scholarly journals Gender-Related Approach to Kidney Cancer Management: Moving Forward

2020 ◽  
Vol 21 (9) ◽  
pp. 3378 ◽  
Author(s):  
Mariangela Mancini ◽  
Marialaura Righetto ◽  
Giovannella Baggio
Keyword(s):  
Kidney Cancer ◽  
Gender Disparities ◽  
Cancer Management ◽  
Oncological Outcomes ◽  
Expression Of Genes ◽  
Related Approach ◽  
Genetic Mechanisms ◽  
Aggressive Histology ◽  
The Relationship ◽  
Made In

Men are more frequently diagnosed with kidney cancer than women, with a more aggressive histology, larger tumors, a higher grade and stage, and worse oncological outcomes. Smoking habits and sex steroid hormones seem to have a possible role in explaining these gender disparities. Moreover, the expression of genes involved in tumor growth and immune response in kidney cancer varies between men and women, having an impact on the gender-related response to oncological therapy, such as anti-angiogenic drugs and immunotherapy. Recent advances have been made in our understanding of the molecular and genetic mechanisms involved in kidney cancer, which could partially explain the gender differences, and they are summarized in this paper. However, other key mechanisms, which fully clarify the striking clinical gender-related differences observed in kidney cancer, are not completely understood at present. We reviewed and summarized the most relevant publications about the relationship between gender and kidney cancer. Efforts should be made to progress in bench and clinical research on gender-related signatures and disparities, and their impact on the clinical management of kidney cancer.

Characterization of Auditory Disability and Its Relation to the Resilience

2018 ◽  
Vol 5 (2) ◽  
pp. 15
Author(s):  
Bibian Bibeca Bumbila García ◽  
Hernán Andrés Cedeño Cedeño ◽  
Tatiana Moreira Chica ◽  
Yaritza Rossana Parrales Ríos
Keyword(s):  
Social Integration ◽  
Conceptual Analysis ◽  
Disabled People ◽  
Disabled Students ◽  
Hearing Disability ◽  
Technical University ◽  
The Relationship ◽  
Made In

The objective of the work is to establish the characterization of the auditory disability and its relationship with resilience at the Technical University of Manabí. The article shows a conceptual analysis related to the inclusion and social integration of disabled students. Based on the fact that the person with disabilities grows and develops in the same way as that of people without disabilities and what usually happens is that disabled people are rejected and discriminated against based on a prefabricated and erroneous conceptualization of these people. The results associated with the application of the SV-RES test prepared by the researchers are shown (Saavedra & Villalta, 2008b). Characterization of the auditory deficit is made in the students, and the limitations that derive from it are pointed out. We analyze the particularities related to communication with students who have a hearing disability and resilience in this type of student, where some personal highlights that in this sense constitute an example of resilience. Finally, the results related to the study of the relationship between students' hearing disability and the level of resilience dimensions are shown.

scholarly journals Slaves to Rome: The Rhetoric of Mastery in Titus' Speech to the Jews (Bellum Judaicum 6.328-50)

Ramus ◽  
2007 ◽  
Vol 36 (1) ◽  
pp. 25-38 ◽  
Author(s):  
Myles Lavan
Keyword(s):  
Historical Account ◽  
Self Presentation ◽  
Image Position ◽  
Relationship Of ◽  
The Relationship ◽  
Made In

(BJ6.350)Those who discard their weapons and surrender their persons, I will let live. Like a lenient master in a household, I will punish the incorrigible but preserve the rest for myself.So ends Titus' address to the embattled defenders of Jerusalem in the sixth book of Josephus'Jewish War(6.328-50). It is the most substantial instance of communication between Romans and Jews in the work. Titus compares himself to the master of a household and the Jewish rebels to his slaves. Is this how we expect a Roman to describe empire? If not, what does it mean for our understanding of the politics of Josephus' history? The question is particularly acute given that this is not just any Roman but Titus himself: heir apparent and, if we believe Josephus, the man who read and approved this historical account. It is thus surprising that, while the speeches of Jewish advocates of submission to Rome such as Agrippa II (2.345-401) and Josephus himself (5.362-419) have long fascinated readers, Titus' speech has received little or no attention. Remarkably, it is not mentioned in any of three recent collections of essays on Josephus. This paper aims to highlight the rhetorical choices that Josephus has made in constructing this voice for Titus—particularly his self-presentation as master—and the interpretive questions these raise for his readers. It should go without saying that the relationship of this text to anything that Titus may have said during the siege is highly problematic. (Potentially more significant, but unfortunately no less speculative, is the question of how it might relate to any speech recorded in the commentaries of Vespasian and Titus that Josephus appears to have used as a source.) What we have is a Josephan composition that is embedded in the broader narrative of theJewish War.

scholarly journals A revision of daily egg production estimation methods, with application to Atlanto-Iberian sardine. 2. Spatially and environmentally explicit estimates of egg production

2011 ◽  
Vol 68 (3) ◽  
pp. 528-536 ◽  
Author(s):  
Miguel Bernal ◽  
Yorgos Stratoudakis ◽  
Simon Wood ◽  
Leire Ibaibarriaga ◽  
Luis Valdés ◽  
...  
Keyword(s):  
Temporal Variability ◽  
Environmental Variables ◽  
Egg Production ◽  
Stock Assessment ◽  
Production Model ◽  
Estimation Methods ◽  
Statistical Framework ◽  
Spatio Temporal ◽  
The Relationship ◽  
Made In

Abstract Bernal, M., Stratoudakis, Y., Wood, S., Ibaibarriaga, L., Uriarte, A., Valdés, L., and Borchers, D. 2011. A revision of daily egg production estimation methods, with application to Atlanto-Iberian sardine. 2. Spatially and environmentally explicit estimates of egg production. – ICES Journal of Marine Science, 68: . A spatially and environmentally explicit egg production model is developed to accommodate a number of assumptions about the relationship between egg production and mortality and associated environmental variables. The general model was tested under different assumptions for Atlanto-Iberian sardine. It provides a flexible estimator of egg production, in which a range of assumptions and hypotheses can be tested in a structured manner within a well-defined statistical framework. Application of the model to Atlanto-Iberian sardine increased the precision of the egg production time-series, and allowed improvements to be made in understanding the spatio-temporal variability in egg production, as well as implications for ecology and stock assessment.

Determination of Underwater Plate Dynamics Using Laser Beams

1974 ◽  
Vol 96 (3) ◽  
pp. 722-728
Author(s):  
Rudolph E. Croteau ◽  
Herman E. Sheets
Keyword(s):  
Near Field ◽  
Surface Displacement ◽  
Coupled System ◽  
Green Laser ◽  
Testing Facility ◽  
Acoustic Testing ◽  
Propeller Blades ◽  
The Relationship ◽  
Made In

Underwater plate vibration and its associated noise are of interest for the analysis of ship structures, propeller blades, and other areas of underwater acoustics. In order to analyze the relationship between a plate vibrating underwater and the acoustic pressure in the near-field, optical interferometric holography, using a blue-green laser beam, was used to determine surface displacement for the vibrating plate, which was excited through a fluid-coupled system. Acoustic measurements of the same source were made in a water tower concurrently with the holography and later at a precision acoustic testing facility. This method permits prediction of underwater plate modal frequencies and shapes with high accuracy.

Unions and the Popular Front: The West Coast Waterfront in the 1930s

1986 ◽  
Vol 30 ◽  
pp. 59-78 ◽  
Author(s):  
Bruce Nelson
Keyword(s):  
New York ◽  
Communist Party ◽  
Good Deal ◽  
The United States ◽  
Popular Front ◽  
Human Face ◽  
History Of ◽  
Patterns Of Behavior ◽  
The Relationship ◽  
Made In

Recent discussions of the history of American communism have generated a good deal of controversy. A youthful generation of “new social historians” has combined with veterans of the Communist party to produce a portrait of the Communist experience in the United States which posits a tension between the Byzantine pursuit of the “correct line” at the top and the impulses and needs of members at the base trying to cope with a complex reality. In the words of one of its most skillful practitioners, “the new Communist history begins with the assumption that … everyone brought to the movement expectations, traditions, patterns of behavior and thought that had little to do with the decisions made in the Kremlin or on the 9th floor of the Communist Party headquarters in New York.” The “new” historians have focused mainly on the lives of individuals, the relationship between communism and ethnic and racial subcultures, and the effort to build the party's influence within particular unions and working-class constituencies. Overall, the portrait has been critical but sympathetic and has served to highlight the party's “human face” and the integrity of its members.

scholarly journals The Relationship between the Occupational Exposure of Trichloroethylene and Kidney Cancer

2014 ◽  
Vol 26 (1) ◽  
Author(s):  
Inah Kim ◽  
Jaehyeok Ha ◽  
June-Hee Lee ◽  
Kye-mook Yoo ◽  
Jaehoon Rho
Keyword(s):  
Occupational Exposure ◽  
Kidney Cancer ◽  
The Relationship

Comparison of UK and European Association of Urology (EAU) guidelines for kidney cancer management

2017 ◽  
Vol 11 (2) ◽  
pp. 132-138
Author(s):  
David Nicol
Keyword(s):  
Kidney Cancer ◽  
European Association ◽  
Treatment Modalities ◽  
Current Evidence ◽  
Specific Strength ◽  
Cancer Management ◽  
Funding Model ◽  
Cancer Networks ◽  
The Uk ◽  
European Association Of Urology

Clinical practice frequently utilises guidelines on how specific conditions should be managed. For urologists in the UK a range of sources are used as guidelines for the management of kidney cancer. These include documents from national bodies such as the National Institute for Health and Care Excellence (NICE), professional bodies as well as those prepared by individual groups of clinicians within regional cancer networks. In this article the European Association of Urology (EAU) guidelines on renal cell carcinoma are compared to guidelines used in the UK for this disease. Broadly consistent variations exist related to regional practice patterns, funding and the currency of the various guidelines. A specific strength of the EAU guidelines is the regular updating of these allowing incorporation of new evidence. These however do not consider the funding model for healthcare of the UK which dictates the availability of some treatment modalities and thus in some areas are not applicable. Current guidelines for kidney cancer developed within the UK are inconsistent and often outdated in terms of evidence sources. Broader use of the EAU guidelines within the economic restrictions of healthcare in the UK may result in a more consistent practise utilising current evidence sources in the management of kidney cancer.

Relations between the Russian Empire and the Orthodox Church of the East as Exemplified in the Collection of Greek Engravings of The Church Archaeological Museum at the Moscow Theological Academy

2020 ◽  
pp. 61-77
Author(s):  
Анна Леонидовна Краснова
Keyword(s):  
Russian Empire ◽  
Orthodox Church ◽  
Church Of The East ◽  
Holy Places ◽  
The Subject ◽  
The Russian Empire ◽  
The 19Th Century ◽  
The Relationship ◽  
The Church ◽  
Made In

В XVIII в. на основании общего интереса к святыням Востока, а также единой тенденции для крупных монастырей изготавливать гравюры на память для паломников, многие греческие гравюры свидетели русско-афонских отношений попадают на территорию Российской Империи. Сохранились такие гравюры и в Церковноархеологического кабинете Московской духовной академии, собрание которых насчитывает 29 эстампов. Пять гравюр из этого собрания имеют надписи на греческом и на славянском языке. Надписи свидетельствуют о месте и времени создания гравюры, о граверах и заказчиках, являются источниками кратких исторических сведений. В статье приведены выявленные дополнительные факты об этих гравюрах, которые свидетельствуют о наличии церковных, экономических и политических отношений на базе культурных связей между Российской Империей и странами православного Востока. The Russ has always been supporting the relationship with the Orthodox Church of the East. As a result of these connections, we have a lot of icons and other gifts from The Mount Athos, The Saint Catherine’s Monastery and others holy places. There are five Greek engravings in the collection of The Museum of Church Archaeology at the Moscow Theological Academy, which have inscriptions in Greek and Slavic. These engravings were to be spread in Slavic countries. They are dated from the 17th to the 19th century. Some of them were made in Moscow. The images and the inscriptions of the engravings are the subject of a research presented in this article.

The Maxslope Taxometric Procedure: Mathematical Derivation, Parameter Estimation, Consistency Tests

2004 ◽  
Vol 95 (2) ◽  
pp. 517-550 ◽  
Author(s):  
William M. Grove
Keyword(s):  
Parameter Estimation ◽  
Nonlinear Regression ◽  
Classification Accuracy ◽  
Sufficient Conditions ◽  
Sufficient Condition ◽  
Indicator Variable ◽  
Regression Slope ◽  
The Relationship ◽  
Mathematical Derivation ◽  
Made In

This article first explains concepts in taxometrics, including the meaning of “taxon” in relation to taxometric procedures. It then mathematically develops the MAXSLOPE procedure of Grove and Meehl which relies on nonlinear regression of one taxometric indicator variable on another. Sufficient conditions for MAXSLOPE's validity are set forth. The relationship between the point of maximum regression slope (MAXSLOPE point) and the HITMAX cut, i.e., the point on a variable which, if used as a diagnostic cut-off score, yields maximum classification accuracy, is analyzed. A sufficient condition is given for the MAXSLOPE point to equal the HITMAX cut; however, most distributions have different MAXSLOPE and HITMAX points. Equations and an algorithm are spelled out for making a graphical test for the existence of a taxon, estimating taxometric parameters, and conducting consistency tests; the latter serve as stringent checks on the validity of a taxonic conjecture. The plausibility of assumptions made, in deriving MAXSLOPE equations, is discussed, and the qualitative effects of violations of these assumptions are explained.

Zebrafish embryos exposed to deltamethrin exhibit abnormalities despite induced expression of related genes (you, you-too, momo and u-boot)

2018 ◽  
Vol 35 (1) ◽  
pp. 11-19
Author(s):  
Kuder Reshma Shabnam ◽  
Dharmapuri Gangappa ◽  
Gundala Harold Philip
Keyword(s):  
Vital Role ◽  
Primary Objective ◽  
Chain Reaction ◽  
Environmental Persistence ◽  
Expression Of Genes ◽  
Pericardial Edema ◽  
Eye Pigmentation ◽  
Polymerase Chain ◽  
Relationship Of ◽  
The Relationship

Evaluation of the toxic effects of a widely used synthetic pyrethroid, deltamethrin (DM), was carried out in this study. This pesticide is preferred for pest control because of its low environmental persistence and toxicity. We investigated the expression pattern of four genes, namely, you ( you), yot ( you-too), momo ( mom) and ubo ( u-boot) during early development of zebrafish, that is, from 12 hpf to 48 hpf stages. These stages are selected as most of the important developmental aspects take place during this period. All four genes are known to play a vital role in development of notochord and somites. To understand the effect of DM on development, embryos of 4 hpf stage were exposed to two concentrations (100 and 200 µg/L) of DM, and observations were made at 12, 24 and 48 hpf stages. Our earlier studies have shown phenotypic abnormalities such as notochord bending, tail deformation, yolk sac and pericardial edema, lightening of body and eye pigmentation and interfered in somite patterning, during these stages of development. Understanding the relationship of phenotypic abnormalities with these four genes has been our primary objective. These four genes were analyzed by Reverse transcription (RT)-polymerase chain reaction and intensity of the bands has shown induction in their expression after exposure to the toxicant. In spite of the expression of genes, it was noticed that DM caused abnormalities. It can be said from the results that translational pathway could have been affected.

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