scholarly journals Structure, Function, and Regulation of the SRMS Tyrosine Kinase

2020 ◽  
Vol 21 (12) ◽  
pp. 4233 ◽  
Author(s):  
Chakia J. McClendon ◽  
W. Todd Miller
Keyword(s):  
Tyrosine Kinase ◽  
Cell Signaling ◽  
Structure Function ◽  
Cancer Cell ◽  
Tyrosine Kinases ◽  
Structural Model ◽  
Downstream Signaling ◽  
Current State ◽  
Cancer Cell Signaling ◽  
Nonreceptor Tyrosine Kinases

Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (SRMS) is a tyrosine kinase that was discovered in 1994. It is a member of a family of nonreceptor tyrosine kinases that also includes Brk (PTK6) and Frk. Compared with other tyrosine kinases, there is relatively little information about the structure, function, and regulation of SRMS. In this review, we summarize the current state of knowledge regarding SRMS, including recent results aimed at identifying downstream signaling partners. We also present a structural model for the enzyme and discuss the potential involvement of SRMS in cancer cell signaling.

scholarly journals The ARG Tyrosine Kinase Interacts with Siva-1 in the Apoptotic Response to Oxidative Stress

2001 ◽  
Vol 276 (15) ◽  
pp. 11465-11468 ◽  
Author(s):  
Cheng Cao ◽  
Xinping Ren ◽  
Surender Kharbanda ◽  
Anthony Koleske ◽  
K. V. S. Prasad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tyrosine Kinase ◽  
Cell Signaling ◽  
Tyrosine Kinases ◽  
Functional Significance ◽  
Related Gene ◽  
Apoptotic Response ◽  
Arg Tyrosine Kinase ◽  
Nonreceptor Tyrosine Kinases ◽  
Dependent Mechanism

The Abl family of mammalian nonreceptor tyrosine kinases consists of c-Abl and ARG (Abl-related gene). Certain insights are available regarding the involvement c-Abl in the response of cells to stress. ARG, however, has no known function in cell signaling. The present studies demonstrate that ARG associates with the proapoptotic Siva-1 protein. The functional significance of the ARG-Siva-1 interaction is supported by the finding that ARG is activated by oxidative stress and that this response involves ARG-mediated phosphorylation of Siva-1 on Tyr48. The proapoptotic effects of Siva-1 are accentuated in cells stably expressing ARG and are inhibited in ARG-deficient cells. Moreover, the proapoptotic effects of Siva-1 are abrogated by mutation of the Tyr48site. We also show that the apoptotic response to oxidative stress is attenuated in ARG-deficient cells and that this defect is corrected by reconstituting ARG expression. These findings support a model in which the activation of ARG by oxidative stress induces apoptosis by a Siva-1-dependent mechanism.

Modulation of cancer cell signaling by long noncoding RNAs

2019 ◽  
Vol 120 (8) ◽  
pp. 12224-12246 ◽  
Author(s):  
Seyed Ali Mirhosseini ◽  
Mohammad Sarfi ◽  
Sadra Samavarchi Tehrani ◽  
Mohammad Mirazakhani ◽  
Mahmood Maniati ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Cancer Cell ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cancer Cell Signaling

scholarly journals Effect of atmospheric gas plasmas on cancer cell signaling

2013 ◽  
Vol 134 (7) ◽  
pp. 1517-1528 ◽  
Author(s):  
Musarat Ishaq ◽  
Margaret Meg Evans ◽  
Kostya Ken Ostrikov
Keyword(s):  
Cell Signaling ◽  
Cancer Cell ◽  
Cancer Cell Signaling
Sign in / Sign up

Export Citation Format

Share Document