scholarly journals Protective Effect of Angiotensin 1–7 on Sarcopenia Induced by Chronic Liver Disease in Mice

2020 ◽  
Vol 21 (11) ◽  
pp. 3891 ◽  
Author(s):  
Francisco Aguirre ◽  
Johanna Abrigo ◽  
Francisco Gonzalez ◽  
Andrea Gonzalez ◽  
Felipe Simon ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Fiber Diameter ◽  
Morphological Changes ◽  
Fiber Type ◽  
Renin Angiotensin System ◽  
Ubiquitin Proteasome System ◽  
Protective Role ◽  
Chronic Liver ◽  
Fiber Types

Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular alterations observed in the muscle tissue under CLD is the decline in the muscle strength and function, as well as the increased fatigue. Morphological changes, such as a decrease in the fiber diameter and transition in the fiber type, are also reported. At the molecular level, sarcopenia for CLD is characterized by: (i) a decrease in the sarcomeric protein, such as myosin heavy chain (MHC); (ii) an increase in the ubiquitin–proteasome system markers, such as atrogin-1/MAFbx1 and MuRF-1/TRIM63; (iii) an increase in autophagy markers, such as LC3II/LC3I ratio. Among the regulators of muscle mass is the renin-angiotensin system (RAS). The non-classical axis of RAS includes the Angiotensin 1–7 [Ang-(1-7)] peptide and its receptor Mas, which in skeletal muscle has anti-atrophic effect in models of muscle wasting induced by immobilization, lipopolysaccharide, myostatin or angiotensin II. In this paper, we evaluated the effect of Ang-(1-7) on the sarcopenia by CLD in a murine model induced by the 5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) hepatotoxin administered through diet. Our results show that Ang-(1-7) administration prevented the decline of the function and strength of muscle and increased the fatigue detected in the DDC-fed mice. Besides, we observed that the decreased fiber diameter and MHC levels, as well as the transition of fiber types, were all abolished by Ang-(1-7) in mice fed with DDC. Finally, Ang-(1-7) can decrease the atrogin-1 and MuRF-1 expression as well as the autophagy marker in mice treated with DDC. Together, our data support the protective role of Ang-(1-7) on the sarcopenia by CLD in mice.

scholarly journals Genetic Susceptibility to Chronic Liver Disease in Individuals from Pakistan

2020 ◽  
Vol 21 (10) ◽  
pp. 3558
Author(s):  
Asad Mehmood Raja ◽  
Ester Ciociola ◽  
Imran Nazir Ahmad ◽  
Faisal Saud Dar ◽  
Syed Muhammad Saqlan Naqvi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Genetic Susceptibility ◽  
Chronic Liver Disease ◽  
Disease Risk ◽  
Protective Role ◽  
Chronic Liver ◽  
Control Group ◽  
Chi Square ◽  
Logistic Analysis ◽  
Common Genetic Variants

Chronic liver disease, with viral or non-viral etiology, is endemic in many countries and is a growing burden in Asia. Among the Asian countries, Pakistan has the highest prevalence of chronic liver disease. Despite this, the genetic susceptibility to chronic liver disease in this country has not been investigated. We performed a comprehensive analysis of the most robustly associated common genetic variants influencing chronic liver disease in a cohort of individuals from Pakistan. A total of 587 subjects with chronic liver disease and 68 healthy control individuals were genotyped for the HSD17B13 rs7261356, MBOAT7 rs641738, GCKR rs1260326, PNPLA3 rs738409, TM6SF2 rs58542926 and PPP1R3B rs4841132 variants. The variants distribution between case and control group and their association with chronic liver disease were tested by chi-square and binary logistic analysis, respectively. We report for the first time that HSD17B13 variant results in a 50% reduced risk for chronic liver disease; while MBOAT7; GCKR and PNPLA3 variants increase this risk by more than 35% in Pakistani individuals. Our genetic analysis extends the protective role of the HSD17B13 variant against chronic liver disease and disease risk conferred by the MBOAT7; GCKR and PNPLA3 variants in the Pakistani population.

ACSL4 and its tumor protective role in chronic liver disease

2021 ◽  
Author(s):  
J Piche ◽  
T Otto ◽  
A Mohs ◽  
MM Woitok ◽  
C Trautwein
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Protective Role ◽  
Chronic Liver

Renin–angiotensin system inhibitors and fibrosis in chronic liver disease: a systematic review

2016 ◽  
Vol 10 (5) ◽  
pp. 819-828 ◽  
Author(s):  
Gaeun Kim ◽  
Juyoung Kim ◽  
Yoo Li Lim ◽  
Moon Young Kim ◽  
Soon Koo Baik
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Renin Angiotensin System ◽  
Chronic Liver ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5

2020 ◽  
Vol 21 (21) ◽  
pp. 7922
Author(s):  
Johanna Abrigo ◽  
Fabián Campos ◽  
Francisco Gonzalez ◽  
Francisco Aguirre ◽  
Andrea Gonzalez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Bile Acids ◽  
Fiber Type ◽  
Ring Finger ◽  
Chronic Liver ◽  
Receptor Expression ◽  
Skeletal Muscle Atrophy ◽  
And Oxidative Stress

Sarcopenia is a condition of muscle dysfunction, commonly associated with chronic liver disease (CLD), characterized by a decline in muscle strength, the activation of the ubiquitin-proteasome system (UPS), and oxidative stress. We recently described a murine model of CLD-induced sarcopenia by intake of hepatotoxin 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), which presents an increase in plasma bile acids (BA). BA induced skeletal muscle atrophy through a mechanism dependent on the Takeda G protein-coupled receptor 5 (TGR5) receptor. In the present study, we evaluated the role of TGR5 signaling in the development of sarcopenia using a model of DDC-induced CLD in C57BL6 wild-type (WT) mice and mice deficient in TGR5 expression (TGR5−/− mice). The results indicate that the decline in muscle function and contractibility induced by the DDC diet is dependent on TGR5 expression. TGR5 dependence was also observed for the decrease in fiber diameter and sarcomeric proteins, as well as for the fast-to-slow shift in muscle fiber type. UPS overactivation, indicated by increased atrogin-1/MAFbx (atrogin-1) and muscle RING-finger protein-1 (MuRF-1) protein levels and oxidative stress, was abolished in tibialis anterior muscles from TGR5−/− mice. Our results collectively suggest that all sarcopenia features induced by the DDC-supplemented diet in mice are dependent on TGR5 receptor expression.

Genetic predictors of spontaneous viral elimination or chronic liver disease in hepatitis C infection

2001 ◽  
Vol 120 (5) ◽  
pp. A7-A7
Author(s):  
S ROSS ◽  
S MASCHERETTI ◽  
H HINRICHSEN ◽  
P BUGGISCH ◽  
U FOELSCH ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hepatitis C Infection ◽  
Genetic Predictors
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