scholarly journals Towards A New Approach for the Description of Cyclo–2,4-Dihydroxybenzoate, A Substance Which Effectively Mimics Zearalenone in Imprinted Polymers Designed for Analyzing Selected Mycotoxins in Urine

2019 ◽  
Vol 20 (7) ◽  
pp. 1588
Author(s):  
Renata Gadzała-Kopciuch ◽  
Katarzyna Kwaśniewska ◽  
Agnieszka Ludwiczak ◽  
Piotr Skrzyniarz ◽  
Rafał Jakubowski ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Physicochemical Characteristics ◽  
Crystallographic Analysis ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Relative Standard ◽  
First Time

A method of purifying cyclododecyl 2,4-dihydroxybenzoate as a potential replacement template molecule for preparation of molecularly-imprinted polymers for isolation of zearalenone in urine was developed. Full physicochemical characteristics of cyclododecyl 2,4-dihydroxybenzoate for the first time included crystallographic analysis and molecular modelling, which made possible the determination of the similarity between the cyclododecyl 2,4-dihydroxybenzoate and zearalenone molecules. The obtained molecularly-imprinted polymers show very high in vitro selectivity towards zearalenone due to specific interactions (e.g., hydrogen bonding, molecular recognition interaction). The achieved extraction recovery exceeds 94% at the tested concentration levels (20–500 ng·mL−1) with a relative standard deviation below 2%. Immunosorbents were found to have lower recoveries (below 92.5%) and RSD value between 2 and 4% for higher concentrations of the studied substance (400 ng·mL−1).

scholarly journals Synthesis and characterization of genistein magnetic molecularly imprinted polymers and their application in soy sauce products

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ziqi Xie ◽  
Yunjing Luo ◽  
Zhen Na ◽  
Wei Zhang ◽  
Yufei Zong
Keyword(s):  
Electron Microscopy ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Soy Sauce ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Magnetic Molecularly Imprinted Polymers ◽  
Relative Standard ◽  
Surface Molecular Imprinting Technique

AbstractIn this study, a novel method based on genistein magnetic molecularly imprinted polymers (Gen-MMIPs) was developed utilizing a surface molecular imprinting technique, in which genistein was used as the template molecule and Fe3O4 was used as the carrier. The synthesis of Gen-MMIPs was characterized by using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), which indicated that the diameter of the Gen-MMIPs was approximately 500 nm. Via analysis with a vibrating sample magnetometer (VSM), the saturation magnetization of Gen-MMIPs was determined to be 24.79 emu g−1. Fourier transform infrared (FT-IR) spectroscopy showed that polymer groups were on the surface of the magnetic carrier. Adsorption experiments suggested that the genistein adsorption capability of Gen-MMIPs was 5.81 mg g−1, and adsorption equilibrium was achieved within 20 min. Gen-MMIPs as dispersive solid-phase extraction (dSPE) adsorbents combined with HPLC were used to selectively separate genistein in soy sauce samples, and the recoveries ranged from 85.7 to 88.5% with relative standard deviations (RSDs) less than 5%, which proved that this method can be used for the detection of genistein residues in real samples.

scholarly journals Synthesis and Characterization of Genistein Magnetic Molecularly Imprinted Polymers and Its Application in Soy Sauce Products

2021 ◽  
Author(s):  
Ziqi Xie ◽  
Yunjing Luo ◽  
Zhen Na ◽  
Wei Zhang ◽  
Yunfei Zong
Keyword(s):  
Electron Microscopy ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Soy Sauce ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Magnetic Molecularly Imprinted Polymers ◽  
Relative Standard ◽  
Surface Molecular Imprinting Technique

Abstract In this study, a novel method based on genistein magnetic molecularly imprinted polymers (Gen-MMIPs) was developed by surface molecular imprinting technique, in which genistein was used as the template molecule and Fe3O4 was used as the carrier. The synthesis of Gen-MMIPs were characterized by using of scanning electron microscopy (SEM) and transmission electron microscopy (TEM), which indicated the diameters of Gen-MMIPs were about 500 nm. Through the technique of vibrating sample magnetometer (VSM), the saturation magnetization of Gen-MMIPs were detected as 24.79 emu/g. Fourier transform infrared (FR-IR) spectroscopy showed that polymer groups were on the surface of the magnetic carrier. Adsorption experiment suggested the adsorption capability of Gen-MMIPs to genistein were 1.55 mg/g, and 2 the adsorption equilibrium was achieved within 20 min. Gen-MMIPs as dispersive solid-phase extraction adsorbent combined with HPLC was used to selectively separate genistein in soy sauce samples, the recoveries were ranged from 85.7% to 88.5% with the relative standard deviations (RSD) less than 5%, which proved this method can be used for the detection of genistein residues in real samples.

scholarly journals Preparation of Restricted Access Media-Molecularly Imprinted Polymers for the Detection of Chloramphenicol in Bovine Serum

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Shanwen Zhao ◽  
Chanling Wei ◽  
Zhian Sun ◽  
Huachun Liu ◽  
Yanqiang Zhou ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Bovine Serum ◽  
Crosslinking Agent ◽  
Template Molecule ◽  
Functional Monomer ◽  
Molecularly Imprinted ◽  
Restricted Access ◽  
Imprinted Polymers ◽  
Relative Standard ◽  
Restricted Access Media

Chloramphenicol- (CAP-) restricted access media-molecularly imprinted polymers (CAP-RAM-MIPs) were prepared by precipitation polymerization using CAP as a template molecule, 2-diethylaminoethyl methacrylate (DEAEM) as a functional monomer, ethylene glycol dimethyl acrylate (EDMA) as a crosslinking agent, glycidyl methacrylate (GMA) as an outer hydrophilic functional monomer, and acetonitrile as a pore former and solvent. The CAP-RAM-MIPs were successfully characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, and thermogravimetric analysis. The adsorption performance was investigated in detail using static, dynamic, and selective adsorption experiments. Adsorption equilibrium could be reached within 11 min. The CAP-RAM-MIPs had a high adsorption rate and good specific adsorption properties. Scatchard fitting curves indicated there were two binding sites for CAP-RAM-MIPs. Adsorption was Freundlich multilayer adsorption and consistent with the quasi-second kinetic model. Using CAP-RAM-MIPs for selective separation and enrichment CAP in bovine serum in combination with high-performance liquid chromatography (HPLC), CAP recovery ranged from 94.1 to 97.9% with relative standard deviations of 0.7–1.5%. This material has broad application prospects in enrichment and separation.

scholarly journals CONSTRUCTION OF A NEW ELECTROCHEMICAL SENSOR BASED ON A NEW MOLECULARLY IMPRINTED POLYMERS(MIPS) FOR HIGHLY SELECTIVE AND SENSITIVE DETERMINATION OF CLEBOPRIDE (CBD) IN PHARMACEUTICAL COMMERCIAL SAMPLES

2021 ◽  
Vol 52 (2) ◽  
pp. 367-376
Author(s):  
Y. K. Al-Bayati
Keyword(s):  
Ethylene Glycol ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Pharmaceutical Preparation ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Relative Standard ◽  
Sensitive Determination ◽  
Cross Linker

Clebopride (CBD) selective molecularly imprinted polymers(MIPs) were based on ion-pair by prepared four polymers(MIPs) using CBD as the template a well as (Acryl amide) (AAM), 2-Acrylamido-2-Methyl-1-Propane sulphonic Acid (2-AAMMPSA as monomer, used N,N-ethylenebismethacrylamide (EBMAA) ,ethylene glycol dimethacrylate ethylene glycol(EGDMAC), N, N-methylene bisacrylamide (NNMBAAM)) as cross linker and used benzoyl peroxide as initiator . NIPs prepared by using the same composition of MIPs except the template (CBD). The MIPs were prepared using variation  ratio of monomer and cross linker .These MIPs applicate as solid phase extraction for determination CBD in pharmaceutical preparation used UV as detector .the results gave good response, where the reconstruction percentage (Rec%) value of CBD drug took the range (99- 101% ), and the relative standard deviation (RSD%) value took the range (0.27% - 0.93 %) for standard solution and Rec% took values of (98- 99) %, and RSD% took values of (0.86 – 1.62) % of CBD drug for the Clebopride pharmaceutical.

scholarly journals Development of Water-Compatible Molecularly Imprinted Polymers Based on Functionalized β-Cyclodextrin for Controlled Release of Atropine

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 130 ◽  
Author(s):  
Yahui He ◽  
Shaomei Zeng ◽  
A. M. Abd El-Aty ◽  
Ahmet Hacımüftüoğlu ◽  
Woldemariam Kalekristos Yohannes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Molecularly Imprinted Polymers ◽  
Isotherm Models ◽  
Template Molecule ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Potential Applications

Herein, a novel method for molecularly imprinted polymers (MIPs) using methacrylic acid functionalized beta-cyclodextrin (MAA-β-CD) monomer is presented, which was designed as a potential water-compatible composite for the controlled release of atropine (ATP). The molecularly imprinted microspheres with pH-sensitive characteristics were fabricated using thermally-initiated precipitation polymerization, employing ATP as a template molecule. The effects of different compounds and concentrations of cross-linking agents were systematically investigated. Uniform microspheres were obtained when the ratio between ATP, MAA-β-CD, and trimethylolpropane trimethacrylate (TRIM) was 1:4:20 (mol/mol/mol) in polymerization system. The ATP loading equilibrium data was best suited to the Freundlich and Langmuir isotherm models. The in vitro drug release study was assessed under simulated oral administration conditions (pH 1.5 and 7.4). The potential usefulness of MIPs as drug delivery devices are much better than non-molecularly imprinted polymers (NIPs). The study shows that the prepared polymers are a pH stimuli-responsive system, which controlled the release of ATP, indicating the potential applications in the field of drug delivery.

scholarly journals Preparation of Monodisperse Enrofloxacin Molecularly Imprinted Polymer Microspheres and Their Recognition Characteristics

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Xiaoxiao Wang ◽  
Yanqiang Zhou ◽  
Yuling Niu ◽  
Shanwen Zhao ◽  
Bolin Gong
Keyword(s):  
Molecularly Imprinted Polymers ◽  
High Performance ◽  
Limit Of Detection ◽  
Solid Phase ◽  
Food Samples ◽  
Diglycidyl Ether ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Relative Standard

This study presents a new strategy for the detection of enrofloxacin (ENR) in food samples by the use of monodisperse ENR molecularly imprinted polymers (MIPs). Using enrofloxacin as template molecule, methacrylic acid as functional monomer, and ethylene diglycidyl ether as cross-linker, surface molecularly imprinted polymers (MIPs) were prepared on the surface of polymeric glycidyl methacrylate-ethylene glycol dimethacrylate (PGMA-EDMA) microspheres. The surface morphology and imprinting behavior of PGMA-EDMA@MIPs were investigated and optimized. Synthesized PGMA-EDMA@MIPs showed good physical and chemical stability and specific recognition toward fluoroquinolones. The introduction of PGMA-EDMA microspheres greatly increased the adsorption area of PGMA-EDMA@MIPs and increased the adsorption capacity of target molecules. The core shell structure increased the adsorption rate, and adsorption equilibrium was achieved within 6 min, much higher than that of MIPs synthesized by traditional methods. Enrofloxacin in milk samples was detected by molecular imprinting solid phase extraction (MISPE) combined with high performance liquid chromatography (HPLC). Implementing this method resulted in a recovery rate of 94.6~109.6% with a relative standard deviation (RSD) of less than 3.2%. The limit of detection (LOD) of this method was identified as three times the signal-to-noise ratio (10 μg/L). In summary, this work proposed a sensitive, rapid, and convenient method for the determination of trace ENR in food samples.

Preparation and Properties of Ginsenoside Rg1 Molecularly Imprinted Polymers

2012 ◽  
Vol 550-553 ◽  
pp. 1715-1718 ◽  
Author(s):  
Li Na Yi ◽  
Xiao Ying Yin ◽  
Yi Fan Jiang ◽  
Qing Shan Liu
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Scatchard Analysis ◽  
Template Molecule ◽  
Ginsenoside Rg1 ◽  
Traditional Herbal Medicine ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Scatchard Equation ◽  
Novel Method

Molecularly imprinted polymers (MIPs) were prepared by precipitation polymerization with ginsenoside Rg1 as the template molecule. The morphology of MIPs was characterized by scanning electronmicroscope (SEM) and its static adsorption capacity was measured by the Scatchard equation. Scatchard analysis revealed that the homogeneous binding sites were formed in the polymers. The application of MIPs with high affinity toward the template molecule might offer a novel method for the enrichment and determination of active compounds in the traditional herbal medicine.

scholarly journals Synthesis of Molecularly Imprinted Polymers for the Selective Extraction of Polymyxins from Environmental Water Samples

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 131 ◽  
Author(s):  
Xuqin Song ◽  
Esther Turiel ◽  
Limin He ◽  
Antonio Martín-Esteban
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Water Samples ◽  
Solid Phase ◽  
Environmental Water ◽  
Resistant Bacteria ◽  
Colistin Resistance ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Relative Standard

The emergence of colistin resistance gen has aroused public concern. It is significant to assess the concentrations of polymyxins residues in aquatic environment since resistant bacteria carrying colistin resistance gen are frequently isolated from wastewater; surface water and ground water. However; no literature on the determination of polymyxins in water is available; probably due to the absence of an efficient extraction method. Accordingly; molecularly imprinted polymers were synthesized by precipitation polymerization with colistin as the template. The polymers were successfully used as sorbents for the determination of polymyxins from water based on molecularly imprinted solid-phase extraction and high-performance liquid chromatography–ultraviolet detection. The molecularly imprinted cartridge showed excellent affinity and cross-reactivity to analytes in aqueous media. Recoveries obtained from water samples were between 65.9% and 90.1%, with relative standard deviations lower than 10.2%. Limits of detection were between 1.0 and 2.0 μg L−1 concentration levels. Compared with C18 cartridge; the molecularly imprinted cartridge could remove more interference from co-extracted matrices. This method is practical for the routine monitoring of polymyxin residues in environmental water; which will benefit studies on drug-resistance and occurrence of polymyxins in the environment.

Molecularly imprinted polymers for the detection of viruses: challenges and opportunities

The Analyst ◽  
2021 ◽  
Author(s):  
Ghazaleh Jamalipour Soufi ◽  
Siavash Iravani ◽  
Rajender S Varma
Keyword(s):  
Drug Delivery ◽  
Drug Discovery ◽  
Structure Determination ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Cell Culturing ◽  
Challenges And Opportunities

Molecularly imprinted polymers (MIPs) have numerous applications in sensing field, the detection/recognition of virus, the structure determination of proteins, drug delivery, artificial/biomimetic antibodies, drug discovery, and cell culturing. There are...

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