scholarly journals Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases

2020 ◽  
Vol 21 (14) ◽  
pp. 4931
Author(s):  
Thanasekaran Jayakumar ◽  
Periyakali Saravana Bhavan ◽  
Joen-Rong Sheu
Keyword(s):  
Natural Products ◽  
Proteolytic Enzymes ◽  
Biological Activities ◽  
Biological Effects ◽  
The Body ◽  
Matrix Proteins ◽  
Joint Diseases ◽  
Therapeutic Drugs ◽  
Therapeutic Value ◽  
Long Time

Osteoarthritis (OA) is the most common type of arthritis that occurs in an aged population. It affects any joints in the body and degenerates the articular cartilage and the subchondral bone. Despite the pathophysiology of OA being different, cartilage resorption is still a symbol of osteoarthritis. Matrix metalloproteinases (MMPs) are important proteolytic enzymes that degrade extra-cellular matrix proteins (ECM) in the body. MMPs contribute to the turnover of cartilage and its break down; their levels have increased in the joint tissues of OA patients. Application of chondroprotective drugs neutralize the activities of MMPs. Natural products derived from herbs and plants developed as traditional medicine have been paid attention to, due to their potential biological effects. The therapeutic value of natural products in OA has increased in reputation due to their clinical impact and insignificant side effects. Several MMPs inhibitor have been used as therapeutic drugs, for a long time. Recently, different types of compounds were reviewed for their biological activities. In this review, we summarize numerous natural products for the development of MMPs inhibitors in arthritic diseases and describe the major signaling targets that were involved for the treatments of these destructive joint diseases.

scholarly journals Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems—A Novel Research Direction

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 79
Author(s):  
Svetlana N. Morozkina ◽  
Thi Hong Nhung Vu ◽  
Yuliya E. Generalova ◽  
Petr P. Snetkov ◽  
Mayya V. Uspenskaya
Keyword(s):  
Molecular Mechanisms ◽  
Biological Activities ◽  
Research Direction ◽  
Biological Action ◽  
The Body ◽  
Biologically Active ◽  
Polymer Systems ◽  
Anti Cancer ◽  
Long Time ◽  
Cancer Agent

For a long time, the pharmaceutical industry focused on natural biologically active molecules due to their unique properties, availability and significantly less side-effects. Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases thanks to its numerous biological activities. Many research studies have proven that mangiferin possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity. It is especially important that it has no toxicity. However, mangiferin is not being currently applied to clinical use because its oral bioavailability as well as its absorption in the body are too low. To improve the solubility, enhance the biological action and bioavailability, mangiferin integrated polymer systems have been developed. In this paper, we review molecular mechanisms of anti-cancer action as well as a number of designed polymer-mangiferin systems. Taking together, mangiferin is a very promising anti-cancer molecule with excellent properties and the absence of toxicity.

The uniqueness and therapeutic value of natural products from West African medicinal plants, part III: least abundant compound classes

RSC Advances ◽  
2014 ◽  
Vol 4 (75) ◽  
pp. 40095-40110 ◽  
Author(s):  
Conrad V. Simoben ◽  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Biological Activities ◽  
West African ◽  
Therapeutic Value

In this review, a continuation of our in-depth coverage of natural products derived from West African medicinal plants with diverse biological activities has been given.

The uniqueness and therapeutic value of natural products from West African medicinal plants, part II: terpenoids, geographical distribution and drug discovery

RSC Advances ◽  
2014 ◽  
Vol 4 (67) ◽  
pp. 35348-35370 ◽  
Author(s):  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Conrad V. Simoben ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Geographical Distribution ◽  
Biological Activities ◽  
West African ◽  
Therapeutic Value

In this review series, an attempt has been made to give indepth coverage of natural products derived from West African medicinal plants with diverse biological activities.

scholarly journals Evidences of Herbal Medicine-Derived Natural Products Effects in Inflammatory Lung Diseases

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Fernanda Paula R. Santana ◽  
Nathalia M. Pinheiro ◽  
Márcia Isabel B. Mernak ◽  
Renato F. Righetti ◽  
Mílton A. Martins ◽  
...  
Keyword(s):  
Natural Products ◽  
Herbal Medicine ◽  
Biological Activities ◽  
Biological Effects ◽  
Pulmonary Inflammation ◽  
Experimental Models ◽  
Chronic Obstructive ◽  
Anti Inflammatory

Pulmonary inflammation is a hallmark of many respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory syndrome distress (ARDS). Most of these diseases are treated with anti-inflammatory therapy in order to prevent or to reduce the pulmonary inflammation. Herbal medicine-derived natural products have been used in folk medicine and scientific studies to evaluate the value of these compounds have grown in recent years. Many substances derived from plants have the biological effectsin vitroandin vivo, such as flavonoids, alkaloids, and terpenoids. Among the biological activities of natural products derived from plants can be pointed out the anti-inflammatory, antiviral, antiplatelet, antitumor anti-allergic activities, and antioxidant. Although many reports have evaluated the effects of these compounds in experimental models, studies evaluating clinical trials are scarce in the literature. This review aims to emphasize the effects of these different natural products in pulmonary diseases in experimental models and in humans and pointing out some possible mechanisms of action.

scholarly journals Uncovering Novel Peptide Chemistry from Bacterial Natural Products

2021 ◽  
Vol 75 (6) ◽  
pp. 543-547
Author(s):  
Florian Hubrich ◽  
Alessandro Lotti ◽  
Thomas A. Scott ◽  
Jörn Piel
Keyword(s):  
Natural Products ◽  
Bioactive Peptides ◽  
Biological Activities ◽  
Biological Properties ◽  
Post Translational Modifications ◽  
Peptide Chemistry ◽  
Chemical Structures ◽  
Therapeutic Value ◽  
Modified Peptides ◽  
Unique Chemical

Nature has evolved a remarkable array of biosynthetic enzymes that install diverse chemistries into natural products (NPs), bestowing them with a range of important biological properties that are of considerable therapeutic value. This is epitomized by the ribosomally synthesized and post-translationally modified peptides (RiPPs), a class of peptide natural products that undergo extensive post-translational modifications to produce structurally diverse bioactive peptides. In this review, we provide an overview of our research into the proteusin RiPP family, describing characterized members and the maturation enzymes responsible for their unique chemical structures and biological activities. The diverse enzymology identified in the first two proteusin pathways highlights the enormous potential of the RiPP class for new lead structures and novel pharmacophore-installing maturases as biocatalytic tools for drug discovery efforts.

scholarly journals Gold-Catalyzed Synthetic Strategies towards Four-Carbon Ring Systems

Catalysts ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1178
Author(s):  
Guillermo Otárola ◽  
Juan J. Vaquero ◽  
Estíbaliz Merino ◽  
Manuel A. Fernández-Rodríguez
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
High Reactivity ◽  
Synthetic Methods ◽  
Efficient Manner ◽  
Ring Systems ◽  
Carbon Ring ◽  
Wide Range ◽  
Long Time ◽  
Complex Organic

Four carbon ring systems are frequently present in natural products with remarkable biological activities such as terpenoids, alkaloids, and steroids. The development of new strategies for the assembly of these structures in a rapid and efficient manner has attracted the interest of synthetic chemists for a long time. The current research is focused mainly on the development of synthetic methods that can be performed under mild reaction conditions with a high tolerance to functional groups. In recent years, gold complexes have turned into excellent candidates for this aim, owing to their high reactivity, and are thus capable of promoting a wide range of transformations under mild conditions. Their remarkable efficiency has been thoroughly demonstrated in the synthesis of complex organic molecules from simple starting materials. This review summarizes the main synthetic strategies described for gold-catalyzed four-carbon ring formation, as well as their application in the synthesis of natural products.

The uniqueness and therapeutic value of natural products from West African medicinal plants. Part I: uniqueness and chemotaxonomy

RSC Advances ◽  
2014 ◽  
Vol 4 (54) ◽  
pp. 28728-28755 ◽  
Author(s):  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Conrad V. Simoben ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Biological Activities ◽  
West African ◽  
Therapeutic Value

This review gives an in depth coverage of the natural products derived from West African medicinal plants with diverse biological activities.

Imidazole Scaffold based Compounds in the Development of Therapeutic Drugs

2021 ◽  
Vol 21 ◽  
Author(s):  
Fanjie Hu ◽  
Lina Zhang ◽  
Kutty Selva Nandakumar ◽  
Kui Cheng
Keyword(s):  
Natural Products ◽  
Hydrogen Bonds ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Imidazole Ring ◽  
Heterocyclic Ring ◽  
Pharmacological Activities ◽  
Therapeutic Drugs ◽  
Recent Developments ◽  
Aromatic Heterocyclic

: Imidazole has an important five-membered aromatic heterocyclic ring, which is available widely in natural products and synthetic molecules. The special structural characteristics of imidazole ring enable it to bind with various enzymes and receptors through hydrogen bonds, coordination, ion-dipole and cation-π interactions, hydrophobic effects, and Van der Waals forces. These interactions promote several biological activities involving anti-tumor, anti-inflammatory, anti-microbial and anti-viral properties. Herein, we review and discuss the recent developments occurred in using imidazole derivatives along with their special pharmacological activities for various diseases treatment.

Biofunctional properties of milk protein derived bioactive peptides -A review

2015 ◽  
Vol 34 (4) ◽  
Author(s):  
Prasad Patil ◽  
Akanksha Wadehra ◽  
Varsha Garg ◽  
Kanchan Munjal ◽  
Sudhir Kumar Tomar ◽  
...  
Keyword(s):  
Milk Protein ◽  
Bioactive Peptides ◽  
Therapeutic Potential ◽  
Proteolytic Enzymes ◽  
Biological Activities ◽  
Milk Proteins ◽  
Physiological Effect ◽  
Amino Acid Sequences ◽  
The Body ◽  
Biologically Active

Milk has long been acknowledged as a source of macro- and micro nutrients. Presently, several identified biologically active substances from milk and their derivatives has attracted much attention from the scientific community. These bioactive compounds confer many health benefits that might support disease prevention. Worldwide, there is an increasing interest in the therapeutic potential of bioactive peptides which collectively present a cornucopia of bioactivities for utilization in humans. Bioactive peptides are hydrolysates with specific amino acid sequences that exert a positive physiological effect on the body. Most of the biological activities are encrypted within the primary sequence of the native protein and can be released during digestion by proteolytic enzymes in the gastrointestinal tract or during fermentation and food processing. Milk protein is an important source of bioactive peptides which may contribute to regulate the nervous, gastrointestinal, and cardiovascular systems as well as the immune system. Milk protein derived bioactive peptides are shown to have antihypertensive, antimicrobial, immunomodulatory, antioxidative and mineral-binding properties. Bioactive peptides derived from milk proteins are of particular interest to the food industry due to the potential functional and physiological roles that they exhibit.

scholarly journals Molecular hydrogen as a possible therapeutic factor in complex rehabilitation therapy in patients with muscular skeletal disorders (literature review)

2021 ◽  
pp. 92-97
Author(s):  
Vasyl Makolinets ◽  
Tamara Grashenkova ◽  
Volodymyr Moseichuk ◽  
Kyrylo Makolinets ◽  
Vladyslav Moseichuk
Keyword(s):  
Free Radicals ◽  
Molecular Hydrogen ◽  
The Body ◽  
Matrix Proteins ◽  
Cartilage Tissue ◽  
Joint Diseases ◽  
Chain Reactions ◽  
Hydrogen Water ◽  
Normal Metabolism ◽  
The Brain

The paper presents an analysis of foreign scientific and medical data on the therapeutic factor — molecular hydrogen. The effectiveness of its application in the complex therapy of many diseases is revealed. The effect is achieved due to the small size of the mo­lecule, which passes through biological membranes and inhibits dangerous free radicals in the mitochondria, as well as in the nuc­leus, which reduces the possibility of DNA damaging. Molecular hydrogen neutralizes oxidants in the brain due to its ability to cross the blood-brain barrier. It normalizes the functions and metabolic processes in the body and, as an antioxidant, is selective: it does not affect the useful free radicals involved in important metabo­lic processes and selectively eliminates only the most dangerous oxidants — hydroxyl radicals. Interacting with them, hydrogen converts them into water molecules without the formation of by-products and chain reactions. Unlike other known antioxidants, molecular hydrogen does not disrupt normal metabolism, does not cause negative changes in cells, activates the body’s own anti­oxidant systems. The possibility and expediency of the use of molecular hydrogen in the case of pathology of the musculoskeletal system has been confirmed. The peculiarities of its effect on bone and cartilage tissue in the experiment are shown. It has been determined that the use of molecular hydrogen is a new pharmacological strategy aimed at the selective removal of ONOO—, and can be an effective method in the treatment of joint diseases. Because cartilage receives nutrients through a diffusion-loading mechanism, and molecular hydrogen penetrates rapidly into tissues, it can be useful for the prevention of diseases of joints of degenerative origin. It reduces oxidative stress and slows down the reduction of matrix proteins and inhibition of proteinase degradation. Its effectiveness has been proven after injuries to the spinal cord, muscles and tendons, comorbid diseases such as hypertension, coronary heart disease, diabetes and metabolic syndrome. Key words. Molecular hydrogen, hydrogen water, hydrogen inhalations, joint diseases, consequences of musculoskeletal injuries, comorbid pathology.

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