scholarly journals Mast Cells and Angiogenesis in Human Plasma Cell Malignancies

2019 ◽  
Vol 20 (3) ◽  
pp. 481 ◽  
Author(s):  
Domenico Ribatti ◽  
Roberto Tamma ◽  
Angelo Vacca
Keyword(s):  
Mast Cells ◽  
Human Plasma ◽  
Plasma Cell ◽  
Hematological Malignancies ◽  
Selective Inhibition ◽  
Therapeutic Resistance ◽  
Invasion And Metastasis ◽  
Inhibition Of Angiogenesis ◽  
Hematological Tumors

Bone marrow angiogenesis plays an important role in the pathogenesis and progression of hematological malignancies. It is well known that tumor microenvironment promotes tumor angiogenesis, proliferation, invasion, and metastasis, and also mediates mechanisms of therapeutic resistance. An increased number of mast cells has been demonstrated in angiogenesis associated with hematological tumors. In this review we focused on the role of mast cells in angiogenesis in human plasma cell malignancies. In this context, mast cells might act as a new target for the adjuvant treatment of these tumors through the selective inhibition of angiogenesis, tissue remodeling and tumor-promoting molecules, permitting the secretion of cytotoxic cytokines and preventing mast cell-mediated immune suppression.

scholarly journals The Underestimated Role of Mast Cells in the Pathogenesis of Rhinopathies

2021 ◽  
pp. 1-7
Author(s):  
Matteo Gelardi ◽  
Rossana Giancaspro ◽  
Michele Cassano ◽  
Domenico Ribatti
Keyword(s):  
Mast Cells ◽  
Tissue Repair ◽  
Inflammatory Cells ◽  
Selective Inhibition ◽  
Biological Processes ◽  
Biological Mechanisms ◽  
Tailored Therapy ◽  
Pathological Conditions ◽  
Nasal Cytology

Mast cells (MCs) are involved in several biological processes, such as defense against pathogens, immunomodulation, tissue repair after injury, and angiogenesis. MCs have been shown to change from protective immune cells to potent pro-inflammatory cells, influencing the progression of many pathological conditions, including autoimmune diseases and cancers. The role of MCs in the pathogenesis of rhinopathies has often been underestimated, since previous studies have focused their attention on eosinophils and neutrophils, while MCs were considered involved exclusively in allergic rhinitis. However, recent nasal cytology findings have shown the involvement of MCs in several rhinopathies, such as NARMA, NARESMA, and CRSwNP. These recent evidences highlight the crucial role that MCs play in orchestrating the inflammation of the nasal mucosa, through complex biological mechanisms, not yet fully understood. In this context, a better understanding of these mechanisms is fundamental for practicing Precision Medicine, which requires careful population selection and stratification into subgroups based on the phenotype/endotype of the patients, in order to guarantee the patient a tailored therapy. Based on this background, further studies are needed to understand the pathophysiological mechanisms involving MCs and, consequently, to develop targeted therapies aimed to obtain a selective inhibition of tissue remodeling and preventing MC-mediated immune suppression.

scholarly journals Steering Mast Cells or Their Mediators as a Prospective Novel Therapeutic Approach for the Treatment of Hematological Malignancies

2021 ◽  
Vol 11 ◽  
Author(s):  
Deeksha Mehtani ◽  
Niti Puri
Keyword(s):  
Mast Cells ◽  
Tumor Microenvironment ◽  
Therapeutic Approach ◽  
Hematological Malignancies ◽  
Tumor Type ◽  
Growth And Survival ◽  
Lymphoid Malignancies ◽  
Cell Accumulation ◽  
Growth Prognosis

Tumor cells require signaling and close interaction with their microenvironment for their survival and proliferation. In the recent years, Mast cells have earned a greater importance for their presence and role in cancers. It is known that mast cells are attracted towards tumor microenvironment by secreted soluble chemotactic factors. Mast cells seem to exert a pro-tumorigenic role in hematological malignancies with a few exceptions where they showed anti-cancerous role. This dual role of mast cells in tumor growth and survival may be dependent on the intrinsic characteristics of the particular tumor, differences in tumor microenvironment according to tumor type, and the interactions and heterogeneity of mediators released by mast cells in the tumor microenvironment. In many studies, Mast cells and their mediators have been shown to affect tumor survival and growth, prognosis, inflammation, tumor vascularization and angiogenesis. Modulating mast cell accumulation, viability, activity and mediator release patterns may thus be important in controlling these malignancies. In this review, we emphasize on the role of mast cells in lymphoid malignancies and discuss strategies for targeting and steering mast cells or their mediators as a potential therapeutic approach for the treatment of these malignancies.

scholarly journals Abstract 2414: ADAR1-dependent RNA editing is a mechanism of therapeutic resistance in human plasma cell malignancies

2016 ◽  
Author(s):  
Elisa Lazzari ◽  
Leslie A. Crews ◽  
Christina Wu ◽  
Heather Leu ◽  
Shawn Ali ◽  
...  
Keyword(s):  
Human Plasma ◽  
Rna Editing ◽  
Plasma Cell ◽  
Therapeutic Resistance

Author response for "The role of galanin in the differentiation of mucosal mast cells in mice"

2019 ◽  
Author(s):  
Tomoko Yamaguchi ◽  
Yumi Ikeda ◽  
Katsuhisa Tashiro ◽  
Yasuyuki Ohkawa ◽  
Kenji Kawabata
Keyword(s):  
Mast Cells ◽  
Author Response ◽  
Mucosal Mast Cells

Thrombin Augments Vascular Cell-dependent Migration of Human Mast Cells: Role of MGF

1997 ◽  
Vol 77 (03) ◽  
pp. 577-584 ◽  
Author(s):  
Mehrdad Baghestanian ◽  
Roland Hofbauer ◽  
Hans G Kress ◽  
Johann Wojta ◽  
Astrid Fabry ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Mast Cells ◽  
Umbilical Vein ◽  
Vascular Cells ◽  
Migratory Response ◽  
Thrombin Activation ◽  
Umbilical Vein Endothelial Cells ◽  
Primary Tissue ◽  
Local Expression

SummaryRecent data suggest that auricular thrombosis is associated with accumulation of mast cells (MC) in the upper endocardium (where usually no MC reside) and local expression of MGF (mast cell growth factor) (25). In this study, the role of vascular cells, thrombin-activation and MGF, in MC-migration was analyzed. For this purpose, cultured human auricular endocardial cells (HAUEC), umbilical vein endothelial cells (HUVEC) and uterine-(HUTMEC) and skin-derived (HSMEC) microvascular endothelial cells were exposed to thrombin or control medium, and the migration of primary tissue MC (lung, n = 6) and HMC-1 cells (human MC-line) against vascular cells (supernatants) measured. Supernatants (24 h) of unstimulated vascular cells (monolayers of endocardium or endothelium) as well as recombinant (rh) MGF induced a significant migratory response in HMC-1 (control: 3025 ± 344 cells [100 ± 11.4%] vs. MGF, 100 ng/ml: 8806 ± 1019 [291 ± 34%] vs. HAUEC: 9703 ± 1506 [320.8 ± 49.8%] vs. HUTMEC: 8950 ± 1857 [295.9 ± 61.4%] vs. HSMEC: 9965 ± 2018 [329.4 ± 66.7%] vs. HUVEC: 9487 ± 1402 [313.6 ± 46.4%], p <0.05) as well as in primary lung MC. Thrombin-activation (5 U/ml, 12 h) of vascular cells led to an augmentation of the directed migration of MC as well as to a hirudin-sensitive increase in MGF synthesis and release. Moreover, a blocking anti-MGF antibody was found to inhibit MC-migration induced by unstimulated or thrombin-activated vascular cells. Together, these data show that endocardial and other vascular cells can induce migration of human MC. This MC-chemotactic signal of the vasculature is associated with expression and release of MGF, augmentable by thrombin, and may play a role in the pathophysiology of (auricular) thrombosis.

Bifunctional Role of Kruppel-Like Factor 4 in Hematological Malignancies

2016 ◽  
Vol 7 (1-2) ◽  
pp. 141-151
Author(s):  
Mario Morales-Martinez ◽  
Luz A. Franco-Cea ◽  
Liliana Moreno Vargas ◽  
Otoniel Martinez-Maza ◽  
Sara Huerta-Yepez ◽  
...  
Keyword(s):  
Hematological Malignancies
Sign in / Sign up

Export Citation Format

Share Document