scholarly journals Reference Ranges of 8-Isoprostane Concentrations in Exhaled Breath Condensate (EBC): A Systematic Review and Meta-Analysis

2020 ◽  
Vol 21 (11) ◽  
pp. 3822 ◽  
Author(s):  
Yara Shoman ◽  
Pascal Wild ◽  
Maud Hemmendinger ◽  
Melanie Graille ◽  
Jean-Jacques Sauvain ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Analytical Methods ◽  
Reference Range ◽  
Exhaled Breath Condensate ◽  
Meta Analysis ◽  
Individual Characteristics ◽  
Exhaled Breath ◽  
Reference Ranges ◽  
Breath Condensate

Isoprostanes are physiopathologic mediators of oxidative stress, resulting in lipid peroxidation. 8-isoprostane seems particularly useful for measuring oxidative stress damage. However, no reference range values are available for 8-isoprosante in exhaled breath condensate (EBC) of healthy adults, enabling its meaningful interpretation as a biomarker. We conducted this systematic review and meta-analysis according to the protocol following PROSPERO (CRD42020146623). After searching and analyzing the literature, we included 86 studies. After their qualitative synthesis and risk of bias assessment, 52 studies were included in meta-analysis. The latter focused on studies using immunological analytical methods and investigated how the concentrations of 8-isoprostane differ based on gender. We found that gender had no significant effect in 8-isoprostane concentration. Among other studied factors, such as individual characteristics and factors related to EBC collection, only the device used for EBC collection significantly affected measured 8-isoprostane concentrations. However, adjustment for the factors related to EBC collection, yielded uncertainty whether this effect is due to the device itself or to the other factors. Given this uncertainty, we estimated the reference range values of 8-isoprostane stratified by gender and EBC collection device. A better standardization of EBC collection seems necessary; as well more studies using chemical analytical methods to extend this investigation.

scholarly journals Relationships between adult asthma and oxidative stress markers and pH in exhaled breath condensate: a systematic review

Allergy ◽  
2016 ◽  
Vol 71 (6) ◽  
pp. 741-757 ◽  
Author(s):  
F. M. Aldakheel ◽  
P. S. Thomas ◽  
J. E. Bourke ◽  
M. C. Matheson ◽  
S. C. Dharmage ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Oxidative Stress Markers ◽  
Adult Asthma ◽  
Stress Markers ◽  
Breath Condensate ◽  
And Oxidative Stress

Oxidative Stress Markers In The Exhaled Breath Condensate Of Children With OSA

2011 ◽  
Author(s):  
Athanasios Kaditis ◽  
Georgia Malakasioti ◽  
Emmanouel Alexopoulos ◽  
Vasiliki Varlami ◽  
Christina Befani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Breath Condensate

Exhaled breath condensate in pediatric asthma: Promising new advance or pouring cold water on a lot of hot air? A systematic review

2013 ◽  
Vol 48 (5) ◽  
pp. 419-442 ◽  
Author(s):  
P.S. Thomas ◽  
A.J. Lowe ◽  
P. Samarasinghe ◽  
C.J. Lodge ◽  
Y. Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cold Water ◽  
Exhaled Breath Condensate ◽  
Pediatric Asthma ◽  
Exhaled Breath ◽  
Hot Air ◽  
Breath Condensate

Analysis of Oxidative Stress in Exhaled Breath Condensate From Patients With Severe Pulmonary Infections

2006 ◽  
Vol 42 (3) ◽  
pp. 113-119 ◽  
Author(s):  
P.V. Romero ◽  
B. Rodríguez ◽  
S. Martínez ◽  
R. Cañizares ◽  
D. Sepúlveda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Pulmonary Infections ◽  
Breath Condensate

scholarly journals Early Effect Markers and Exposure Determinants of Metalworking Fluids Among Metal Industry Workers: Protocol for a Field Study (Preprint)

2019 ◽  
Author(s):  
Nancy B Hopf ◽  
Eve Bourgkard ◽  
Valérie Demange ◽  
Sébastien Hulo ◽  
Jean-Jacques Sauvain ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Health Outcomes ◽  
Exhaled Breath Condensate ◽  
Metalworking Fluids ◽  
Exhaled Breath ◽  
Genotoxic Effects ◽  
Oxidative Potential ◽  
Exposure Determinants ◽  
Exposure Biomarkers ◽  
Breath Condensate

BACKGROUND Exposure to aerosols from metalworking fluids (MWF) has previously been related to a series of adverse health outcomes (eg, cancer, respiratory diseases). Our present epidemiological study focuses on occupational exposures to MWF and a panel of exposure and effect biomarkers. We hypothesize that these health outcomes are caused by particle exposure that generates oxidative stress, leading to airway inflammation and ultimately to chronic respiratory diseases. We aimed to assess whether MWF exposure, in particular as characterized by its oxidative potential, is associated with biomarkers of oxidative stress and inflammation as well as genotoxic effects. OBJECTIVE The ultimate goal is to develop exposure reduction strategies based on exposure determinants that best predict MWF-related health outcomes. The following relationships will be explored: (1) exposure determinants and measured exposure; (2) occupational exposure and preclinical and clinical effect markers; (3) exposure biomarkers and biomarkers of effect in both exhaled breath condensate and urine; and (4) biomarkers of effect, genotoxic effects and respiratory symptoms. METHODS At least 90 workers from France and Switzerland (30 controls, 30 exposed to straight MWF and 30 to aqueous MWF) were followed over three consecutive days after a nonexposed period of at least two days. The exposure assessment is based on MWF, metal, aldehyde, and ultrafine particle number concentrations, as well as the intrinsic oxidative potential of aerosols. Furthermore, exposure biomarkers such as metals, metabolites of polycyclic aromatic hydrocarbons and nitrosamine are measured in exhaled breath condensate and urine. Oxidative stress biomarkers (malondialdehyde, 8-isoprostane, 8-hydroxy-2’-deoxyguanosine, nitrates, and nitrites) and exhaled nitric oxide, an airway inflammation marker, are repeatedly measured in exhaled breath condensate and urine. Genotoxic effects are assessed using the buccal micronucleus cytome assay. The statistical analyses will include modelling exposure as a function of exposure determinants, modelling the evolution of the biomarkers of exposure and effect as a function of the measured exposure, and modelling respiratory symptoms and genotoxic effects as a function of the assessed long-term exposure. RESULTS Data collection, which occurred from January 2018 until June 2019, included 20 companies. At the date of writing, the study included 100 subjects and 29 nonoccupationally exposed controls. CONCLUSIONS This study is unique as it comprises human biological samples, questionnaires, and MWF exposure measurement. The biomarkers collected in our study are all noninvasive and are useful in monitoring MWF exposed workers. The aim is to develop preventative strategies based on exposure determinants related to health outcomes. INTERNATIONAL REGISTERED REPOR DERR1-10.2196/13744

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