scholarly journals Applications of Noble Metal-Based Nanoparticles in Medicine

2018 ◽  
Vol 19 (12) ◽  
pp. 4031 ◽  
Author(s):  
Bartosz Klębowski ◽  
Joanna Depciuch ◽  
Magdalena Parlińska-Wojtan ◽  
Jarek Baran
Keyword(s):  
Drug Delivery ◽  
Noble Metal ◽  
Proton Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Therapeutic Modalities ◽  
Size Dependent

Nanoparticles have unique, size-dependent properties, which means they are widely used in various branches of industry. The ability to control the properties of nanoparticles makes these nanomaterials very interesting for medicine and pharmacology. The application of nanoparticles in medicine is associated with the design of specific nanostructures, which can be used as novel diagnostic and therapeutic modalities. There are a lot of applications of nanoparticles, e.g., as drug delivery systems, radiosensitizers in radiation or proton therapy, in bioimaging, or as bactericides/fungicides. This paper aims to introduce the characteristics of noble metal-based nanoparticles with particular emphasis on their applications in medicine and related sciences.

Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems

2013 ◽  
Vol 1 (34) ◽  
pp. 4273 ◽  
Author(s):  
Jun Yue ◽  
Shi Liu ◽  
Zhigang Xie ◽  
Ying Xing ◽  
Xiabin Jing
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Antitumor Efficacy ◽  
Polymer Micelle ◽  
Size Dependent

scholarly journals Robust and Repeatable Biofabrication of Bacteria-Mediated  Drug Delivery Systems: Effect of Conjugation Chemistry, Assembly Process  Parameters, and Nanoparticle Size

2021 ◽  
Author(s):  
Ying Zhan ◽  
Austin Fergusson ◽  
Lacey R. McNally ◽  
Richey M. Davis ◽  
Bahareh Behkam
Keyword(s):  
Drug Delivery ◽  
Growth Rate ◽  
Process Parameters ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Dependent Manner ◽  
Assembly Process ◽  
Antitumor Effects ◽  
Therapeutic Modalities

Bacteria-mediated drug delivery systems comprising nanotherapeutics conjugated onto bacteria synergistically augment the efficacy of both therapeutic modalities in cancer therapy. Nanocarriers preserve therapeutics’ bioavailability and reduce systemic toxicity, while bacteria selectively colonize the cancerous tissue, impart intrinsic and immune-mediated antitumor effects, and propel nanotherapeutics interstitially. The optimal bacteria-nanoparticle (NP) conjugates would carry the maximal NP load with minimal motility speed hindrance for effective interstitial distribution. Furthermore, a well-defined and repeatable NP attachment density distribution is crucial to determining these biohybrid systems’ efficacious dosage and robust performance. Herein, we utilized our Nanoscale Bacteria-Enabled Autonomous Delivery System (NanoBEADS) platform to investigate the effects of assembly process parameters of mixing method, volume, and duration on NP attachment density and repeatability. We also evaluated the effect of linkage chemistry and NP size on NP attachment density, viability, growth rate, and motility of NanoBEADS. We show that the linkage chemistry impacts NP attachment density while the self-assembly process parameters affect the repeatability and, to a lesser extent, attachment density. Lastly, the attachment density affects NanoBEADS’ growth rate and motility in an NP size-dependent manner. These findings will contribute to the development of scalable and repeatable bacteria-nanoparticle biohybrids for applications in drug delivery and beyond. Corresponding author(s) Email:  [email protected]  

Thermally Activated Noble Metal Nanoparticles Incorporated in Electrospun Fiber-based Drug Delivery Systems

2019 ◽  
Vol 4 (1) ◽  
pp. 21-31 ◽  
Author(s):  
Enza Fazio ◽  
Alessandro Ridolfo ◽  
Giulia Neri
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Release ◽  
Noble Metal ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Photothermal Effect ◽  
Release Mechanism ◽  
Time Interval ◽  
Visible Radiation

Background: Nanosystems based on PEG-PLGA copolymer have attracted increasing interest in several biomedicine fields, due to their unique properties. Commonly, PEG-PLGA copolymer was used to formulate nanoparticles (NPs) for drug delivery applications. Only recently, the engineering of polymeric nanofibrous membrane able to be use like drug nanocarrier was investigated. Objective: The goal of this work is the development of two new drug delivery systems based on PEGylated-PLGA nanofibrous scaffolds, obtained by electrospinning deposition, simultaneous loaded with: i) silibinin, a therapeutic agent, ii) Au/Ag and iii) non-toxic Fe2O3 magnetic nanoparticles. Another interest aspect of the present work regards how the morphological structure can influence the drug release which has been fine-tuned by two external stimuli: a light source and a magnetic field. Methods: Noble metal nanocolloids were prepared in water by the pulsed laser ablation technique. The PEG-PLGA@Au/Ag-SLB added with Fe2O3-PVA nanofibers were fabricated by the electrospinning deposition method. Results: The use of “Surface Plasmon Resonance”-mediated localized photothermal effect, determined by the nanoparticles resonant absorption of visible radiation, allows to these systems to be able to employ for photothermal drug delivery therapies in proximity of tumor cells. All data obtained about the fiber scaffolds are compared to NPs based on the same PEG-PLGA copolymer, loaded with silibinin, Fe2O3 and Au/Ag nanoparticles alternatively. Nanofibers respects to NPs, showed interesting sustained responsive silibinin release for at least 60 h, without the burst effect. A diffusion-based theoretical model approach allowed to precisely describe the release mechanism. Conclusion: The effective and controlled silibilin drug release, upon application of either light irradiation or magnetic field for a definite time interval, has been demonstrated. Under the light stimulus, the fiber-shaped nanosystem reached a cumulative drug release value as high as 70% in the long time. On the overall, the information obtained could be useful to design suitable “on demand” nanocomposites in view of a therapeutic treatments protocol that requires a fast pharmacological action.

scholarly journals Robust and Repeatable Biofabrication of Bacteria-Mediated  Drug Delivery Systems: Effect of Conjugation Chemistry, Assembly Process  Parameters, and Nanoparticle Size

2021 ◽  
Author(s):  
Ying Zhan ◽  
Austin Fergusson ◽  
Lacey R. McNally ◽  
Richey M. Davis ◽  
Bahareh Behkam
Keyword(s):  
Drug Delivery ◽  
Growth Rate ◽  
Process Parameters ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Dependent Manner ◽  
Assembly Process ◽  
Antitumor Effects ◽  
Therapeutic Modalities

Bacteria-mediated drug delivery systems comprising nanotherapeutics conjugated onto bacteria synergistically augment the efficacy of both therapeutic modalities in cancer therapy. Nanocarriers preserve therapeutics’ bioavailability and reduce systemic toxicity, while bacteria selectively colonize the cancerous tissue, impart intrinsic and immune-mediated antitumor effects, and propel nanotherapeutics interstitially. The optimal bacteria-nanoparticle (NP) conjugates would carry the maximal NP load with minimal motility speed hindrance for effective interstitial distribution. Furthermore, a well-defined and repeatable NP attachment density distribution is crucial to determining these biohybrid systems’ efficacious dosage and robust performance. Herein, we utilized our Nanoscale Bacteria-Enabled Autonomous Delivery System (NanoBEADS) platform to investigate the effects of assembly process parameters of mixing method, volume, and duration on NP attachment density and repeatability. We also evaluated the effect of linkage chemistry and NP size on NP attachment density, viability, growth rate, and motility of NanoBEADS. We show that the linkage chemistry impacts NP attachment density while the self-assembly process parameters affect the repeatability and, to a lesser extent, attachment density. Lastly, the attachment density affects NanoBEADS’ growth rate and motility in an NP size-dependent manner. These findings will contribute to the development of scalable and repeatable bacteria-nanoparticle biohybrids for applications in drug delivery and beyond. Corresponding author(s) Email:  [email protected]  

scholarly journals Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 191 ◽  
Author(s):  
Vijay Mishra ◽  
Kuldeep Bansal ◽  
Asit Verma ◽  
Nishika Yadav ◽  
Sourav Thakur ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Routes Of Administration ◽  
Size Dependent ◽  
Solid Lipid ◽  
Nano Drug Delivery

Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications.

scholarly journals The Effect of Ligands on Noble Metal Nanoparticles as Drug Delivery Systems to the Brain

2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Shailee Shroff ◽  
Chad Curtis
Keyword(s):  
Drug Delivery ◽  
Metal Nanoparticles ◽  
Noble Metal ◽  
Invasive Surgery ◽  
Drug Delivery Systems ◽  
Cell Types ◽  
Delivery Systems ◽  
Metal Nanoparticle ◽  
Noble Metal Nanoparticles ◽  
The Brain

metal nanoparticles have been used to address these diseases in the brain, however very few of these formulations have made it through clinical trials. This review will be discussing the role of noble metal nanoparticles as drug delivery systems specifically to the brain. A common problem many researchers and clinical physicians are facing problems because they are unable to access the brain without highly invasive surgery. Nanoparticles allow access to the brain without invasive surgery. Noble metal nanoparticles (NMNPs) are of particular interest because of their inherent characteristics which are amplified or reduced by ligands. The various ligands available change the method of transportation for a NMNPs traveling through the blood barrier. We will examine various ligands and their benefits and potential drawbacks. Furthermore, the optimal usage for each ligand and associated nanoparticle will also be examined. This review will go into detail about pure noble metal nanoparticle, glucose, PEG, CTAB, Transferrin, Anti-Microbial Peptide, and Chitosan as coatings. All of these are commonly used among researchers. The absorptivity into various cell types in the brain along with future implications will be examined.

scholarly journals Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1117 ◽  
Author(s):  
Ali Raza ◽  
Tahir Rasheed ◽  
Faran Nabeel ◽  
Uzma Hayat ◽  
Muhammad Bilal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Essential Element ◽  
Delivery Systems ◽  
Individual Variability ◽  
Release Mechanism ◽  
Stimuli Responsive ◽  
Site Specific ◽  
Therapeutic Modalities ◽  
Polymeric Carriers

In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. This particular work focuses on the smart chemistry and mechanism of action aspects of several types of stimuli-responsive polymeric carriers that play a crucial role in extracellular and intracellular sections of diseased tissues or cells. With ever increasing scientific knowledge and awareness, research is underway around the globe to design new types of stimuli (external/internal) responsive polymeric carriers for biotechnological applications at large and biomedical and/or pharmaceutical applications, in particular. Both external/internal and even dual/multi-responsive behavior of polymeric carriers is considered an essential element of engineering so-called ‘smart’ DDS, which controls the effective and efficient dose loading, sustained release, individual variability, and targeted permeability in a sophisticated manner. So far, an array of DDS has been proposed, developed, and implemented. For instance, redox, pH, temperature, photo/light, magnetic, ultrasound, and electrical responsive DDS and/or all in all dual/dual/multi-responsive DDS (combination or two or more from any of the above). Despite the massive advancement in DDS arena, there are still many challenging concerns that remain to be addressed to cover the research gap. In this context, herein, an effort has been made to highlight those concerning issues to cover up the literature gap. Thus, the emphasis was given to the drug release mechanism and applications of endogenous and exogenous based stimuli-responsive DDS in the clinical settings.

Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems

2017 ◽  
Vol 9 (22) ◽  
pp. 18619-18625 ◽  
Author(s):  
Ting Wang ◽  
Lu Wang ◽  
Xiaoming Li ◽  
Xingjie Hu ◽  
Yuping Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Trafficking ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Size Dependent

scholarly journals Robust and Repeatable Biofabrication of Bacteria-Mediated  Drug Delivery Systems: Effect of Conjugation Chemistry, Assembly Process  Parameters, and Nanoparticle Size

2021 ◽  
Author(s):  
Ying Zhan ◽  
Austin Fergusson ◽  
Lacey R. McNally ◽  
Richey M. Davis ◽  
Bahareh Behkam
Keyword(s):  
Drug Delivery ◽  
Growth Rate ◽  
Process Parameters ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Dependent Manner ◽  
Assembly Process ◽  
Antitumor Effects ◽  
Therapeutic Modalities

Bacteria-mediated drug delivery systems comprising nanotherapeutics conjugated onto bacteria synergistically augment the efficacy of both therapeutic modalities in cancer therapy. Nanocarriers preserve therapeutics’ bioavailability and reduce systemic toxicity, while bacteria selectively colonize the cancerous tissue, impart intrinsic and immune-mediated antitumor effects, and propel nanotherapeutics interstitially. The optimal bacteria-nanoparticle (NP) conjugates would carry the maximal NP load with minimal motility speed hindrance for effective interstitial distribution. Furthermore, a well-defined and repeatable NP attachment density distribution is crucial to determining these biohybrid systems’ efficacious dosage and robust performance. Herein, we utilized our Nanoscale Bacteria-Enabled Autonomous Delivery System (NanoBEADS) platform to investigate the effects of assembly process parameters of mixing method, volume, and duration on NP attachment density and repeatability. We also evaluated the effect of linkage chemistry and NP size on NP attachment density, viability, growth rate, and motility of NanoBEADS. We show that the linkage chemistry impacts NP attachment density while the self-assembly process parameters affect the repeatability and, to a lesser extent, attachment density. Lastly, the attachment density affects NanoBEADS’ growth rate and motility in an NP size-dependent manner. These findings will contribute to the development of scalable and repeatable bacteria-nanoparticle biohybrids for applications in drug delivery and beyond. Corresponding author(s) Email:  [email protected]  

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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