scholarly journals Effects of Iron Oxide Nanoparticles (γ-Fe2O3) on Liver, Lung and Brain Proteomes following Sub-Acute Intranasal Exposure: A New Toxicological Assessment in Rat Model Using iTRAQ-Based Quantitative Proteomics

2019 ◽  
Vol 20 (20) ◽  
pp. 5186 ◽  
Author(s):  
Askri ◽  
Cunin ◽  
Ouni ◽  
Béal ◽  
Rachidi ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Quantitative Proteomics ◽  
Oxide Nanoparticles ◽  
Toxicological Assessment ◽  
Toxicological Effects ◽  
Proteomic Approach ◽  
Cytoskeleton Remodeling ◽  
The Brain ◽  
Intranasal Instillation

Iron Oxide Nanoparticles (IONPs) present unique properties making them one of the most used NPs in the biomedical field. Nevertheless, for many years, growing production and use of IONPs are associated with risks that can affect human and the environment. Thus, it is essential to study the effects of these nanoparticles to better understand their mechanism of action and the molecular perturbations induced in the organism. In the present study, we investigated the toxicological effects of IONPs (γ-Fe2O3) on liver, lung and brain proteomes in Wistar rats. Exposed rats received IONP solution during 7 consecutive days by intranasal instillation at a dose of 10 mg/kg body weight. An iTRAQ-based quantitative proteomics was used to study proteomic variations at the level of the three organs. Using this proteomic approach, we identified 1565; 1135 and 1161 proteins respectively in the brain, liver and lung. Amon them, we quantified 1541; 1125 and 1128 proteins respectively in the brain, liver and lung. Several proteins were dysregulated comparing treated samples to controls, particularly, proteins involved in cytoskeleton remodeling, cellular metabolism, immune system stimulation, inflammation process, response to oxidative stress, angiogenesis, and neurodegenerative diseases.

scholarly journals Superparamagnetic Iron Oxide Nanoparticles—Current and Prospective Medical Applications

Materials ◽  
2019 ◽  
Vol 12 (4) ◽  
pp. 617 ◽  
Author(s):  
Joanna Dulińska-Litewka ◽  
Agnieszka Łazarczyk ◽  
Przemysław Hałubiec ◽  
Oskar Szafrański ◽  
Karolina Karnas ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Pancreatic Tumors ◽  
Oxide Nanoparticles ◽  
Medical Sciences ◽  
Fast Development ◽  
Magnetic Resonance Imaging Mri ◽  
The Brain

The recent, fast development of nanotechnology is reflected in the medical sciences. Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are an excellent example. Thanks to their superparamagnetic properties, SPIONs have found application in Magnetic Resonance Imaging (MRI) and magnetic hyperthermia. Unlike bulk iron, SPIONs do not have remnant magnetization in the absence of the external magnetic field; therefore, a precise remote control over their action is possible. This makes them also useful as a component of the advanced drug delivery systems. Due to their easy synthesis, biocompatibility, multifunctionality, and possibility of further surface modification with various chemical agents, SPIONs could support many fields of medicine. SPIONs have also some disadvantages, such as their high uptake by macrophages. Nevertheless, based on the ongoing studies, they seem to be very promising in oncological therapy (especially in the brain, breast, prostate, and pancreatic tumors). The main goal of our paper is, therefore, to present the basic properties of SPIONs, to discuss their current role in medicine, and to review their applications in order to inspire future developments of new, improved SPION systems.

Effects of biological buffer solutions on the peroxidase-like catalytic activity of Fe3O4 nanoparticles

Nanoscale ◽  
2019 ◽  
Vol 11 (39) ◽  
pp. 18393-18406 ◽  
Author(s):  
Mariana Raineri ◽  
Elin L. Winkler ◽  
Teobaldo E. Torres ◽  
Marcelo Vasquez Mansilla ◽  
Marcela S. Nadal ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Fe3o4 Nanoparticles ◽  
Oxide Nanoparticles ◽  
Toxicological Effects ◽  
Buffer Solutions

Biological buffering solutions need to be carefully considered when evaluating iron oxide nanoparticles (IONP) catalytic activity and their potential toxicological effects, because buffer species can interact with the surface of the particles.

scholarly journals Toxicological assessment of silica-coated iron oxide nanoparticles in human astrocytes

2018 ◽  
Vol 118 ◽  
pp. 13-23 ◽  
Author(s):  
Natalia Fernández-Bertólez ◽  
Carla Costa ◽  
Fátima Brandão ◽  
Gözde Kiliç ◽  
José Alberto Duarte ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Toxicological Assessment ◽  
Human Astrocytes

scholarly journals Silver, Gold, and Iron Oxide Nanoparticles Alter miRNA Expression but Do Not Affect DNA Methylation in HepG2 Cells

Materials ◽  
2019 ◽  
Vol 12 (7) ◽  
pp. 1038 ◽  
Author(s):  
Kamil Brzóska ◽  
Iwona Grądzka ◽  
Marcin Kruszewski
Keyword(s):  
Dna Methylation ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Mirna Expression ◽  
Hepg2 Cells ◽  
Methylation Status ◽  
Superparamagnetic Iron Oxide ◽  
Cellular Level ◽  
Oxide Nanoparticles ◽  
Toxicological Assessment

The increasing use of nanoparticles (NPs) in various applications entails the need for reliable assessment of their potential toxicity for humans. Originally, studies concerning the toxicity of NPs focused on cytotoxic and genotoxic effects, but more recently, attention has been paid to epigenetic changes induced by nanoparticles. In the present research, we analysed the DNA methylation status of genes related to inflammation and apoptosis as well as the expression of miRNAs related to these processes in response to silver (AgNPs), gold (AuNPs), and superparamagnetic iron oxide nanoparticles (SPIONs) at low cytotoxic doses in HepG2 cells. There were no significant differences between treated and control cells in the DNA methylation status. We identified nine miRNAs, the expression of which was significantly altered by treatment with nanoparticles. The highest number of changes was induced by AgNPs (six miRNAs), followed by AuNPs (four miRNAs) and SPIONs (two miRNAs). Among others, AgNPs suppressed miR-34a expression, which is of particular interest since it may be responsible for the previously observed AgNPs-mediated HepG2 cells sensitisation to tumour necrosis factor (TNF). Most of the miRNAs affected by NP treatment in the present study have been previously shown to inhibit cell proliferation and tumourigenesis. However, based on the observed changes in miRNA expression we cannot draw definite conclusions regarding the pro- or anti-tumour nature of the NPs under study. Further research is needed to fully elucidate the relation between observed changes in miRNA expression and the effect of NPs observed at the cellular level. The results of the present study support the idea of including epigenetic testing during the toxicological assessment of the biological interaction of nanomaterials.

scholarly journals Thrombo-tag, an in vivo formed nanotracer for the detection of thrombi in mice by fast pre-targeted molecular imaging

Nanoscale ◽  
2020 ◽  
Vol 12 (45) ◽  
pp. 22978-22987
Author(s):  
José M. Adrover ◽  
Juan Pellico ◽  
Irene Fernández-Barahona ◽  
Sandra Martín-Salamanca ◽  
Jesús Ruiz-Cabello ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Molecular Imaging ◽  
Iron Oxide Nanoparticles ◽  
Rapid Detection ◽  
Oxide Nanoparticles ◽  
The Brain ◽  
Targeted Molecular Imaging

68Ga-core doped iron oxide nanoparticles permit the rapid detection of thrombi in the brain by fast pretargeting imaging.

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