scholarly journals Phosphoproteomics-Based Characterization of Cancer Cell Signaling Networks

10.5772/52915 ◽  
2013 ◽  
Author(s):  
Hiroko Kozuka-Hata ◽  
Yumi Goto ◽  
Masaaki Oyam
Keyword(s):  
Cell Signaling ◽  
Cancer Cell ◽  
Signaling Networks ◽  
Cell Signaling Networks ◽  
Cancer Cell Signaling

Systems Biology and grid technologies: Challenges for understanding complex cell signaling networks

2007 ◽  
Vol 23 (3) ◽  
pp. 428-434 ◽  
Author(s):  
Irina Strizh ◽  
Alexei Joutchkov ◽  
Nikolay Tverdokhlebov ◽  
Sergey Golitsyn
Keyword(s):  
Systems Biology ◽  
Cell Signaling ◽  
Signaling Networks ◽  
Complex Cell ◽  
Cell Signaling Networks

scholarly journals Exploring the neuropsychiatric spectrum using high-content functional analysis of single-cell signaling networks

2018 ◽  
Vol 25 (10) ◽  
pp. 2355-2372 ◽  
Author(s):  
Santiago G. Lago ◽  
Jakub Tomasik ◽  
Geertje F. van Rees ◽  
Jordan M. Ramsey ◽  
Frieder Haenisch ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Cell Signaling ◽  
Single Cell ◽  
Signaling Networks ◽  
Cell Signaling Networks

scholarly journals Spatial Modeling of Cell Signaling Networks

2012 ◽  
pp. 195-221 ◽  
Author(s):  
Ann E. Cowan ◽  
Ion I. Moraru ◽  
James C. Schaff ◽  
Boris M. Slepchenko ◽  
Leslie M. Loew
Keyword(s):  
Cell Signaling ◽  
Spatial Modeling ◽  
Signaling Networks ◽  
Cell Signaling Networks

PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling

2021 ◽  
Vol 61 (1) ◽  
pp. 723-743
Author(s):  
Timothy R. Baffi ◽  
Ksenya Cohen-Katsenelson ◽  
Alexandra C. Newton
Keyword(s):  
Cell Signaling ◽  
Current Knowledge ◽  
Signaling Networks ◽  
Pleckstrin Homology Domain ◽  
Proliferation And Apoptosis ◽  
Tumor Suppressive Function ◽  
Prosurvival Kinase ◽  
Signaling Field ◽  
Leucine Rich Repeat Protein

Whereas protein kinases have been successfully targeted for a variety of diseases, protein phosphatases remain an underutilized therapeutic target, in part because of incomplete characterization of their effects on signaling networks. The pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) is a relatively new player in the cell signaling field, and new roles in controlling the balance among cell survival, proliferation, and apoptosis are being increasingly identified. Originally characterized for its tumor-suppressive function in deactivating the prosurvival kinase Akt, PHLPP may have an opposing role in promoting survival, as recent evidence suggests. Additionally, identification of the transcription factor STAT1 as a substrate unveils a role for PHLPP as a critical mediator of transcriptional programs in cancer and the inflammatory response. This review summarizes the current knowledge of PHLPP as both a tumor suppressor and an oncogene and highlights emerging functions in regulating gene expression and the immune system. Understanding the context-dependent functions of PHLPP is essential for appropriate therapeutic intervention.

Modulation of cancer cell signaling by long noncoding RNAs

2019 ◽  
Vol 120 (8) ◽  
pp. 12224-12246 ◽  
Author(s):  
Seyed Ali Mirhosseini ◽  
Mohammad Sarfi ◽  
Sadra Samavarchi Tehrani ◽  
Mohammad Mirazakhani ◽  
Mahmood Maniati ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Cancer Cell ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cancer Cell Signaling
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