scholarly journals The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1

2018 ◽  
Vol 19 (7) ◽  
pp. 1909 ◽  
Author(s):  
Felipe Lima ◽  
Viviane Seba ◽  
Gabriel Silva ◽  
Guilherme Torrezan ◽  
Carlos Polaquini ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Osteosarcoma Cells ◽  
Curcumin Analog ◽  
Human Osteosarcoma ◽  
Anticancer Effects ◽  
Human Osteosarcoma Cells

scholarly journals Transcriptional Regulation of theSIS/PDGF-BGene in Human Osteosarcoma Cells by the Sp Family of Transcription Factors

1996 ◽  
Vol 271 (20) ◽  
pp. 11792-11797 ◽  
Author(s):  
Yuxin Liang ◽  
Donald F. Robinson ◽  
Jörg Dennig ◽  
Guntram Suske ◽  
William E. Fahl
Keyword(s):  
Transcriptional Regulation ◽  
Transcription Factors ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells

scholarly journals Curcumin Analog DK1 Induces Apoptosis in Human Osteosarcoma Cells In Vitro through Mitochondria-Dependent Signaling Pathway

Molecules ◽  
2018 ◽  
Vol 23 (1) ◽  
pp. 75 ◽  
Author(s):  
Muhammad Aziz ◽  
Yazmin Hussin ◽  
Nurul Che Rahim ◽  
Noraini Nordin ◽  
Nurul Mohamad ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Osteosarcoma Cells ◽  
Curcumin Analog ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
Dependent Signaling Pathway

Anticancer effects of zoledronic acid against human osteosarcoma cells

2006 ◽  
Vol 24 (6) ◽  
pp. 1145-1152 ◽  
Author(s):  
B. Kubista ◽  
K. Trieb ◽  
F. Sevelda ◽  
C. Toma ◽  
F. Arrich ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Anticancer Effects ◽  
Human Osteosarcoma Cells

scholarly journals GO-Y078, a Curcumin Analog, Induces Both Apoptotic Pathways in Human Osteosarcoma Cells via Activation of JNK and p38 Signaling

2021 ◽  
Vol 14 (6) ◽  
pp. 497
Author(s):  
Peace Wun-Ang Lu ◽  
Renn-Chia Lin ◽  
Jia-Sin Yang ◽  
Eric Wun-Hao Lu ◽  
Yi-Hsien Hsieh ◽  
...  
Keyword(s):  
Flow Cytometric Analysis ◽  
Annexin V ◽  
Metastatic Potential ◽  
Osteosarcoma Cells ◽  
Curcumin Analog ◽  
Term Survival ◽  
Human Osteosarcoma ◽  
Effector Caspase ◽  
Human Osteosarcoma Cells ◽  
Apoptotic Pathways

Osteosarcoma is the most common primary bone malignancy in teenagers and continues to confer a generally poor prognosis due to its highly metastatic potential. Poor solubility in water and instability of curcumin limits its bioavailability for use in the adjuvant situation to improve the prognosis and the long-term survival of patients with osteosarcoma. To further obtain information regarding the apoptosis induced by a new curcumin analog, GO-Y078, in human osteosarcoma cells, flow cytometric analysis, annexin V-FITC/PI apoptosis staining assay, human apoptosis array, and Western blotting were employed. GO-Y078 dose-dependently decreased viabilities of human osteosarcoma U2OS, MG-63, 143B, and Saos-2 cells and induced sub-G1 fraction arrest and apoptosis in U2OS and 143B cells. In addition to the effector caspase 3 and poly adenosine diphosphate-ribose polymerase, GO-Y078 significantly activated both initiators of extrinsic caspase 8 and intrinsic caspase 9, whereas cellular inhibitors of apoptosis 1 (cIAP-1) and X-chromosome-linked IAP (XIAP) in U2OS and 143B cells were significantly repressed. Moreover, GO-Y078 increased phosphorylation of extracellular signal-regulated protein kinases (ERK)1/2, c-Jun N-terminal kinases (JNK)1/2, and p38 in U2OS and 143B cells. Using inhibitors of JNK (JNK-in-8) and p38 (SB203580), GO-Y078′s increases in cleaved caspases 8, 9, and 3 could be expectedly suppressed, but they could not be affected by co-treatment with the ERK inhibitor (U0126). Altogether, GO-Y078 simultaneously induces both apoptotic pathways and cell arrest in U2OS and 143B cells through activating JNK and p38 signaling and repressing IAPs. These findings contribute to a better understanding of the mechanisms responsible for GO-Y078′s apoptotic effects on human osteosarcoma cells.

scholarly journals Ginsenoside Rg1 Drives Stimulations of Timosaponin AIII-Induced Anticancer Effects in Human Osteosarcoma Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Sang Yeol Lee
Keyword(s):  
Cell Migration ◽  
Ginsenoside Rg1 ◽  
Osteosarcoma Cells ◽  
Human Organ ◽  
Human Osteosarcoma ◽  
Anticancer Effects ◽  
Organ Systems ◽  
Human Osteosarcoma Cells ◽  
Mg63 Cells ◽  
Timosaponin Aiii

A ginsenoside Rg1 is an active compound extracted from the stem and/or root of ginseng. Rg1 has been known to affect various human organ systems including the immune, cardiovascular, and nervous systems with its pharmacological effects. Timosaponin AIII (TA3) is a type of spirostanol saponins that are the major compounds of Anemarrhena asphodeloides. TA3 exerts anticancer effects in various human cancers, and the effects include attenuations of cancer cell migration and induction of apoptosis. In this study, I report that Rg1 drives the stimulation of TA3-induced cytotoxic effects in MG63 human osteosarcoma cells. Rg1 stimulates TA3-induced apoptosis in MG63 cells via selective intensification of caspase-3 activation. Rg1 and TA3 synergistically induced antimetastatic effects such as attenuation of MG63 cell migration and inhibitions of matrix metalloproteinases (MMP-2 and MMP-9). Rg1 and TA3 synergistically suppressed JNK, p38, ERK, β-catenin, and CREB signaling, which are key regulators of cancer metastasis. Finally, the synergistic anticancer effects of Rg1 and TA3 were also observed in U2OS human osteosarcoma cells, and this may indicate that the synergy is not limited specifically to MG63 cells. The results presented here suggest that the combinatorial use of Rg1 and TA3 may be a promising way to develop an effective antiosteosarcoma agent.

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