without dengue infection, and to determine the relationship between proteinuria in dengue patients and the degree of disease severity. The study was conducted in March-June 2020 at the Clinical Laboratory and Inpatient Clinic of Vita Medika Kepung, Kediri Regency. The method used was the consecutive sampling technique. The minimum sample size was 100 respondents with criteria for suspected dengue infection, onset fever > 4 days, age > 2 years, and no indication of other infectious diseases (blood and urine), divided into two groups, group with positive dengue infection and non-dengue group. The results showed that proteinuria was detected in 26% of respondents, secondary dengue infection and positive serological test of IgG, IgM only IgG were detected in 24 (92.3%) respondents and positive IgG and IgM were found in 2 (7.7%) respondents, this was shown by the p-value = 0.000 in the Chi-Square test with a Prevalence Ratio (PR) value of 11,987. In addition, Chi-Square test results indicated that a higher urine protein/albumin led to more severe disease, with p-value = 0.012 and 0.025 (p <0.05) and PR values of 3.333 and 2.800. The results of this study concluded that there was a close relationship between high levels of protein/albumin in the urine with the degree of disease severity in patients with dengue infection. In addition, an increase in urine protein/albumin levels is always followed by a decrease in serum protein/albumin levels.

scholarly journals Interleukin-6: A promising disease severity index for dengue virus infection

2017 ◽  
Vol 7 (5) ◽  
pp. 266-269 ◽  
Author(s):  
Fariha Kanwal ◽  
◽  
Changrui Lu ◽  
Ishtiaq Qadri ◽  
Muhammad Sohail ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Interleukin 6 ◽  
Severity Index ◽  
Disease Severity Index ◽  
Dengue Virus Infection

scholarly journals Interleukin-33 contributes to disease severity in Dengue virus infection in mice

Immunology ◽  
2018 ◽  
Vol 155 (4) ◽  
pp. 477-490 ◽  
Author(s):  
Rafael E. Marques ◽  
Anne-Gaëlle Besnard ◽  
Isabelle Maillet ◽  
Caio T. Fagundes ◽  
Danielle G. Souza ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Dengue Virus Infection ◽  
Interleukin 33

scholarly journals Dengue virus infection among long-term travelers from the Netherlands: A prospective study, 2008-2011

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192193 ◽  
Author(s):  
Femke W. Overbosch ◽  
Janke Schinkel ◽  
Ineke G. Stolte ◽  
Maria Prins ◽  
Gerard J. B. Sonder
Keyword(s):  
Virus Infection ◽  
The Netherlands ◽  
Dengue Virus ◽  
Prospective Study ◽  
Dengue Virus Infection ◽  
A Prospective Study

Dengue virus infection-enhancing and neutralizing antibody balance in children of the Philippines and Indonesia

2012 ◽  
Vol 14 (13) ◽  
pp. 1152-1159 ◽  
Author(s):  
Atsushi Yamanaka ◽  
Yuko Tabuchi ◽  
Kris C. Mulyatno ◽  
Helen Susilowati ◽  
Eryk Hendrianto ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Neutralizing Antibody ◽  
The Philippines ◽  
Dengue Virus Infection
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