scholarly journals Cell Signaling Pathways in Mammary Carcinoma Induced in Rats with Low versus High Inherent Aerobic Capacity

2019 ◽  
Vol 20 (6) ◽  
pp. 1506 ◽  
Author(s):  
Tymofiy Lutsiv ◽  
John McGinley ◽  
Elizabeth Neil ◽  
Henry Thompson
Keyword(s):  
Physical Activity ◽  
Fatty Acid ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Aerobic Capacity ◽  
Mammary Cancer ◽  
Breast Cancer Incidence ◽  
Acid Oxidation ◽  
Inverse Association ◽  
Cell Signaling Pathways

An inverse association exists between physical activity and breast cancer incidence and outcomes. An objective indicator of an individual’s recent physical activity exposure is aerobic capacity. We took advantage of the fact that there is an inherited as well as inducible component of aerobic capacity to show that experimentally induced mammary cancer is inversely related to inherent aerobic capacity (IAC). The objective of this study was to determine whether cell signaling pathways involved in the development of mammary cancer differed in rats with low inherent aerobic capacity (LIAC, n = 55) versus high inherent aerobic capacity (HIAC, n = 57). Cancer burden was 0.21 ± 0.16 g/rat in HIAC versus 1.14 ± 0.45 in LIAC, p < 0.001. Based on protein expression, cancer in LIAC animals was associated with upregulated glucose utilization, and protein and fatty acid synthesis. Signaling in cancers from HIAC rats was associated with energy sensing, fatty acid oxidation and cell cycle arrest. These findings support the thesis that pro-glycolytic, metabolic inflexibility in LIAC favors not only insulin resistance and obesity but also tumor development and growth. This provides an unappreciated framework for understanding how obesity and low aerobic fitness, hallmarks of physical inactivity, are associated with higher cancer risk and poorer prognosis.

scholarly journals Are signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiforme?

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
William G. O'Neal ◽  
Debomoy K. Lahiri, Ph.D ◽  
Mahua Dey, M.D ◽  
Ruizhi Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glioblastoma Multiforme ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Synaptic Proteins ◽  
Low Grade ◽  
Inverse Association ◽  
Potential Impact ◽  
Cell Signaling Pathways

Background: Epidemiological studies suggest an inverse association between cancer and neurodegenerative disorders, including Alzheimer’s disease (AD). AD and cancers, such as glioblastoma multiforme (GBM), are characterized by abnormal but opposing cellular behavior. AD is characterized by accumulation of the processing products of amyloid β (Aβ) and its metabolizing enzymes amyloid precursor protein (APP), β-secretase (or BACE1), and γ-secretase. Our rationale is unraveling cell signaling pathways linking AD and GBM. We hypothesized low-grade gliomas (LGG) and high-grade gliomas (HGG) would have differential expression of neuronal and synaptic markers. Furthermore, protein expression profiles of these markers, APP metabolites, and BACE1 would be different among LGG, HGG, and AD cases.  Experimental Design or project methods: Specific neuronal protein markers (e.g., NSE), presynaptic proteins (e.g., synaptophysin and SNAP25), and post-synaptic proteins (e.g., PSD-95) have been measured in glioma samples. Characterization are done by Western immunoblotting and ELISA. Protein biomarkers will be analyzed in LGG and HGG of biopsy samples, and the results will be compared with brain samples from AD cases.  Results: Using specific primary and secondary antibodies and optimal protein range, we have standardized an immunoblotting procedure to detect our desired proteins in blinded LGG and HGG samples. After unblinding and analyzing results, expression signals will be compared between GBM and AD brain samples.  Conclusion and potential impact: Our results would shed light on diverging and/or shared cell signaling pathways between AD and GBM. In addition, potential impact would be utilizing GBM-derived cultures to test and develop therapeutics for both AD and GBM.

scholarly journals Cell signaling pathways associated with a reduction in mammary cancer burden by dietary common bean ( Phaseolus vulgaris L.)

2011 ◽  
Vol 33 (1) ◽  
pp. 226-232 ◽  
Author(s):  
Matthew D. Thompson ◽  
Meghan M. Mensack ◽  
Weiqin Jiang ◽  
Zongjian Zhu ◽  
Matthew R. Lewis ◽  
...  
Keyword(s):  
Phaseolus Vulgaris ◽  
Cell Signaling ◽  
Common Bean ◽  
Signaling Pathways ◽  
Mammary Cancer ◽  
Phaseolus Vulgaris L ◽  
Cancer Burden ◽  
Cell Signaling Pathways

Cell signaling pathways as molecular targets to eliminate AML stem cells

2021 ◽  
Vol 160 ◽  
pp. 103277
Author(s):  
Ana Carolina B. da C. Rodrigues ◽  
Rafaela G.A. Costa ◽  
Suellen L.R. Silva ◽  
Ingrid R.S.B. Dias ◽  
Rosane B. Dias ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Molecular Targets ◽  
Cell Signaling Pathways

scholarly journals Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

2021 ◽  
pp. 108634
Author(s):  
Ibrahim Jantan ◽  
Md. Areeful Haque ◽  
Laiba Arshad ◽  
Hemavathy Harikrishnan ◽  
Abdi Wira Septama ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Chronic Inflammation ◽  
Dietary Polyphenols ◽  
Cell Signaling Pathways

RAGE Activation by S100P in Colon Cancer Stimulates Growth, Migration, and Cell Signaling Pathways

2007 ◽  
Vol 50 (8) ◽  
pp. 1230-1240 ◽  
Author(s):  
Maren K. Fuentes ◽  
Shraddha S. Nigavekar ◽  
Thiruvengadam Arumugam ◽  
Craig D. Logsdon ◽  
Ann Marie Schmidt ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Cell Signaling Pathways

scholarly journals The crosstalk between EGF, IGF, and Insulin cell signaling pathways - computational and experimental analysis

2009 ◽  
Vol 3 (1) ◽  
pp. 88 ◽  
Author(s):  
Rafal Zielinski ◽  
Pawel F Przytycki ◽  
Jie Zheng ◽  
David Zhang ◽  
Teresa M Przytycka ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Experimental Analysis ◽  
Cell Signaling Pathways
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